The changing landscape of membrane protein structural biology through developments in electron microscopy.

Abstract:

:Membrane proteins are ubiquitous in biology and are key targets for therapeutic development. Despite this, our structural understanding has lagged behind that of their soluble counterparts. This review provides an overview of this important field, focusing in particular on the recent resurgence of electron microscopy (EM) and the increasing role it has to play in the structural studies of membrane proteins, and illustrating this through several case studies. In addition, we examine some of the challenges remaining in structural determination, and what steps are underway to enhance our knowledge of these enigmatic proteins.

journal_name

Mol Membr Biol

authors

Rawson S,Davies S,Lippiat JD,Muench SP

doi

10.1080/09687688.2016.1221533

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

12-22

issue

1-2

eissn

0968-7688

issn

1464-5203

journal_volume

33

pub_type

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