Abstract:
:Vascular-targeted drug delivery systems could provide more efficient and effective pharmaceutical interventions for treating a variety of diseases including cardiovascular, pulmonary, inflammatory, and malignant disorders. However, several factors must be taken into account when designing these systems. The diverse blood hemodynamics and rheology, and the natural clearance process that tend to decrease the circulation time of foreign particles all lessen the probability of successful carrier interaction with the vascular wall. An effective vascular-targeted drug delivery system must be able to navigate through the bloodstream while avoiding immune clearance, attach to the vascular wall, and release its therapeutic cargo at the intended location. This review will summarize and analyze current literature reporting on (1) nanocarrier fabrication methods and materials that allow for optimum therapeutic encapsulation, protection, and release; (2) localization and binding dynamics of nanocarriers as influenced by hemodynamics and blood rheology in medium-to-large vessels; (3) blood cells' responses to various types of nanocarrier compositions and its effects on particle circulation time; and (4) properties that affect nanocarrier internalization at the target site.
journal_name
Mol Membr Bioljournal_title
Molecular membrane biologyauthors
Huang RB,Mocherla S,Heslinga MJ,Charoenphol P,Eniola-Adefeso Odoi
10.3109/09687688.2010.499548subject
Has Abstractpub_date
2010-08-01 00:00:00pages
190-205issue
4-6eissn
0968-7688issn
1464-5203journal_volume
27pub_type
杂志文章,评审abstract::Neurotransmitter receptor trafficking in and out synapses has emerged as a key process to regulate synaptic transmission during synaptic development and plasticity both at excitatory and inhibitory synapses. Lateral diffusion of surface neurotransmitter receptors has recently emerged as a key pathway to regulate recep...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/09687680801958364
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abstract::Hereditary spherocytosis (HS), a common human inherited haemolytic anaemia, is associated with partial deficiency of different erythrocyte membrane proteins. In a subset of dominant HS, a partial membrane expression deficiency of band 3, the erythrocyte anion exchanger (AE1), have previously been characterized, and se...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.1080/096876899294526
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journal_title:Molecular membrane biology
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abstract::Eleven sequenced anion exchanger (AE; band 3) proteins, including five AE1, four AE2 and two AE3 proteins, comprise the anion exchanger family (AEF) of homologous proteins. Eliminating the rat and rabbit proteins that are nearly identical to the corresponding mouse proteins, seven dissimilar members of this family wer...
journal_title:Molecular membrane biology
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doi:10.3109/09687689509027507
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journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687688.2013.850178
更新日期:2013-12-01 00:00:00
abstract::In hair cells of the inner ear, phosphatidylserine (PS), detected with fluorescent annexin V labeling, was rapidly exposed on the external leaflet of apical plasma membranes upon dissection of the organ of Corti. PS externalization was unchanged by caspase inhibition, suggesting that externalization did not portend ap...
journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
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journal_title:Molecular membrane biology
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abstract::Dengue fever is one of the most widespread tropical diseases in the world. The disease is caused by a virus member of the Flaviviridae family, a group of enveloped positive sense single-stranded RNA viruses. Dengue virus infection is mediated by virus glycoprotein E, which binds to the cell surface. After uptake by en...
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journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/09687860500041411
更新日期:2005-01-01 00:00:00
abstract::At least four different types of interaction between protein transmembrane helices have been described to date. These include the use of charge-pair interactions that can play a positive or negative role in the assembly of multi-subunit complexes such as the T cell receptor, or recruit signal transducing accessory mol...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
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更新日期:1996-04-01 00:00:00
abstract::Modification of proteins with the lipid palmitate, a process called palmitoylation, is important for the normal function of neuronal cells. However, most attention has focused on how palmitoylation regulates the targeting and trafficking of neurotransmitter receptors and non-enzymatic scaffold proteins. In this review...
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更新日期:2015-08-01 00:00:00
abstract::A group of prenyltransferases produce linear lipids by catalyzing consecutive condensation reactions of farnesyl diphosphate (FPP) with specific numbers of isopentenyl diphosphate (IPP), a common building block of isoprenoid compounds. Depending on the stereochemistry of the double bonds formed during IPP condensation...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687688.2012.674162
更新日期:2012-11-01 00:00:00
abstract::Palmitoylation is required for the activities of several cancer-associated proteins, making the palmitoyl acyltransferase (PAT) enzymes that catalyze these reactions potential targets for anticancer therapeutics. In this study, we sought to identify and characterize a human PAT with activity toward N-terminally myrist...
journal_title:Molecular membrane biology
pub_type: 杂志文章
doi:10.3109/09687681003616854
更新日期:2010-04-01 00:00:00
abstract::The entry of substrates into, and the export of glururonides from, the lumen of hepatic endoplasmic reticulum (ER) in vitro (sealed microsomes) has been measured using radioactivity-labelled materials and a rapid filtration assay. Analysis of liver microsomes from a jaundiced patient showed the accumulation of bilirub...
journal_title:Molecular membrane biology
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doi:10.3109/09687689509072429
更新日期:1995-07-01 00:00:00
abstract::A lactate permease was biochemically identified in Candida albicans RM1000 presenting the following kinetic parameters at pH 5.0: Km 0.33+/-0.09 mM and Vmax 0.85+/-0.06 nmol s(-1) mg dry wt(-1). Lactate uptake was competitively inhibited by pyruvic and propionic acids; acetic acid behaved as a non-competitive substrat...
journal_title:Molecular membrane biology
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doi:10.1080/09687860400011373
更新日期:2004-11-01 00:00:00
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journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.1080/09687688.2016.1221533
更新日期:2016-03-01 00:00:00
abstract::The peptide specificity of both presequence-monolayer interactions and the ability of presequences to induce interbilayer contacts between large unilamellar vesicles was investigated. A range of different synthetic peptides that are documented for their mitochondrial protein import abilities were used for this purpose...
journal_title:Molecular membrane biology
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doi:10.3109/09687689409162234
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abstract::ADP-ribosylation factor related protein 1 (ARFRP1) is a member of the ARF-family of GTPases which operate as molecular switches in the regulation of intracellular protein traffic. Deletion of the mouse Arfrp1 gene leads to embryonic lethality during early gastrulation, suggesting that ARFRP1 is required for cell adhes...
journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
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abstract::Glycosyl-phosphatidylinositol (GPI)-anchored proteins are enriched in cholesterol- and sphingolipid-rich lipid rafts within the membrane. Rafts are known to have roles in cellular organization and function, but little is understood about the factors controlling the distribution of proteins in rafts. We have used atomi...
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journal_title:Molecular membrane biology
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更新日期:2007-09-01 00:00:00
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journal_title:Molecular membrane biology
pub_type: 杂志文章
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更新日期:2011-08-01 00:00:00
abstract::Treatment of BHK fibroblasts with V. cholerae sialidase for 20 min caused the breakdown of about 70% of total cellular ganglioside GM3 and the production of an approximately equivalent amount of lactosylceramide. On removal of the enzyme, a slow resynthesis of GM3 from lactosylceramide was observed, equivalent to abou...
journal_title:Molecular membrane biology
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更新日期:1998-10-01 00:00:00
abstract::We have previously shown that a mixture of cerebrosides obtained from dried tubers of herb Typhonium giganteum Engl. plays a neuroprotective role in the ischemic brain through its effect on activation of BK(Ca) channels. It is very curious to know whether a single pure cerebroside compound could activate the BK(Ca) ch...
journal_title:Molecular membrane biology
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abstract::Organellar and cytosolic pH homeostasis is central to most cellular processes, including vesicular trafficking, post-translational modification/processing of proteins, and receptor-ligand interactions. SLC9A7 (NHE7) was identified as a unique (Na+, K+)/H+ exchanger that dynamically cycles between the trans-Golgi netwo...
journal_title:Molecular membrane biology
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abstract::The number of Signal Peptidase I (SPasel) molecules per E. coli cell was determined using western blot techniques. Different strains were found to contain approximately 1000 SPasel molecules per cell during exponential growth. Based on the activity of SPasel in vitro it could be estimated that this amount is sufficien...
journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
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abstract::Previous work from our laboratory has established bovine hippocampal membranes as a convenient natural source for studying neuronal receptors such as the G-protein coupled serotonin1A receptor. In this paper, we have explored the organization and dynamics of bovine hippocampal membranes using environment-sensitive and...
journal_title:Molecular membrane biology
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