DHHC20: a human palmitoyl acyltransferase that causes cellular transformation.

abstract：:Nanoparticles present a new collection of contrast agents for the field of in vivo molecular imaging. This review focuses on promising molecular imaging probes for optical and magnetic resonance imaging based on four representative nanomaterial(s) platforms: quantum dots, upconversion phosphors, superparamagnetic iron...

journal_title：Molecular membrane biology

authors： Rosenblum LT,Kosaka N,Mitsunaga M,Choyke PL,Kobayashi H

更新日期：2010-10-01 00:00:00

abstract：:Time and distance scales in membranes are discussed in relation to the inference of domain structure from spectroscopic measurements. Each type of spectroscopy has a natural time scale set by the magnitude of the interactions that determine the spectral width. For fluid membranes, the lateral diffusion of the lipid mo...

journal_title：Molecular membrane biology

authors： Bloom M,Thewalt JL

更新日期：1995-01-01 00:00:00

abstract：:Lipid rafts are specialized plasma membrane microdomains in which glycosphingolipids and cholesterol are major structural components. Their relative insolubility to nonionic detergents is the most widely used method to purify these structures. Several signalling proteins are associated with these microdomains in T lym...

journal_title：Molecular membrane biology

authors： Salgado FJ,Piñeiro A,Canda-Sánchez A,Lojo J,Nogueira M

更新日期：2005-05-01 00:00:00

abstract：:Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated C1(-) channel. Malfunction of CFTR causes cystic fibrosis (CF). CFTR belongs to an ATP-binding cassette (ABC) transporter superfamily which includes P-glycoprotein (Pgp), the molecule that is responsible for multidrug resistance in cancer c...

journal_title：Molecular membrane biology

authors： Chen M,Zhang JT

更新日期：1996-01-01 00:00:00

abstract：:Eleven sequenced anion exchanger (AE; band 3) proteins, including five AE1, four AE2 and two AE3 proteins, comprise the anion exchanger family (AEF) of homologous proteins. Eliminating the rat and rabbit proteins that are nearly identical to the corresponding mouse proteins, seven dissimilar members of this family wer...

journal_title：Molecular membrane biology

authors： Espanol MJ,Saier MH Jr

更新日期：1995-04-01 00:00:00

abstract：:The transverse distribution of phosphatidylglycerol (PG) across the inner membrane of Escherichia coli was studied. The oxidation of PG by periodate was used to discriminate between the PG present in the cytoplasmic and in the periplasmic leaflet of the inner membrane. Applied to large unilamellar vesicles derived of ...

journal_title：Molecular membrane biology

authors： Huijbregts RP,de Kroon AI,de Kruijff B

更新日期：1997-01-01 00:00:00

abstract：:Gap junctions are plasma membrane spatial microdomains constructed of assemblies of channel proteins called connexins in vertebrates and innexins in invertebrates. The channels provide direct intercellular communication pathways allowing rapid exchange of ions and metabolites up to approximately 1 kD in size. Approxim...

journal_title：Molecular membrane biology

authors： Evans WH,Martin PE

更新日期：2002-04-01 00:00:00

abstract：:Small GTPase Rab36 is homologous to Rab34 with 56% amino acid sequence identity. Rab34 was characterized as a Golgi-associated Rab protein and regulates lysosomal positioning through interaction with RILP; however, the properties and functions of Rab36 have not been investigated. To investigate Rab36, we constructed E...

journal_title：Molecular membrane biology

authors： Chen L,Hu J,Yun Y,Wang T

更新日期：2010-01-01 00:00:00

abstract：:TGN38 is a heavily glycosylated, type I integral membrane protein which is predominantly localized to the trans Golgi network (TGN), but which constitutively traffics between the TGN and the cell surface. The trafficking of TGN38 has been extensively studied in non-polarized cells, and a short, tyrosine-based, peptide...

journal_title：Molecular membrane biology

authors： Reaves BJ,Roquemore EP,Luzio JP,Banting G

更新日期：1998-07-01 00:00:00

abstract：:Elucidating the detailed mechanism of activation of membrane protein receptors and their ligand binding is essential for structure-based drug design. Membrane protein crystal structure analysis successfully aids in understanding these fundamental molecular interactions. However, protein crystal structure analysis of t...

journal_title：Molecular membrane biology

authors： Hirozane Y,Motoyaji T,Maru T,Okada K,Tarui N

更新日期：2014-08-01 00:00:00

abstract：:Amiodarone (AMI) is a low water-solubility drug, which is very useful in the treatment of severe cardiac disease. Its adverse effects are associated with toxicity in different tissues. Several antioxidants have been shown to reduce, and prevent AMI toxicity. The aim of this work was to develop and characterize Dimyris...

journal_title：Molecular membrane biology

authors： Benedini L,Antollini S,Fanani ML,Palma S,Messina P,Schulz P

更新日期：2014-03-01 00:00:00

abstract：:Constitutive secretion is used to deliver newly synthesized proteins to the cell surface and to the extracellular milieu. The trans-Golgi network is a key station along this route that mediates sorting of proteins into distinct transport pathways, aided in part by clathrin and adaptor proteins. Subsequent movement of ...

journal_title：Molecular membrane biology

authors： Ponnambalam S,Baldwin SA

更新日期：2003-04-01 00:00:00

abstract：:A group of prenyltransferases produce linear lipids by catalyzing consecutive condensation reactions of farnesyl diphosphate (FPP) with specific numbers of isopentenyl diphosphate (IPP), a common building block of isoprenoid compounds. Depending on the stereochemistry of the double bonds formed during IPP condensation...

journal_title：Molecular membrane biology

authors： Teng KH,Liang PH

更新日期：2012-11-01 00:00:00

abstract：:Ionotropic glutamate receptors belong to the superfamily of P-loop channels as well as K(+), Na(+), and Ca(2+) channels. However, the structural similarity between ion channels of the glutamate receptors and K(+) channels is a matter of discussion. The aim of this study was to analyze differences between the structure...

journal_title：Molecular membrane biology

authors： Tikhonov DB

更新日期：2007-03-01 00:00:00

abstract：:This review describes the numerous and innovative methods used to study the structure and function of viral fusion peptides. The systems studied include both intact fusion proteins and synthetic peptides interacting with model membranes. The strategies and methods include dissecting the fusion process into intermediat...

journal_title：Molecular membrane biology

authors： Durell SR,Martin I,Ruysschaert JM,Shai Y,Blumenthal R

更新日期：1997-07-01 00:00:00

abstract：:Recent advances have revealed much about the signaling events and molecular components associated with autophagy. Although it is clear that there are multiple points of intersection and connection between autophagy and known vesicular membrane transport processes between membrane compartments, autophagy is modulated b...

journal_title：Molecular membrane biology

authors： Chan SN,Tang BL

更新日期：2013-12-01 00:00:00

abstract：:PagP is a bacterial outer membrane protein consisting of an 8 stranded transmembrane beta-barrel and an N-terminal alpha-helix. It is an enzyme which catalyses transfer of a palmitoyl chain from a phospholipid to lipid A. Molecular dynamics simulations have been used to compare the dynamic behaviour in simulations sta...

journal_title：Molecular membrane biology

authors： Cox K,Sansom MS

更新日期：2009-05-01 00:00:00

abstract：:Membrane proteins are ubiquitous in biology and are key targets for therapeutic development. Despite this, our structural understanding has lagged behind that of their soluble counterparts. This review provides an overview of this important field, focusing in particular on the recent resurgence of electron microscopy ...

journal_title：Molecular membrane biology

authors： Rawson S,Davies S,Lippiat JD,Muench SP

更新日期：2016-03-01 00:00:00

abstract：:The entry of substrates into, and the export of glururonides from, the lumen of hepatic endoplasmic reticulum (ER) in vitro (sealed microsomes) has been measured using radioactivity-labelled materials and a rapid filtration assay. Analysis of liver microsomes from a jaundiced patient showed the accumulation of bilirub...

journal_title：Molecular membrane biology

authors： Waddell ID,Robertson K,Burchell A,Hume R,Burchell B

更新日期：1995-07-01 00:00:00

abstract：:The transporter SbtA is a high affinity Na+-dependent HCO3- uptake system present in a majority of cyanobacterial clades. It functions in conjunction with CO2 uptake systems and other HCO3- uptake systems to allow cyanobacteria to accumulate high levels of HCO3- used to support efficient photosynthetic CO2 fixation vi...

journal_title：Molecular membrane biology

authors： Price GD,Shelden MC,Howitt SM

更新日期：2011-08-01 00:00:00

abstract：:Neurotransmitter transporters are regulated through a variety of signal transduction mechanisms which appear to operate in order to maintain appropriate levels of transmitter in the synaptic cleft. One such mechanism is the trafficking of the transporter in association with synaptic vesicle release machinery. This rep...

journal_title：Molecular membrane biology

authors： Horton N,Quick MW

更新日期：2001-01-01 00:00:00

abstract：:The eukaryotic endomembrane system (ES) is served by hundreds of dedicated proteins. Experimental characterization of the ES-associated molecular machinery in several model eukaryotes complemented by a recent progress in phylogenomics and comparative genomics have revealed a conserved complex core of the machinery tha...

journal_title：Molecular membrane biology

authors： Elias M

更新日期：2010-11-01 00:00:00

abstract：:We have previously shown that a mixture of cerebrosides obtained from dried tubers of herb Typhonium giganteum Engl. plays a neuroprotective role in the ischemic brain through its effect on activation of BK(Ca) channels. It is very curious to know whether a single pure cerebroside compound could activate the BK(Ca) ch...

journal_title：Molecular membrane biology

authors： Xu H,Qi J,Wang G,Deng H,Qi Z

更新日期：2011-02-01 00:00:00

abstract：:2B is a 99 amino acid membrane protein encoded by enteroviruses such as polio and coxsackie viruses with two transmembrane domains. The protein is found to make membranes of infected cells permeable. Using a computational approach which positions the models and assesses stability by molecular dynamics (MD) simulations...

journal_title：Molecular membrane biology

authors： Patargias G,Barke T,Watts A,Fischer WB

更新日期：2009-08-01 00:00:00

abstract：:Glu-269, which is located on the hydrophilic face of putative helix VIII in the lactose permease of Escherichia coli, has been replaced with Asp, Gln or Cys by oligonucleotide-directed, site specific mutagenesis. Cells expressing Asp-269 permease exhibit no lactose accumulation or lactose-induced H+ translocation, but...

journal_title：Molecular membrane biology

authors： Ujwal ML,Sahin-Tóth M,Persson B,Kaback HR

更新日期：1994-01-01 00:00:00

abstract：:Membrane microdomains enriched in cholesterol, sphingolipids (rafts), and specific proteins are involved in important physiological functions. However their structure, size and stability are still controversial. Given that detergent-resistant membranes (DRMs) are in the liquid-ordered state and are rich in raft-like c...

journal_title：Molecular membrane biology

authors： Casadei BR,De Oliveira Carvalho P,Riske KA,Barbosa Rde M,De Paula E,Domingues CC

更新日期：2014-09-01 00:00:00

abstract：:The present review introduces the concept of 'non-permanent membrane proteins', to encompass the wide variety of proteins that are not found in a stable membrane-bound form under physiological conditions, yet they interact with the membrane at some stage of their specific course of action. Non-permanent membrane prote...

journal_title：Molecular membrane biology

authors： Goñi FM

更新日期：2002-10-01 00:00:00

abstract：:Trypsin activation of Cry4B, a 130-kDa Bacillus thuringiensis (Bt) protein, produces a 65-kDa toxin active against mosquito larvae. The active toxin is made of two protease resistant-products of ca. 45 kDa and ca. 20 kDa. The cloned 21-kDa fragment consisting of the N-terminal region of the toxin was previously shown ...

journal_title：Molecular membrane biology

authors： Puntheeranurak T,Uawithya P,Potvin L,Angsuthanasombat C,Schwartz JL

更新日期：2004-01-01 00:00:00

abstract：:Notch receptor signalling plays a central role in development and its misfunction has been linked to a number of diseases. In the cannonical Notch signalling pathway, ligand binding to Notch activates a series of proteolytic cleavages that release the Notch intracellular domain for trafficking to the nucleus, where it...

journal_title：Molecular membrane biology

authors： Wilkin MB,Baron M

更新日期：2005-07-01 00:00:00

abstract：:The ATP binding cassette (ABC) transporter Atm1p of the mitochondrial inner membrane performs crucial roles in both the biogenesis of cytosolic/nuclear iron-sulfur proteins and cellular iron homeostasis. Since the function of the mitochondrial iron-sulfur cluster (ISC) assembly machinery is also required for these two...

journal_title：Molecular membrane biology

authors： Kuhnke G,Neumann K,Mühlenhoff U,Lill R

更新日期：2006-03-01 00:00:00