Abstract:
:Recent advances have revealed much about the signaling events and molecular components associated with autophagy. Although it is clear that there are multiple points of intersection and connection between autophagy and known vesicular membrane transport processes between membrane compartments, autophagy is modulated by a distinct set of molecular components, and the autophagosome has a unique membrane composition. A key question that has yet to be resolved with regards to autophagosome formation is its membrane source. Various evidences have indicated that membranes from the endoplasmic reticulum (ER), mitochondria, Golgi, endosomes and the plasma membrane could all potentially act as a source of autophagosomal membrane in non-specialized macroautophagy. Recent investigations have generated advances in terms of the mitochondria's involvement in starvation-induced autophagy, and refined localization of autophagosome formation to ER-mitochondria contact sites. On the other hand, data accumulates on the delivery of membrane sources to the pre-autophagosome structure by Atg9-containing mobile carriers, which likely originated from the Golgi-endosome system. The answer to the question on the origin of membrane materials for autophagosome biogenesis awaits further reconciliation of these different findings.
journal_name
Mol Membr Bioljournal_title
Molecular membrane biologyauthors
Chan SN,Tang BLdoi
10.3109/09687688.2013.850178subject
Has Abstractpub_date
2013-12-01 00:00:00pages
394-402issue
8eissn
0968-7688issn
1464-5203journal_volume
30pub_type
杂志文章abstract::At least four different types of interaction between protein transmembrane helices have been described to date. These include the use of charge-pair interactions that can play a positive or negative role in the assembly of multi-subunit complexes such as the T cell receptor, or recruit signal transducing accessory mol...
journal_title:Molecular membrane biology
pub_type: 杂志文章,评审
doi:10.3109/09687689609160579
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journal_title:Molecular membrane biology
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doi:10.3109/09687689709044325
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journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
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journal_title:Molecular membrane biology
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