Abstract:
:2B is a 99 amino acid membrane protein encoded by enteroviruses such as polio and coxsackie viruses with two transmembrane domains. The protein is found to make membranes of infected cells permeable. Using a computational approach which positions the models and assesses stability by molecular dynamics (MD) simulations a putative tetrameric bundle model of 2B is generated. The bundles show a pore lining motif of three lysines followed by a serine. The bundle is discussed in terms of different possible orientations of the helices in the membrane and the consequences this has on the in vivo activity of 2B.
journal_name
Mol Membr Bioljournal_title
Molecular membrane biologyauthors
Patargias G,Barke T,Watts A,Fischer WBdoi
10.1080/09687680903164101subject
Has Abstractpub_date
2009-08-01 00:00:00pages
309-20issue
5eissn
0968-7688issn
1464-5203pii
914173869journal_volume
26pub_type
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