Light-sensitive lipid-based nanoparticles for drug delivery: design principles and future considerations for biological applications.

abstract：:Spontaneous membrane adsorption, folding and insertion of the synthetic WALP16 and KALP16 peptides was studied by computer simulations starting from completely extended conformations. The peptides were simulated using an unmodified all-atom force field in combination with an efficient Monte Carlo sampling algorithm. T...

journal_title：Molecular membrane biology

authors： Ulmschneider MB,Ulmschneider JP

更新日期：2008-04-01 00:00:00

abstract：:Amiodarone (AMI) is a low water-solubility drug, which is very useful in the treatment of severe cardiac disease. Its adverse effects are associated with toxicity in different tissues. Several antioxidants have been shown to reduce, and prevent AMI toxicity. The aim of this work was to develop and characterize Dimyris...

journal_title：Molecular membrane biology

authors： Benedini L,Antollini S,Fanani ML,Palma S,Messina P,Schulz P

更新日期：2014-03-01 00:00:00

abstract：:Glu-269, which is located on the hydrophilic face of putative helix VIII in the lactose permease of Escherichia coli, has been replaced with Asp, Gln or Cys by oligonucleotide-directed, site specific mutagenesis. Cells expressing Asp-269 permease exhibit no lactose accumulation or lactose-induced H+ translocation, but...

journal_title：Molecular membrane biology

authors： Ujwal ML,Sahin-Tóth M,Persson B,Kaback HR

更新日期：1994-01-01 00:00:00

abstract：:Intracellular pH was measured with the pH-sensitive fluorescent probe BCECF in spinal cord neurones cultured from rat embryos. At an external pH of 7.3, the average steady-state pHi was 7.18 +/- 0.03 (SEM, n = 97) and 7.02 +/- 0.01 (n = 221) in HEPES-buffered and in bicarbonate-buffered medium, respectively. In both e...

journal_title：Molecular membrane biology

authors： Brechenmacher C,Rodeau JL

更新日期：2000-04-01 00:00:00

abstract：:A group of prenyltransferases produce linear lipids by catalyzing consecutive condensation reactions of farnesyl diphosphate (FPP) with specific numbers of isopentenyl diphosphate (IPP), a common building block of isoprenoid compounds. Depending on the stereochemistry of the double bonds formed during IPP condensation...

journal_title：Molecular membrane biology

authors： Teng KH,Liang PH

更新日期：2012-11-01 00:00:00

abstract：:Gap junctions are plasma membrane spatial microdomains constructed of assemblies of channel proteins called connexins in vertebrates and innexins in invertebrates. The channels provide direct intercellular communication pathways allowing rapid exchange of ions and metabolites up to approximately 1 kD in size. Approxim...

journal_title：Molecular membrane biology

authors： Evans WH,Martin PE

更新日期：2002-04-01 00:00:00

abstract：:The ATP binding cassette (ABC) transporter Atm1p of the mitochondrial inner membrane performs crucial roles in both the biogenesis of cytosolic/nuclear iron-sulfur proteins and cellular iron homeostasis. Since the function of the mitochondrial iron-sulfur cluster (ISC) assembly machinery is also required for these two...

journal_title：Molecular membrane biology

authors： Kuhnke G,Neumann K,Mühlenhoff U,Lill R

更新日期：2006-03-01 00:00:00

abstract：:The transverse distribution of phosphatidylglycerol (PG) across the inner membrane of Escherichia coli was studied. The oxidation of PG by periodate was used to discriminate between the PG present in the cytoplasmic and in the periplasmic leaflet of the inner membrane. Applied to large unilamellar vesicles derived of ...

journal_title：Molecular membrane biology

authors： Huijbregts RP,de Kroon AI,de Kruijff B

更新日期：1997-01-01 00:00:00

abstract：:Eleven sequenced anion exchanger (AE; band 3) proteins, including five AE1, four AE2 and two AE3 proteins, comprise the anion exchanger family (AEF) of homologous proteins. Eliminating the rat and rabbit proteins that are nearly identical to the corresponding mouse proteins, seven dissimilar members of this family wer...

journal_title：Molecular membrane biology

authors： Espanol MJ,Saier MH Jr

更新日期：1995-04-01 00:00:00

abstract：:4-Hydroxy-2-nonenal (4-HNE) is a reactive aldehyde and a lipid peroxidation product formed in biological tissues under physiological and pathological conditions. Its concentration increases with oxidative stress and induces deleterious modifications of proteins and membranes. Mitochondrial and cytosolic isoforms of cr...

journal_title：Molecular membrane biology

authors： Maniti O,François-Moutal L,Lecompte MF,Vial C,Lagarde M,Guichardant M,Marcillat O,Granjon T

更新日期：2015-01-01 00:00:00

abstract：:At least four different types of interaction between protein transmembrane helices have been described to date. These include the use of charge-pair interactions that can play a positive or negative role in the assembly of multi-subunit complexes such as the T cell receptor, or recruit signal transducing accessory mol...

journal_title：Molecular membrane biology

authors： Harrison PT

更新日期：1996-04-01 00:00:00

abstract：:Lipid rafts are specialized plasma membrane microdomains in which glycosphingolipids and cholesterol are major structural components. Their relative insolubility to nonionic detergents is the most widely used method to purify these structures. Several signalling proteins are associated with these microdomains in T lym...

journal_title：Molecular membrane biology

authors： Salgado FJ,Piñeiro A,Canda-Sánchez A,Lojo J,Nogueira M

更新日期：2005-05-01 00:00:00

abstract：:Neurotransmitter receptor trafficking in and out synapses has emerged as a key process to regulate synaptic transmission during synaptic development and plasticity both at excitatory and inhibitory synapses. Lateral diffusion of surface neurotransmitter receptors has recently emerged as a key pathway to regulate recep...

journal_title：Molecular membrane biology

authors： Groc L,Choquet D

更新日期：2008-05-01 00:00:00

abstract：:Vascular-targeted drug delivery systems could provide more efficient and effective pharmaceutical interventions for treating a variety of diseases including cardiovascular, pulmonary, inflammatory, and malignant disorders. However, several factors must be taken into account when designing these systems. The diverse bl...

journal_title：Molecular membrane biology

authors： Huang RB,Mocherla S,Heslinga MJ,Charoenphol P,Eniola-Adefeso O

更新日期：2010-08-01 00:00:00

abstract：:The mitochondrial ADP/ATP carrier imports ADP from the cytosol into the mitochondrial matrix for its conversion to ATP by ATP synthase and exports ATP out of the mitochondrion to replenish the eukaryotic cell with chemical energy. Here the substrate specificity of the human mitochondrial ADP/ATP carrier AAC1 was deter...

journal_title：Molecular membrane biology

authors： Mifsud J,Ravaud S,Krammer EM,Chipot C,Kunji ER,Pebay-Peyroula E,Dehez F

更新日期：2013-03-01 00:00:00

abstract：:Constitutive secretion is used to deliver newly synthesized proteins to the cell surface and to the extracellular milieu. The trans-Golgi network is a key station along this route that mediates sorting of proteins into distinct transport pathways, aided in part by clathrin and adaptor proteins. Subsequent movement of ...

journal_title：Molecular membrane biology

authors： Ponnambalam S,Baldwin SA

更新日期：2003-04-01 00:00:00

abstract：:This review describes the numerous and innovative methods used to study the structure and function of viral fusion peptides. The systems studied include both intact fusion proteins and synthetic peptides interacting with model membranes. The strategies and methods include dissecting the fusion process into intermediat...

journal_title：Molecular membrane biology

authors： Durell SR,Martin I,Ruysschaert JM,Shai Y,Blumenthal R

更新日期：1997-07-01 00:00:00

abstract：:Equilibrative Nucleoside Transporters (SLC29) are a family of proteins that transport nucleosides, nucleobases and nucleoside analogue drugs across cellular membranes. ENT1 is expressed ubiquitously in mammalian tissues and responsible for a significant portion of nucleoside analog drug uptake in humans. Despite the i...

journal_title：Molecular membrane biology

authors： Reyes G,Nivillac NM,Karim MZ,Desouza L,Siu KW,Coe IR

更新日期：2011-09-01 00:00:00

abstract：:Calpain, an intracellular calcium-dependent protease, is activated at cell membranes and cleaves cytoskeletal and submembranous proteins. Calpain is inferred to be a calcium-dependent regulator for cytoskeletal reorganization. Calpastatin, an endogenous calpain inhibitor, inhibits not only the proteolytic activity of ...

journal_title：Molecular membrane biology

authors： Kawasaki H,Kawashima S

更新日期：1996-10-01 00:00:00

abstract：:The eukaryotic endomembrane system (ES) is served by hundreds of dedicated proteins. Experimental characterization of the ES-associated molecular machinery in several model eukaryotes complemented by a recent progress in phylogenomics and comparative genomics have revealed a conserved complex core of the machinery tha...

journal_title：Molecular membrane biology

authors： Elias M

更新日期：2010-11-01 00:00:00

abstract：:Caveolae are approximately 50-100 nm membrane micro-invaginations associated with the plasma membrane of a wide variety of cells. Although they were first identified in transmission electron micrographs approximately 40 years ago, their exact function(s) has remained controversial. Two well-established functions inclu...

journal_title：Molecular membrane biology

authors： Lisanti MP,Tang Z,Scherer PE,Kübler E,Koleske AJ,Sargiacomo M

更新日期：1995-01-01 00:00:00

abstract：:2B is a 99 amino acid membrane protein encoded by enteroviruses such as polio and coxsackie viruses with two transmembrane domains. The protein is found to make membranes of infected cells permeable. Using a computational approach which positions the models and assesses stability by molecular dynamics (MD) simulations...

journal_title：Molecular membrane biology

authors： Patargias G,Barke T,Watts A,Fischer WB

更新日期：2009-08-01 00:00:00

abstract：:The molecular events and the protein components that are involved in signalling by the T cell receptor (TCR) for antigen have been extensively studied. Activation of signalling cascades following TCR stimulation depends on the phosphorylation of the receptor by the tyrosine kinase Lck, which localizes to the cytoplasm...

journal_title：Molecular membrane biology

authors： Kabouridis PS

更新日期：2006-01-01 00:00:00

abstract：:Dengue fever is one of the most widespread tropical diseases in the world. The disease is caused by a virus member of the Flaviviridae family, a group of enveloped positive sense single-stranded RNA viruses. Dengue virus infection is mediated by virus glycoprotein E, which binds to the cell surface. After uptake by en...

journal_title：Molecular membrane biology

authors： Stauffer F,Melo MN,Carneiro FA,Sousa FJ,Juliano MA,Juliano L,Mohana-Borges R,Da Poian AT,Castanho MA

更新日期：2008-02-01 00:00:00

abstract：:Numerous cell surface receptors propagate activation signals to the interior of the cell via tyrosine phosphorylation of transmembrane proteins. This leads to the phosphotyrosine (PiY)-mediated recruitment of cytoplasmic signalling protein complexes which catalyze crucial biochemical signalling reactions. Here we desc...

journal_title：Molecular membrane biology

authors： Sangani D,Venien-Bryan C,Harder T

更新日期：2009-04-01 00:00:00

abstract：:Trypsin activation of Cry4B, a 130-kDa Bacillus thuringiensis (Bt) protein, produces a 65-kDa toxin active against mosquito larvae. The active toxin is made of two protease resistant-products of ca. 45 kDa and ca. 20 kDa. The cloned 21-kDa fragment consisting of the N-terminal region of the toxin was previously shown ...

journal_title：Molecular membrane biology

authors： Puntheeranurak T,Uawithya P,Potvin L,Angsuthanasombat C,Schwartz JL

更新日期：2004-01-01 00:00:00

abstract：:The Amt/Mep/Rh family of integral membrane proteins comprises ammonium transporters of bacteria, archaea and eukarya, as well as the Rhesus proteins found in animals. They play a central role in the uptake of reduced nitrogen for biosynthetic purposes, in energy metabolism, or in renal excretion. Recent structural inf...

journal_title：Molecular membrane biology

authors： Andrade SL,Einsle O

更新日期：2007-09-01 00:00:00

abstract：:PagP is a bacterial outer membrane protein consisting of an 8 stranded transmembrane beta-barrel and an N-terminal alpha-helix. It is an enzyme which catalyses transfer of a palmitoyl chain from a phospholipid to lipid A. Molecular dynamics simulations have been used to compare the dynamic behaviour in simulations sta...

journal_title：Molecular membrane biology

authors： Cox K,Sansom MS

更新日期：2009-05-01 00:00:00

abstract：:TGN38 is a heavily glycosylated, type I integral membrane protein which is predominantly localized to the trans Golgi network (TGN), but which constitutively traffics between the TGN and the cell surface. The trafficking of TGN38 has been extensively studied in non-polarized cells, and a short, tyrosine-based, peptide...

journal_title：Molecular membrane biology

authors： Reaves BJ,Roquemore EP,Luzio JP,Banting G

更新日期：1998-07-01 00:00:00

abstract：:The serotonin1A (5-HT1A) receptors are members of a superfamily of seven transmembrane domain receptors that couple to G-proteins. They appear to be involved in various behavioural and cognitive functions. This paper reports an efficient strategy to solubilize 5-HT1A receptors from bovine hippocampal membranes using t...

journal_title：Molecular membrane biology

authors： Chattopadhyay A,Harikumar KG,Kalipatnapu S

更新日期：2002-07-01 00:00:00