解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Plasma and liver lipids were studied in male weanling rats fed diets containing moderate levels of fat (6% by weight) as sunflower oil (SF diet, rich in linoleic acid), salmon oil (SM diet, rich in long-chain n-3 fatty acids), or a blend of peanut and rapeseed oil (PR diet, rich in oleic acid). After nine weeks of fee...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02522983
更新日期:1996-08-01 00:00:00
abstract::31P Nuclear magnetic resonance (NMR) spectra of human erythrocyte lysates dissolved in sodium cholate were acquired. The narrow resonances of phospholipids were mostly well resolved, allowing identification and accurate quantitative analysis of phospholipid classes of the erythrocyte membranes. The ether-linked phosph...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02522893
更新日期:1996-07-01 00:00:00
abstract::Wistar male rats were treated for six days with broad spectrum beta-lactam antibiotics, latamoxef, and cefotaxime. On the seventh day, the number of fecal anaerobic microbes decreased, total fecal bile acids decreased, and bile acid pools increased. Secondary bile acids such as beta-hyocholic, hyodeoxycholic, lithocho...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02523830
更新日期:1996-06-01 00:00:00
abstract::Material dealing with the chemistry, biochemistry, and biological activities of oxysterols is reviewed for the period 1987-1995. Particular attention is paid to the presence of oxysterols in tissues and foods and to their physiological relevance. ...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02522641
更新日期:1996-05-01 00:00:00
abstract::The all-cis-5,9,12-heptadecatrienoic acid was identified in the cellular slime mold Polysphondylium pallidum. The structural elucidation was accomplished by capillary gas chromatography, argentation thin-layer chromatography, and gas chromatography/mass spectrometry. This fatty acid has not been reported previously. ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02522934
更新日期:1996-04-01 00:00:00
abstract::By in vivo and in vitro studies of L-(3-3H)serine and [9,10(n)-3H]palmitic acid incorporation into phospholipids, we show a change in the renewal of the ceramide moiety of sphingomyelin in the gills of euryhaline fish (sea bass and eels) when the animals were subjected to abrupt alterations in environmental salinity. ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02522924
更新日期:1996-04-01 00:00:00
abstract::The effect of hydroperoxy and hydroxy derivatives of various fatty acids on human platelet aggregation was determined to delineate potencies and structure-activity function. In this regard, the 22-carbon n-3 fatty acids are the most potent inhibitors in comparison to the n-6 lipoxygenase derivatives. Submicromolar lev...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02637097
更新日期:1996-03-01 00:00:00
abstract::Skeletal muscle plays a major role in insulin-stimulated glucose disposal. This paper reviews the range of evidence in humans and experimental animals demonstrating close associations between insulin action and two major aspects of muscle morphology: fatty acid composition of the major structural lipid (phospholipid) ...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02637087
更新日期:1996-03-01 00:00:00
abstract::The beta-adrenergic system in cardiac muscle cells is influenced by the n-3 polyunsaturated fatty acid (PUFA) content in cell membranes. This study deals with the specific effect of docosahexaenoic acid (DHA) as compared to other n-3 PUFA, without modification of the arachidonic acid content. Increasing the DHA conten...
journal_title:Lipids
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract::A patient with classic Zellweger syndrome was treated with docosahexaenoic acid ethyl ester (DHA-EE) for three months. Five other patients with Zellweger variants (four of them less than one-year-old and a five-year-old) were treated with DHA-EE until normalization of the DHA levels in erythrocytes. When arachidonic a...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02637067
更新日期:1996-03-01 00:00:00
abstract::Among many factors, elevated lipids and lipid peroxide levels in blood are major risk factors in the development of cardiovascular disease in diabetic patients. This study has examined whether oral supplementation of vitamin E, an antioxidant, has any effect on blood lipid peroxidation products (LP) and lipid profile ...
journal_title:Lipids
pub_type: 临床试验,杂志文章
doi:10.1007/BF02637057
更新日期:1996-03-01 00:00:00
abstract::Insulin and dietary fructose independently induce stearoyl-CoA desaturase 1 (SCD1) gene expression in diabetic mouse liver. In the present study, we again used diabetic mice and supplemented a high fructose diet with polyunsaturated fatty acids (PUFA) to determine the selective repression of SCD1 gene expression by di...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02637047
更新日期:1996-03-01 00:00:00
abstract::Fatty acid composition of plasma phospholipids (PL), triglycerides (TG), and sterol esters (STE) was determined by high-resolution capillary gas-liquid chromatography in 22 obese children (age: 13.7 +/- 1.4 y, body weight relative to normal weight for height: 170 +/- 24%, mean +/- SD) and compared with data obtained i...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02529877
更新日期:1996-03-01 00:00:00
abstract::Six oils of marine, algal, and microbial origin were analyzed for stereospecific distribution of component fatty acids. The general procedure involved preparation of sn-1,2-(2,3)-diacylglycerols by partial deacylation with ethylmagnesium bromide or pancreatic lipase, separation of X-1,3- and sn-1,2(2,3)-diacylglycerol...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02522622
更新日期:1996-02-01 00:00:00
abstract::Growth hormone (GH) has many metabolic effects, but its mechanism(s) of action are not fully understood. We studied the short-term effects of endogenously produced GH on liver delta 6-desaturase activity and adipose and liver lipid fraction fatty acid composition in transgenic mice. MG101 transgenic mice ages 73-114 d...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02522612
更新日期:1996-02-01 00:00:00
abstract::The contents and compositions of the 1-O-alk-1'-enyl-2-acyl, 1-O-alkyl-2-acyl, and 1,2-diacyl glycerophospholipids in the muscle and viscera of the ascidian Halocynthia roretzi, and of the gonad of the sea urchin Strongylocentrotus intermedius, which are eaten to some extent in Alaska and in Asia, were analyzed by gas...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02522404
更新日期:1996-01-01 00:00:00
abstract::alpha-Monoolein was prepared from glycidol and oleic acid by the regioselective opening of glycidol in the presence of an anionic resin. During the reaction, the lipochemical synthesis medium becomes enriched in monoolein, the effective emulsifying agent. This mixture can be analyzed by thin-layer chromatography coupl...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02522406
更新日期:1996-01-01 00:00:00
abstract::Antioxidants may have a role in the prevention of atherosclerosis. In the present trial, we investigated the antioxidant properties of Palm Vitee, a gamma-tocotrienol-, and alpha-tocopherol enriched fraction of palm oil, in patients with carotid atherosclerosis. Serum lipids, fatty acid peroxides, platelet aggregation...
journal_title:Lipids
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02536621
更新日期:1995-12-01 00:00:00
abstract::The hypothesis that the essential oil from Tagetes minuta L. can interact with biological membranes was investigated by assessing its ability of perturbing the binding of a benzodiazepine [flunitrazepam (FNTZ)] to crude members from chick brains. The essential oil from T. minuta L. inhibited [3H]FNTZ specific binding ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536610
更新日期:1995-12-01 00:00:00
abstract::Three series of experiments demonstrated that sesame seed and its lignans cause significant elevation of alpha-tocopherol content in rats. In Experiment 1, 20% sesame seed (with a negligible amount of alpha-tocopherol) supplementing 10 (low), 50 (normal), or 250 (high) mg/kg alpha-tocopherol diets (protein and fat con...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536287
更新日期:1995-11-01 00:00:00
abstract::In order to further characterize low density lipoprotein (LDL)-platelet interaction, we investigated the effect of protease pretreatment of human platelets on the subsequent binding of iodinated LDL (125I-LDL). Our results showed that the platelet LDL receptor had a proteolytic susceptibility different from that of bo...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537484
更新日期:1995-10-01 00:00:00
abstract::The effects of beta-muricholic acid and hyocholic acid on cholesterol cholelithiasis were examined in two animal models. The following experiments were carried out: A) In a gallstone prevention study, prairie dogs were fed the lithogenic diet with or without 0.1% beta-muricholic or 0.1% hyocholic acid for eight weeks....
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02533962
更新日期:1995-09-01 00:00:00
abstract::Using the spectrofluorimetric method described by Wittenauer et al. [Wittenauer, L.A., Shirai, K., Jackson, R.L., and Johnson, J.D. (1984) Biochem. Biophys. Res. Commun. 118, 894-901] for phospholipase A2 (PLA2) measurement, we have detected a phospholipase activity in Ailsa Craig and in mutant rin tomatoes at their n...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537801
更新日期:1995-08-01 00:00:00
abstract::Levels of serum lipids and lipoproteins, and the fatty acid composition of plasma phospholipids, were measured in two genetically comparable, but widely separated, populations. The 1975 mortality rates for ischemic heart disease were significantly higher in one of these populations, the Manitoban residents of pure Ice...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537002
更新日期:1995-07-01 00:00:00
abstract::The source of free fatty acids (FFA) and the pathways contributing to the accumulation of neutral fats in livers of rats fed a cholesterol-enriched diet were investigated in this report. Supplementation with 1% cholesterol in the diet for four weeks resulted in hepatomegaly in the rats. The contents of cholesterol and...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537027
更新日期:1995-06-01 00:00:00
abstract::For three weeks, male Sprague-Dawley rats at either four weeks (young) or eight months (adult) of age were pair-fed one of the purified diets free of or containing either 0.2% of oxidized cholesterol mixture (cholesterol oxidation products) or 0.2% of cholesterol. Although the food intake was similar, dietary oxidized...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536298
更新日期:1995-05-01 00:00:00
abstract::The mechanism of the self-assembly of the lamellar structure of natural stratum corneum lipids (SCL) has been a subject of considerable interest. We have examined this question by using a synthetic pseudo-ceramide (sphingolipid E, SLE) which was analogous to the naturally occurring ceramide type 2. The thermotropic pr...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536040
更新日期:1995-04-01 00:00:00
abstract::Considerable progress has been made in the selection and characterization of mutants that are defective in the synthesis of ergosterol in the yeast, Saccharomyces cerevisiae. Mutations in nearly every step of the yeast sterol biosynthetic pathway have been induced and selected. These mutants have been used to elucidat...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/BF02537825
更新日期:1995-03-01 00:00:00
abstract::The antioxidant effects of natural estrogens (estrone, E1; 17 beta-estradiol), synthetic estrogens (17 alpha-ethynylestradiol, EE2; mestranol, MES; diethylstilbestrol, DES) and catecholestrogens (2-hydroxyestradiol; 4-hydroxyestradiol, 4-OHE2) on lipid peroxidation induced by different means in rat liver microsomes we...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02538267
更新日期:1995-02-01 00:00:00
abstract::In previous studies, zinc-deficient rats force-fed a diet with coconut oil as the major dietary fat developed a fatty liver, whereas zinc-deficient rats force-fed a diet with linseed oil did not. The present study was conducted to elucidate the reason for this phenomenon. In a bifactorial experiment, rats were fed zin...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537043
更新日期:1995-01-01 00:00:00
abstract::In the present study, changes in phospholipid compositions of liver microsomes, erythrocyte membranes, platelets, aorta, cardiac muscle and brain of rats fed olive oil were compared with those of rats fed sunflower oil. Four groups of rats starting at weaning were fed for four weeks a basal diet containing 5 or 25% ol...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536252
更新日期:1994-12-01 00:00:00
abstract::Although migrating birds use stored triacylglycerol as their primary fuel for flight, they must retain sufficient stores of omega 6 and omega 3 fatty acids to sustain reproduction after the spring migration. Hepatic monoacylglycerol:acyl-coenzyme A acyltransferase (EC 2.3.1.22) (MGAT) activity is associated with physi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536701
更新日期:1994-11-01 00:00:00
abstract::A procedure for the preparation of specific molecular species of D-erythro-lactosylceramide involving deacylation and reacylation of lactosylceramide prepared from bovine brain gangliosides is described. Lactosylceramide was N-deacylated by alkaline hydrolysis and the resulting four lysolactosylceramides, which contai...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02538917
更新日期:1994-10-01 00:00:00
abstract::Diets that contain high levels of n-3 fatty acids from fish oil have been shown to significantly effect macrophage cytolytic capacity, tumor necrosis factor alpha production and eicosanoid production. The present study was undertaken to determine whether n-3 fatty acids from vegetable origin [linseed oil (LIN)] would ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536100
更新日期:1994-09-01 00:00:00
abstract::Milk fatty acids consist of about 20-25% palmitic acid (16:0), with about 70% of 16:0 esterified to the sn-2 position of the milk triacylglycerols. Hydrolysis of dietary triacylglycerols by endogeneous lipases produces sn-2 monoacylglycerols and free fatty acids, which are absorbed, reesterified, and then secreted int...
journal_title:Lipids
pub_type: 临床试验,杂志文章
doi:10.1007/BF02536625
更新日期:1994-08-01 00:00:00
abstract::The objective of this study was to examine whether whole body oxidation rates of dietary linoleic, alpha-linolenic and oleic acids differ when the acids are provided in identical quantities. Male rats were fed for 10 wk a 15% fat (w/w) diet containing equal amounts of linoleic, alpha-linolenic and oleic acids (22.7, 2...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02578246
更新日期:1994-07-01 00:00:00
abstract::Naturally occurring tetraalkylsubstituted furan fatty acids (F-acids) were tested as potential substrates for soybean lipoxygenase-1. For this purpose, F-acid methyl ester and phosphatidylcholines containing F-acids at the sn-2 position of the glycerol residue were incubated with the enzyme. Oxidation of F-acids only ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537308
更新日期:1994-06-01 00:00:00
abstract::The purpose of the study was to compare the polyunsaturated fatty acid (PUFA) status in patients with X-linked adrenoleukodystrophy or adrenomyeloneuropathy (X-ALD/AMN) with that in disorders of peroxisome biogenesis (PB). Total fatty acids and plasmalogens were quantified in plasma and red cells from 28 patients with...
journal_title:Lipids
pub_type: 杂志文章,多中心研究
doi:10.1007/BF02536332
更新日期:1994-04-01 00:00:00
abstract::We have previously shown that adipose cells from young genetically obese Zucker rats are characterized by very high metabolic activity together with an increase in a wide range of membrane-mediated functions. The aim of the present study was to examine whether the physical properties of the membranes and the compositi...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02536730
更新日期:1994-03-01 00:00:00
abstract::A novel phospholipid containing a chromanol structure at its polar head group was synthesized from egg yolk phosphatidylcholine and 2,5,7,8-tetramethyl-6-hydroxy-2-(hydroxyethyl)chroman by transphosphatidylation catalyzed by phospholipase D from Streptomyces lydicus. The structure of the product synthesized was shown ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/BF02537147
更新日期:1994-02-01 00:00:00