听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览CANCER RESEARCH期刊下所有文献
  • Cytokinetic definition of acute and chronic breast cancer.

    abstract::The purpose of this paper is to report the extant observations at the Ellis Fischel State Cancer Hospital-Cancer Research Center and in the literature on the gross rates of growth of human mammary cancer as measured for primary cancers in the breast by mammography and for metastatic cancer in the skin and lymph nodes ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Spratt JS Jr,Kaltenbach ML,Spratt JA

    更新日期:1977-01-01 00:00:00

  • Schedule-dependent antitumor effects of methotrexate and 5-fluorouracil.

    abstract::The antitumor effects of methotrexate with 5-fluorouracil against the Sarcoma 180 mouse tumor model were found to be schedule dependent. Pretreatment of tumor-bearing animals with methotrexate significantly enhanced the antitumor activity of the combination relative to simultaneous treatment or to those with methotrex...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Bertino JR,Sawicki WL,Lindquist CA,Gupta VS

    更新日期:1977-01-01 00:00:00

  • DNA synthesis inpermeable mouse ascites sarcoma cells.

    abstract::DNA synthesis was studied in mouse ascites sarcoma cells using a permeable cell system. The sarcoma was induced by the Schmidt-Ruppin strain of Rous sarcoma virus. The cells were made permeable to nucleoside triphosphates by treatment with a hypotonic buffer containing 10 mM Tris Cl, 4 mM MgCl2, 1 mM EDTA, and 6 mM 2-...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Seki S,Oda T

    更新日期:1977-01-01 00:00:00

  • Distribution and degradation of [3H]methotrexate after intravenous and cerebral intraventricular injection in primates.

    abstract::Four hr after either a single injection or continuous infusion of methotrexate (MTX) plus purified [3',5',9(n)-3H]MTX in cynomolgus or rhesus monkeys, 80 to 98% of the 3H radioactivity present in the plasma was found not to represent intact MTX. The percentage of 3H-containing MTX products in the urine after 4 hr was ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Kimelberg HK,Biddlecome SM,Bourke RS

    更新日期:1977-01-01 00:00:00

  • The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides.

    abstract::The cytotoxic effect of methotrexate (MTX) for mouse bone marrow cells has been studied by in vitro of the granulocyte precursor cell (CFU-C) in a medium containing dialyzed fetal calf serum and dialyzed L-cell supernatant. The formation of 50-cell colonies was inhibited to 50% of control by 10(-8) M MTX. Further incr...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Pinedo HM,Zaharko DS,Bull JM,Chabner BA

    更新日期:1976-12-01 00:00:00

  • The interaction of rhodium(II) carboxylates with enzymes.

    abstract::The effect of rhodium(II) acetate, propionate, and methoxyacetate on the activity of 17 enzymes was evaluated. The enzymes were preincubated with the rhodium(II) complexes in order to detect irreversible inhibition. All enzymes that have essential sulfhydryl groups in or near their active site were found to be irrever...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Howard RA,Spring TG,Bear JL

    更新日期:1976-12-01 00:00:00

  • Suppression of Moloney sarcoma virus immunity following sensitization with attenuated virus.

    abstract::Murine sarcoma virus (Moloney strain) (MSV-M)-induced tumors are unusual in that they regularly appear less than 2 weeks after virus inoculation, progress for 1 to 2 weeks, and are rejected by normal adult BALB/c mice. Rejectio leaves the animals immune to tumor induction. In the present study, presensitization of nor...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Wood GW

    更新日期:1976-12-01 00:00:00

  • Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models.

    abstract::In Sarcoma 180 and L1210 ascites tumor models, the initial rate of methotrexate accumulation in tumor cells in the peritoneal cavity and in small intestine (intracellularly) after s.c. doses up to 800 mg/kg, showed saturation kinetics. These results and the fact that initial uptake in these tissues within this dosage ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Sirotnak FM,Donsbach RC,Dorick DM,Moccio DM

    更新日期:1976-12-01 00:00:00

  • Reaction of antigens isolated from herpes simplex virus-transformed cells with sera of squamous cell carcinoma patients.

    abstract::Antigens isolated from herpes simplex virus type 1, herpes simplex virus type 2, or cytomegalovirus-transformed hamster cells were tested against 66 sera from non-cancer individuals or patients with different types of cancer. By use of the microcomplement fixation procedure to quantify all antigen-antibody interaction...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Notter MF,Docherty JJ

    更新日期:1976-12-01 00:00:00

  • In vitro differentiation of teratomas and the distribution of creatine phosphokinase and plasminogen activator in teratocarcinoma-derived cells.

    abstract::Mouse teratocarcinoma cells from embryoid bodies were cultured in vitro to permit their differentiation into a number of cell types. Two enzyme activities, creatine phosphokinase (CPK) and the protease plasminogen activator, were studied to follow the developmental sequence of events in these embryoid body-derived cel...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Topp W,Hall JD,Marsden M,Teresky AK,Rifkin D,Levine AJ,Pollack R

    更新日期:1976-11-01 00:00:00

  • Cell surface changes in HeLa cells as an indication of cell cycle events.

    abstract::A HeLa cell line synchronized by double thymidine block and mitotic shake off was shown to have a characteristic surface morphology for each of the different cell cycle stages. Inhibitors of cell multiplication were used to arrest cells in specific cell cycle phases, and these cells had a surface morphology similar to...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Lundgren E,Roos G

    更新日期:1976-11-01 00:00:00

  • Evidence for altered gene regulation in HeLa cells returned to culture after growing in immunosuppressed rats.

    abstract::HeLa TCRC-1, is a monophenotypic cell line for the production of the carcinoplacental Regan isoenzyme of alkaline phosphatase. It has been previously reported that, when this cell line is grown in immunosuppressed rats, there is an alteration of phenotypic expression in that an isoenzyme that is referred to as oncoamn...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Singer RM

    更新日期:1976-11-01 00:00:00

  • Comparison of antitumor activities of pancreatic ribonuclease and its cross-linked dimer.

    abstract::The cross-linked dimer of bovine pancreatic RNase (M.W. 28,000) is significantly more effective than the monomer in inhibiting tumor development in mice when administered i.p. 1 day after inoculation with sarcoma 180J ascites cells. Animals bearing solid tumors were not affected. In AKR/J mice with advanced leukemia, ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Tarnowski GS,Kassel RL,Mountain IM,Blackburn P,Wilson G,Wang D

    更新日期:1976-11-01 00:00:00

  • Metabolism and metabolic effects of 8-azainosine and 8-azaadenosine.

    abstract::8-Azainosine (8-aza-HR) is of interest because of its activity against experimental tumors. Metabolic studies in cell cultures were performed with 8-aza-HR and with the structurally related nucleoside, 8-azaadenosine (9-beta-D-ribofuranosyl-8-azaadenine) (8-aza-AR), which has a lower degree of antitumor activity than ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Bennett LL Jr,Allan PW

    更新日期:1976-11-01 00:00:00

  • Tumor-caused changes in host protein synthesis under different dietary situations.

    abstract::The effect of the AC33 tumor on protein synthesis in Lewis-Wistar rats was investigated under four different dietary regimens. The four diets used were: (a) 1.25 g amino acids plus 12.5 g glucose per day, (b) 1.25 g amino acids, (c) 1.25 g glucose per day, and (d) 12.5 g glucose per day. The rats were maintained on th...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Stein TP,Oram-Smith JC,Leskiw MJ,Wallace HW,Miller EE

    更新日期:1976-11-01 00:00:00

  • Identification and characterization of the insulin receptor in the R3230AC mammary adenocarcinoma of the rat.

    abstract::The binding of labeled insulin to dissociated R3230AC mammary adenocarcinoma cells from diabetic and intact rats was investigated in vitro. At 20 degrees, specific binding (total binding minus binding in the presence of 1000-fold excess or 10(-6) M unlabeled insulin) reached a plateau at 45 to 60 min and was directly ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Harmon JT,Hilf R

    更新日期:1976-11-01 00:00:00

  • Cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in normal and chronic lymphocytic leukemia lymphocytes.

    abstract::The specific activity of cyclic adenosine 3':5'-monophosphate phosphodiesterase was measured in lymphocytes isolated from the blood of normal subjects, from patients with chronic lymphocytic leukemia, and from tonsil tissue. The mean specific activity of cyclic adenosine 3':5'-monophosphate phosphodiesterase in the ly...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Scher NS,Quagliata F,Malathi VG,Faig D,Melton RA,Silber R

    更新日期:1976-11-01 00:00:00

  • Immunization against feline oncarnavirus disease using a killed tumor cell vaccine.

    abstract::Specific pathogen-free cats were immunized with an inactivated feline oncornavirus tumor cell vaccine. Immunized cats produced high antibody titers to the feline oncornavirus-associated cell membrane antigen and were protected from oncogenic feline sarcoma virus challenge. However, immunization did not produce virus-n...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Olsen RG,Hoover EA,Mathes LE,Heding L,Schaller JP

    更新日期:1976-10-01 00:00:00

  • Effects of bleomycin on human tongue carcinoma cells as revealed by electron microscopy.

    abstract::Five patients with tongue carcinoma were treated for 20 days with bleomycin, 15 mg/day, given by one-shot infusion through the superficial temporal artery. Specimens were taken 7, 14, and 20 days after the initial administration for light and electron microscope observations. The first alterations observed were the de...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Yasuzumi G,Hyo Y,Hoshiya T,Yasuzumi F

    更新日期:1976-10-01 00:00:00

  • Effects of actinomycin D on cell cycle kinetics and the DNA of Chinese hamster and mouse mammary tumor cells cultivated in vitro.

    abstract::Actinomycin D produces changes in the cell cycle kinetics of Chinese hamster (HA1) and mouse mammary tumor cells (EMT6) cultivated in vitro. There was a reduced rate of progression of the cells through S phase and a G2 arrest, the duration and degree of which were drug dose dependent. The lethal effects of the drug on...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Roots R,Smith KC

    更新日期:1976-10-01 00:00:00

  • Inhibition of DNA synthesis in normal and malignant human cells by triazinate (Baker's antifol) and methotrexate.

    abstract::Triazinate (TZT), a triazine folate antagonist, is a potent inhibitor of dihydrofolate reductase from mammalian cells. Because antitumor activity of triazinate in experimental tumors correlated closely with the in vitro inhibition of DNA synthesis in tumor cells derived from these tumors, we studied cells from patient...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Skeel RT,Sawicki WL,Cashmore AR,Bertino JR

    更新日期:1976-10-01 00:00:00

  • Growth rates of normal and abnormal human mammary epithelia in cell culture.

    abstract::The in vitro growth rates of different classifications of human mammary epithelium were compared. Samples included 4 established breast cell lines and excised tissue or breast fluid cells originating WOMEN FOR 40 DIFFERENT AND comprising 3 classifications: normal, nonmalignant atypical, and malignant. Growth was quant...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Buehring GC,Williams RR

    更新日期:1976-10-01 00:00:00

  • Biosynthesis of albumin via a precursor protein in Morris hepatoma 5123tc.

    abstract::The mechanism of albumin biosynthesis was studied in Morris hepatoma 5123tc in vivo and in hepatoma cell suspensions obtained by solubilizing the intercellular matrix with collagenase and hyaluronidase. In the in vivo experiments, L-[-14C]leucine was injected i.v. into rats bearing hepatomas in the muscles of both hin...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Edwards K,Schreiber G,Dryburgh H,Millership A,Urban J

    更新日期:1976-09-01 00:00:00

  • Expression of early fetal antigens on transformed mouse cells.

    abstract::We have used immunoprecipitation of radioactivity from labeled cell membrane preparations to study further the association between the histocompatibility-2 (H-2) peptides and a tumor-associated embryonic antigen (Ag I) on the surface of L-cells. Since earlier studies had shown that Ag I and H-2 co-cap on L-cells, the ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Gooding LR

    更新日期:1976-09-01 00:00:00

  • The effect of exposure to dibutyryl cyclic adenylic acid on the membrane antigenicity of SV40 tumor cells.

    abstract::When SV40 tumor cells (F5-1) in culture were treated with dibutyryl cyclic adenylic acid (DbcAMP),marked alterations occurred in their growth and morphology. Additionally, the incorporation or uptake of labeled thymidine, uridine, phenylalanine, and choline were reduced by this treatment. These modifications with DbcA...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hannon WH,Anderson NG,Coggin JH Jr

    更新日期:1976-09-01 00:00:00

  • Continuity of a rabbit antigen between generations.

    abstract::The rabbit uterine protein, blastokinin, is detectable as an antigen in both male and female genital tract tissues, in preimplantation embryos, and in lungs from late fetal stages, immatures, and adults. Thus, it serves as an example of how an antigen of normal tissue exists in a developmental progression from one gen...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Daniel JC Jr,Milazzo JT

    更新日期:1976-09-01 00:00:00

  • Effects of 5-mercapto-2'-deoxyuridine on the incorporation of nucleosides into RNA and DNA in a primary lymphocyte culture system.

    abstract::The effects of 5-mercapto-2'-deoxyuridine (MUdr) on DNA synthesis in a primary murine spleen lymphocyte culture system stimulated by phytohemagglutinin (PHA) were studied. Inhibition of thymidine incorporation into acid insoluble nucleic acid material was 50% at 0.5 mM MUdR concentration, while inhibition of deoxyurid...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Bogyo D,Bardos TJ,Chmielewicz ZF

    更新日期:1976-09-01 00:00:00

  • Effects of the immunosuppressive drug niridazole in isogeneic and allogeneic mouse tumor systems in vivo.

    abstract::In both isogeneic (Sarcoma 1 in A/JAX mice) and allogeneic (Sarcoma 180 in C57BL/6 mice) mouse tumor systems, treatment of the tumor-bearing mice with niridazole, an antiprarasitic drug, known to be a potent suppressor of cell mediated but not humoral immunity caused enhancement of metastases to regional popliteal nod...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Deodhar SD,Lee VW,Chiang T,Mahmoud AF,Watten KS

    更新日期:1976-09-01 00:00:00

  • Effects of single cyclophosphamide doses on the kinetics of thoracic duct lymph and blood leukocytes in calves.

    abstract::After 5 or 20 mg cyclophosphamide per kg body weight, given once i.v., the output in thoracic duct lymph of small and large lymphoid cells, cells incorporating [3H]lymidine in vitro, mitotic cells, pyknotic cells, and/or the number of lymphocytes and neutrophils in peripheral blood were measured in six calves. The med...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Wagner JP,Chanana AD,Cottier H,Cronkite EP,Gassmann A,Joel DD,Laissue JA

    更新日期:1976-09-01 00:00:00

  • Behavior of transaldolase (EC 2.2.1.2) and transketolase (EC 2.2.1.1) Activities in normal, neoplastic, differentiating, and regenerating liver.

    abstract::The objective of this investigation was to throw light on the biological behavior and metabolic regulation of hepatic enzymes of the nonoxidative branch of the pentose phosphate pathway. The activities of transaldolase (EC 2.2.1.2) and trasketolase (EC 2.2.1.1) Were compared in biological conditions that involve modu...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Heinrich PC,Morris HP,Weber G

    更新日期:1976-09-01 00:00:00

  • Intracellular synthesis of alpha-fetoprotein and fibrinogen without secretion by Zajdela rat ascites hepatoma cells.

    abstract::Transplabtable Zajdela rat ascites hepatoma cells, previously considered "nonproducers," synthesize detectable amounts of intracellular alpha-fetoprotein (AFP) and fibrinogen, but fail to secret or release these serum proteins. Evidence for defective secretory mechanisms for serum proteins in these hepatoma cells (a) ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Sarcione EJ,Smalley JR

    更新日期:1976-09-01 00:00:00

  • Effects of high hoses of estrogen on prolactin-binding activity and growth of carcinogen-induced mammary cancers in rats.

    abstract::Specific binding sites for prolactin (PRL) were present in membrane preparations from 7,12-dimethylbenz(a)-anthracene-induced rat mammary tumors. The specific binding of PRL was time and temperature dependent. A significant negative correlation was noted between administered doses of estrogen and the subsequent bindin...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Kledzik GS,Bradley CJ,Marshall S,Campbell GA,Meites J

    更新日期:1976-09-01 00:00:00

  • Inhibition of ribonucleotide reductase activity and nucleic acid synthesis in tumor cells by the dialdehyde derivatives of inosine (NSC 118994) and inosinic acid.

    abstract::Periodate-oxidized inosine (Inox; NSC 118994) and periodate-oxidized 5'-inosinic acid (PI-IMP) were prepared and studied for their effects on ribonucleotide reductase activity in partially purified extracts from Ehrlich tumor cells and on nucleic acid synthesis in intact tumor cells in culture. Ribonucleotide reductas...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Cory JG,Mansell MM,Whitford TW Jr

    更新日期:1976-09-01 00:00:00

  • Changes in transfer RNA's in human malignant trophoblastic cells (BeWo line).

    abstract::Ten aminoacyl transfer RNA's prepared from human malignant trophoblastic cells (BeWo line) were compared with the corresponding aminoacyl transfer RNA's from normal human chorionic tissue by cochromatography on a RPC-5 column. Phenylalanyl transfer RNA (Phe-tRNA) of BeWo cells had, in addition to the single species of...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Kuchino Y,Borek E

    更新日期:1976-08-01 00:00:00

  • Effect of vincristine on sister chromatid exchanges of normal human lymphocytes.

    abstract::In vitro analysis of the mitosis from 3-day lymphocyte cultures from two normal males and two normal females treated with bromodeoxyuridine and stained with acridine orange after addition of vincristine during different times demonstrated that vincristine inhibits the progression of the second division. When the secon...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Stoll C,Borgaonkar DS,Levy JM

    更新日期:1976-08-01 00:00:00

  • Histological comparison of the growth of rat bladder carcinoma R-4909 observed for two years in vitro and in vivo.

    abstract::A transplantable bladder tumor (Chapman R-4909) of the rat, when first received in our laboratory, grew with a complex histopathology. The predominant component was transitional cell carcinoma, but there were foci of keratinization, including pearl formation, and foci of a less well-defined cystic appearance. We repor...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Toyoshima K,Abaza N,Leighton J

    更新日期:1976-08-01 00:00:00

  • Separation and characterization of transcriptionally active and inactive nuclear subfractions of AKR mouse embryo cells.

    abstract::This study was initiated with the objective of separating and characterizing two or more nuclear subfractions, which could then be compared with respect to their relative propensity for binding carcinogenic polycyclic aromatic hydrocarbons. Nuclei were isolated from cloned AKR-2B mouse embryo cells, which are suscepti...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Webster RA,Moses HL,Spelsberg TC

    更新日期:1976-08-01 00:00:00

  • Kinetic properties of alcohol dehydrogenase in hepatocellular carcinoma and normal tissues of rat.

    abstract::It was previously reported that the properties of alcohol dehydrogenase of a rat hepatocellular carcinoma (Becker H-252), a tumor of intermediate growth rate, were different from those of the liver enzyme, suggesting different isozymes. To determine whether the degree of differentiation affected the isozyme of alcohol...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Cederbaum AI,Rubin E

    更新日期:1976-07-01 00:00:00

  • Heterotopic urinary bladder with a communicating reservoir.

    abstract::A heterotopic bladder attached to an Ommaya reservoir was transplanted to the back of a syngeneic rat. Following transplantation, the mucosa underwent ischemic necrosis. However, it was rapidly reepithelialized in 2 weeks as a result of spreading of the epithelium originating from the ureterotrigonal region. By light ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Oyasu R,Manning DJ,Matsumoto M,Hopp ML

    更新日期:1976-07-01 00:00:00

  • Distribution and disposition of platinum following intravenous administration of cis-diamminedichloroplatinum(II) (NSC 119875) to dogs.

    abstract::cis-Diamminedichloroplatinum(II) is an antineoplastic drug that is undergoing a renewed clinical interest as a drug for use in combination regimens. In order to increase the understanding of the pharmacokinetics of this drug, the plasma clearance and organ distribution of platinum were followed in female beagle dogs t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Litterst CL,Gram TE,Dedrick RL,Leroy AF,Guarino AM

    更新日期:1976-07-01 00:00:00

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