Schedule-dependent antitumor effects of methotrexate and 5-fluorouracil.

abstract：:Tumor-suppressors have commanded attention due to the selection for their inactivating mutations in human tumors. However, relatively little is understood about the inverse, namely, that tumors do not select for a large proportion of seemingly favorable mutations in tumor-suppressor genes. This could be explained by a...

journal_title：Cancer research

authors： Cunningham SC,Gallmeier E,Hucl T,Dezentje DA,Calhoun ES,Falco G,Abdelmohsen K,Gorospe M,Kern SE

更新日期：2006-06-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) expression by human breast cancer has been shown to predict poor patient outcome, as has amplification of the c-erbB-2 proto-oncogene. We have developed a quantitative immunohistochemical method for measuring protein levels of both receptors and have applied this to a series of ...

journal_title：Cancer research

authors： Robertson KW,Reeves JR,Smith G,Keith WN,Ozanne BW,Cooke TG,Stanton PD

更新日期：1996-08-15 00:00:00

abstract：:We developed a fully automated three-dimensional cell tracking system that quantified the effect of extracellular matrix components on the infiltration and migration of tumor cells. The three-dimensional trajectories of two highly invasive cell lines, the human HT-1080 fibrosarcoma and the human MDA-MB-231 adenocarcin...

journal_title：Cancer research

authors： Demou ZN,McIntire LV

更新日期：2002-09-15 00:00:00

abstract：:Gastric carcinoma is one of the most common cancers and lethal malignancies worldwide. Thus far, the regulatory mechanisms of its aggressiveness are still poorly understood. To understand the pathogenesis and to develop new therapeutic strategies, it is essential to dissect the molecular mechanisms that regulate progr...

journal_title：Cancer research

authors： Yeh TS,Wu CW,Hsu KW,Liao WJ,Yang MC,Li AF,Wang AM,Kuo ML,Chi CW

更新日期：2009-06-15 00:00:00

abstract：:Metastasis is the primary cause of death from breast cancer. A xenograft model was used to identify genes potentially involved with metastasis, comparing expression in the poorly metastatic GI101A human breast cancer cell line and a highly metastatic variant, GILM2. cDNA microarray analyses of these isogenic variants ...

journal_title：Cancer research

authors： Kluger HM,Chelouche Lev D,Kluger Y,McCarthy MM,Kiriakova G,Camp RL,Rimm DL,Price JE

更新日期：2005-07-01 00:00:00

abstract：:To determine whether there are differences between the U1, U2, and U3 small nuclear RNA's of human cancer cells (HeLa cells) and human normal fibroblasts (IMR-90 cells), and between these uridine-rich small nuclear RNA's of human and Novikoff hepatoma cells, the cells were first incubated in Eagle's medium with [32P]P...

journal_title：Cancer research

authors： Nohga K,Reddy R,Busch H

更新日期：1981-06-01 00:00:00

abstract：:A novel chromosomal translocation, t(2;11)(q31;p15), was identified in a patient with therapy-related acute myelogenous leukemia (t-AML). Fluorescence in situ hybridization experiments mapped the breakpoint near NUP98; Southern blot analysis demonstrated that the nucleoporin gene NUP98 was disrupted by this translocat...

journal_title：Cancer research

authors： Raza-Egilmez SZ,Jani-Sait SN,Grossi M,Higgins MJ,Shows TB,Aplan PD

更新日期：1998-10-01 00:00:00

abstract：:To identify molecular alterations involved in the initiation and progression of breast carcinomas, we analyzed the global gene expression profiles of normal mammary epithelial cells and in situ, invasive, and metastatic breast carcinomas using serial analysis of gene expression (SAGE). We identified sets of genes expr...

journal_title：Cancer research

authors： Porter DA,Krop IE,Nasser S,Sgroi D,Kaelin CM,Marks JR,Riggins G,Polyak K

更新日期：2001-08-01 00:00:00

abstract：:Two characteristics of immune responses to weakly immunogenic plasma cell tumors were demonstrated in this study. (a) Elevated lymphoproliferative responses following in vivo inoculation of sublethal doses of plasma cell tumors were detected by a mixed lymphocyte-tumor interaction (MLTI) assay. Specificity of elevated...

journal_title：Cancer research

authors： Boyer PJ,Fahey JL

更新日期：1976-04-01 00:00:00

abstract：:Early diagnosis of lung cancer based on conventional screening procedures has been unable thus far to decrease lung cancer mortality. We explored the possibility of using microsatellite instability in the detection and screening of early phases of lung carcinogenesis. We studied tumor, histopathologically normal bronc...

journal_title：Cancer research

authors： Miozzo M,Sozzi G,Musso K,Pilotti S,Incarbone M,Pastorino U,Pierotti MA

更新日期：1996-05-15 00:00:00

abstract：:It is becoming increasingly clear that tumor growth and progression is not entirely due to genetic aberrations but also reflective of tumor cell plasticity. It follows therefore that proteins contributing to tumor progression oscillate in their expression a contention yet to be shown. Because the urokinase-type plasmi...

journal_title：Cancer research

authors： Yang L,Avila H,Wang H,Trevino J,Gallick GE,Kitadai Y,Sasaki T,Boyd DD

更新日期：2006-08-15 00:00:00

abstract：:Aberrant FLT3 expression and/or mutation plays a significant role in leukemogenesis. This has prompted the development of selective small molecule tyrosine kinase inhibitors against FLT3. However, like most tyrosine kinase inhibitors, those against FLT3 are not completely specific and at the doses required to complete...

journal_title：Cancer research

authors： Piloto O,Levis M,Huso D,Li Y,Li H,Wang MN,Bassi R,Balderes P,Ludwig DL,Witte L,Zhu Z,Hicklin DJ,Small D

更新日期：2005-02-15 00:00:00

abstract：:Destruction of cancer cells by cytotoxic T lymphocytes depends on immunogenic tumor peptides generated by proteasomes and presented by human leukocyte antigen (HLA) molecules. Functional differences arising from alleles of immunoproteasome subunits have not been recognized so far. We analyzed the genetic polymorphism ...

journal_title：Cancer research

authors： Fellerhoff B,Gu S,Laumbacher B,Nerlich AG,Weiss EH,Glas J,Kopp R,Johnson JP,Wank R

更新日期：2011-12-01 00:00:00

abstract：:Synovial sarcoma is a soft tissue malignancy characterized by the fusion of SS18 to either SSX1, SSX2, or SSX4 genes. SS18 and SSX are transcriptional cofactors involved in activation and repression of gene transcription, respectively. SS18 interacts with SWI/SNF, whereas SSX associates with the polycomb chromatin rem...

journal_title：Cancer research

authors： Lubieniecka JM,de Bruijn DR,Su L,van Dijk AH,Subramanian S,van de Rijn M,Poulin N,van Kessel AG,Nielsen TO

更新日期：2008-06-01 00:00:00

abstract：:We used comparative genomic hybridization to study malignant fibrous histiocytomas (MFHs) from 19 patients to detect changes in the copy number of DNA sequences, along entire chromosomes. Together with losses and gains in various chromosomal regions, distinct high-level amplifications were found at six loci (4q12-21, ...

journal_title：Cancer research

authors： Sakabe T,Shinomiya T,Mori T,Ariyama Y,Fukuda Y,Fujiwara T,Nakamura Y,Inazawa J

更新日期：1999-02-01 00:00:00

abstract：:The induction of epidermal ornithine decarboxylase (EC 4.1.1.17) (ODC) following topical application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mice can be inhibited by topical application of putrescine, the product of the enzyme. The degree of inhibition depended on both the dose and t...

journal_title：Cancer research

authors： Weekes RG,Verma AK,Boutwell RK

更新日期：1980-11-01 00:00:00

abstract：:ALDH1(+)CD44(+) cells are putative tumor-initiating cells (TIC) in head and neck squamous cell carcinomas (HNC). miR-145 regulates tumorigenicity in various cancers but the breadth of its mechanistic contributions and potential therapeutic applications are not completely known. Here, we report that ALDH1(+)CD44(+)-HNC...

journal_title：Cancer research

authors： Yu CC,Tsai LL,Wang ML,Yu CH,Lo WL,Chang YC,Chiou GY,Chou MY,Chiou SH

更新日期：2013-06-01 00:00:00

abstract：:We have studied the sensitivities of four hematopoietic stem cell types to heat stress as well as their abilities to develop thermotolerance. Granulocyte-macrophage colony forming units were the most heat resistant bone marrow progenitors tested. Of the erythroid progenitors tested, erythrocyte colony forming units we...

journal_title：Cancer research

authors： Mivechi NF,Li GC

更新日期：1986-01-01 00:00:00

abstract：:Cyclooxygenase-2 and prostaglandin E(2) (PGE(2)) levels are increased in colorectal cancers and a subset of adenomas. PGE(2) signaling through the EP4 receptor has previously been associated with colorectal tumorigenesis. However, changes in EP4 expression during adenoma to carcinoma progression have not been investig...

journal_title：Cancer research

authors： Chell SD,Witherden IR,Dobson RR,Moorghen M,Herman AA,Qualtrough D,Williams AC,Paraskeva C

更新日期：2006-03-15 00:00:00

abstract：:The cellular effects of alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), and N1,N8-bis(ethyl)spermidine (BES), an apparent regulator of the enzyme were compared in cultured L1210 cells. Unlike DFMO, BES has no direct inhibitory effect on ODC activity. Rather the polyamine analogue i...

journal_title：Cancer research

authors： Porter CW,Ganis B,Vinson T,Marton LJ,Kramer DL,Bergeron RJ

更新日期：1986-12-01 00:00:00

abstract：:This study was initiated with the objective of separating and characterizing two or more nuclear subfractions, which could then be compared with respect to their relative propensity for binding carcinogenic polycyclic aromatic hydrocarbons. Nuclei were isolated from cloned AKR-2B mouse embryo cells, which are suscepti...

journal_title：Cancer research

authors： Webster RA,Moses HL,Spelsberg TC

更新日期：1976-08-01 00:00:00

abstract：:The adhesion molecules E-selectin (ELAM-1) and P-selectin (GMP-140/CD62) recognize the carbohydrate motives sialyl-Le(x), sialyl-diLe(x), or sialyl-Lea, though with different affinity. We found that the melanoma cell line NKI-4 bound to E-selectin, but not to P-selectin. This melanoma cell line did not express sialyl-...

journal_title：Cancer research

authors： Kunzendorf U,Krüger-Krasagakes S,Notter M,Hock H,Walz G,Diamantstein T

更新日期：1994-02-15 00:00:00

abstract：:Approximately 25% of breast cancers do not express the estrogen receptor-α (ERα) and consequently do not respond to endocrine therapy. In these tumors, ERα repression is often due to epigenetic modifications such as methylation and histone deacetylation. For this reason, we investigated the ability of the histone deac...

journal_title：Cancer research

authors： Sabnis GJ,Goloubeva O,Chumsri S,Nguyen N,Sukumar S,Brodie AM

更新日期：2011-03-01 00:00:00

abstract：:Two distinct marker chromosomes, presenting with intercalated C- and distamycin A-Dapi-positive regions, were observed in a metastatic and a primary melanoma. To establish the origin of these heterochromatic sequences, we performed in situ hybridization analysis using specific probes for human repetitive DNA. The mark...

journal_title：Cancer research

authors： Doneda L,Ginelli E,Agresti A,Larizza L

更新日期：1989-01-15 00:00:00

abstract：:Inhibin is a heterodimeric TGFβ family ligand that is expressed in many cancers and is a selective biomarker for ovarian cancers; however, its tumor-specific functions remain unknown. Here, we demonstrate that the α subunit of inhibin (INHA), which is critical for the functionality of dimeric inhibin A/B, correlates w...

journal_title：Cancer research

authors： Singh P,Jenkins LM,Horst B,Alers V,Pradhan S,Kaur P,Srivastava T,Hempel N,Győrffy B,Broude EV,Lee NY,Mythreye K

更新日期：2018-06-01 00:00:00

abstract：:Treatment of L1210 cells with glucose, 1-methyl-3-isobutylxanthine, theophylline, and prostaglandins E1 and E2 was used to increase to varying degrees the endogenous level of cyclic adenosine 3':5'-monophosphate (cAMP). In an inverse manner these agents decreased the rate of methotrexate (MTX) transport into the cells...

journal_title：Cancer research

authors： Henderson GB,Zevely EM,Huennekens FM

更新日期：1978-03-01 00:00:00

abstract：:N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN), which specifically induces bladder tumors, was shown to be mutagenic to Salmonella typhimurium strains TA 1535 and TA100 in the presence of an S-9 mix prepared from the liver of rats treated with polychlorinated biphenyl. Reduced nicotinamide adenine dinucleotide was a more...

journal_title：Cancer research

authors： Nagao M,Suzuki E,Yasuo K,Yahagi T,Seino Y

更新日期：1977-02-01 00:00:00

abstract：:Angiogenesis is a crucial step in tumor growth and progression. Its quantitation by microvessel counting is of prognostic value in several types of malignancies. Scarce data are available on angiogenesis in gastrointestinal tumors. We studied 36 adenomas and 178 large bowel carcinomas to evaluate the onset of angiogen...

journal_title：Cancer research

authors： Bossi P,Viale G,Lee AK,Alfano R,Coggi G,Bosari S

更新日期：1995-11-01 00:00:00

abstract：:Mesothelin is a cell-surface tumor-associated antigen expressed in several human cancers. The limited expression of mesothelin on normal tissues and its high expression in many cancers make it an attractive candidate for targeted therapies using monoclonal antibodies, immunoconjugates, and immunotoxins. Mesothelin is ...

journal_title：Cancer research

authors： Zhang Y,Chertov O,Zhang J,Hassan R,Pastan I

更新日期：2011-09-01 00:00:00

abstract：:To define transcriptional dependencies of triple-negative breast cancer (TNBC), we identified transcription factors highly and specifically expressed in primary TNBCs and tested their requirement for cell growth in a panel of breast cancer cell lines. We found that EN1 (engrailed 1) is overexpressed in TNBCs and its d...

journal_title：Cancer research

authors： Peluffo G,Subedee A,Harper NW,Kingston N,Jovanović B,Flores F,Stevens LE,Beca F,Trinh A,Chilamakuri CSR,Papachristou EK,Murphy K,Su Y,Marusyk A,D'Santos CS,Rueda OM,Beck AH,Caldas C,Carroll JS,Polyak K

更新日期：2019-08-15 00:00:00