Abstract：
:Early diagnosis of lung cancer based on conventional screening procedures has been unable thus far to decrease lung cancer mortality. We explored the possibility of using microsatellite instability in the detection and screening of early phases of lung carcinogenesis. We studied tumor, histopathologically normal bronchial mucosa, and cytological specimens of 51 lung cancer patients for the presence of clonal variations at microsatellite polymorphisms. Microsatellite alterations were found in tumor, normal bronchial mucosa and cytological specimens of 25 of 51 (49%) of the patients. The detection of microsatellite alterations in histopathologically normal bronchial specimens and cytological clinical samples with minimal atypia suggests a possible application of this genetic marker in early diagnosis of precancerous lesions and lung cancer.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Miozzo M,Sozzi G,Musso K,Pilotti S,Incarbone M,Pastorino U,Pierotti MAsubject
Has Abstractpub_date
1996-05-15 00:00:00pages
2285-8issue
10eissn
0008-5472issn
1538-7445journal_volume
56pub_type
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