abstract：:Tyrosine phosphorylation (pTyr) plays a pivotal role in signal transduction and is commonly dysregulated in cancer. As a result, profiling tumor pTyr levels may reveal therapeutic insights critical to combating disease. Existing discovery and targeted mass spectrometry-based methods used to monitor pTyr networks invol...

journal_title：Cancer research

authors： Stopfer LE,Flower CT,Gajadhar AS,Patel B,Gallien S,Lopez-Ferrer D,White FM

更新日期：2021-01-28 00:00:00

abstract：:Emerging evidence indicates that gut microbiota affect the response to anticancer therapies by modulating the host immune system. In this study, we investigated the impact of the gut microbiota on immune-mediated trastuzumab antitumor efficacy in preclinical models of HER2-positive breast cancer (BC) and in 24 patient...

journal_title：Cancer research

authors： Di Modica M,Gargari G,Regondi V,Bonizzi A,Arioli S,Belmonte B,De Cecco L,Fasano E,Bianchi F,Bertolotti A,Tripodo C,Villani L,Corsi F,Guglielmetti S,Balsari A,Triulzi T,Tagliabue E

更新日期：2021-01-22 00:00:00

abstract：:Lung cancer is the leading cause of cancer death globally. An improved risk stratification strategy can increase efficiency of low-dose computed tomography (LDCT) screening. Here we assessed whether individual's genetic background has clinical utility for risk stratification in the context of LDCT screening. Based on ...

journal_title：Cancer research

authors： Hung RJ,Warkentin MT,Brhane Y,Chatterjee N,Christiani DC,Landi MT,Caporaso NE,Liu G,Johansson M,Albanes D,Le Marchand L,Tardon A,Rennert G,Bojesen SE,Chen C,Field JK,Kiemeney LA,Lazarus P,Zienolddiny S,Lam S,Andre

更新日期：2021-01-20 00:00:00

abstract：:In the last decade, large-scale genomic studies in patients with hematologic malignancies identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de novo DNA methyltransferase DNMT3A has emerged as one of the most frequently mutated genes in adult myeloid as well as lymphoid malignancie...

journal_title：Cancer research

authors： Venugopal K,Feng Y,Shabashvili D,Guryanova OA

更新日期：2021-01-15 00:00:00

abstract：:Tumors are complex tissues composed of transformed epithelial cells as well as cancer-activated fibroblasts (CAF) that facilitate epithelial tumor cell invasion. We show here that CAFs and other mesenchymal cells rely much more on glutamine than epithelial tumor cells; consequently, they are more sensitive to inhibiti...

journal_title：Cancer research

authors： Mestre-Farrera A,Bruch-Oms M,Peña R,Rodríguez-Morató J,Alba-Castellón L,Comerma L,Quintela-Fandino M,Duñach M,Baulida J,Pozo ÓJ,García de Herreros A

更新日期：2021-01-15 00:00:00

abstract：:Low-grade serous ovarian carcinoma (LGSOC) is a rare tumor subtype with high case fatality rates in patients with metastatic disease. There is a pressing need to develop effective treatments using newly available preclinical models for therapeutic discovery and drug evaluation. Here we use multiomics integration of wh...

journal_title：Cancer research

authors： Shrestha R,Llaurado Fernandez M,Dawson A,Hoenisch J,Volik S,Lin YY,Anderson S,Kim H,Haegert AM,Colborne S,Wong NKY,McConeghy B,Bell RH,Brahmbhatt S,Lee CH,DiMattia GE,Le Bihan S,Morin GB,Collins CC,Carey MS

更新日期：2021-01-13 00:00:00

abstract：:The concept that different leukemias are developmentally distinct and, like in normal hematopoiesis, generated by restricted populations of cells named leukemia-initiating cells (LIC), is becoming more established. These cancer stem-like cells have been assumed to have unique properties, including the capability of se...

journal_title：Cancer research

authors： Tamiro F,Weng AP,Giambra V

更新日期：2021-01-07 00:00:00

abstract：:Although obesity is one of the strongest risk factors for esophageal adenocarcinoma (EAC), the molecular mechanisms underlying this association remain unclear. We recently identified 4 EAC-specific master regulator transcription factors (MRTF) ELF3, KLF5, GATA6, and EHF. In the present study, Gene Set Enrichment Analy...

journal_title：Cancer research

authors： Ma S,Zhou B,Yang Q,Pan Y,Yang W,Freedland SJ,Ding LW,Freeman MR,Breunig JJ,Bhowmick NA,Pan J,Koeffler HP,Lin DC

更新日期：2021-01-05 00:00:00

abstract：:Although the cyclin-dependent kinases CDK4 and CDK6 play fundamental roles in cancer, the specific pathways and downstream targets by which they exert their tumorigenic effects remain elusive. In this study, we uncover distinct and novel functions for these kinases in regulating tumor formation and metastatic coloniza...

journal_title：Cancer research

authors： Dai M,Boudreault J,Wang N,Poulet S,Daliah G,Yan G,Moamer A,Burgos SA,Sabri S,Ali S,Lebrun JJ

更新日期：2020-12-28 00:00:00

abstract：:Whole-slide histology images contain information that is valuable for clinical and basic science investigations of cancer, but extracting quantitative measurements from these images is challenging for researchers who are not image analysis specialists. In this paper, we describe HistomicsML2, a software tool for learn...

journal_title：Cancer research

authors： Lee S,Amgad M,Mobadersany P,McCormick M,Pollack BP,Elfandy H,Hussein H,Gutman DA,Cooper LA

更新日期：2020-12-21 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) inhibitors are approved for treatment of cancers with BRCA1 or BRCA2 defects. In this study, we prepared and characterized a very long-acting PARP inhibitor. Synthesis of a macromolecular prodrug of talazoparib (TLZ) was achieved by covalent conjugation to a PEG40kDa carrier via a β-...

journal_title：Cancer research

authors： Fontaine SD,Ashley GW,Houghton PJ,Kurmasheva RT,Diolaiti M,Ashworth A,Peer CJ,Nguyen R,Figg WD,Beckford-Vera DR,Santi DV

更新日期：2020-12-15 00:00:00

abstract：:SNAI2 overexpression appears to be associated with poor prognosis in breast cancer, yet it remains unclear in which breast cancer subtypes this occurs. Here we show that excess SNAI2 is associated with a poor prognosis of luminal B HER2+/ERBB2+ breast cancers in which SNAI2 expression in the stroma but not the epithel...

journal_title：Cancer research

authors： Blanco-Gómez A,Hontecillas-Prieto L,Corchado-Cobos R,García-Sancha N,Salvador N,Castellanos-Martín A,Sáez-Freire MDM,Mendiburu-Eliçabe M,Alonso-López D,De Las Rivas J,Lorente M,García-Casas A,Del Carmen S,Abad-Hernández MDM,C

更新日期：2020-12-01 00:00:00

abstract：:Colorectal and lung cancers account for one-third of all cancer-related deaths worldwide. Previous studies suggested that Metadherin (MTDH) is involved in the development of colorectal and lung cancers. However, how MTDH regulates the pathogenesis of these cancers remains largely unknown. Using genetically modified mo...

journal_title：Cancer research

authors： Shen M,Xie S,Rowicki M,Michel S,Wei Y,Hang X,Wan L,Lu X,Yuan M,Jin JF,Jaschinski F,Zhou T,Klar R,Kang Y

更新日期：2020-11-25 00:00:00

abstract：:Although immunotherapies of tumors have demonstrated promise for altering the progression of malignancies, immunotherapies have been limited by an immunosuppressive tumor microenvironment (TME) that prevents infiltrating immune cells from performing their anticancer functions. Prominent among immunosuppressive cells a...

journal_title：Cancer research

authors： Cresswell GM,Wang B,Kischuk EM,Broman MM,Alfar RA,Vickman RE,Dimitrov DS,Kularatne SA,Sundaram CP,Singhal S,Eruslanov EB,Crist SA,Elzey BD,Ratliff TL,Low PS

更新日期：2020-11-17 00:00:00

abstract：:In this issue of Cancer Research, Rozeveld and colleagues present intriguing evidence of the importance of lipid droplets and hormone-sensitive lipase (HSL) in regulating the aggressive nature of pancreatic cancer. Initially demonstrating a dependency of preloaded lipids on an invasive phenotype, the authors then esta...

journal_title：Cancer research

authors： Man J,Pajic M,Joshua AM

更新日期：2020-11-15 00:00:00

abstract：:The majority of advanced prostate cancer therapies aim to inhibit androgen receptor (AR) signaling. However, AR reactivation inevitably drives disease progression to castration-resistant prostate cancer (CRPC). Here we demonstrate that protein arginine methyltransferase 5 (PRMT5) functions as an epigenetic activator o...

journal_title：Cancer research

authors： Beketova E,Fang S,Owens JL,Liu S,Chen X,Zhang Q,Asberry AM,Deng X,Malola J,Huang J,Li C,Pili R,Elzey BD,Ratliff TL,Wan J,Hu CD

更新日期：2020-11-15 00:00:00

abstract：:Breast cancer progresses in a multistep process from primary tumor growth and stroma invasion to metastasis. Nutrient-limiting environments promote chemotaxis with aggressive morphologies characteristic of invasion. It is unknown how coexisting cells differ in their response to nutrient limitations and how this impact...

journal_title：Cancer research

authors： Kimmel GJ,Dane M,Heiser LM,Altrock PM,Andor N

更新日期：2020-11-15 00:00:00

abstract：:Although epithelial cell adhesion molecule (EpCAM) has previously been shown to promote tumor progression, the underlying mechanisms remain largely unknown. Here, we report that the EGF-like domain I within the extracellular domain of EpCAM (EpEX) binds EGFR, activating both AKT and MAPK signaling to inhibit forkhead ...

journal_title：Cancer research

authors： Chen HN,Liang KH,Lai JK,Lan CH,Liao MY,Hung SH,Chuang YT,Chen KC,Tsuei WW,Wu HC

更新日期：2020-11-15 00:00:00

abstract：:Adaptive therapy seeks to exploit intra-tumoral competition to avoid, or at least delay, the emergence of therapy resistance in cancer. Motivated by promising results in prostate cancer, there is growing interest in extending this approach to other neoplasms. As such, it is urgent to understand the characteristics of ...

journal_title：Cancer research

authors： Strobl MAR,West J,Viossat Y,Damaghi M,Robertson-Tessi M,Brown JS,Gatenby RA,Maini PK,Anderson ARA

更新日期：2020-11-10 00:00:00

abstract：:Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism in breast cancer cells remains poorly understood. Here, we show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer cells. Loss of ZMYND8 triggered ac...

journal_title：Cancer research

authors： Wang Y,Luo M,Chen Y,Wang Y,Zhang B,Ren Z,Bao L,Wang Y,Wang JE,Fu YX,Luo W,Wang Y

更新日期：2020-11-04 00:00:00

abstract：:Our understanding of noncoding mutations in cancer genomes has been derived primarily from mutational recurrence analysis by aggregating clinical samples on a large scale. These cohort-based approaches cannot directly identify individual pathogenic noncoding mutations from personal cancer genomes. Therefore, although ...

journal_title：Cancer research

authors： Wang C,Li J

更新日期：2020-11-01 00:00:00

abstract：:Plexiform neurofibromas are benign nerve sheath Schwann cell tumors characterized by biallelic mutations in the neurofibromatosis type 1 (NF1) tumor suppressor gene. Atypical neurofibromas show additional frequent loss of CDKN2A/Ink4a/Arf and may be precursor lesions of aggressive malignant peripheral nerve sheath tum...

journal_title：Cancer research

authors： Chaney KE,Perrino MR,Kershner LJ,Patel AV,Wu J,Choi K,Rizvi TA,Dombi E,Szabo S,Largaespada DA,Ratner N

更新日期：2020-11-01 00:00:00

abstract：:T-cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests T-cell metabolic changes precede functional exhaustion. Direct competition between tumor-infiltrating lymphocytes (TIL) and cancer cells for metabolic resources often renders T cells dysfunctional. Environmental stress produces ep...

journal_title：Cancer research

authors： Koss B,Shields BD,Taylor EM,Storey AJ,Byrum SD,Gies AJ,Washam CL,Choudhury SR,Hyun Ahn J,Uryu H,Williams JB,Krager KJ,Chiang TC,Mackintosh SG,Edmondson RD,Aykin-Burns N,Gajewski TF,Wang GG,Tackett AJ

更新日期：2020-11-01 00:00:00

abstract：:Death receptor Fas-mediated apoptosis not only eliminates nonspecific and autoreactive B cells but also plays a major role in antitumor immunity. However, the possible mechanisms underlying impairment of Fas-mediated induction of apoptosis during lymphomagenesis remain unknown. In this study, we employed our developed...

journal_title：Cancer research

authors： Sugihara E,Hashimoto N,Osuka S,Shimizu T,Ueno S,Okazaki S,Yaguchi T,Kawakami Y,Kosaki K,Sato TA,Okamoto S,Saya H

更新日期：2020-10-15 00:00:00

abstract：:Obesity enhances breast cancer risk in postmenopausal women and premenopausal women with genetic or familial risk factors. We have shown previously that within breast tissue, obesity increases macrophage-driven inflammation and promotes expansion of luminal epithelial cell populations that are hypothesized to be the c...

journal_title：Cancer research

authors： Chamberlin T,Clack M,Silvers C,Kuziel G,Thompson V,Johnson H,Arendt LM

更新日期：2020-10-15 00:00:00

abstract：:Melanomas harboring BRAF mutations can be treated with BRAF inhibitors (BRAFi), but responses are varied and tumor recurrence is inevitable. Here we used an integrative approach of experimentation and mathematical flux balance analyses in BRAF-mutated melanoma cells to discover that elevated antioxidant capacity is li...

journal_title：Cancer research

authors： Paudel BB,Lewis JE,Hardeman KN,Hayford CE,Robbins CJ,Stauffer PE,Codreanu SG,Sherrod SD,McLean JA,Kemp ML,Quaranta V

更新日期：2020-10-15 00:00:00

abstract：:Despite significant advances in cancer precision medicine, a significant hurdle to its broader adoption remains the multitude of variants of unknown significance identified by clinical tumor sequencing and the lack of biologically validated methods to distinguish between functional and benign variants. Here we used fu...

journal_title：Cancer research

authors： Hanrahan AJ,Sylvester BE,Chang MT,Elzein A,Gao J,Han W,Liu Y,Xu D,Gao SP,Gorelick AN,Jones AM,Kiliti AJ,Nissan MH,Nimura CA,Poteshman AN,Yao Z,Gao Y,Hu W,Wise HC,Gavrila EI,Shoushtari AN,Tiwari S,Viale A,Abd

更新日期：2020-10-01 00:00:00

abstract：:Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poorly understood. Here we show that intratumoral copper levels influence PD-L1 exp...

journal_title：Cancer research

authors： Voli F,Valli E,Lerra L,Kimpton K,Saletta F,Giorgi FM,Mercatelli D,Rouaen JRC,Shen S,Murray JE,Ahmed-Cox A,Cirillo G,Mayoh C,Beavis PA,Haber M,Trapani JA,Kavallaris M,Vittorio O

更新日期：2020-10-01 00:00:00

abstract：:Heterozygous mutations in the BRCA1 gene predispose women to breast and ovarian cancer, while biallelic BRCA1 mutations are a cause of Fanconi anemia (FA), a rare genetic disorder characterized by developmental abnormalities, early-onset bone marrow failure, increased risk of cancers, and hypersensitivity to DNA-cross...

journal_title：Cancer research

authors： Park D,Bergin SM,Jones D,Ru P,Koivisto CS,Jeon YJ,Sizemore GM,Kladney RD,Hadjis A,Shakya R,Ludwig T

更新日期：2020-10-01 00:00:00

abstract：:Macrophages play important roles in both physiologic and pathologic processes and arise from successive waves of embryonic and adult hematopoiesis. Monocyte-derived macrophages (MOMF) exert distinct functions under pathologic conditions, and leukemia-associated macrophages (LAM) show considerable diversities in activa...

journal_title：Cancer research

authors： Yang F,Feng W,Wang H,Wang L,Liu X,Wang R,Chen C,Yang X,Zhang D,Ren Q,Zheng G

更新日期：2020-09-01 00:00:00

abstract：:Pancreatic neuroendocrine tumors (PanNET) were classified into grades (G) 1 to 3 by the World Health Organization in 2017, but the precise mechanisms of PanNET initiation and progression have remained unclear. In this study, we used a genetically engineered mouse model to investigate the mechanisms of PanNET formation...

journal_title：Cancer research

authors： Yamauchi Y,Kodama Y,Shiokawa M,Kakiuchi N,Marui S,Kuwada T,Sogabe Y,Tomono T,Mima A,Morita T,Matsumori T,Ueda T,Tsuda M,Nishikawa Y,Kuriyama K,Sakuma Y,Ota Y,Maruno T,Uza N,Masuda A,Tatsuoka H,Yabe D,Minamiguc

更新日期：2020-09-01 00:00:00

abstract：:Type 2 diabetes, which is mainly linked to obesity, is associated with increased incidence of liver cancer. We have previously found that in various models of obesity/diabetes, hyperinsulinemia maintains heightened hepatic expression of cyclin D1, suggesting a plausible mechanism linking diabetes and liver cancer prog...

journal_title：Cancer research

authors： Luo C,Liang J,Sharabi K,Hatting M,Perry EA,Tavares CDJ,Goyal L,Srivastava A,Bilodeau M,Zhu AX,Sicinski P,Puigserver P

更新日期：2020-08-15 00:00:00

abstract：:The presence of immunosuppressive macrophages that become activated in the tumor microenvironment constitutes a major factor responsible for tumor growth and malignancy. In line with this knowledge, we report here that macrophage proliferation is a significant feature of advanced stages of cancer. Moreover, we have fo...

journal_title：Cancer research

authors： Giurisato E,Lonardi S,Telfer B,Lussoso S,Risa-Ebrí B,Zhang J,Russo I,Wang J,Santucci A,Finegan KG,Gray NS,Vermi W,Tournier C

更新日期：2020-08-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a deadly and aggressive cancer. Understanding mechanisms that drive preneoplastic pancreatic lesions is necessary to improve early diagnostic and therapeutic strategies. Mutations and inactivation of activin-like kinase (ALK4) have been demonstrated to favor PDAC onset. Surpr...

journal_title：Cancer research

authors： Zhao Y,Wu Z,Chanal M,Guillaumond F,Goehrig D,Bachy S,Principe M,Ziverec A,Flaman JM,Collin G,Tomasini R,Pasternack A,Ritvos O,Vasseur S,Bernard D,Hennino A,Bertolino P

更新日期：2020-08-15 00:00:00

abstract：:Cellular senescence is a potent tumor-suppressive program that prevents neoplastic events. Paradoxically, senescent cells develop an inflammatory secretome, termed the senescence-associated secretory phenotype, which is implicated in age-related pathologies including cancer. Here, we report that senescent cells active...

journal_title：Cancer research

authors： Han L,Long Q,Li S,Xu Q,Zhang B,Dou X,Qian M,Jiramongkol Y,Guo J,Cao L,Chin YE,Lam EW,Jiang J,Sun Y

更新日期：2020-08-15 00:00:00

abstract：:Ras is frequently mutated in cancer, however, there is a lack of consensus in the literature regarding the cancer mutation frequency of Ras, with quoted values varying from 10%-30%. This variability is at least in part due to the selective aggregation of data from different databases and the dominant influence of part...

journal_title：Cancer research

authors： Prior IA,Hood FE,Hartley JL

更新日期：2020-07-15 00:00:00

abstract：:Cancer cells with germline deleterious mutations of BRCA1 or BRCA2 are deficient in homologous recombination repair and therefore sensitive to PARP inhibitor treatment. However, wild-type BRCA1/2-expressing cells with defects in other DNA damage repair pathway components may also exhibit "BRCAness," which in combinati...

journal_title：Cancer research

authors： Cai C

更新日期：2020-07-15 00:00:00

abstract：:Gastrointestinal adenocarcinomas (GIAC) of the tubular gastrointestinal (GI) tract including esophagus, stomach, colon, and rectum comprise most GI cancers and share a spectrum of genomic features. However, the unified epigenomic changes specific to GIAC are poorly characterized. Using 907 GIAC samples from The Cancer...

journal_title：Cancer research

authors： Pan J,Silva TC,Gull N,Yang Q,Plummer JT,Chen S,Daigo K,Hamakubo T,Gery S,Ding LW,Jiang YY,Hu S,Xu LY,Li EM,Ding Y,Klempner SJ,Gayther SA,Berman BP,Koeffler HP,Lin DC

更新日期：2020-07-01 00:00:00

abstract：:Despite the fact that osteosarcoma is one of the most common primary bone malignancies with poor prognosis, the mechanism behind the pathogenesis of osteosarcoma is only partially known. Here we characterized differentially expressed genes by extensive analysis of several publicly available gene expression profile dat...

journal_title：Cancer research

authors： Chen Y,Wang T,Huang M,Liu Q,Hu C,Wang B,Han D,Chen C,Zhang J,Li Z,Liu C,Lei W,Chang Y,Wu M,Xiang D,Chen Y,Wang R,Huang W,Lei Z,Chu X

更新日期：2020-06-15 00:00:00

abstract：:Patient-derived xenografts (PDX) are tumor-in-mouse models for cancer. PDX collections, such as the NCI PDXNet, are powerful resources for preclinical therapeutic testing. However, variations in experimental and analysis procedures have limited interpretability. To determine the robustness of PDX studies, the PDXNet t...

journal_title：Cancer research

authors： Evrard YA,Srivastava A,Randjelovic J,Doroshow JH,Dean DA 2nd,Morris JS,Chuang JH,NCI PDXNet Consortium.

更新日期：2020-06-01 00:00:00