Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis.

abstract：:Twenty-eight patients with metastatic malignant melanoma received anti-p97 murine monoclonal antibody (96.5) infused over 2 h at doses between 1 and 20 mg coupled to either 2.5 or 5.0 mCi of 111In by the bifunctional chelating agent diethyltriaminepentaacetic acid. Clearance of 111In from plasma closely fit an open, o...

journal_title：Cancer research

authors： Rosenblum MG,Murray JL,Haynie TP,Glenn HJ,Jahns MF,Benjamin RS,Frincke JM,Carlo DJ,Hersh EM

更新日期：1985-05-01 00:00:00

abstract：:Extramedullary myelopoiesis occurs commonly in tumor-bearing animals and is known to lead to accumulation of peripheral myeloid-derived suppressor cells (MDSC), which play an important role in immune escape. However, the cellular and molecular mechanisms by which tumors induce extramedullary myelopoiesis are poorly un...

journal_title：Cancer research

authors： Kim EK,Jeon I,Seo H,Park YJ,Song B,Lee KA,Jang Y,Chung Y,Kang CY

更新日期：2014-11-15 00:00:00

abstract：:alpha(v)beta(3) integrin was investigated in multiple myeloma in relation to the in vitro osteoclast-like activity of malignant plasma cells. Myeloma cells from patients with skeleton involvement overexpressed alpha(v)beta(3) and produced erosion pits on bone substrates, whereas this effect was not observed by cells f...

journal_title：Cancer research

authors： Tucci M,De Palma R,Lombardi L,Rodolico G,Berrino L,Dammacco F,Silvestris F

更新日期：2009-08-15 00:00:00

abstract：:The purpose of this study was to evaluate the efficacy of treatment with recombinant interleukin-2 (rIL-2) and lymphokine-activated killer cells in patients with advanced bladder cancer and to study the induced changes in the distribution of leukocyte subsets in blood and tumor. Nine patients with metastatic transitio...

journal_title：Cancer research

authors： Hermann GG,Geertsen PF,von der Maase H,Steven K,Andersen C,Hald T,Zeuthen J

更新日期：1992-02-01 00:00:00

abstract：:Prostate cancer subtypes are poorly defined and functional validation of drivers of ETS rearrangement-negative prostate cancer has not been conducted. Here, we identified an ETS(-) subtype of aggressive prostate cancer (ERG(-)MAP3K7(del)CHD1(del)) and used a novel developmental model and a cell line xenograft model to...

journal_title：Cancer research

authors： Rodrigues LU,Rider L,Nieto C,Romero L,Karimpour-Fard A,Loda M,Lucia MS,Wu M,Shi L,Cimic A,Sirintrapun SJ,Nolley R,Pac C,Chen H,Peehl DM,Xu J,Liu W,Costello JC,Cramer SD

更新日期：2015-03-15 00:00:00

abstract：:Indirect immunofluorescence staining with a large battery of monoclonal antibodies of primary and autologous metastatic lesions removed from seven patients with melanoma has detected heterogeneity in the expression of various types of melanoma-associated antigens (MAAs), of distinct determinants of the high molecular ...

journal_title：Cancer research

authors： Natali P,Bigotti A,Cavaliere R,Liao SK,Taniguchi M,Matsui M,Ferrone S

更新日期：1985-06-01 00:00:00

abstract：:Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), a prevalent cancer in China. LSH expression was inc...

journal_title：Cancer research

authors： He X,Yan B,Liu S,Jia J,Lai W,Xin X,Tang CE,Luo D,Tan T,Jiang Y,Shi Y,Liu Y,Xiao D,Chen L,Liu S,Mao C,Yin G,Cheng Y,Fan J,Cao Y,Muegge K,Tao Y

更新日期：2016-10-01 00:00:00

abstract：:Busulfan causes long-lasting defects in the hematopoietic stem cells and in the immune system of mice. We designed studies to determine whether chloramphenicol further damaged the already defective hematopoietic stem cells of mice that were pretreated with busulfan, and we unexpectedly observed that mice given injecti...

journal_title：Cancer research

authors： Robin E,Berman M,Bhoopalam N,Cohen H,Fried W

更新日期：1981-09-01 00:00:00

abstract：:Radiolabeled first-generation anti-tumor-associated glycoprotein-72 (TAG-72) monoclonal antibody (MAb), B72.3, has proven useful in detecting primary and secondary colorectal carcinoma. It has been anticipated that the development of second-generation, higher affinity, anti-TAG-72 MAbs, CC49 and CC83, would be of grea...

journal_title：Cancer research

authors： Gallinger S,Reilly RM,Kirsh JC,Odze RD,Schmocker BJ,Hay K,Polihronis J,Damani MT,Shpitz B,Stern HS

更新日期：1993-01-15 00:00:00

abstract：:A previous study demonstrated inhibition of growth of primary rat mammary carcinomas after infusion of tumor-bearer plasma absorbed against Sepharose derivatives. In this report we have quantitated changes in individual complement components that occur during absorption of rat plasma with Sepharose derivatives and def...

journal_title：Cancer research

authors： Nakanishi K,Zbar B,Borsos T

更新日期：1985-09-01 00:00:00

abstract：:Chinese hamster ovary cells exposed to the sulfhydryl compound cysteamine combined with heat treatment at 44 degrees C developed thermotolerance within 8 h. After initial treatment either with 15 min cysteamine (0.4 mM) at 37 degrees C immediately followed by 15 min heat at 44 degrees C or with 15 min cysteamine (0.4 ...

journal_title：Cancer research

authors： Issels RD,Bourier S,Böning B,Li GC,Mak JJ,Wilmanns W

更新日期：1987-05-01 00:00:00

abstract：:Multiple endocrine neoplasia 2B (MEN 2B) is an inherited syndrome of early onset endocrine tumors and developmental anomalies. The disease is caused primarily by a methionine to threonine substitution of residue 918 in the kinase domain of the RET receptor (2B-RET); however, the molecular mechanisms that lead to the d...

journal_title：Cancer research

authors： Gujral TS,Singh VK,Jia Z,Mulligan LM

更新日期：2006-11-15 00:00:00

abstract：:It has been proposed that occult, disseminated metastatic cells are refractory to chemotherapy due to lack of proliferation. We have shown that p38 activation induces dormancy of squamous carcinoma cells. We now show that p38 signaling in these cells activates a prosurvival mechanism via the up-regulation of the endop...

journal_title：Cancer research

authors： Ranganathan AC,Zhang L,Adam AP,Aguirre-Ghiso JA

更新日期：2006-02-01 00:00:00

abstract：:Genotoxicity-induced hair loss from chemotherapy and radiotherapy is often encountered in cancer treatment, and there is a lack of effective treatment. In growing hair follicles (HF), quiescent stem cells (SC) are maintained in the bulge region, and hair bulbs at the base contain rapidly dividing, yet genotoxicity-sen...

journal_title：Cancer research

authors： Huang WY,Lai SF,Chiu HY,Chang M,Plikus MV,Chan CC,Chen YT,Tsao PN,Yang TL,Lee HS,Chi P,Lin SJ

更新日期：2017-11-15 00:00:00

abstract：:Low-dose cyclophosphamide (LDC) induces selective apoptosis of endothelial cells within the vascular bed of tumors. Here, we investigated a hypothesis that the effect of LDC is mediated by the pro-apoptotic action of endogenous inhibitors of angiogenesis. Tumors treated with LDC demonstrate similar expression of matri...

journal_title：Cancer research

authors： Hamano Y,Sugimoto H,Soubasakos MA,Kieran M,Olsen BR,Lawler J,Sudhakar A,Kalluri R

更新日期：2004-03-01 00:00:00

abstract：:Changes in the structure of the surface of mastocytoma cells were induced by hyperthermia and were investigated by means of cell electrophoresis. A decrease in the cell electrophoretic mobility was detected as early as 15 min after treatment at 42 degrees and progressed more rapidly under hypoxic conditions than under...

journal_title：Cancer research

authors： Sato C,Nakayama T,Kojima K,Nishimoto Y,Nakamura W

更新日期：1981-10-01 00:00:00

abstract：:Patients diagnosed with leukemia approach their treatment with the hope of cure despite the effect on their quality of life. Some patients will be cured, others will die from treatment, and some will die of their disease. A common theme at the New Directions in Leukemia Research (NDLR 2012) meeting was that cure will ...

journal_title：Cancer research

authors： White DL,Brown AL,D'Andrea RJ,Rice AM

更新日期：2012-09-01 00:00:00

abstract：:The polyglutamylation of aminopterin and methotrexate (N10-methylaminopterin) was compared in the Ehrlich ascites tumor in vitro. Three poly-gamma-glutamyl conjugates of methotrexate and aminopterin were detected, although at an equal (1 microM) extracellular drug concentration, the net accumulation of aminopterin pol...

journal_title：Cancer research

authors： Matherly LH,Voss MK,Anderson LA,Fry DW,Goldman ID

更新日期：1985-03-01 00:00:00

abstract：:Iodide uptake in the thyroid and breast is mediated by the sodium/iodide symporter (NIS). NIS activation is used for radioiodide imaging and therapeutic ablation of thyroid carcinoma. NIS is expressed in >70% of breast cancers but at a level insufficient for radioiodine treatment. All-trans retinoic acid (tRA) induces...

journal_title：Cancer research

authors： Ohashi E,Kogai T,Kagechika H,Brent GA

更新日期：2009-04-15 00:00:00

abstract：:The transmembrane neural cell adhesion receptor L1 is a Wnt/β-catenin target gene expressed in many tumor types. In human colorectal cancer, L1 localizes preferentially to the invasive front of tumors and when overexpressed in colorectal cancer cells, it facilitates their metastasis to the liver. In this study, we inv...

journal_title：Cancer research

authors： Gavert N,Shvab A,Sheffer M,Ben-Shmuel A,Haase G,Bakos E,Domany E,Ben-Ze'ev A

更新日期：2013-09-15 00:00:00

abstract：:We studied the correlation between the formation of brain metastasis and the malignant growth potential of seven human melanoma cell lines, isolated from lymph node metastases (A375-SM, TXM-1, DM-4) or from brain metastases (TXM-13, TXM-18, TXM-34, TXM-40), and the potential of three variants of the mouse K-1735 melan...

journal_title：Cancer research

authors： Zhang RD,Price JE,Schackert G,Itoh K,Fidler IJ

更新日期：1991-04-15 00:00:00

abstract：:C19ORF5 is a sequence homologue of microtubule-associated proteins MAP1A/MAP1B of unknown function, except for its association with mitochondria-associated proteins and the paclitaxel-like microtubule stabilizer and candidate tumor suppressor RASSF1A. Here, we show that when overexpressed in mammalian cells the recomb...

journal_title：Cancer research

authors： Liu L,Vo A,Liu G,McKeehan WL

更新日期：2005-05-15 00:00:00

abstract：:Tumor cell-derived selectin ligands mediate contact to the endothelium, platelets, and leukocytes through binding to selectins that facilitates metastasis. Here, we describe the mechanism of how endogenous (non-tumor derived) selectin ligands contribute to metastasis using α(1,3)fucosyltransferase 7 (Fuc-TVII(-/-))-de...

journal_title：Cancer research

authors： Hoos A,Protsyuk D,Borsig L

更新日期：2014-02-01 00:00:00

abstract：:We examined the DNA methylation pathway in an autochthonous murine prostate cancer model, transgenic adenocarcinoma of mouse prostate (TRAMP). We observed that, compared with strain-matched normal prostates, primary and metastatic TRAMP tumors display increased cytosine DNA methyltransferase (Dnmt) activity, Dnmt1 and...

journal_title：Cancer research

authors： Morey SR,Smiraglia DJ,James SR,Yu J,Moser MT,Foster BA,Karpf AR

更新日期：2006-12-15 00:00:00

abstract：:Checkpoint inhibitors like anti-PD1/PD-L1 have demonstrated significant therapeutic efficacy in a subset of patients partly through reinvigoration of CD8 T cells. However, their impact on myeloid cells remains largely unknown. Here, we report that anti-PD-L1 treatment favorably impacts the phenotype and function of tu...

journal_title：Cancer research

authors： Xiong H,Mittman S,Rodriguez R,Moskalenko M,Pacheco-Sanchez P,Yang Y,Nickles D,Cubas R

更新日期：2019-04-01 00:00:00

abstract：:Three murine hybridomas (TMMR-1-3) were developed by repeated immunizations of mice with four different human osteosarcoma cell lines in an alternating sequence of inoculations. The monoclonal antibodies were screened for reactivities to cultured cell lines and tissue sections of osteosarcomas using flow cytometry and...

journal_title：Cancer research

authors： Tsai CC,McGuire MH,Mellitt RJ,Ritter RA 3rd,Xu JZ,Litwicki DJ,Roodman ST

更新日期：1990-01-01 00:00:00

abstract：:The influence of cyclophosphamide (CY) on Friend virus leukemogenesis was studied in SJL/J, C57BL/10J, and C57BL/10J X SJL/J F1 (hereafter called B10SJF1) mice. All three differ in their susceptibility to the viral oncogenic effect. Immunosuppressive doses of CY, which by themselves produced no cancer, were followed 2...

journal_title：Cancer research

authors： Raikow RB,OKunewick JP,Buffo MJ,Kociban DL

更新日期：1985-02-01 00:00:00

abstract：:Aggressive tumor growth, diffuse tissue invasion, and neurodegeneration are hallmarks of malignant glioma. Although glutamate excitotoxicity is considered to play a key role in glioma-induced neurodegeneration, the mechanism(s) controlling this process is poorly understood. Astrocyte elevated gene-1 (AEG-1) is an onco...

journal_title：Cancer research

authors： Lee SG,Kim K,Kegelman TP,Dash R,Das SK,Choi JK,Emdad L,Howlett EL,Jeon HY,Su ZZ,Yoo BK,Sarkar D,Kim SH,Kang DC,Fisher PB

更新日期：2011-10-15 00:00:00

abstract：:The effect of dietary orotic acid (OA) in liver-pancreas carcinogenesis induced in female Syrian hamsters by N-Nitroso(2-hydroxypropyl) (2-oxopropyl)amine (HPOP) was evaluated. All animals infused with the carcinogen received the same doses. Results of the control group which received no OA or carcinogen were compared...

journal_title：Cancer research

authors： Kokkinakis DM,Albores-Saavedra J

更新日期：1994-10-15 00:00:00

abstract：:We evaluated whether antibody response correlates with tumor therapy by cytokine gene-modified tumor cell vaccines. To characterize the antibody (Ab) response against a known antigen, colon carcinoma C26 cells and C26 variants engineered to produce interleukin (IL) 12 or IL-4 were further transduced to express the hum...

journal_title：Cancer research

authors： Rodolfo M,Melani C,Zilocchi C,Cappetti B,Luison E,Arioli I,Parenza M,Canevari S,Colombo MP

更新日期：1998-12-15 00:00:00