Abstract：
:Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), a prevalent cancer in China. LSH expression was increased in NPC, where it was controlled by the Epstein-Barr virus-encoded protein LMP1. In NPC cells in vitro and in vivo, LSH promoted cancer progression in part by regulating expression of fumarate hydratase (FH), a core component of the tricarboxylic acid cycle. LSH bound to the FH promoter, recruiting the epigenetic silencer factor G9a to repress FH transcription. Clinically, we found that the concentration of TCA intermediates in NPC patient sera was deregulated in the presence of LSH. RNAi-mediated silencing of FH mimicked LSH overexpression, establishing FH as downstream mediator of LSH effects. The TCA intermediates α-KG and citrate potentiated the malignant character of NPC cells, in part by altering IKKα-dependent EMT gene expression. In this manner, LSH furthered malignant progression of NPC by modifying cancer cell metabolism to support EMT. Cancer Res; 76(19); 5743-55. ©2016 AACR.
journal_name
Cancer Resjournal_title
Cancer researchauthors
He X,Yan B,Liu S,Jia J,Lai W,Xin X,Tang CE,Luo D,Tan T,Jiang Y,Shi Y,Liu Y,Xiao D,Chen L,Liu S,Mao C,Yin G,Cheng Y,Fan J,Cao Y,Muegge K,Tao Ydoi
10.1158/0008-5472.CAN-16-0268subject
Has Abstractpub_date
2016-10-01 00:00:00pages
5743-5755issue
19eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-16-0268journal_volume
76pub_type
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