Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction.

abstract：:A crucial ingredient of any hyperthermia procedure is the accurate measurement of achieved temperature. In this paper, we present some accuracy and resolution suggestions and address the problem of temperature measurements when electromagnetic energy is used as the mode of heating. In such cases, conventional metallic...

journal_title：Cancer research

authors： Christensen DA

更新日期：1979-06-01 00:00:00

abstract：:The Xeroderma pigmentosum group D (XPD) protein is an essential participant in nucleotide excision repair and basal transcription. There is evidence that three common polymorphisms of the XPD gene (C156A, Asp312Asn, and Lys751Gln) may be associated with differential DNA repair activity. Because increased DNA repair pl...

journal_title：Cancer research

authors： Park DJ,Stoehlmacher J,Zhang W,Tsao-Wei DD,Groshen S,Lenz HJ

更新日期：2001-12-15 00:00:00

abstract：:A new DNA precipitation assay used together with the alkali unwinding assay may provide a rapid means of detecting DNA damage in addition to strand breaks based on the relative amount of damage measured by the two assays. X-rays, Adriamycin, 4-nitroquinoline-N-oxide, N-methyl-N'-nitrosoguanidine, bleomycin, RSU 1172, ...

journal_title：Cancer research

authors： Olive PL,Chan AP,Cu CS

更新日期：1988-11-15 00:00:00

abstract：:We investigated the potential role of mitochondrial manganese superoxide dismutase (Mn-SOD) in protective activity against irradiation by analyzing cell viability by a colony formation assay and by detecting apoptosis in stably human Mn-SOD gene-transfected HLE, a hepatocellular carcinoma cell line. We found that over...

journal_title：Cancer research

authors： Motoori S,Majima HJ,Ebara M,Kato H,Hirai F,Kakinuma S,Yamaguchi C,Ozawa T,Nagano T,Tsujii H,Saisho H

更新日期：2001-07-15 00:00:00

abstract：:We investigated the effect of iododeoxyuridine (IdUrd) exposure on cis-diamminedichloroplatinum (CDDP) cytotoxicity in the human bladder cancer cell line 647V. Following a 48-h incubation with 2-20 microM IdUrd, a 1-h exposure to 0-120 microM CDDP produced a dose-dependent increase in CDDP cytotoxicity as measured by ...

journal_title：Cancer research

authors： Chi KH,Kunugi KA,Kinsella TJ

更新日期：1994-05-15 00:00:00

abstract：:We recently reported trophic response of transplantable mouse colon cancer cells (MC-26) to pentagastrin, in vivo, and demonstrated gastrin receptors on MC-26 cells, in vitro. In the present study, growth of MC-26 cells in mice, in response to pentagastrin, was studied in relation to binding kinetics and capacity of g...

journal_title：Cancer research

authors： Singh P,Walker JP,Townsend CM Jr,Thompson JC

更新日期：1986-04-01 00:00:00

abstract：:Signaling through the insulin-like growth factor-I receptor (IGF-IR) is implicated in cellular proliferation, apoptosis, carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. Targeted disruption of IGF-IR signaling combined with cytotoxic therapy may therefore yield improved anticancer efficacy ove...

journal_title：Cancer research

authors： Allen GW,Saba C,Armstrong EA,Huang SM,Benavente S,Ludwig DL,Hicklin DJ,Harari PM

更新日期：2007-02-01 00:00:00

abstract：:The effects of 5-mercapto-2'-deoxyuridine (MUdr) on DNA synthesis in a primary murine spleen lymphocyte culture system stimulated by phytohemagglutinin (PHA) were studied. Inhibition of thymidine incorporation into acid insoluble nucleic acid material was 50% at 0.5 mM MUdR concentration, while inhibition of deoxyurid...

journal_title：Cancer research

authors： Bogyo D,Bardos TJ,Chmielewicz ZF

更新日期：1976-09-01 00:00:00

abstract：:Here, we report the molecular regulation of interleukin (IL)-8 expression in human melanoma cells. The inflammatory cytokines IL-1beta and tumor necrosis factor-alpha (TNF-alpha) up-regulated IL-8 expression, in a time- and concentration-dependent manner, in three metastatic melanoma variants, SBC-2 (nonmetastatic), A...

journal_title：Cancer research

authors： Singh RK,Varney ML

更新日期：1998-04-01 00:00:00

abstract：:Serial passages of the poorly differentiated, androgen-sensitive R3327-G prostatic adenocarcinoma were used to study the progressive changes that occur in tumor growth rate and androgen sensitivity. Different in vivo transplant generations (21st to 28th) were compared. The tumor doubling and animal survival times resu...

journal_title：Cancer research

authors： Pollack A,Block NL,Stover BJ,Irvin GL 3rd

更新日期：1985-03-01 00:00:00

abstract：:DAB389 GRP is composed of the catalytic and transmembrane domains of diphtheria toxin fused to gastrin-releasing peptide (GRP). DAB389 GRP is selectively targeted to, and inhibits protein synthesis in, cell lines expressing GRP receptors. Protein synthesis in 5'ET4 cells (BALB/3T3 fibroblasts transfected with the gene...

journal_title：Cancer research

authors： vanderSpek JC,Sutherland JA,Zeng H,Battey JF,Jensen RT,Murphy JR

更新日期：1997-01-15 00:00:00

abstract：:DNA lesions in nuclei isolated from rat tissues following i.p. injection of the carcinogen nickel carbonate were measured by the alkaline elution technique. Kidney, liver, lung, and thymus gland nuclei were examined at 3 and 20 hr after treatment for the presence of DNA single-strand breaks and cross-links. Single-str...

journal_title：Cancer research

authors： Ciccarelli RB,Wetterhahn KE

更新日期：1982-09-01 00:00:00

abstract：:The lack of markers to predict chemotherapy responses in patients poses a major handicap in cancer treatment. We searched for gene expression patterns that correlate with docetaxel or cisplatin response in a mouse model for breast cancer associated with BRCA1 deficiency. Array-based expression profiling did not identi...

journal_title：Cancer research

authors： Rottenberg S,Vollebergh MA,de Hoon B,de Ronde J,Schouten PC,Kersbergen A,Zander SA,Pajic M,Jaspers JE,Jonkers M,Lodén M,Sol W,van der Burg E,Wesseling J,Gillet JP,Gottesman MM,Gribnau J,Wessels L,Linn SC,Jonkers J,

更新日期：2012-05-01 00:00:00

abstract：:Adaptive therapy seeks to exploit intra-tumoral competition to avoid, or at least delay, the emergence of therapy resistance in cancer. Motivated by promising results in prostate cancer, there is growing interest in extending this approach to other neoplasms. As such, it is urgent to understand the characteristics of ...

journal_title：Cancer research

authors： Strobl MAR,West J,Viossat Y,Damaghi M,Robertson-Tessi M,Brown JS,Gatenby RA,Maini PK,Anderson ARA

更新日期：2020-11-10 00:00:00

abstract：:A growing number of observations has suggested that plasmacytoid dendritic cells (pDC) play a critical role in tumor biology. In patients, infiltration of tumors by pDCs generally correlates with a poor prognosis, suggesting that pDCs may play an important role in the host-tumor relationship. Here, we analyze the infl...

journal_title：Cancer research

authors： Terra M,Oberkampf M,Fayolle C,Rosenbaum P,Guillerey C,Dadaglio G,Leclerc C

更新日期：2018-06-01 00:00:00

abstract：:The Vinca alkaloid vincristine and the epipodophyllotoxin derivative teniposide significantly elevate steady state levels of methotrexate in the Ehrlich ascites tumor cell in vitro. However, the presence of circulating serum proteins compromises this drug-cell interaction. In the presence of bovine serum albumin, elev...

journal_title：Cancer research

authors： Gewirtz DA

更新日期：1985-12-01 00:00:00

abstract：:Four of seven human melanoma cell lines were sensitive to killing by L-dopa (D37 1.0-4.7 microM) compared with fibroblasts, Hela, and three ovarian tumor cell lines (D37 12-59 microM). All seven melanoma lines, however, were sensitive to DL-buthionine(S,R)sulfoximine (BSO) (D37 0.73-8.5 microM) compared with the nonme...

journal_title：Cancer research

authors： Kable EP,Favier D,Parsons PG

更新日期：1989-05-01 00:00:00

abstract：:To identify genetic events that characterize cancer progression, we conducted a comprehensive genetic evaluation of 161 primary breast tumors. Similar to the "mountain-and-hill" view of mutations, gene amplification also shows high- and low-frequency alterations in breast cancers. The frequently amplified genes includ...

journal_title：Cancer research

authors： Kadota M,Sato M,Duncan B,Ooshima A,Yang HH,Diaz-Meyer N,Gere S,Kageyama S,Fukuoka J,Nagata T,Tsukada K,Dunn BK,Wakefield LM,Lee MP

更新日期：2009-09-15 00:00:00

abstract：:Overexpression of the adverse prognostic marker ERBB2 occurs in 30% of breast cancers; however, therapies targeting this gene have not proved to be as effective as was initially hoped. Transcriptional profiling meta-analyses have shown that there are approximately 150 genes co-overexpressed with ERBB2, suggesting that...

journal_title：Cancer research

authors： Kourtidis A,Jain R,Carkner RD,Eifert C,Brosnan MJ,Conklin DS

更新日期：2010-03-01 00:00:00

abstract：:Colon carcinoma cells overexpress c-myc due to defective Wnt signaling, but only patients whose tumors have an amplified c-myc gene show improved disease-free and overall survival in response to 5-fluoruracil (5FU). Here we show that in two colon carcinoma cell lines that do not have an amplified c-myc gene but differ...

journal_title：Cancer research

authors： Arango D,Corner GA,Wadler S,Catalano PJ,Augenlicht LH

更新日期：2001-06-15 00:00:00

abstract：:Urine from 22 patients with a variety of disseminated cancers and from an equivalent number of nonmalignant controls of similar age and sex was tested for the presence of transforming growth factor (TGF) activity as measured by the ability to promote the growth in soft agar of nontransformed indicator cells. Cancer pa...

journal_title：Cancer research

authors： Sherwin SA,Twardzik DR,Bohn WH,Cockley KD,Todaro GJ

更新日期：1983-01-01 00:00:00

abstract：:Microtubule inhibitors as chemotherapeutic drugs are widely used for cancer treatment. However, the development of multidrug resistance (MDR) in cancer is a major challenge for microtubule inhibitors in their clinical implementation. From a high-throughput drug screen using cells transformed by oncogenic RAS, we ident...

journal_title：Cancer research

authors： Ning N,Yu Y,Wu M,Zhang R,Zhang T,Zhu C,Huang L,Yun CH,Benes CH,Zhang J,Deng X,Chen Q,Ren R

更新日期：2018-10-15 00:00:00

abstract：:Aberrant activation of Wnt signaling plays an important role in hepatocarcinogenesis. In addition to direct effects on tumor cells, Wnt signaling might be involved in the organization of tumor microenvironment. In this study, we have explored whether Wnt signaling blockade by exogenous expression of Wnt antagonists co...

journal_title：Cancer research

authors： Hu J,Dong A,Fernandez-Ruiz V,Shan J,Kawa M,Martínez-Ansó E,Prieto J,Qian C

更新日期：2009-09-01 00:00:00

abstract：:Brain tumors are thought to originate from stem/progenitor cell populations that acquire specific genetic mutations. Although current preclinical models have relevance to human pathogenesis, most do not recapitulate the histogenesis of the human disease. Recently, a large series of human gliomas and medulloblastomas w...

journal_title：Cancer research

authors： Henriquez NV,Forshew T,Tatevossian R,Ellis M,Richard-Loendt A,Rogers H,Jacques TS,Reitboeck PG,Pearce K,Sheer D,Grundy RG,Brandner S

更新日期：2013-09-15 00:00:00

abstract：:Host resistance to tumor growth was studied in athymic nude mice of C57BL background. Animals were pretreated in the left hind leg by local hyperthermia, local X-irradiation, or combined local hyperthermia and X-irradiation. Twenty-four hr posttreatment, the animals were inoculated with the metastatic Lewis lung carci...

journal_title：Cancer research

authors： Yerushalmi A,Weinstein Y

更新日期：1979-03-01 00:00:00

abstract：:The POU-domain transcription factor Oct-1 is widely expressed in adult tissues and has been proposed to regulate a large group of target genes. Microarray expression profiling was used to evaluate gene expression changes in Oct-1-deficient mouse fibroblasts. A number of genes associated with cellular stress exhibited ...

journal_title：Cancer research

authors： Tantin D,Schild-Poulter C,Wang V,Haché RJ,Sharp PA

更新日期：2005-12-01 00:00:00

abstract：:Diets enriched in n-3 polyunsaturated fatty acids (n-3 PUFA) may protect against breast cancer but biochemical mechanisms are unclear. Our studies showed that the n-3 fatty acid docosahexaenoic acid (DHA) up-regulated syndecan-1 (SDC-1) in human breast cancer cells, and we tested the hypothesis that DHA-mediated up-re...

journal_title：Cancer research

authors： Sun H,Berquin IM,Owens RT,O'Flaherty JT,Edwards IJ

更新日期：2008-04-15 00:00:00

abstract：:Heteroantisera were produced in rabbits by immunization with cultivated cells from rat intestinal carcinomas. The sera were made specific by in vivo absorption in syngeneic rats. On immunofluorescence, these sera recognized a membrane-associated antigen common to five different intestinal carcinomas and to fetal intes...

journal_title：Cancer research

authors： Martin F,Knobel S,Martin M,Bordes M

更新日期：1975-02-01 00:00:00

abstract：:The metabolism of the rat esophageal carcinogen N-nitrosomethylbenzylamine (NMBzA) was studied using microsomes prepared from liver and esophageal mucosa of untreated male Sprague-Dawley rats. NMBzA was extensively metabolized to benzaldehyde, benzyl alcohol, and formaldehyde by hepatic microsomes. The rate of metabol...

journal_title：Cancer research

authors： Labuc GE,Archer MC

更新日期：1982-08-01 00:00:00

abstract：:The peroxiredoxins (Prx) are conserved antioxidant proteins that use cysteine as the primary site of oxidation during the reduction of peroxides. Many organisms have more than one isoform of Prx. Deletion of TSA1, one of five Prxs in yeast Saccharomyces cerevisiae, results in accumulation of a broad spectrum of mutati...

journal_title：Cancer research

authors： Iraqui I,Faye G,Ragu S,Masurel-Heneman A,Kolodner RD,Huang ME

更新日期：2008-02-15 00:00:00