A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum-based chemotherapy in patients with advanced colorectal cancer.

abstract：:The fusion transcript AML1/ETO was detected in the bone marrow of two t(8;21)-negative acute myelogenous leukemia (AML) patients by means of reverse transcription-polymerase chain reaction. This fusion transcript is identical to the one transcribed from the t(8;21) translocation base, as deduced from (a) the size and ...

journal_title：Cancer research

authors： Maruyama F,Yang P,Stass SA,Cork A,Freireich EJ,Lee MS,Chang KS

更新日期：1993-10-01 00:00:00

abstract：:Benzo(a)pyrene and 210Po were administered both simultaneously and sequentially by intratracheal instillations to Syrian golden hamsters in experiments designed to identify any synergistic interactions between these carcinogens. Their effects were additive after simultaneous administration. A significant synergistic i...

journal_title：Cancer research

authors： Little JB,McGandy RB,Kennedy AR

更新日期：1978-07-01 00:00:00

abstract：:In this issue of Cancer Research, Xia and colleagues show that MYC-induced metabolic reprograming results in dependency on the serine-glycine-one-carbon (SGOC) metabolic pathway in neuroblastoma. This occurs through MYCN and ATF4 activation of the SGOC biosynthetic pathway in MYCN-amplified cells. Furthermore, inhibit...

journal_title：Cancer research

authors： Garcia AR,Arsenian-Henriksson M

更新日期：2019-08-01 00:00:00

abstract：:Bleomycin treatment produced dose-dependent changes in lung collagen content and in several measurable histopathological parameters. NIH/Swiss mice were treated twice weekly for 6 weeks with bleomycin, 0, 1, 20, or 40 mg/kg s.c. The two highest doses produced mortalities of 35 and 100%, respectively, as well as loss o...

journal_title：Cancer research

authors： Sikic BI,Young DM,Mimnaugh EG,Gram TE

更新日期：1978-03-01 00:00:00

abstract：:Androgen receptors (ARs) belong to the family of hormone receptors that are ligand-dependent transcription factors. Endocrine therapy provides effective treatment for prostate cancer until mutations arise that alter the ligand responsiveness of AR. In this study, structural models were developed for the functional dom...

journal_title：Cancer research

authors： McDonald S,Brive L,Agus DB,Scher HI,Ely KR

更新日期：2000-05-01 00:00:00

abstract：:Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism. Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CA...

journal_title：Cancer research

authors： Fultang L,Gamble LD,Gneo L,Berry AM,Egan SA,De Bie F,Yogev O,Eden GL,Booth S,Brownhill S,Vardon A,McConville CM,Cheng PN,Norris MD,Etchevers HC,Murray J,Ziegler DS,Chesler L,Schmidt R,Burchill SA,Haber M,De Sant

更新日期：2019-02-01 00:00:00

abstract：:Tumor recurrence in prostate cancer has been attributed to the presence of CD44-expressing tumor-initiating cells. In this study, we report that miR-708 is a key negative regulator of this CD44(+) subpopulation of prostate cancer cells, with important implications for diagnosis and prognosis of this disease. miR-708 w...

journal_title：Cancer research

authors： Saini S,Majid S,Shahryari V,Arora S,Yamamura S,Chang I,Zaman MS,Deng G,Tanaka Y,Dahiya R

更新日期：2012-07-15 00:00:00

abstract：:The potentiation of monoclonal antibody/ligand toxin (immunotoxin) cytotoxicity by the ionophore monensin (Mo) or by human serum albumin-monensin (HSA-Mo) conjugates was investigated. Since disulfide cross-linked HSA-Mo (HSA-SPDP-Mo) is rapidly inactivated by human serum (M. Colombatti et al., Cancer Res., 50: 1385-13...

journal_title：Cancer research

authors： Candiani C,Franceschi A,Chignola R,Pasti M,Anselmi C,Benoni G,Tridente G,Colombatti M

更新日期：1992-02-01 00:00:00

abstract：:The influence of microtubule-associated proteins on the interaction of vincristine with microtubules and tubulin was examined. Microtubules containing associated proteins were prepared in vitro from tubulin preparations which contained the proteins or from pure 6S tubulin and isolated microtubule-associated proteins. ...

journal_title：Cancer research

authors： Donoso JA,Haskins KM,Himes RH

更新日期：1979-05-01 00:00:00

abstract：:The thymidylate synthase inhibitor 5-fluorouracil (5-FU) continues to play a pivotal role in the treatment of cancer. A downstream event of thymidylate synthase inhibition involves the induction of a self-defeating base excision repair process. With the depletion of TTP pools, there is also an increase in dUMP. Metabo...

journal_title：Cancer research

authors： Fischer JA,Muller-Weeks S,Caradonna SJ

更新日期：2006-09-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and constitutes 15% of adult leukemias. Although overall prognosis for pediatric ALL is favorable, high-risk pediatric patients and most adult patients have significantly worse outcomes. Multiagent chemotherapy is standard of care for both pedi...

journal_title：Cancer research

authors： Chao MP,Alizadeh AA,Tang C,Jan M,Weissman-Tsukamoto R,Zhao F,Park CY,Weissman IL,Majeti R

更新日期：2011-02-15 00:00:00

abstract：:Predisposition to prostate cancer has a genetic component, and there are reports of familial clustering of breast and prostate cancer. Two highly penetrant genes that predispose individuals to breast cancer (BRCA1 and BRCA2) are known to confer an increased risk of prostate cancer of about 3-fold and 7-fold, respectiv...

journal_title：Cancer research

authors： Gayther SA,de Foy KA,Harrington P,Pharoah P,Dunsmuir WD,Edwards SM,Gillett C,Ardern-Jones A,Dearnaley DP,Easton DF,Ford D,Shearer RJ,Kirby RS,Dowe AL,Kelly J,Stratton MR,Ponder BA,Barnes D,Eeles RA

更新日期：2000-08-15 00:00:00

abstract：:Targeted therapies can be defined as drugs developed against a specific target based on its important biological function in cancer. In contrast, nontargeted therapies are drugs identified by phenotypic screening of natural products or chemical libraries against established cancer cell lines or preclinical animal mode...

journal_title：Cancer research

authors： Hait WN,Hambley TW

更新日期：2009-02-15 00:00:00

abstract：:A new DNA precipitation assay used together with the alkali unwinding assay may provide a rapid means of detecting DNA damage in addition to strand breaks based on the relative amount of damage measured by the two assays. X-rays, Adriamycin, 4-nitroquinoline-N-oxide, N-methyl-N'-nitrosoguanidine, bleomycin, RSU 1172, ...

journal_title：Cancer research

authors： Olive PL,Chan AP,Cu CS

更新日期：1988-11-15 00:00:00

abstract：:Two malignant sublines, M4 and RMS4 , were previously derived from the recloned L6 line of rat myogenic cells. Comparative studies in tissue culture and inoculation into suckling rats indicated that M4 cells and RMS4 cells may be considered as low-malignant and high-malignant cells, respectively, while L6 cells are no...

journal_title：Cancer research

authors： Hillion J,Leibovitch SA,Leibovitch MP,Raymondjean M,Kruh J,Harel J

更新日期：1984-07-01 00:00:00

abstract：:Oligomerization of the nonreceptor tyrosine kinase c-Abl can activate its transforming potential. Domains mediating oligomerization within the BCR-ABL and TEL-ABL oncoproteins are required for transforming activity, and fusion of inducible dimerization domains to c-Abl can generate chimeric proteins with dimerization-...

journal_title：Cancer research

authors： Fan PD,Cong F,Goff SP

更新日期：2003-02-15 00:00:00

abstract：:A cascade of events leading to hypertrophy has been proposed and implicated in growth regulation in a variety of normal and neoplastic cells and tissues. There is a tightly coupled temporal sequence: (a) cyclic adenosine 3':5'-monophosphate-dependent protein kinase (cAPK) activation; (b) ornithine decarboxylase (ODC) ...

journal_title：Cancer research

authors： Olson JW,Russell DH

更新日期：1980-12-01 00:00:00

abstract：:To directly examine a multistage carcinogenesis model and the role of UV light in human tissues, we grafted human skin onto mice with severe combined immunodeficiency disease. We found that the maximum dose of UV radiation in the B range (UVB; 280-320 nm) tolerated by these grafts was 500 J/m2 three times weekly. One ...

journal_title：Cancer research

authors： Soballe PW,Montone KT,Satyamoorthy K,Nesbit M,Herlyn M

更新日期：1996-02-15 00:00:00

abstract：:Various hormones and growth factors are involved in the growth regulation of breast (tumor) cells. In this report we show for the first time that an analogue of the neuropeptide somatostatin (Sandostatin) can also influence the proliferation of human breast cancer cells (MCF-7), namely, in an inhibitory fashion. With ...

journal_title：Cancer research

authors： Setyono-Han B,Henkelman MS,Foekens JA,Klijn GM

更新日期：1987-03-15 00:00:00

abstract：:5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The sensitivity of Ehrlich ascites tumor cells in CF-1 mice to 5'-dFUrd, as well as to 5-fluorouridine, was established. 5'-dFUrd was a more effective antitumor agent and was less toxic over a ...

journal_title：Cancer research

authors： Armstrong RD,Diasio RB

更新日期：1980-09-01 00:00:00

abstract：:The possible contribution of endocrine disrupters to human disease, particularly those compounds that modulate the estrogen receptor (ER), has recently drawn considerable attention. The tissue specificity of effects mediated by the ER is well recognized, although the mechanism of this specificity is not understood suf...

journal_title：Cancer research

authors： Hunter DS,Hodges LC,Vonier PM,Fuchs-Young R,Gottardis MM,Walker CL

更新日期：1999-07-01 00:00:00

abstract：:Ras signaling originates from transient nanoscale compartmentalized regions of the plasma membrane composed of specific proteins and lipids. The highly specific lipid composition of these nanodomains, termed nanoclusters, facilitates effector recruitment and therefore influences signal transduction. This suggests that...

journal_title：Cancer research

authors： Fuentes NR,Mlih M,Barhoumi R,Fan YY,Hardin P,Steele TJ,Behmer S,Prior IA,Karpac J,Chapkin RS

更新日期：2018-07-15 00:00:00

abstract：:As recently characterized, following s.c. implantation into syngeneic C57BL/6 mice, E0771 tumor invades locally into dermal layers and peritoneum, metastasizes to the lung, and induces a nonspecific immunosuppression in the host. Using this breast medullar adenocarcinoma model, a therapy consisting of a single moderat...

journal_title：Cancer research

authors： Ewens A,Luo L,Berleth E,Alderfer J,Wollman R,Hafeez BB,Kanter P,Mihich E,Ehrke MJ

更新日期：2006-05-15 00:00:00

abstract：:The human cytomegalovirus (HCMV), potentially associated with the development of malignancies, encodes the constitutively active chemokine receptor US28. Previously, we have shown that US28 expression induces an oncogenic phenotype both in vitro and in vivo. Microarray analysis revealed differential expression of gene...

journal_title：Cancer research

authors： Maussang D,Langemeijer E,Fitzsimons CP,Stigter-van Walsum M,Dijkman R,Borg MK,Slinger E,Schreiber A,Michel D,Tensen CP,van Dongen GA,Leurs R,Smit MJ

更新日期：2009-04-01 00:00:00

abstract：:Single-chain antigen-binding proteins, or sFvs, represent potentially unique molecules for targeted delivery of drugs, toxins, or radionuclides to a tumor site. In previous studies (Cancer Res., 51:6363-6371, 1991) using a human colon carcinoma xenograft model, it was demonstrated that the sFv has an extremely rapid p...

journal_title：Cancer research

authors： Yokota T,Milenic DE,Whitlow M,Schlom J

更新日期：1992-06-15 00:00:00

abstract：:The EphA2 receptor tyrosine kinase is found at low levels on nontransformed adult breast epithelial cells but is frequently overexpressed on aggressive breast cancer cells. Recent studies have documented an inverse relationship between EphA2 and estrogen receptor expression in breast cancer cell lines. In our present ...

journal_title：Cancer research

authors： Lu M,Miller KD,Gokmen-Polar Y,Jeng MH,Kinch MS

更新日期：2003-06-15 00:00:00

abstract：:The Notch family of proteins plays an integral role in determining cell fates, such as proliferation, differentiation, and apoptosis. We show that Notch-1 and its ligands, Delta-like-1 and Jagged-1, are overexpressed in many glioma cell lines and primary human gliomas. Immunohistochemistry of a primary human glioma ti...

journal_title：Cancer research

authors： Purow BW,Haque RM,Noel MW,Su Q,Burdick MJ,Lee J,Sundaresan T,Pastorino S,Park JK,Mikolaenko I,Maric D,Eberhart CG,Fine HA

更新日期：2005-03-15 00:00:00

abstract：:Certain bis(2,6-dioxopiperazine) derivatives, which include ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl]propane; ADR-529) and its racemic compound ICRF 159 (Razoxane), have been investigated as antineoplastic agents. In addition, ICRF-187 is currently under intense study as an agent to ameliorate the cardiac toxic...

journal_title：Cancer research

authors： Gorbsky GJ

更新日期：1994-02-15 00:00:00

abstract：:Several studies have shown that neuroblastoma and retinoblastoma tumor cells often have elevated N-myc mRNA levels compared to normal adult neuronal or retinal tissues, and it has been suggested that increased expression of this protooncogene may play an important role in tumorigenesis or malignant progression in cell...

journal_title：Cancer research

authors： Amy CM,Bartholomew JC

更新日期：1987-12-01 00:00:00

abstract：:Monoclonal antibodies (MABs) reactive with human renal cell carcinoma (RCC) were generated following immunization of mice with either RCC homogenates, RCC cell lines, or fetal kidney homogenates. The characteristics of four highly reactive immunoglobulin G1 MABs, designated UMVA-RCC-A6H, UMVA-RCC-A36, UMVA-RCC-C5H and...

journal_title：Cancer research

authors： Vessella RL,Moon TD,Chiou RK,Nowak JA,Arfman EW,Palme DF,Peterson GA,Lange PH

更新日期：1985-12-01 00:00:00