Abstract：
:The POU-domain transcription factor Oct-1 is widely expressed in adult tissues and has been proposed to regulate a large group of target genes. Microarray expression profiling was used to evaluate gene expression changes in Oct-1-deficient mouse fibroblasts. A number of genes associated with cellular stress exhibited altered expression. Consistent with this finding, Oct-1-deficient fibroblasts were hypersensitive to gamma radiation, doxorubicin, and hydrogen peroxide and harbored elevated reactive oxygen species. Expression profiling identified a second group of genes dysregulated in Oct-1-deficient fibroblasts following irradiation, including many associated with oxidative and metabolic stress. A number of these genes contain octamer sequences in their immediate 5' regulatory regions, some of which are conserved in human. These results indicate that Oct-1 modulates the activity of genes important for the cellular response to stress.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Tantin D,Schild-Poulter C,Wang V,Haché RJ,Sharp PAdoi
10.1158/0008-5472.CAN-05-2399subject
Has Abstractpub_date
2005-12-01 00:00:00pages
10750-8issue
23eissn
0008-5472issn
1538-7445pii
65/23/10750journal_volume
65pub_type
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