Characterization of the inhibitory effects of transforming growth factor-beta on a human colon carcinoma cell line.

abstract：:Earlier studies (Baeckström et al., J. Biol. Chem., 266: 21537-21547, 1991) have revealed that the colon carcinoma cell line COLO 205 produces two different proteins carrying the carcinoma-associated sialyl-Le(a) carbohydrate epitope. One is the MUC1 mucin apoprotein, and the other protein is smaller and has not been ...

journal_title：Cancer research

authors： Baeckström D,Nilsson O,Price MR,Lindholm L,Hansson GC

更新日期：1993-02-15 00:00:00

abstract：:Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and progression are largely unknown. For colorectal cancer (CRC), investigation of this problem has been hindered by a paucity of specific markers for identificati...

journal_title：Cancer research

authors： Huang EH,Hynes MJ,Zhang T,Ginestier C,Dontu G,Appelman H,Fields JZ,Wicha MS,Boman BM

更新日期：2009-04-15 00:00:00

abstract：:Culturing DOV 13 ovarian carcinoma cells on three-dimensional collagen lattice but not on thin-layer collagen induces processing of promatrix metalloproteinase (MMP)-2 to a M(r) 62,000 form, suggesting that multivalent integrin aggregation may participate in proteinase regulation. To address the role of collagen-bindi...

journal_title：Cancer research

authors： Ellerbroek SM,Fishman DA,Kearns AS,Bafetti LM,Stack MS

更新日期：1999-04-01 00:00:00

abstract：:Asian diets high in soy are associated with lower risk for breast cancer compared with Western diets. Moreover, higher levels of two putative carcinogenic metabolites of 17beta-estradiol, 4- and 16alpha-hydroxyestrogen, and lower amounts of anticarcinogenic metabolites, 2-hydroxyestrogens, have been associated with gr...

journal_title：Cancer research

authors： Lu LJ,Cree M,Josyula S,Nagamani M,Grady JJ,Anderson KE

更新日期：2000-03-01 00:00:00

abstract：:The urokinase-type plasminogen activator receptor (uPAR) has a well-established role in cancer progression, but it has been little studied at earlier stages of cancer initiation. Here, we show that uPAR deficiency in the mouse dramatically reduces susceptibility to the classical two-stage protocol of inflammatory skin...

journal_title：Cancer research

authors： Mazzieri R,Pietrogrande G,Gerasi L,Gandelli A,Colombo P,Moi D,Brombin C,Ambrosi A,Danese S,Mignatti P,Blasi F,D'Alessio S

更新日期：2015-11-15 00:00:00

abstract：:Transforming growth factor betas (TGF-beta) play a dual role in carcinogenesis, functioning as tumor suppressors early in the process, and then switching to act as prometastatic factors in late-stage disease. We have previously shown that high molecular weight TGF-beta antagonists can suppress metastasis without the p...

journal_title：Cancer research

authors： Nam JS,Suchar AM,Kang MJ,Stuelten CH,Tang B,Michalowska AM,Fisher LW,Fedarko NS,Jain A,Pinkas J,Lonning S,Wakefield LM

更新日期：2006-06-15 00:00:00

abstract：:Malignant changes are often accompanied by alterations in activity and composition of the plasminogen activators (PA). To study the relationship between PA expression and the development of colorectal cancer, we determined urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) activit...

journal_title：Cancer research

authors： de Bruin PA,Griffioen G,Verspaget HW,Verheijen JH,Lamers CB

更新日期：1987-09-01 00:00:00

abstract：:An accurate method of classification of the surface membrane characteristics of blast cells from patients with acute lymphoblastic leukemia would allow a more definitive study of the nature of this disease. Monoclonal antibodies have been produced to the surface antigens of leukemic blasts form a patient with high-ris...

journal_title：Cancer research

authors： Zipf TF,Fox RI,Dilley J,Levy R

更新日期：1981-11-01 00:00:00

abstract：:Our objectives were to test whether polymorphic variation in the (CAG)n repeat of the androgen receptor (AR) gene affects penetrance of germ-line BRCA mutations for ovarian cancer or age of diagnosis for ovarian cancer. Using a case-series study design, 179 consecutive Ashkenazi Jewish ovarian cancer patients were gen...

journal_title：Cancer research

authors： Levine DA,Boyd J

更新日期：2001-02-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with a poor clinical outcome. Previously, we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60% of patients with AML and that ROS production promotes proliferation of AML cells...

journal_title：Cancer research

authors： Robinson AJ,Hopkins GL,Rastogi N,Hodges M,Doyle M,Davies S,Hole PS,Omidvar N,Darley RL,Tonks A

更新日期：2020-03-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most frequent and incurable type of brain tumor of adults. Hypoxia has been shown to direct GBM toward a more aggressive and malignant state. Here we show that hypoxia increases Notch1 activation, which in turn induces the expression of transient receptor potential 6 (TRPC6) in pri...

journal_title：Cancer research

authors： Chigurupati S,Venkataraman R,Barrera D,Naganathan A,Madan M,Paul L,Pattisapu JV,Kyriazis GA,Sugaya K,Bushnev S,Lathia JD,Rich JN,Chan SL

更新日期：2010-01-01 00:00:00

abstract：:Because both Rhodamine 123 (R123) and hyperthermia have been shown to be cytotoxic, we examined their effect, independently and in combination, on five different human malignant cell lines in vitro and on cultured melanoma cells grown intradermally in nude mice. The cell lines examined include two human melanomas, UCL...

journal_title：Cancer research

authors： Goffney WH,Wong JH,Kern DH,Chase D,Krag DN,Storm FK

更新日期：1990-02-01 00:00:00

abstract：:The glutathione transferase (GST) isoenzyme profile was determined in two human tumor cell lines, U1690 derived from a small cell lung cancer and U1810 derived from a non-small cell lung cancer. U1810 cells are 3.2-fold more resistant to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) than are U1690 cells, a finding ascri...

journal_title：Cancer research

authors： Berhane K,Hao XY,Egyházi S,Hansson J,Ringborg U,Mannervik B

更新日期：1993-09-15 00:00:00

abstract：:The complement cascade is a part of the innate immune system that acts primarily to remove pathogens and injured cells. However, complement activation is also peculiarly associated with tumor progression. Here we report mechanistic insights into this association in multiple immunocompetent orthotopic models of lung ca...

journal_title：Cancer research

authors： Kwak JW,Laskowski J,Li HY,McSharry MV,Sippel TR,Bullock BL,Johnson AM,Poczobutt JM,Neuwelt AJ,Malkoski SP,Weiser-Evans MC,Lambris JD,Clambey ET,Thurman JM,Nemenoff RA

更新日期：2018-01-01 00:00:00

abstract：:The tumor suppressor gene in lung cancer (TSLC1) encodes a membrane glycoprotein containing extensive homology in the extracellular domain with the immunoglobulin-superfamily cell adhesion molecules. The intracellular cytoplasmic domain (CT) contains a protein 4.1 (FERM) binding motif, and a PDZ-interacting motif. Exp...

journal_title：Cancer research

authors： Mao X,Seidlitz E,Ghosh K,Murakami Y,Ghosh HP

更新日期：2003-11-15 00:00:00

abstract：:Transformation with ras oncogenes results in increased radiation sur vival in many but not all cells. In addition, prenyltransferase inhibitors which inhibit ras proteins by blocking posttranslational modification radiosensitize cells with oncogenic ras. These findings suggest that oncogenic ras contributes to intrins...

journal_title：Cancer research

authors： Bernhard EJ,Stanbridge EJ,Gupta S,Gupta AK,Soto D,Bakanauskas VJ,Cerniglia GJ,Muschel RJ,McKenna WG

更新日期：2000-12-01 00:00:00

abstract：:Pancreatic cancer is an aggressive neoplasm with no current viable, effective treatment options. In the majority of cases, at first diagnosis, pancreatic cancer has already become metastatic so that conventional treatment regimens provide minimal, if any, clinical benefit in prolonging life or ameliorating the negativ...

journal_title：Cancer research

authors： Sarkar D,Su ZZ,Vozhilla N,Park ES,Randolph A,Valerie K,Fisher PB

更新日期：2005-10-01 00:00:00

abstract：:Treatment of non-T/non-B human leukemic cell line REH with 5 X 10(-9) M 12-O-tetradecanoylphorbol-13-acetate (TPA) at 37 degrees resulted in their adherence to culture flasks by 24 to 36 hr and, after 72 hr, the entire surface of the flask/coverslips became covered with macrophage-like cells containing pseudopodia. Wr...

journal_title：Cancer research

authors： Srivastava BI,Koga M,Srivastava P

更新日期：1984-07-01 00:00:00

abstract：:Capan 1, a human pancreatic cancer cell line, is routinely grown in 10% fetal calf serum (FCS). In order to characterize the factors needed for its proliferation, FCS was replaced by a synthetic serum (Ultroser G). For Capan 1 proliferation we found that Ultroser G was as efficient as FCS. A subfraction of Ultroser G ...

journal_title：Cancer research

authors： Clerc P,Bensaadi N,Pradel P,Estival A,Clemente F,Vaysse N

更新日期：1991-07-15 00:00:00

abstract：:Retinoic acid receptors and retinoid X receptors form heterodimers, bind to retinoic acid response elements, and transactivate the transcription of retinoid-responsive genes. Two synthetic retinoids [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid (TTAB) and 6-(5,6,7,8-tetrahydro-5,5,8,8-tetrameth...

journal_title：Cancer research

authors： Lotan R,Dawson MI,Zou CC,Jong L,Lotan D,Zou CP

更新日期：1995-01-15 00:00:00

abstract：:Members of cutaneous melanoma (CM) families with dysplastic nevi (DN) are at high risk of developing CM. Using a shuttle vector plasmid, pSP189, cell lines from three patients with CM plus DN were previously found to have elevated post-UV plasmid mutability. To investigate familial occurrence of this cellular phenotyp...

journal_title：Cancer research

authors： Moriwaki SI,Tarone RE,Tucker MA,Goldstein AM,Kraemer KH

更新日期：1997-10-15 00:00:00

abstract：:Actinomycin D produces changes in the cell cycle kinetics of Chinese hamster (HA1) and mouse mammary tumor cells (EMT6) cultivated in vitro. There was a reduced rate of progression of the cells through S phase and a G2 arrest, the duration and degree of which were drug dose dependent. The lethal effects of the drug on...

journal_title：Cancer research

authors： Roots R,Smith KC

更新日期：1976-10-01 00:00:00

abstract：:Overexpression of ABCB1 (MDR1) P-glycoprotein, a multidrug efflux pump, is one mechanism by which tumor cells may develop multidrug resistance (MDR), preventing the successful chemotherapeutic treatment of cancer. Sesquiterpenes from Celastraceae family are natural compounds shown previously to reverse MDR in several ...

journal_title：Cancer research

authors： Muñoz-Martínez F,Lu P,Cortés-Selva F,Pérez-Victoria JM,Jiménez IA,Ravelo AG,Sharom FJ,Gamarro F,Castanys S

更新日期：2004-10-01 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumor in children. Osteosarcoma patients who respond poorly to chemotherapy are at a higher risk of relapse and adverse outcome. Therefore, it was the aim of this study to identify prognostic factors at the time of diagnosis to characterize the genes predictive of poor su...

journal_title：Cancer research

authors： Mintz MB,Sowers R,Brown KM,Hilmer SC,Mazza B,Huvos AG,Meyers PA,Lafleur B,McDonough WS,Henry MM,Ramsey KE,Antonescu CR,Chen W,Healey JH,Daluski A,Berens ME,Macdonald TJ,Gorlick R,Stephan DA

更新日期：2005-03-01 00:00:00

abstract：:Thirty-seven consecutive patients with germ cell cancers (34 testicular, three extragonadal) and elevated serum levels of alpha-fetoprotein (AFP) and/or human chorionic gonadotropin (HCG) were treated with vinblastine, bleomycin, and cis-diamminedichloroplatinum induction chemotherapy. The AFP and/or HCG normalized in...

journal_title：Cancer research

authors： Vogelzang NJ,Lange PH,Goldman A,Vessela RH,Fraley EE,Kennedy BJ

更新日期：1982-11-01 00:00:00

abstract：:The inactivation of p53 functions enhances the efficiency and decreases the latency of producing induced pluripotent stem cells (iPSC) in culture. The formation of iPSCs in culture starts with a rapid set of cell divisions followed by an epigenetic reprogramming of the DNA and chromatin. The mechanisms by which the p5...

journal_title：Cancer research

authors： Yi L,Lu C,Hu W,Sun Y,Levine AJ

更新日期：2012-11-01 00:00:00

abstract：:The p21-activated Ser/Thr kinase 1 (PAK1) kinase has an essential role in tumorigenesis and cell survival in many cancers, but its regulation is not fully understood. In this study, we showed that in response to irradiation of lung cancer cells, PAK1 was upregulated, tyrosine phosphorylated, and translocated to the nu...

journal_title：Cancer research

authors： Kim E,Youn H,Kwon T,Son B,Kang J,Yang HJ,Seong KM,Kim W,Youn B

更新日期：2014-10-01 00:00:00

abstract：:This study investigates the effect of variations in dietary vitamin E on the incidence of dimethylhydrazine-induced colonic tumors in mice. Two groups of 65 LACA mice were given 28 weekly s.c. injections of dimethylhydrazine. The only difference in the management of the two groups was the dietary content of vitamin E;...

journal_title：Cancer research

authors： Cook MG,McNamara P

更新日期：1980-04-01 00:00:00

abstract：:In this study, we identified 53 aberrantly hypermethylated DNA sequences in adult T-cell leukemia (ATL) cells using methylated CpG island amplification/representational difference analysis method. We also observed a proportionate increase in the methylation density of these regions with disease progression. Seven gene...

journal_title：Cancer research

authors： Yasunaga J,Taniguchi Y,Nosaka K,Yoshida M,Satou Y,Sakai T,Mitsuya H,Matsuoka M

更新日期：2004-09-01 00:00:00

abstract：:It has been proposed that cellular retinoic acid binding protein is essential for retinoid-induced differentiation of embryonal carcinoma line PCC4.aza1R. To assess the generality of this proposal, we have tested for the presence of cellular retinoic acid binding protein activities in several other embryonal carcinoma...

journal_title：Cancer research

authors： Matthaei KI,McCue PA,Sherman MI

更新日期：1983-06-01 00:00:00