In vitro and in vivo cytotoxicity of rhodamine 123 combined with hyperthermia.

abstract：:It has been postulated that the expression of the ribonucleoprotein telomerase is necessary to overcome cellular senescence and that malignant tumors must express telomerase to maintain their immortality. In most human adult tissues, telomerase activity is not detected. In contrast, several murine tissues express vari...

journal_title：Cancer research

authors： Bednarek A,Budunova I,Slaga TJ,Aldaz CM

更新日期：1995-10-15 00:00:00

abstract：:Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and progression are largely unknown. For colorectal cancer (CRC), investigation of this problem has been hindered by a paucity of specific markers for identificati...

journal_title：Cancer research

authors： Huang EH,Hynes MJ,Zhang T,Ginestier C,Dontu G,Appelman H,Fields JZ,Wicha MS,Boman BM

更新日期：2009-04-15 00:00:00

abstract：:Association studies in large series of breast cancer patients can be used to identify single-nucleotide polymorphisms (SNP) contributing to breast cancer susceptibility. Previous studies have suggested associations between variants in TP53 (R72P) and MDM2 (SNP309) and cancer risk. Data from molecular studies suggest a...

journal_title：Cancer research

authors： Schmidt MK,Reincke S,Broeks A,Braaf LM,Hogervorst FB,Tollenaar RA,Johnson N,Fletcher O,Peto J,Tommiska J,Blomqvist C,Nevanlinna HA,Healey CS,Dunning AM,Pharoah PD,Easton DF,Dörk T,Van't Veer LJ,Breast Cancer Associati

更新日期：2007-10-01 00:00:00

abstract：:Retroviral-mediated delivery of the P140K mutant O(6)-methylguanine-DNA methyltransferase (MGMT(P140K)) into hematopoietic stem cells (HSC) has been proposed as a means to protect against dose-limiting myelosuppressive toxicity ensuing from chemotherapy combining O(6)-alkylating agents (e.g., temozolomide) with pseudo...

journal_title：Cancer research

authors： Milsom MD,Jerabek-Willemsen M,Harris CE,Schambach A,Broun E,Bailey J,Jansen M,Schleimer D,Nattamai K,Wilhelm J,Watson A,Geiger H,Margison GP,Moritz T,Baum C,Thomale J,Williams DA

更新日期：2008-08-01 00:00:00

abstract：:The aim of this study was to evaluate the promoter methylation status and loss of heterozygosity (LOH) of the SEMA3B in non-small cell lung cancers (NSCLCs). We analyzed the methylation status of semaphorin 3B (SEMA3B) promoter and LOH at 3p21.3 in eight NSCLC cell lines and 27 primary tumors. Hypermethylation of SEMA...

journal_title：Cancer research

authors： Kuroki T,Trapasso F,Yendamuri S,Matsuyama A,Alder H,Williams NN,Kaiser LR,Croce CM

更新日期：2003-06-15 00:00:00

abstract：:A new approach to selective photodynamic therapy (PDT) was developed by designing chlorin e6 (Ce6)-containing macromolecules, which are sensitive to tumor-associated proteases. The agents are nontoxic in their native state but become fluorescent and produce singlet oxygen on protease conversion. Coupled with optimized...

journal_title：Cancer research

authors： Choi Y,Weissleder R,Tung CH

更新日期：2006-07-15 00:00:00

abstract：:In this study, we have demonstrated the overexpression of cyclin D1 protein in 24 (92%) of 26 low-grade squamous intraepithelial lesions infected with low-risk human papillomaviruses (HPV 6, 11, 42, 43, and 44) and the absence of cyclin D1 expression in 25 (87%) of 29 lesions infected with high-risk HPVs (HPV 16, 18, ...

journal_title：Cancer research

authors： Southern SA,Herrington CS

更新日期：1998-07-15 00:00:00

abstract：:A series of nitrofuran-based compounds were identified as inhibitors of estrogen signaling in a cell-based, high-throughput screen of a diverse library of small molecules. These highly related compounds were subsequently found to inhibit topoisomerase II in vitro at concentrations similar to that required for the inhi...

journal_title：Cancer research

authors： Polycarpou-Schwarz M,Müller K,Denger S,Riddell A,Lewis J,Gannon F,Reid G

更新日期：2007-05-01 00:00:00

abstract：:A bovine serum albumin-conjugated doxorubicin via the glutaraldehyde bridge (BSA-DXR conjugate) showed potent dose-dependent inhibition of cell growth against daunorubicin-resistant AH66 (AH66DR) cells as well as parental AH66 (AH66P) cells in vitro as compared to treatment with DXR or BSA-glutaraldehyde conjugate wit...

journal_title：Cancer research

authors： Ohkawa K,Hatano T,Yamada K,Joh K,Takada K,Tsukada Y,Matsuda M

更新日期：1993-09-15 00:00:00

abstract：:By using the newly developed adhesive tumor cell culture system, we analyzed the chromosomal constitutions of primary lung tumor and nonmalignant normal lung tissue from 10 previously untreated patients with non-small cell lung cancer. Chromosomal analyses were successfully carried out in banded chromosome preparation...

journal_title：Cancer research

authors： Lee JS,Pathak S,Hopwood V,Tomasovic B,Mullins TD,Baker FL,Spitzer G,Neidhart JA

更新日期：1987-12-01 00:00:00

abstract：:Expression of non-self antigens by tumors can induce activation of T cells in vivo, although this activation can lead to either immunity or tolerance. CD8+ T-cell activation can be direct (if the tumor expresses MHC class I molecules) or indirect (after the capture and cross-presentation of tumor antigens by dendritic...

journal_title：Cancer research

authors： Zeelenberg IS,Ostrowski M,Krumeich S,Bobrie A,Jancic C,Boissonnas A,Delcayre A,Le Pecq JB,Combadière B,Amigorena S,Théry C

更新日期：2008-02-15 00:00:00

abstract：:Tumor-associated macrophages (TAMs) produce angiogenic factors and in breast cancer are associated with high vascular grade and poor survival. TAMs preferentially migrate to hypoxic areas within tumors and strongly express hypoxia-inducible factor (HIF)-2 alpha. This study examined whether HIF-2 alpha was involved in ...

journal_title：Cancer research

authors： Leek RD,Talks KL,Pezzella F,Turley H,Campo L,Brown NS,Bicknell R,Taylor M,Gatter KC,Harris AL

更新日期：2002-03-01 00:00:00

abstract：:Previous studies have shown dose-dependent growth inhibition of the human mammary carcinoma cell line MDA-MB-231 xenotransplanted in athymic mice using retinol. In this study, the growth inhibitory effect of retinoic acid (RA) and 13-cis-retinoic acid (13-cis-RA) was examined in vitro and in vivo. With both agents the...

journal_title：Cancer research

authors： Halter SA,Fraker LD,Adcock D,Vick S

更新日期：1988-07-01 00:00:00

abstract：:It has recently been reported that the human myeloma cell line U266 proceeds to undergo apoptosis after cultivation with the antiestrogen tamoxifen, thus raising the possibility that antiestrogens may be candidates for use in myeloma therapy. To obtain basic information on the effects of antiestrogens on myeloma cells...

journal_title：Cancer research

authors： Otsuki T,Yamada O,Kurebayashi J,Moriya T,Sakaguchi H,Kunisue H,Yata K,Uno M,Yawata Y,Ueki A

更新日期：2000-03-01 00:00:00

abstract：:Aberrant signal transduction has been implicated in malignant transformation, growth, and progression. This has led to the proposal to use inhibitors of signal transduction pathways to treat cancer. One approach to circumventing potential toxicity and improving efficacy would be to target pathways upon which cancer ce...

journal_title：Cancer research

authors： Kohn EC,Sandeen MA,Liotta LA

更新日期：1992-06-01 00:00:00

abstract：:Multiple DNA microsatellites with frequent loss of heterozygosity (LOH) in melanomas have been demonstrated. The finding that free DNA is enriched in blood of melanoma patients prompted studies to determine whether tumor-specific DNA, such as DNA microsatellites exhibiting LOH, can be detected in blood and have clinic...

journal_title：Cancer research

authors： Fujiwara Y,Chi DD,Wang H,Keleman P,Morton DL,Turner R,Hoon DS

更新日期：1999-04-01 00:00:00

abstract：:Previous studies have favored a basic difference in the regulation of specialized protein production by cells derived from the usual tissue of origin (eutopic) and cancer cells derived from a tissue not normally producing the protein (ectopic). Thus N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate was believed to...

journal_title：Cancer research

authors： Rosen SW,Calvert I,Weintraub BD,Tseng JS,Rabson AS

更新日期：1980-11-01 00:00:00

abstract：:Constitutively photomorphogenic 1 (COP1), a RING finger ubiquitin ligase with substrates including c-Jun and p53, was recently found to be overexpressed in a number of breast and ovarian tumor samples. In addition to its E3 activity, COP1 was also shown to be able to inhibit activator protein 1 (AP-1) transcription. T...

journal_title：Cancer research

authors： Yi C,Li S,Chen X,Wiemer EA,Wang J,Wei N,Deng XW

更新日期：2005-07-01 00:00:00

abstract：:The effects of chemical carcinogenesis to produce premalignant hyperplastic nodules in rat liver on concomitant immune function were studied. Induction of hyperplastic nodules in Fischer rats was accomplished using a combined regimen of diethylnitrosamine, 2-acetylaminofluorene, and partial hepatectomy. Hyperplastic n...

journal_title：Cancer research

authors： Leu RW,Norton TR,Herriott MJ,Ringer DP,Kearns RJ

更新日期：1985-07-01 00:00:00

abstract：:Allelic loss of chromosome 18q has been noted in intestinal type gastric adenocarcinomas. Smad4 is a gene located at 18q that was recently cloned in humans and found to be significantly altered in pancreatic cancers. We sought to determine whether Smad4 genetic alterations played a significant role in gastric tumorige...

journal_title：Cancer research

authors： Powell SM,Harper JC,Hamilton SR,Robinson CR,Cummings OW

更新日期：1997-10-01 00:00:00

abstract：:The supply of oxygen and nutrients to solid tumors is inefficient because cancer tissues have an inadequate number of microvessels, thus inducing the selective growth of the most aggressive cancer cells. This explains why many of the factors underlying a poor prognosis are induced in hypoxic/hypoglycemic conditions. A...

journal_title：Cancer research

authors： Raspaglio G,De Maria I,Filippetti F,Martinelli E,Zannoni GF,Prislei S,Ferrandina G,Shahabi S,Scambia G,Ferlini C

更新日期：2010-07-15 00:00:00

abstract：:Little is known about the genetic changes underlying invasive tumor growth in bladder cancer. Because alterations that are linked to invasive tumor growth may be detectable in minimally invasive (stage pT1) but not in noninvasive (stage pTa) tumors, we searched for genetic differences between 28 pTa and 28 papillary p...

journal_title：Cancer research

authors： Richter J,Jiang F,Görög JP,Sartorius G,Egenter C,Gasser TC,Moch H,Mihatsch MJ,Sauter G

更新日期：1997-07-15 00:00:00

abstract：:A partial-length A-myb complementary DNA recently cloned by low-stringency hybridization with a c-myb probe to complementary DNA libraries derived from human cell lines showed a high degree of homology with the DNA-binding domain of c-myb and B-myb, suggesting that A-myb also encoded a DNA-binding protein. We report h...

journal_title：Cancer research

authors： Ma XP,Calabretta B

更新日期：1994-12-15 00:00:00

abstract：:A recent pilot study that we performed on 12 individuals who are involved in the cultivation and processing of grains and legumes suggests to us that we may have in hand a relatively quick, inexpensive, and highly sensitive assay that identifies individuals at increased risk for the development of lymphoid malignancy....

journal_title：Cancer research

authors： Kirsch IR,Lipkowitz S

更新日期：1992-10-01 00:00:00

abstract：:Anaplastic large cell lymphomas (ALCL) are mainly characterized by the reciprocal translocation t(2;5)(p23;q35) that involves the anaplastic lymphoma kinase (ALK) gene and generates the fusion protein NPM-ALK with intrinsic tyrosine kinase activity. NPM-ALK triggers several signaling cascades, leading to increased cel...

journal_title：Cancer research

authors： Voena C,Conte C,Ambrogio C,Boeri Erba E,Boccalatte F,Mohammed S,Jensen ON,Palestro G,Inghirami G,Chiarle R

更新日期：2007-05-01 00:00:00

abstract：:A potential tumor suppressor gene, STK11 , encoding a serine threonine kinase, has recently been identified on chromosome 19p13. Germ-line mutations of this gene have been found in patients with Peutz-Jeghers syndrome (PJS). To further investigate the relevance of STK11 mutations in PJS, we analyzed its coding sequenc...

journal_title：Cancer research

authors： Resta N,Simone C,Mareni C,Montera M,Gentile M,Susca F,Gristina R,Pozzi S,Bertario L,Bufo P,Carlomagno N,Ingrosso M,Rossini FP,Tenconi R,Guanti G

更新日期：1998-11-01 00:00:00

abstract：:We studied loss of heterozygosity (LOH) on human chromosome 7q to determine the location of a putative tumor suppressor gene (TSG) in human primary prostate carcinomas. Samples were obtained from 16 primary prostate carcinomas surgically removed from patients at The University of Texas M. D. Anderson Cancer Center. Pa...

journal_title：Cancer research

authors： Zenklusen JC,Thompson JC,Troncoso P,Kagan J,Conti CJ

更新日期：1994-12-15 00:00:00

abstract：:The specific activity (dpm/mg protein) of the acid-soluble nuclear material extracted from spleens or lymph nodes (but not other tissues) of tumor-bearing BALB/c mice was approximately twice that of the corresponding tissues from tumor-free mice of the same age and sex following i.p. injection of L-[U-14C]lysine. Auto...

journal_title：Cancer research

authors： Mashburn LT

更新日期：1985-05-01 00:00:00

abstract：:Regulation of the expression of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) has been investigated in a number of human lymphoblastoid cell lines. In a number of Mex- cell lines that do not express methyltransferase activity, CpG sequences in the mgmt gene were hypomethylated with respect to met...

journal_title：Cancer research

authors： Cairns-Smith S,Karran P

更新日期：1992-10-01 00:00:00

abstract：:The p27 tumor suppressor negatively regulates G1 cell cycle progression. However, human malignancies rarely select for deletion/inactivation of p27, a hallmark of tumor suppressor genes. Instead, p27 is degraded or relocalized to the cytoplasm in aggressive malignancies, supporting the notion that p27 sequestration fr...

journal_title：Cancer research

authors： Denicourt C,Saenz CC,Datnow B,Cui XS,Dowdy SF

更新日期：2007-10-01 00:00:00