Plasma DNA microsatellites as tumor-specific markers and indicators of tumor progression in melanoma patients.

abstract：:The growth of a panel of eight different human glioblastoma cell lines was examined in a human tumor cloning assay in agar, a tritiated thymidine uptake assay, and by counting cell numbers, in cultures performed in the absence or presence of increasing concentrations (1 to 100 ng/ml) of recombinant human stem cell fac...

journal_title：Cancer research

authors： Berdel WE,de Vos S,Maurer J,Oberberg D,von Marschall Z,Schroeder JK,Li J,Ludwig WD,Kreuser ED,Thiel E

更新日期：1992-06-15 00:00:00

abstract：:The Notch ligand Dll4 has a recognized role during both physiologic and tumor angiogenesis, as it contributes to regulate Notch activity in endothelial cells (EC). The effects of Dll4 on Notch signaling in tumor cells expressing Notch receptors remain, however, largely unknown. Here, we report that escape of human T-c...

journal_title：Cancer research

authors： Indraccolo S,Minuzzo S,Masiero M,Pusceddu I,Persano L,Moserle L,Reboldi A,Favaro E,Mecarozzi M,Di Mario G,Screpanti I,Ponzoni M,Doglioni C,Amadori A

更新日期：2009-02-15 00:00:00

abstract：:In vitro cell-mediated cytotoxicity (CMC) assays have been carried out in human melanoma system with blood effector lymphocytes on [3H]proline-labeled target cells in a 48-hr microcytotoxicity technique. Three lymphocyte purification procedures (Ficoll:Hypaque gradient, plasma gel sedimentation followed by nylon colum...

journal_title：Cancer research

authors： Mukherji B,Vassos D,Flowers A,Binder SC,Nathanson L

更新日期：1975-12-01 00:00:00

abstract：:Antiangiogenic therapy is efficacious in metastatic renal cell carcinoma (mRCC). However, the ability of antiangiogenic drugs to delay tumor progression and extend survival is limited, due to either innate or acquired drug resistance. Furthermore, there are currently no validated biomarkers that predict which mRCC pat...

journal_title：Cancer research

authors： Robinson SP,Boult JKR,Vasudev NS,Reynolds AR

更新日期：2017-08-01 00:00:00

abstract：:Human kallikrein 10 (hK10) is a secreted serine protease that is highly expressed in ovarian tissue. We hypothesized that hK10 might represent a novel serological marker for ovarian cancer. We quantified by immunoassay, hK10 in sera from 97 normal women (controls), 141 patients with benign gynecologic diseases, and 14...

journal_title：Cancer research

authors： Luo LY,Katsaros D,Scorilas A,Fracchioli S,Bellino R,van Gramberen M,de Bruijn H,Henrik A,Stenman UH,Massobrio M,van der Zee AG,Vergote I,Diamandis EP

更新日期：2003-02-15 00:00:00

abstract：:Suramin, a polysulfonated naphthylurea widely used in the treatment of trypanosomiasis and onchocerciasis, is currently being investigated as an antitumor agent for the treatment of advanced cancer. Suramin exerts a wide variety of biological effects. We have shown that suramin inhibits cell proliferation and DNA synt...

journal_title：Cancer research

authors： Jindal HK,Anderson CW,Davis RG,Vishwanatha JK

更新日期：1990-12-15 00:00:00

abstract：:Preexisting and acquired resistance to epidermal growth factor receptor (EGFR) inhibitors limits their clinical usefulness in patients with advanced non-small cell lung cancer (NSCLC). This study characterizes the efficacy and mechanisms of the combination of gefitinib or erlotinib with OSU-03012, a celecoxib-derived ...

journal_title：Cancer research

authors： Wang YC,Kulp SK,Wang D,Yang CC,Sargeant AM,Hung JH,Kashida Y,Yamaguchi M,Chang GD,Chen CS

更新日期：2008-04-15 00:00:00

abstract：:Aflatoxicol, R0, was isolated from Mt. Shasta strain rainbow trout (Salmo gairdneri), and liver homogenates were incubated with aflatoxin B1. Its identity was confirmed by mass, infrared, and ultraviolet spectrometry. The structure was identical to one of the diastereomers prepared by chemical reduction of aflatoxin B...

journal_title：Cancer research

authors： Schoenhard GL,Lee DJ,Howell SE,Pawlowski NE,Libbey LM,Sinnhuber RO

更新日期：1976-06-01 00:00:00

abstract：:cis-Diamminedichloroplatinum(II) is an antineoplastic drug that is undergoing a renewed clinical interest as a drug for use in combination regimens. In order to increase the understanding of the pharmacokinetics of this drug, the plasma clearance and organ distribution of platinum were followed in female beagle dogs t...

journal_title：Cancer research

authors： Litterst CL,Gram TE,Dedrick RL,Leroy AF,Guarino AM

更新日期：1976-07-01 00:00:00

abstract：:Most cancer cells utilize aerobic glycolysis, and activation of the phosphoinositide 3-kinase/Akt/mTOR pathway can promote this metabolic program to render cells glucose dependent. Although manipulation of glucose metabolism may provide a means to specifically eliminate cancer cells, mechanistic links between cell met...

journal_title：Cancer research

authors： Coloff JL,Macintyre AN,Nichols AG,Liu T,Gallo CA,Plas DR,Rathmell JC

更新日期：2011-08-01 00:00:00

abstract：:Lipoblastomas are pediatric neoplasms resulting from transformation of adipocytes. These benign tumors are typically composed of adipose cells in different stages of maturation within a variably myxoid matrix, and they contain clonal rearrangements of chromosome band 8q12. Because lipoblastomas resemble embryonic adip...

journal_title：Cancer research

authors： Hibbard MK,Kozakewich HP,Dal Cin P,Sciot R,Tan X,Xiao S,Fletcher JA

更新日期：2000-09-01 00:00:00

abstract：:The role of the cyclin-dependent kinase (CDK) inhibitor p21 as a mediator of p53-induced growth arrest is well established. In addition, recent data provide strong evidence for new emerging functions of p21, including a role as a modulator of apoptosis. The mechanisms, however, by which p21 interferes with the death m...

journal_title：Cancer research

authors： Sohn D,Essmann F,Schulze-Osthoff K,Jänicke RU

更新日期：2006-12-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1) is a member of the CEA family of immunoglobulin-like adhesion molecules with two major splice variants, CEACAM1(a)-4L and CEACAM1(b)-4S, differing in the length of their COOH-terminal cytoplasmic tail. Both forms are down-regulated in prostate a...

journal_title：Cancer research

authors： Laurie NA,Comegys MM,Carreiro MP,Brown JF,Flanagan DL,Brilliant KE,Hixson DC

更新日期：2005-12-01 00:00:00

abstract：:Anti-VEGF pathway therapies primarily target immature blood vessels in tumors. However, emerging approaches to combine with targeted therapies impacting the later stages of remodeling and vessel maturation are expected to improve clinical efficacy by expanding the target vessel population. The angiopoietin/Tie ligand/...

journal_title：Cancer research

authors： Gerald D,Chintharlapalli S,Augustin HG,Benjamin LE

更新日期：2013-03-15 00:00:00

abstract：:Inflammation predisposes to tumorigenesis in various organs by potentiating a susceptibility to genetic aberrations. The mechanism underlying the enhanced genetic instability through chronic inflammation, however, is not clear. Here, we demonstrated that TNFα stimulation induced transcriptional downregulation of MSH2,...

journal_title：Cancer research

authors： Eso Y,Takai A,Matsumoto T,Inuzuka T,Horie T,Ono K,Uemoto S,Lee K,Edelmann W,Chiba T,Marusawa H

更新日期：2016-08-01 00:00:00

abstract：:In this study, we performed high-resolution array comparative genomic hybridization with an array of 4153 bacterial artificial chromosome clones to assess copy number changes in 44 archival breast cancers. The tumors were flow sorted to exclude non-tumor DNA and increase our ability to detect gene copy number changes....

journal_title：Cancer research

authors： Loo LW,Grove DI,Williams EM,Neal CL,Cousens LA,Schubert EL,Holcomb IN,Massa HF,Glogovac J,Li CI,Malone KE,Daling JR,Delrow JJ,Trask BJ,Hsu L,Porter PL

更新日期：2004-12-01 00:00:00

abstract：:Biochemical quantitation of estrogen receptors has been used to predict prognosis in breast cancer. Immunocytochemical analysis of estrogen receptors correlates with biochemical analysis but has very few follow-up studies in the literature to validate it as a prognostic indicator. 257 patients were followed for up to ...

journal_title：Cancer research

authors： Kinsel LB,Szabo E,Greene GL,Konrath J,Leight GS,McCarty KS Jr

更新日期：1989-02-15 00:00:00

abstract：:Antivascular therapy directed against VEGF or its receptors (VEGFR) has been successful when administered at early stages of tumor vessel growth but is less effective when administered later. Tumor blood vessels are heterogeneous, so vessel subpopulations may differ in their requirements for tumor cell-secreted VEGF a...

journal_title：Cancer research

authors： Sitohy B,Nagy JA,Jaminet SC,Dvorak HF

更新日期：2011-11-15 00:00:00

abstract：:Antineoplastic drug resistance is a major obstacle to improved treatment of most adult cancers in humans. Novobiocin, an antibacterial agent which inhibits the eukaryotic topoisomerase II enzyme, increases the cytotoxicity of several alkylating agents in vitro by the formation of lethal DNA-DNA interstrand cross-links...

journal_title：Cancer research

authors： Eder JP,Wheeler CA,Teicher BA,Schnipper LE

更新日期：1991-01-15 00:00:00

abstract：:CD38 is a leukocyte differentiation antigen that has been thought to be a phenotypic marker of different subpopulations of T- and B-lymphocytes. In myeloid cells, CD38 is expressed during early stages of differentiation. Virtually no information is available on regulation and functions of CD38. Recently we reported th...

journal_title：Cancer research

authors： Drach J,McQueen T,Engel H,Andreeff M,Robertson KA,Collins SJ,Malavasi F,Mehta K

更新日期：1994-04-01 00:00:00

abstract：:Inactivation of the p53 tumor suppressor gene is a common finding in human cancer. In most cases, inactivation is due to a point mutation in the gene, but rearrangement of the p53 gene is sometimes observed. We analyzed the inactivation of p53 in the human pancreas cancer cell line Hs766T, which harbors a structural a...

journal_title：Cancer research

authors： Slebos RJ,Resnick MA,Taylor JA

更新日期：1998-12-01 00:00:00

abstract：:Phosphoinositol-3-kinase (PI3K)/protein kinase B (AKT) and Fms-like tyrosine kinase 3 (FLT3) signaling are aberrantly activated in acute myelogenous leukemia (AML) cells. Constitutively activated AKT and FLT3 regulate leukemia cell survival and resistance to chemotherapy. In this study, we investigated the effects of ...

journal_title：Cancer research

authors： Zeng Z,Samudio IJ,Zhang W,Estrov Z,Pelicano H,Harris D,Frolova O,Hail N Jr,Chen W,Kornblau SM,Huang P,Lu Y,Mills GB,Andreeff M,Konopleva M

更新日期：2006-04-01 00:00:00

abstract：:The effect of 17beta-estradiol on an estrogen receptor-positive human breast cancer cell line (MCF-7) was studied. Low concentrations (10(-9) M) of 17beta-estradiol enhanced the rate of cell proliferation; the overall cell cycle time was shortened; and the proportion of cells in the S phase increased. Higher concentra...

journal_title：Cancer research

authors： Weichselbaum RR,Hellman S,Piro AJ,Nove JJ,Little JB

更新日期：1978-08-01 00:00:00

abstract：:Tumorigenic activities of the (+)- and (-)-enantiomers of the diastereomeric, bay-region benzo(c)phenanthrene 3,4-diol-1,2-epoxides were evaluated in two mouse tumor models. In an initiation-promotion experiment on mouse skin, a single topical application of 10, 25, or 75 nmol of the compounds was followed by 20 weeks...

journal_title：Cancer research

authors： Levin W,Chang RL,Wood AW,Thakker DR,Yagi H,Jerina DM,Conney AH

更新日期：1986-05-01 00:00:00

abstract：:A genome-wide computational screen was performed to identify tumor-associated alternative RNA splicing isoforms. A BLAST algorithm was used to compare 11,014 genes from RefSeq with 3,471,822 human expressed sequence tag sequences. The screen identified 26,258 alternative splicing isoforms of which 845 were significant...

journal_title：Cancer research

authors： Wang Z,Lo HS,Yang H,Gere S,Hu Y,Buetow KH,Lee MP

更新日期：2003-02-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men in America. Currently, steroid receptor coactivators have been proposed to mediate the development and progression of prostate cancer, at times in a steroid-independent manner. Steroid receptor coactivator-3 (SRC-3, p/CIP, AIB1, ACTR, RAC3, and TRAM-1) is a member of th...

journal_title：Cancer research

authors： Zhou HJ,Yan J,Luo W,Ayala G,Lin SH,Erdem H,Ittmann M,Tsai SY,Tsai MJ

更新日期：2005-09-01 00:00:00

abstract：:High levels of reactive oxygen species (ROS) present in human prostate epithelia are an important etiologic factor in prostate cancer (CaP) occurrence, recurrence, and progression. Androgen induces ROS production in the prostate by a yet unknown mechanism. Here, to the best of our knowledge, we report for the first ti...

journal_title：Cancer research

authors： Basu HS,Thompson TA,Church DR,Clower CC,Mehraein-Ghomi F,Amlong CA,Martin CT,Woster PM,Lindstrom MJ,Wilding G

更新日期：2009-10-01 00:00:00

abstract：:The mammary carcinoma cell line MFM-223 is characterized by high androgen and low estrogen and progesterone receptor levels. With the dextran charcoal method, androgen binding was determined at 160 fmol/mg protein corresponding to approximately 100,000 binding sites per cell in whole cell binding assays. The estrogen ...

journal_title：Cancer research

authors： Hackenberg R,Lüttchens S,Hofmann J,Kunzmann R,Hölzel F,Schulz KD

更新日期：1991-10-15 00:00:00

abstract：:Activation of c-Met signaling and beta-catenin mutations are frequent genetic events observed in liver cancer development. Recently, we demonstrated that activated beta-catenin can cooperate with c-Met to induce liver cancer formation in a mouse model. Cyclin D1 (CCND1) is an important cell cycle regulator that is con...

journal_title：Cancer research

authors： Patil MA,Lee SA,Macias E,Lam ET,Xu C,Jones KD,Ho C,Rodriguez-Puebla M,Chen X

更新日期：2009-01-01 00:00:00

abstract：:We searched for potential suppressors of tumor metastasis by identifying the genes that are frequently down-regulated in hepatocellular carcinomas (HCC) while being negatively correlated with clinical parameters relevant to tumor metastasis, and we report here on the identification of N-myc downstream regulated gene 2...

journal_title：Cancer research

authors： Lee DC,Kang YK,Kim WH,Jang YJ,Kim DJ,Park IY,Sohn BH,Sohn HA,Lee HG,Lim JS,Kim JW,Song EY,Kim DM,Lee MN,Oh GT,Kim SJ,Park KC,Yoo HS,Choi JY,Yeom YI

更新日期：2008-06-01 00:00:00