Retinoic acid-induced expression of CD38 antigen in myeloid cells is mediated through retinoic acid receptor-alpha.

abstract：:Radiation resistance poses a major clinical challenge in cancer treatment, but little is known about how microRNA (miR) may regulate this phenomenon. In this study, we used next-generation sequencing to perform an unbiased comparison of miR expression in PC3 prostate cancer cells rendered resistant to fractionated rad...

journal_title：Cancer research

authors： Huang X,Taeb S,Jahangiri S,Emmenegger U,Tran E,Bruce J,Mesci A,Korpela E,Vesprini D,Wong CS,Bristow RG,Liu FF,Liu SK

更新日期：2013-12-01 00:00:00

abstract：:STAT1 exists in phosphorylated (pSTAT1) and unphosphorylated (uSTAT1) forms each regulated by IFN-γ. Although STAT1 is a key mediator of the IFN-γ signaling pathway, an essential component of the host cancer immunosurveillance system, STAT1 is also overexpressed in certain human cancers where the functions of pSTAT1 a...

journal_title：Cancer research

authors： Zimmerman MA,Rahman NT,Yang D,Lahat G,Lazar AJ,Pollock RE,Lev D,Liu K

更新日期：2012-09-15 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immature myeloid cells that expand in tumor-bearing hosts in response to soluble factors produced by tumor and stromal cells. MDSC expansion has been linked to loss of immune effector cell function and reduced efficacy of immune-based cancer therapie...

journal_title：Cancer research

authors： Stiff A,Trikha P,Wesolowski R,Kendra K,Hsu V,Uppati S,McMichael E,Duggan M,Campbell A,Keller K,Landi I,Zhong Y,Dubovsky J,Howard JH,Yu L,Harrington B,Old M,Reiff S,Mace T,Tridandapani S,Muthusamy N,Caligiuri MA

更新日期：2016-04-15 00:00:00

abstract：:The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) correlates with poor prognosis. The ABC subtype of DLBCL is associated with constitutive activation of the NF-κB pathway, and oncogenic lesions have been identified in its regulators, including CARD11/CARMA1 (caspase recruitment domain-co...

journal_title：Cancer research

authors： Naylor TL,Tang H,Ratsch BA,Enns A,Loo A,Chen L,Lenz P,Waters NJ,Schuler W,Dörken B,Yao YM,Warmuth M,Lenz G,Stegmeier F

更新日期：2011-04-01 00:00:00

abstract：:Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been well documented, the significance of other MT-MMPs is rather unknown. We have investigated the involvement of MT4-...

journal_title：Cancer research

authors： Chabottaux V,Sounni NE,Pennington CJ,English WR,van den Brûle F,Blacher S,Gilles C,Munaut C,Maquoi E,Lopez-Otin C,Murphy G,Edwards DR,Foidart JM,Noël A

更新日期：2006-05-15 00:00:00

abstract：:Carcinogenic heterocyclic amines are activated by N-acetyltransferase (NAT) enzymes, encoded by NAT1 and NAT2, to genotoxic compounds that can form DNA adducts in the colon epithelium. We have examined the relation of polymorphisms in the genes coding for both enzymes to risk of colorectal cancer and the gene-environm...

journal_title：Cancer research

authors： Chen J,Stampfer MJ,Hough HL,Garcia-Closas M,Willett WC,Hennekens CH,Kelsey KT,Hunter DJ

更新日期：1998-08-01 00:00:00

abstract：:An animal model to investigate the invasive and metastatic properties of human bladder transitional cell carcinoma (HTCC) was established. Two long-term HTCC cell lines (RT4 and EJ) and one HTCC cell line derived in our laboratory (LD-71) were tumorigenic when injected s.c. into nude mice but had little potential to i...

journal_title：Cancer research

authors： Ahlering TE,Dubeau L,Jones PA

更新日期：1987-12-15 00:00:00

abstract：:Monoclonal antibodies (MAbs) 123C3 and 123A8 generated against a membrane preparation of a small cell lung carcinoma (SCLC) specimen recognize not only SCLC and bronchial carcinoids but also a significant portion of non-small cell lung carcinomas (non-SCLC) of various histological types. Together with 13 other monoclo...

journal_title：Cancer research

authors： Moolenaar CE,Muller EJ,Schol DJ,Figdor CG,Bock E,Bitter-Suermann D,Michalides RJ

更新日期：1990-02-15 00:00:00

abstract：:Claudin proteins form a large family of integral membrane proteins crucial for tight junction formation and function. Our previous studies have revealed that claudin-3 and claudin-4 proteins are highly overexpressed in ovarian cancer. To clarify the roles of claudins in ovarian tumorigenesis, we have generated human o...

journal_title：Cancer research

authors： Agarwal R,D'Souza T,Morin PJ

更新日期：2005-08-15 00:00:00

abstract：:N-Nitrosodibutylamine and its omega-hydroxylated metabolite N-nitrosobutyl(4-hydroxybutyl)amine (NB4HBA) induce tumors in the urine bladder of different animal species through their common urinary metabolite N-nitrosobutyl(3-carboxypropyl)amine (NB3CPA), resulting from the oxidation of the alcoholic group of NB4HBA to...

journal_title：Cancer research

authors： Bonfanti M,Magagnotti C,Bonati M,Fanelli R,Airoldi L

更新日期：1988-07-01 00:00:00

abstract：:Myc oncoproteins exert tumorigenic effects by regulating expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known histone methyltransferase that catalyzes...

journal_title：Cancer research

authors： Wong M,Tee AEL,Milazzo G,Bell JL,Poulos RC,Atmadibrata B,Sun Y,Jing D,Ho N,Ling D,Liu PY,Zhang XD,Hüttelmaier S,Wong JWH,Wang J,Polly P,Perini G,Scarlett CJ,Liu T

更新日期：2017-05-01 00:00:00

abstract：:A novel monoclonal antibody was raised by immunization of mice with colorectal tumor cell lines. The fusion was screened by immunohistochemistry for binding to primary colorectal tumors. Subsequent analysis on primary disaggregated colorectal tumors show that the antibody recognizes a cell surface antigen expressed by...

journal_title：Cancer research

authors： Durrant LG,Harding SJ,Green NH,Buckberry LD,Parsons T

更新日期：2006-06-01 00:00:00

abstract：:Mutational synergism was examined in Chinese hamster V79 cells exposed to methyl methanesulfonate followed by N-acetoxy-2-acetylaminofluorene (AcAAF) at different time intervals. Treatment with 500 micron methyl methanesulfonate resulted in 95% survival of cloning ability and induced approximately 4 azaguanine-resista...

journal_title：Cancer research

authors： Myhr BC,DiPaolo JA

更新日期：1978-08-01 00:00:00

abstract：:Pheochromocytomas are tumors originating from chromaffin cells, the large majority of which are sporadic neoplasms. The genetic and molecular events determining their tumorigenesis continue to remain unknown. On the other hand, RET germ-line mutations cause the inheritance of familial tumors in multiple endocrine neop...

journal_title：Cancer research

authors： Le Hir H,Colucci-D'Amato LG,Charlet-Berguerand N,Plouin PF,Bertagna X,de Franciscis V,Thermes C

更新日期：2000-03-01 00:00:00

abstract：:We compared L-phenylalanine mustard (L-PAM)-induced cytotoxicity and DNA cross-linking with and without a 42-h preincubation with the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO, 1 mM) in a human lymphoma cell line. The combination showed increased toxicity with a Do ratio of 1.6. L-PAM-induc...

journal_title：Cancer research

authors： Ducore JM,McNamara L

更新日期：1986-03-01 00:00:00

abstract：:Palytoxin (PTX), one of the most toxic nonprotein molecules known, is cytotoxic at picomolar concentrations against a wide variety of cell types. In contrast to most cytotoxins, PTX exerts its activity extracellularly. A method for targeting PTX to tumor cells is described in which a monoclonal antibody-enzyme conjuga...

journal_title：Cancer research

authors： Bignami GS,Senter PD,Grothaus PG,Fischer KJ,Humphreys T,Wallace PM

更新日期：1992-10-15 00:00:00

abstract：:The effect of a continuous i.v. infusion of alpha-difluoromethylornithine (DFMO) on the polyamine metabolism of tumor and normal host tissue was determined. Non-tumor-bearing Fischer 344 rats or rats bearing a transplantable fibrosarcoma received continuous infusions of DFMO through a central venous catheter at three ...

journal_title：Cancer research

authors： Grossie VB Jr,Ota DM,Ajani JA,Nishioka K

更新日期：1987-04-01 00:00:00

abstract：:The prostate-specific antigen (PSA) promoter (PSA-P) has been identified, characterized, and determined to be tissue specific. Compared with high expression of the genomic PSA gene in prostate cells, expression of the transgene driven by the putative PSA promoter is low. This suggests that the identified promoter may ...

journal_title：Cancer research

authors： Pang S,Dannull J,Kaboo R,Xie Y,Tso CL,Michel K,deKernion JB,Belldegrun AS

更新日期：1997-02-01 00:00:00

abstract：:The use of targeted therapeutics directed against BRAF(V600)-mutant metastatic melanoma improves progression-free survival in many patients; however, acquired drug resistance remains a major medical challenge. By far, the most common clinical resistance mechanism involves reactivation of the MAPK (RAF/MEK/ERK) pathway...

journal_title：Cancer research

authors： Goetz EM,Ghandi M,Treacy DJ,Wagle N,Garraway LA

更新日期：2014-12-01 00:00:00

abstract：:The abundance of circulating tumor cells (CTC) indicates patient prognosis. Molecular characterization of CTCs may add additional information about a patient's disease. However, currently available methods are limited by contamination with blood cells. We describe a study using a modified CTC-chip to capture CTCs from...

journal_title：Cancer research

authors： Helzer KT,Barnes HE,Day L,Harvey J,Billings PR,Forsyth A

更新日期：2009-10-01 00:00:00

abstract：:Copy number alterations are crucial for the development of colorectal cancer. Our whole-genome analysis identified tocopherol alpha transfer protein-like (TTPAL) as preferentially amplified in colorectal cancer. Here we demonstrate that frequent copy number gain of TTPAL leads to gene overexpression in colorectal canc...

journal_title：Cancer research

authors： Gou H,Liang JQ,Zhang L,Chen H,Zhang Y,Li R,Wang X,Ji J,Tong JH,To KF,Sung JJY,Chan FKL,Fang JY,Yu J

更新日期：2019-07-01 00:00:00

abstract：:Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies. However, it remains unclear how β-catenin signaling regulates the tumor immune ...

journal_title：Cancer research

authors： Ji L,Qian W,Gui L,Ji Z,Yin P,Lin GN,Wang Y,Ma B,Gao WQ

更新日期：2020-05-15 00:00:00

abstract：:Pentraxin-3 (PTX3) is a member of the pentraxin family of innate immune regulators, which includes C-reactive protein (CRP). PTX3 has been implicated in angiogenesis, proliferation, and immune escape in cancer. In the present study, we evaluated PTX3 tissue expression and serum concentration as a biomarker to discrimi...

journal_title：Cancer research

authors： Stallone G,Cormio L,Netti GS,Infante B,Selvaggio O,Fino GD,Ranieri E,Bruno F,Prattichizzo C,Sanguedolce F,Tortorella S,Bufo P,Grandaliano G,Carrieri G

更新日期：2014-08-15 00:00:00

abstract：:HsRec2/Rad51B is a 350-amino acid protein with a molecular mass of 38,300 Da that appears to be involved in cell cycle regulation and UV-induced apoptosis. The mouse and human genes were isolated based on their homology to a recombinational repair gene from Ustilago maydis and contain functional domains to hRAD51 and ...

journal_title：Cancer research

authors： Havre PA,Rice MC,Noe M,Kmiec EB

更新日期：1998-10-15 00:00:00

abstract：:The ability of osteosarcoma cells to form lung metastases has been inversely correlated to cell surface Fas expression. Downregulation of Fas allows osteosarcoma cells to circumvent FasL-mediated apoptosis upon entrance into the FasL(+) lung microenvironment. However, the mechanism of Fas regulation remains unclear. H...

journal_title：Cancer research

authors： Huang G,Nishimoto K,Zhou Z,Hughes D,Kleinerman ES

更新日期：2012-02-15 00:00:00

abstract：:The transcription factor NRF2 (NFE2L2) is a pivotal activator of genes encoding cytoprotective and detoxifying enzymes that limit the action of cytotoxic therapies in cancer. NRF2 acts by binding antioxidant response elements (ARE) in its target genes, but there is relatively limited knowledge about how it is negative...

journal_title：Cancer research

authors： Wang H,Liu K,Geng M,Gao P,Wu X,Hai Y,Li Y,Li Y,Luo L,Hayes JD,Wang XJ,Tang X

更新日期：2013-05-15 00:00:00

abstract：:In vitro analysis of the mitosis from 3-day lymphocyte cultures from two normal males and two normal females treated with bromodeoxyuridine and stained with acridine orange after addition of vincristine during different times demonstrated that vincristine inhibits the progression of the second division. When the secon...

journal_title：Cancer research

authors： Stoll C,Borgaonkar DS,Levy JM

更新日期：1976-08-01 00:00:00

abstract：:Ionizing radiation is a major tool for cancer treatment. The response of eukaryotic cells to ionizing radiation includes apoptosis, a process which requires activation of multiple genes. We sought to determine whether radiation-induced gene expression plays a role in radiation-induced apoptosis. We found Apo2 ligand (...

journal_title：Cancer research

authors： Gong B,Almasan A

更新日期：2000-10-15 00:00:00

abstract：:We have identified RGS17 as a commonly induced gene in lung and prostate tumors. Through microarray and gene expression analysis, we show that expression of RGS17 is up-regulated in 80% of lung tumors, and also up-regulated in prostate tumors. Through knockdown and overexpression of RGS17 in tumor cells, we show that ...

journal_title：Cancer research

authors： James MA,Lu Y,Liu Y,Vikis HG,You M

更新日期：2009-03-01 00:00:00

abstract：:Mouse leukemia (P388) cells were incubated in cell culture medium containing nitrogen mustard [2-chloro-N-(2-chloroethyl)-N-methylethanamine] for 4 h. The nucleophosmin immunoband with a molecular weight of 37,000 (p37; other molecular weights are similarly designated) was observed in both control and nitrogen mustard...

journal_title：Cancer research

authors： Chan PK

更新日期：1989-06-15 00:00:00