Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity.

abstract：:Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2 (FERMT2) promotes metastatic progressi...

journal_title：Cancer research

authors： Sossey-Alaoui K,Pluskota E,Bialkowska K,Szpak D,Parker Y,Morrison CD,Lindner DJ,Schiemann WP,Plow EF

更新日期：2017-09-15 00:00:00

abstract：:Cloned cell lines derived from the androgen-responsive Shionogi 115 mouse mammary carcinoma, when cultured in the presence of 3.5 X 10(-8) M testosterone, retain their responsiveness to testosterone and 5alpha-dihydrotestosterone and exhibit fibroblast-like morphology; their growth is poorly regulated by cell density....

journal_title：Cancer research

authors： Yates J,King RJ

更新日期：1978-11-01 00:00:00

abstract：:The papillomaviruses associated with human anogenital carcinomas encode two transforming genes, E6 and E7. The oncoprotein products of these two genes complex with the tumor suppressor gene products p53 and pRB, respectively. The loss of the normal function of these tumor suppressor gene products, either as a conseque...

journal_title：Cancer research

authors： Howley PM

更新日期：1991-09-15 00:00:00

abstract：:Inactivation of p53 signaling by mutation of p53 itself or abrogation of its normal function by other transfactors, such as MDM2, is a key event in the development of most human cancers. To identify novel regulators of p53, we have used a phenotype-based selection in which a total cDNA library in a retroviral vector h...

journal_title：Cancer research

authors： Agarwal MK,Ruhul Amin AR,Agarwal ML

更新日期：2007-01-01 00:00:00

abstract：:We have studied the effects of partial polyamine depletion, induced by treatment with alpha-difluoromethylornithine (DFMO) on cell cycle phase distributions in five cultured human carcinoma cell lines. We used flow cytometry of cells stained with chromomycin-A3 and computer analysis to measure phase distributions of t...

journal_title：Cancer research

authors： Seidenfeld J,Block AL,Komar KA,Naujokas MF

更新日期：1986-01-01 00:00:00

abstract：:(Z)-1,2-Diphenyl-1-(4-hydroxyphenyl)but-1-ene (metabolite E) has been detected in the plasma of patients treated with tamoxifen. We therefore investigated whether the cis/trans isomers of metabolite E can be activated to form DNA adducts detected by 32P postlabeling. Microsomal activation of metabolite E produced two ...

journal_title：Cancer research

authors： Pongracz K,Pathak DN,Nakamura T,Burlingame AL,Bodell WJ

更新日期：1995-07-15 00:00:00

abstract：:Gastric and intestinal phenotypic expression in 37 surgically obtained primary signet ring cell carcinomas, five of their metastases to lymph nodes, and three signet ring cell carcinomas transplanted into nude mice were determined by biochemical, mucin, histochemical, and ultrastructural studies. Crude extracts of can...

journal_title：Cancer research

authors： Tatematsu M,Furihata C,Katsuyama T,Miki K,Honda H,Konishi Y,Ito N

更新日期：1986-09-01 00:00:00

abstract：:Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism in breast cancer cells remains poorly understood. Here, we show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer cells. Loss of ZMYND8 triggered ac...

journal_title：Cancer research

authors： Wang Y,Luo M,Chen Y,Wang Y,Zhang B,Ren Z,Bao L,Wang Y,Wang JE,Fu YX,Luo W,Wang Y

更新日期：2020-11-04 00:00:00

abstract：:Recent evidence from our laboratory and from others suggested that pretreatment with alpha-difluoromethylornithine (DFMO) sensitizes some human and rodent tumor cell lines to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Many human tumor cells are resistant to chloroethylnitrosourea-induced DNA interstrand cross-linkin...

journal_title：Cancer research

authors： Seidenfeld J,Barnes D,Block AL,Erickson LC

更新日期：1987-09-01 00:00:00

abstract：:Black cohosh is an herbal extract that is often used as an alternative to estrogen-based replacement therapies to treat hot flushes that frequently accompany the transition to menopause. Although cancer-free women as well as breast cancer patients and survivors use black cohosh to relieve vasomotor symptoms, there is ...

journal_title：Cancer research

authors： Davis VL,Jayo MJ,Ho A,Kotlarczyk MP,Hardy ML,Foster WG,Hughes CL

更新日期：2008-10-15 00:00:00

abstract：:In our previous studies carried out on inbred rats of the Sprague-Dawley strain (L. Gross and Y. Dreyfuss, Proc. Natl. Acad. Sci. USA, 76: 5910-5913, 1979), the tumor incidence was increased following irradiation (150 rads, 5 times, at weekly intervals), from 22 to 93% in females and from 5 to 59% in males. Experiment...

journal_title：Cancer research

authors： Gross L,Dreyfuss Y,Faraggiana T

更新日期：1988-05-01 00:00:00

abstract：:To assess the in vivo behavior of cytotoxic agents linked to antibodies, deferoxamine, known to form stable chelates with 67Ga, was conjugated with monoclonal antibodies using three different methods. One method used a homocoupling reagent, glutaraldehyde, whereas two other methods used heterocoupling reagents, N-succ...

journal_title：Cancer research

authors： Koizumi M,Endo K,Kunimatsu M,Sakahara H,Nakashima T,Kawamura Y,Watanabe Y,Saga T,Konishi J,Yamamuro T

更新日期：1988-03-01 00:00:00

abstract：:APCL, a central nervous system-specific sequence homologue of the adenomatous polyposis coli tumor suppressor, can regulate the cytoplasmic level of beta-catenin as the adenomatous polyposis coli tumor suppressor does, but its overall biological function remains unclear. Using a yeast two-hybrid system, we attempted t...

journal_title：Cancer research

authors： Nakagawa H,Koyama K,Murata Y,Morito M,Akiyama T,Nakamura Y

更新日期：2000-01-01 00:00:00

abstract：:Microtubule inhibitors as chemotherapeutic drugs are widely used for cancer treatment. However, the development of multidrug resistance (MDR) in cancer is a major challenge for microtubule inhibitors in their clinical implementation. From a high-throughput drug screen using cells transformed by oncogenic RAS, we ident...

journal_title：Cancer research

authors： Ning N,Yu Y,Wu M,Zhang R,Zhang T,Zhu C,Huang L,Yun CH,Benes CH,Zhang J,Deng X,Chen Q,Ren R

更新日期：2018-10-15 00:00:00

abstract：:CDC25A phosphatase activates multiple cyclin-dependent kinases (CDK) during cell cycle progression. Inactivation of CDC25A by ubiquitin-mediated degradation is a major mechanism of DNA damage-induced S-G(2) checkpoint. Although increased CDC25A expression has been reported in various human cancer tissues, it remains u...

journal_title：Cancer research

authors： Ray D,Terao Y,Nimbalkar D,Hirai H,Osmundson EC,Zou X,Franks R,Christov K,Kiyokawa H

更新日期：2007-07-15 00:00:00

abstract：:Medulloblastoma (MB) represents the most frequent malignant brain tumor of childhood but only a few cell lines and animal models of this primitive neuroectodermal tumor (PNET) have thus far been established. Using specific cell culture conditions, we were able to derive four human MB cell lines (MHH-MED-1-4) as well a...

journal_title：Cancer research

authors： Pietsch T,Scharmann T,Fonatsch C,Schmidt D,Ockler R,Freihoff D,Albrecht S,Wiestler OD,Zeltzer P,Riehm H

更新日期：1994-06-15 00:00:00

abstract：:Initially isolated as the dominant suppressor of the mutant epidermal growth factor receptor (ellipse), the Dachshund gene plays a key role in metazoan development regulating the Retinal Determination Gene Network. Herein, the DACH1 gene was expressed in normal prostate epithelial cells with reduced expression in huma...

journal_title：Cancer research

authors： Wu K,Katiyar S,Witkiewicz A,Li A,McCue P,Song LN,Tian L,Jin M,Pestell RG

更新日期：2009-04-15 00:00:00

abstract：:Twenty-four patients suspected of having ovarian carcinoma received i.v. injection with a combination of radiolabeled intact IgG (1 mg) and F(ab')2 fragments (1 mg) of the chimeric monoclonal antibody MOv18, each form labeled with 1.85 MBq 131I or 125I. Laparotomy was performed either 2 or 6 days after injection, and ...

journal_title：Cancer research

authors： Buist MR,Kenemans P,den Hollander W,Vermorken JB,Molthoff CJ,Burger CW,Helmerhorst TJ,Baak JP,Roos JC

更新日期：1993-11-15 00:00:00

abstract：:Tissue survival responses to ionizing radiation are nonlinear with dose, rather yielding tissue-specific descending curves that impede straightforward analysis of biologic effects. Apoptotic cell death often occurs at low doses, while at clinically relevant intermediate doses, double-strand break misrepair yields mito...

journal_title：Cancer research

authors： Martin ML,Adileh M,Hsu KS,Hua G,Lee SG,Li C,Fuller JD,Rotolo JA,Bodo S,Klingler S,Haimovitz-Friedman A,Deasy JO,Fuks Z,Paty PB,Kolesnick RN

更新日期：2020-03-01 00:00:00

abstract：:Determination of neopterin [D-erythro-6-(1',2',3'-trihydroxypropyl)pterin] in body fluids is a powerful diagnostic tool in a variety of diseases in which activation of cellular immune mechanisms is involved, such as certain malignancies, allograft rejection, and autoimmune and infectious diseases. In vitro, neopterin ...

journal_title：Cancer research

authors： Werner-Felmayer G,Werner ER,Fuchs D,Hausen A,Reibnegger G,Wachter H

更新日期：1990-05-15 00:00:00

abstract：:Natural killer (NK) cells are cytotoxic lymphocytes involved in innate immunity. NK-92, a human NK cell line, may be targeted to tumor-associated antigens in solid malignancies where it exhibits antitumor efficacy, but its clinical utility for treating brain tumors is limited by an inability to cross the blood-brain b...

journal_title：Cancer research

authors： Alkins R,Burgess A,Ganguly M,Francia G,Kerbel R,Wels WS,Hynynen K

更新日期：2013-03-15 00:00:00

abstract：:This study shows that it is not possible to cause regression of the immunogenic SA-1 sarcoma by adoptive immunotherapy with tumor-sensitized T-cells, unless the tumor-bearing recipient is exposed to a sublethal dose of gamma-irradiation to remove a barrier that prevents adoptive immunity from being expressed. This bar...

journal_title：Cancer research

authors： Awwad M,North RJ

更新日期：1990-04-15 00:00:00

abstract：:DNA polymerase beta (Polbeta) is a DNA repair protein that functions in base excision repair and meiosis. The enzyme has deoxyribose phosphate lyase and polymerase activity, but it is error prone because it bears no proofreading activity. Errors in DNA repair can lead to the accumulation of mutations and consequently ...

journal_title：Cancer research

authors： Fotiadou P,Henegariu O,Sweasy JB

更新日期：2004-06-01 00:00:00

abstract：:Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we investigated the role of CD73 on the activity of the anti-HER2/ErbB2 monoclonal antibody (mAb) trastuzumab. In a prospective, randomized phase III clinical trial ev...

journal_title：Cancer research

authors： Turcotte M,Allard D,Mittal D,Bareche Y,Buisseret L,José V,Pommey S,Delisle V,Loi S,Joensuu H,Kellokumpu-Lehtinen PL,Sotiriou C,Smyth MJ,Stagg J

更新日期：2017-10-15 00:00:00

abstract：:Epithelial cell lines derived from rat tracheal implants 2 and 9 months after a 4-week exposure to 200 micrograms dimethylbenz(a)anthracene-beeswax pellets, and previously assayed for growth in soft agarose and tumorigenicity, were tested at the same time of subculture for cytochalasin B-induced multinucleation to det...

journal_title：Cancer research

authors： Marchok AC,Martin DH

更新日期：1987-07-01 00:00:00

abstract：:Neuroblastoma arises from the embryonal neural crest secondary to a block in differentiation. Long-term patient survival correlates inversely with the extent of differentiation, and treatment with retinoic acid or other prodifferentiation agents improves survival modestly. In this study, we show the histone chaperone ...

journal_title：Cancer research

authors： Barbieri E,De Preter K,Capasso M,Chen Z,Hsu DM,Tonini GP,Lefever S,Hicks J,Versteeg R,Pession A,Speleman F,Kim ES,Shohet JM

更新日期：2014-02-01 00:00:00

abstract：:The long-standing strategy for the treatment of metastatic prostate cancer has been to reduce androgenic stimulation of tumor growth by removal of the testes, the primary site of testosterone synthesis. However, a low level of androgenic stimulation may continue, even after castration, by the conversion of adrenal and...

journal_title：Cancer research

authors： Klus GT,Nakamura J,Li JS,Ling YZ,Son C,Kemppainen JA,Wilson EM,Brodie AM

更新日期：1996-11-01 00:00:00

abstract：:Coded skin fibroblast cell strains from ataxia telangiectasia (AT) families and apparently normal individuals were obtained from two different sources. AT homozygous strains were clearly identified on the basis of marked hypersensitivity to cell killing by X-irradiation. AT heterozygotes were intermediate in their cyt...

journal_title：Cancer research

authors： Nagasawa H,Kraemer KH,Shiloh Y,Little JB

更新日期：1987-01-15 00:00:00

abstract：:Carefully orchestrated interactions between mitochondrial proteins that facilitate cell death remain a topic of intense research, however, key steps remain to be elucidated, especially those that drive selective killing in cancer cells. How mitochondrial dysfunction and its regulation in cancer can be robustly leverag...

journal_title：Cancer research

authors： Rao VA

更新日期：2019-12-15 00:00:00

abstract：:To identify molecular alterations involved in the initiation and progression of breast carcinomas, we analyzed the global gene expression profiles of normal mammary epithelial cells and in situ, invasive, and metastatic breast carcinomas using serial analysis of gene expression (SAGE). We identified sets of genes expr...

journal_title：Cancer research

authors： Porter DA,Krop IE,Nasser S,Sgroi D,Kaelin CM,Marks JR,Riggins G,Polyak K

更新日期：2001-08-01 00:00:00