Abstract：
:(Z)-1,2-Diphenyl-1-(4-hydroxyphenyl)but-1-ene (metabolite E) has been detected in the plasma of patients treated with tamoxifen. We therefore investigated whether the cis/trans isomers of metabolite E can be activated to form DNA adducts detected by 32P postlabeling. Microsomal activation of metabolite E produced two major (a and b) and up to six minor DNA adducts. Activation with horseradish peroxidase or silver(I)oxide produced the same adducts (a and b). Microsomal activation of tamoxifen produced one major (no. 6) and several minor DNA adducts. Rechromatography showed that adducts a and b formed by enzymatic and chemical activation of metabolite E were the same as adducts 9 and 4 produced by microsomal activation of tamoxifen. These results demonstrate that activation of metabolite E can lead to DNA adduct formation.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Pongracz K,Pathak DN,Nakamura T,Burlingame AL,Bodell WJsubject
Has Abstractpub_date
1995-07-15 00:00:00pages
3012-5issue
14eissn
0008-5472issn
1538-7445journal_volume
55pub_type
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