Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.

abstract：:An immunogenic tumor and a nonimmunogenic tumor were used in C57BL/Ka and CBA/Rij mice, respectively, in a study in which lymph node morphology was quantitatively measured. Lymph nodes were cut in semiseries, and a morphometrical analysis was done on the paracortical and cortical areas as major parts of the active lym...

journal_title：Cancer research

authors： van de Velde CJ,Meyer CJ,Cornellsse CJ,van der Velde EA,van Putten LM,Swaveling A

更新日期：1978-03-01 00:00:00

abstract：:The association between total serum cholesterol and triglycerides and the incidence rate of breast cancer has been examined in 242 incident cases of breast cancer that developed among 24,329 Norwegian women during 11-14 years of follow-up. At the time of lipid measurement they were between 35 and 51 years of age. Ther...

journal_title：Cancer research

authors： Vatten LJ,Foss OP

更新日期：1990-04-15 00:00:00

abstract：:Muscle-invasive bladder cancer (MIBC) generally responds poorly to treatment and tends to exhibit significant mortality. Here we show that expression of the tumor suppressor p14ARF (ARF) is upregulated in aggressive subtypes of MIBC. Accumulation of ARF in the nucleolus is associated with poor outcome and attenuated r...

journal_title：Cancer research

authors： Owczarek TB,Kobayashi T,Ramirez R,Rong L,Puzio-Kuter AM,Iyer G,Teo MY,Sánchez-Vega F,Wang J,Schultz N,Zheng T,Solit DB,Al-Ahmadie HA,Abate-Shen C

更新日期：2017-02-15 00:00:00

abstract：:Previous work in our laboratory has demonstrated that antisera to proteins found in the urine of bladder cancer patients can distinguish between urine samples from these patients and those from normal individuals when tested by a complement-fixation assay. Antisera which were reactive with individual tumor-associated ...

journal_title：Cancer research

authors： De Fazio SR,Gozzo JJ,Monaco AP

更新日期：1982-07-01 00:00:00

abstract：:Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer with poor prognosis. As transient and stable modifications to chromatin have emerged as critical mechanisms in oncogenic signaling, efforts to target epigenetic modifiers as a therapeutic strategy have accelerated in recent years. To identify chromatin...

journal_title：Cancer research

authors： Bhat AV,Palanichamy Kala M,Rao VK,Pignata L,Lim HJ,Suriyamurthy S,Chang KT,Lee VK,Guccione E,Taneja R

更新日期：2019-05-01 00:00:00

abstract：:New facets to Knudson's [corrected] "two-hit" hypothesis have been proposed recently in relation to adenomatous polyposis coli (APC): protein inactivation may be selected weakly, and the two hits may be interdependent. We reviewed published data on 165 sporadic and 102 familial adenomatous polyposis-associated colorec...

journal_title：Cancer research

authors： Cheadle JP,Krawczak M,Thomas MW,Hodges AK,Al-Tassan N,Fleming N,Sampson JR

更新日期：2002-01-15 00:00:00

abstract：:CpG island methylation within promoters is known to silence individual genes in cancer. The involvement of this process in silencing gene pairs controlled by bidirectional promoters is unclear. In a screen for hypermethylated CpG islands in cancer, bidirectional promoters constituted 25.2% of all identified promoters,...

journal_title：Cancer research

authors： Shu J,Jelinek J,Chang H,Shen L,Qin T,Chung W,Oki Y,Issa JP

更新日期：2006-05-15 00:00:00

abstract：:A theoretical drawback to alpha-particle therapy with 213Bi is the short range of the particle track coupled with the short half-life of the radionuclide, thereby potentially limiting effective cytotoxicity to rapidly accessible, disseminated individual tumor cells (e.g., as in leukemia). In this work, a prostate carc...

journal_title：Cancer research

authors： Ballangrud AM,Yang WH,Charlton DE,McDevitt MR,Hamacher KA,Panageas KS,Ma D,Bander NH,Scheinberg DA,Sgouros G

更新日期：2001-03-01 00:00:00

abstract：:Regulators of differentiated cell fate can offer targets for managing cancer development and progression. Here, we identify Runx2 as a new regulator of epithelial cell fate in mammary gland development and breast cancer. Runx2 is expressed in the epithelium of pregnant mice in a strict temporally and hormonally regula...

journal_title：Cancer research

authors： Owens TW,Rogers RL,Best S,Ledger A,Mooney AM,Ferguson A,Shore P,Swarbrick A,Ormandy CJ,Simpson PT,Carroll JS,Visvader J,Naylor MJ

更新日期：2014-09-15 00:00:00

abstract：:Axillary lymph node dissection (ALND) has been a part of breast cancer management since the 1900s. The idea that axillary metastases do not require surgical removal is a repudiation of the Halstedian concept of breast cancer biology, yet multiple prospective randomized studies show that the incidence of nodal recurren...

journal_title：Cancer research

authors： Morrow M

更新日期：2013-12-15 00:00:00

abstract：:p53 alterations in human tumors often involve missense mutations that may confer dominant-negative or gain-of-function properties. Dominant-negative effects result in inactivation of wild-type p53 protein in heterozygous mutant cells and as such in a p53 null phenotype. Gain-of-function effects can directly promote tu...

journal_title：Cancer research

authors： Wijnhoven SW,Speksnijder EN,Liu X,Zwart E,vanOostrom CT,Beems RB,Hoogervorst EM,Schaap MM,Attardi LD,Jacks T,van Steeg H,Jonkers J,de Vries A

更新日期：2007-05-15 00:00:00

abstract：:SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a tumor suppressor in cancer. Here, we challenge this concept by presenting evidence that skin-specific deletion of SIRT6 in the mouse inhibits sk...

journal_title：Cancer research

authors： Ming M,Han W,Zhao B,Sundaresan NR,Deng CX,Gupta MP,He YY

更新日期：2014-10-15 00:00:00

abstract：:The chemosensitivity of human tumor xenografts to mitozolomide, 8-carbamoyl-3-(2-chloroethyl)imidazo[5-1-d]-1,2,3,5-tetrazin-4(3H) -one, was studied in 3 different assay systems. In concentrations of 1 to 500 micrograms/ml, mitozolomide completely inhibited the colony-forming ability in soft agar of cell suspensions f...

journal_title：Cancer research

authors： Fodstad O,Aamdal S,Pihl A,Boyd MR

更新日期：1985-04-01 00:00:00

abstract：:Genetic changes found in human osteogenic sarcoma cells, including loss of the p53 and Rb tumor suppressor elements and overexpression of the cyclin G1 (CYCG1) proto-oncogene, suggest the potential of gene transfer as a treatment for metastatic disease. In this study, we examined the effects of antisense cyclin G1, in...

journal_title：Cancer research

authors： Skotzko M,Wu L,Anderson WF,Gordon EM,Hall FL

更新日期：1995-12-01 00:00:00

abstract：:The influence of cyclophosphamide (CY) on Friend virus leukemogenesis was studied in SJL/J, C57BL/10J, and C57BL/10J X SJL/J F1 (hereafter called B10SJF1) mice. All three differ in their susceptibility to the viral oncogenic effect. Immunosuppressive doses of CY, which by themselves produced no cancer, were followed 2...

journal_title：Cancer research

authors： Raikow RB,OKunewick JP,Buffo MJ,Kociban DL

更新日期：1985-02-01 00:00:00

abstract：:Integrin β3 is critical for tumor invasion, neoangiogenesis, and inflammation, making it a promising cancer target. However, preclinical and clinical data of integrin β3 antagonists have demonstrated no benefit or worse outcomes. We hypothesized that integrin β3 could affect tumor immunity and evaluated tumors in mice...

journal_title：Cancer research

authors： Su X,Esser AK,Amend SR,Xiang J,Xu Y,Ross MH,Fox GC,Kobayashi T,Steri V,Roomp K,Fontana F,Hurchla MA,Knolhoff BL,Meyer MA,Morgan EA,Tomasson JC,Novack JS,Zou W,Faccio R,Novack DV,Robinson SD,Teitelbaum SL,DeNar

更新日期：2016-06-15 00:00:00

abstract：:When pancreatic cancer cannot be removed surgically, patients frequently experience morbidity and death from progression of their primary tumor. Radiation therapy (RT) cannot yet substitute for an operation because radiation causes fatal bleeding and ulceration of the nearby stomach and intestines before achieving tum...

journal_title：Cancer research

authors： Fujimoto TN,Colbert LE,Huang Y,Molkentine JM,Deorukhkar A,Baseler L,de la Cruz Bonilla M,Yu M,Lin D,Gupta S,Cabeceiras PK,Kingsley CV,Tailor RC,Sawakuchi GO,Koay EJ,Piwnica-Worms H,Maitra A,Taniguchi CM

更新日期：2019-05-01 00:00:00

abstract：:Sixteen steroids with different endocrine activities were administered to female rats for 6 or 7 days, in a broad range of doses. Liver growth was recorded by measuring weight and DNA contents and monooxygenase activity by assaying the turnover of five different substrates. According to their effects on these paramete...

journal_title：Cancer research

authors： Schulte-Hermann R,Ochs H,Bursch W,Parzefall W

更新日期：1988-05-01 00:00:00

abstract：:Mithramycin (MIT) and tolfenamic acid (TA) inhibit the activity of the transcription factor Sp1. In the present study, we investigated whether pancreatic cancer treatment with a combination of these compounds has a synergistic effect on Sp1 activity, tumor growth, and their underlying response mechanisms. Treatment of...

journal_title：Cancer research

authors： Jia Z,Gao Y,Wang L,Li Q,Zhang J,Le X,Wei D,Yao JC,Chang DZ,Huang S,Xie K

更新日期：2010-02-01 00:00:00

abstract：:Primary melanocytes attach poorly to collagen type IV and laminin, in contrast to their firm attachment to collagen type I/III and fibronectin [Gilchrest et al., In vitro (Rockville), 21: 114-120, 1985]. We have now found that metastatic B16 melanoma cells attach well to collagen type IV, laminin, vitronectin, and fib...

journal_title：Cancer research

authors： Rieber M,Gross A,Rieber MS

更新日期：1987-10-01 00:00:00

abstract：:Allelic loss of chromosome region 3p21.3 occurs early and frequently in non-small-cell lung cancer, and numerous tumor suppressor genes at this locus may be targets of inactivation. Using an incident case series study of non-small-cell lung cancer, we sought to determine the prevalence of loss of heterozygosity (LOH) ...

journal_title：Cancer research

authors： Marsit CJ,Hasegawa M,Hirao T,Kim DH,Aldape K,Hinds PW,Wiencke JK,Nelson HH,Kelsey KT

更新日期：2004-12-01 00:00:00

abstract：:Protein synthesis is a vital cellular process that regulates growth and metabolism. It is controlled via signaling networks in response to environmental changes, including the presence of nutrients, mitogens, or starvation. The phosphorylation state of proteins involved in translation initiation is a limiting factor t...

journal_title：Cancer research

authors： Grzmil M,Hemmings BA

更新日期：2012-08-15 00:00:00

abstract：:Multiple fusions following immunization of athymic mice with the extensively characterized human glioma cell line D-54 MG resulted in the selection of several antibodies (Mabs) highly reactive with tumors of neuroectodermal origin and unreactive with normal nervous system tissue. Two Mabs, C12 and D12, which localized...

journal_title：Cancer research

authors： Wikstrand CJ,McLendon RE,Bullard DE,Fredman P,Svennerholm L,Bigner DD

更新日期：1986-11-01 00:00:00

abstract：:The MCT-1 oncogene was originally identified from lymphoma cell lines. Herein we establish that MCT-1 is highly expressed in 85% of human diffuse large B-cell lymphomas (DLBCL) and that knocking down MCT-1 by a specific short hairpin RNA in DLBCL cells induces apoptosis, supporting a critical role for MCT-1 in DLBCL c...

journal_title：Cancer research

authors： Dai B,Zhao XF,Hagner P,Shapiro P,Mazan-Mamczarz K,Zhao S,Natkunam Y,Gartenhaus RB

更新日期：2009-10-01 00:00:00

abstract：:Although ethanol has generally not been found to induce cancer in experimental animals, the consumption of alcoholic beverages has been linked to increased risks of several cancers in humans. Risks of oral, pharyngeal, laryngeal, esophageal, and liver cancer are elevated among drinkers, typically in proportion to the ...

journal_title：Cancer research

authors： Blot WJ

更新日期：1992-04-01 00:00:00

abstract：:Malignant gliomas are resistant to various proapoptotic therapies, such as radiotherapy and conventional chemotherapy. In this study, we show that selenite is preferentially cytotoxic to various human glioma cells over normal astrocytes via autophagic cell death. Overexpression of Akt, survivin, XIAP, Bcl-2, or Bcl-xL...

journal_title：Cancer research

authors： Kim EH,Sohn S,Kwon HJ,Kim SU,Kim MJ,Lee SJ,Choi KS

更新日期：2007-07-01 00:00:00

abstract：:The human inducible nitric oxide synthase (hiNOS) gene is regulated by nuclear factor kappaB (NF-kappaB) and has recently been shown to be a target of the Wnt/beta-catenin pathway. In this study, we tested the hypothesis that Wnt/beta-catenin signaling might regulate cytokine- or tumor necrosis factor alpha (TNFalpha)...

journal_title：Cancer research

authors： Du Q,Zhang X,Cardinal J,Cao Z,Guo Z,Shao L,Geller DA

更新日期：2009-05-01 00:00:00

abstract：:Triple-negative breast cancers (TNBC) are highly aggressive, lack FDA-approved targeted therapies, and frequently recur, making the discovery of novel therapeutic targets for this disease imperative. Our previous analysis of the molecular mechanisms of action of bromodomain and extraterminal protein inhibitors (BETi) ...

journal_title：Cancer research

authors： Sahni JM,Gayle SS,Webb BM,Weber-Bonk KL,Seachrist DD,Singh S,Sizemore ST,Restrepo NA,Bebek G,Scacheri PC,Varadan V,Summers MK,Keri RA

更新日期：2017-10-01 00:00:00

abstract：:Our recent study found that activation of signal transducer and activator of transcription 3 (Stat3) is up-regulated in human brain metastatic cells and contributes to brain metastasis of melanoma. However, the molecular mechanisms underlying this increased Stat3 activation and effect on brain metastasis are unknown. ...

journal_title：Cancer research

authors： Huang FJ,Steeg PS,Price JE,Chiu WT,Chou PC,Xie K,Sawaya R,Huang S

更新日期：2008-12-01 00:00:00

abstract：:Medulloblastoma is frequently disseminated throughout the central nervous system by the time of diagnosis. Conventional therapeutic approaches have not reduced the high mortality associated with metastatic medulloblastoma and little is known regarding the molecular mechanisms that promote tumor invasion. Previously, w...

journal_title：Cancer research

authors： Hernan R,Fasheh R,Calabrese C,Frank AJ,Maclean KH,Allard D,Barraclough R,Gilbertson RJ

更新日期：2003-01-01 00:00:00