Production and characterization of two human glioma xenograft-localizing monoclonal antibodies.

abstract：:We analyzed the gene expression profiles of clinical lung carcinomas using a cDNA microarray containing 27,648 genes or expressed sequence tags, and identified CDCA5 (cell division cycle associated 5) to be upregulated in the majority of lung cancers. Tumor tissue microarray analysis of 262 non-small cell lung cancer ...

journal_title：Cancer research

authors： Nguyen MH,Koinuma J,Ueda K,Ito T,Tsuchiya E,Nakamura Y,Daigo Y

更新日期：2010-07-01 00:00:00

abstract：:B7-H4 (VTCN1, B7x, B7s) is a ligand for inhibitory coreceptors on T cells implicated in antigenic tolerization. B7-H4 is expressed by tumor cells and tumor-associated macrophages (TAM), but its potential contributions to tumoral immune escape and therapeutic targeting have been less studied. To interrogate B7-H4 expre...

journal_title：Cancer research

authors： Dangaj D,Lanitis E,Zhao A,Joshi S,Cheng Y,Sandaltzopoulos R,Ra HJ,Danet-Desnoyers G,Powell DJ Jr,Scholler N

更新日期：2013-08-01 00:00:00

abstract：:In this study of breast cancer specimens, the relationship between cytosolic estrogen (ER) and progesterone receptor (PR) content to the size of the respective growth fraction (GF) (expressed as percentage of proliferating tumor cells) was investigated. We applied the recently developed ligand-binding assay for extrac...

journal_title：Cancer research

authors： Vollmer G,Gerdes J,Knuppen R

更新日期：1989-07-15 00:00:00

abstract：:Intracarotid infusion of bradykinin selectively increases the delivery of compounds into brain tumors. This study sought to determine the role of cyclic GMP in increased permeability across the blood-tumor barrier (BTB) after infusion of bradykinin. In permeability studies, 186 Wistar rats with RG2 gliomas and C6 glio...

journal_title：Cancer research

authors： Sugita M,Black KL

更新日期：1998-03-01 00:00:00

abstract：:Depletion of CD4+CD25+ regulatory T cells (Treg) by treatment with alphaCD25 antibody synergizes with vaccination protocols to engender protective immunity in mice. The effectiveness of targeting CD25 to eliminate Treg is limited by the fact that CD25, the low-affinity interleukin-2 receptor, is up-regulated on conven...

journal_title：Cancer research

authors： Nair S,Boczkowski D,Fassnacht M,Pisetsky D,Gilboa E

更新日期：2007-01-01 00:00:00

abstract：:The chemosensitivity of human tumor xenografts to mitozolomide, 8-carbamoyl-3-(2-chloroethyl)imidazo[5-1-d]-1,2,3,5-tetrazin-4(3H) -one, was studied in 3 different assay systems. In concentrations of 1 to 500 micrograms/ml, mitozolomide completely inhibited the colony-forming ability in soft agar of cell suspensions f...

journal_title：Cancer research

authors： Fodstad O,Aamdal S,Pihl A,Boyd MR

更新日期：1985-04-01 00:00:00

abstract：:The relationship between adenosine deaminase (ADA) and a human membrane thymus leukemia (HTL) antigen-detected by an antithymocyte serum was explored. A freeze-thaw extract of the T-cell-derived cell line, MOLT 4, was applied to an immunoabsorbant column of a rabbit antiserum to calf ADA. The bound MOLT 4 ADA was elut...

journal_title：Cancer research

authors： Dowell BL,Segars JH,Metzgar RS

更新日期：1981-01-01 00:00:00

abstract：:In 1956, Otto Warburg proposed that the origin of cancer cells was closely linked to a permanent respiratory defect that bypassed the Pasteur effect (i.e., the inhibition of anaerobic fermentation by oxygen). Since then, permanent defects in oxygen consumption that could explain the dependence of cancer cells on aerob...

journal_title：Cancer research

authors： Samudio I,Fiegl M,McQueen T,Clise-Dwyer K,Andreeff M

更新日期：2008-07-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is an aggressive and incurable subtype of B-cell non-Hodgkin lymphomas. Although patients often respond initially to first-line treatment with chemotherapy plus monoclonal antibodies, relapse and decreased response to further lines of treatment eventually occurs. Harnessing the immune system...

journal_title：Cancer research

authors： Cheng F,Wang H,Horna P,Wang Z,Shah B,Sahakian E,Woan KV,Villagra A,Pinilla-Ibarz J,Sebti S,Smith M,Tao J,Sotomayor EM

更新日期：2012-09-01 00:00:00

abstract：:Metastasis is the defining feature of advanced malignancy, yet remains challenging to study in laboratory environments. Here, we describe a high-throughput zebrafish system for comprehensive, in vivo assessment of metastatic biology. First, we generated several stable cell lines from melanomas of transgenic mitfa-BRAF...

journal_title：Cancer research

authors： Heilmann S,Ratnakumar K,Langdon E,Kansler E,Kim I,Campbell NR,Perry E,McMahon A,Kaufman C,van Rooijen E,Lee W,Iacobuzio-Donahue C,Hynes R,Zon L,Xavier J,White RM

更新日期：2015-10-15 00:00:00

abstract：:Hypoxia drives malignant progression in part by promoting accumulation of the oncogenic transcription factor hypoxia inducible factor-1α (HIF-1α) in tumor cells. Tumor aggressiveness also relates to elevation of the cancer stem cell-associated membrane protein CD24, which has been causally implicated in tumor formatio...

journal_title：Cancer research

authors： Thomas S,Harding MA,Smith SC,Overdevest JB,Nitz MD,Frierson HF,Tomlins SA,Kristiansen G,Theodorescu D

更新日期：2012-11-01 00:00:00

abstract：:Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME). CD47 has been shown to mediate immune evasion, as the CD47-SIRPα axis prevents phagocytosis of tumor cells by macrophages and other myeloid cells....

journal_title：Cancer research

authors： Ma D,Liu S,Lal B,Wei S,Wang S,Zhan D,Zhang H,Lee RS,Gao P,Lopez-Bertoni H,Ying M,Li JJ,Laterra J,Wilson MA,Xia S

更新日期：2019-05-15 00:00:00

abstract：:Elucidation of the mechanism by which oxaliplatin induces cell death is essential to enhancing its action. We investigated the effects of oxaliplatin and 17-allylamino-17-demethoxygeldanamycin (17-AAG) in a panel of four colon adenocarcinoma cell lines. Cytotoxicity assays demonstrated at least additivity in three of ...

journal_title：Cancer research

authors： Rakitina TV,Vasilevskaya IA,O'Dwyer PJ

更新日期：2003-12-15 00:00:00

abstract：:Neuroblastomas often undergo spontaneous differentiation and/or regression in vivo, which is at least partly regulated by the signals through neurotrophins and their receptors. Recently, glial cell line-derived neurotrophic factor (GDNF) and a second family member, neurturin (NTN), have been found to mediate their sig...

journal_title：Cancer research

authors： Hishiki T,Nimura Y,Isogai E,Kondo K,Ichimiya S,Nakamura Y,Ozaki T,Sakiyama S,Hirose M,Seki N,Takahashi H,Ohnuma N,Tanabe M,Nakagawara A

更新日期：1998-05-15 00:00:00

abstract：:p21 (WAF1/CIP1; CDKN1a) is a universal cell-cycle inhibitor directly controlled by p53 and p53-independent pathways. Knowledge of the regulation and function of p21 in normal and cancer cells has opened up several areas of investigation and has led to novel therapeutic strategies. The discovery in 1993 and subsequent ...

journal_title：Cancer research

authors： El-Deiry WS

更新日期：2016-09-15 00:00:00

abstract：:We and others have established that the developmental Notch receptor signaling pathway is active in breast cancer cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating the hierarchy of stem and progenitor cells in both normal and cancer epithelium has been elucida...

journal_title：Cancer research

authors： Harrison H,Farnie G,Brennan KR,Clarke RB

更新日期：2010-11-15 00:00:00

abstract：:Estradiol and triphenylethylene antiestrogen actions have been studied extensively in breast cancer cell lines. However, their effects are still poorly understood on normal human breast cells. We have developed a culture system of normal human breast epithelial (HBE) cells. It has been shown previously that cultured H...

journal_title：Cancer research

authors： Malet C,Gompel A,Spritzer P,Bricout N,Yaneva H,Mowszowicz I,Kuttenn F,Mauvais-Jarvis P

更新日期：1988-12-15 00:00:00

abstract：:Measurement of pH in tissue has shown that the microenvironment in tumors is generally more acidic than in normal tissues. Major mechanisms which lead to tumor acidity probably include the production of lactic acid and hydrolysis of ATP in hypoxic regions of tumors. Further reduction in pH may be achieved in some tumo...

journal_title：Cancer research

authors： Tannock IF,Rotin D

更新日期：1989-08-15 00:00:00

abstract：:A large number of poor prognosis neuroblastoma (NB) tumors constitutively express brain-derived neurotrophic factor (BDNF) and variably express the gene for its tyrosine kinase (Trk) receptor TrkB. Good prognosis NB tumors typically express high levels of TrkA mRNA, which encodes the signal transducing receptor for ne...

journal_title：Cancer research

authors： Matsumoto K,Wada RK,Yamashiro JM,Kaplan DR,Thiele CJ

更新日期：1995-04-15 00:00:00

abstract：:The objective of this investigation was to throw light on the biological behavior and metabolic regulation of hepatic enzymes of the nonoxidative branch of the pentose phosphate pathway. The activities of transaldolase (EC 2.2.1.2) and trasketolase (EC 2.2.1.1) Were compared in biological conditions that involve modu...

journal_title：Cancer research

authors： Heinrich PC,Morris HP,Weber G

更新日期：1976-09-01 00:00:00

abstract：:To improve tumor:tissue ratios in immunoscintigraphy, a three-step targeting method has been developed. The reagents used were (a) a radioactive, low molecular weight chelate prepared from ionic gallium and a phenolic polyaminocarboxylic acid, which can be labeled either with the single-photon emitter 67Ga or with the...

journal_title：Cancer research

authors： Schuhmacher J,Klivényi G,Matys R,Stadler M,Regiert T,Hauser H,Doll J,Maier-Borst W,Zöller M

更新日期：1995-01-01 00:00:00

abstract：:We describe a system that allows us to easily isolate and characterize mutants in yeast topoisomerase II that are resistant to antitumor agents that target this enzyme. The system uses yeast strains that are sensitive to those agents and that carry temperature-sensitive top2 mutations. The temperature-sensitive mutati...

journal_title：Cancer research

authors： Liu YX,Hsiung Y,Jannatipour M,Yeh Y,Nitiss JL

更新日期：1994-06-01 00:00:00

abstract：:Telomerase activity (TA) is detected in most human cancers but, with few exceptions, not in normal somatic cells. Little is known about TA in soft tissue tumors. We have examined a series of benign and malignant soft tissue tumors for TA using the telomerase repeat amplification protocol assay. Analysis of the express...

journal_title：Cancer research

authors： Yan P,Coindre JM,Benhattar J,Bosman FT,Guillou L

更新日期：1999-07-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is associated with Burkitt lymphoma, nasopharyngeal carcinoma, opportunistic lymphomas in immunocompromised hosts, and a fraction of gastric cancers. Aberrant promoter methylation accompanies human gastric carcinogenesis, though the contribution of EBV to such somatic methylation changes has n...

journal_title：Cancer research

authors： Matsusaka K,Kaneda A,Nagae G,Ushiku T,Kikuchi Y,Hino R,Uozaki H,Seto Y,Takada K,Aburatani H,Fukayama M

更新日期：2011-12-01 00:00:00

abstract：:High-resolution magic angle spinning proton (HRMAS 1H) magnetic resonance spectroscopy produces well-resolved spectra of metabolites from intact tissue specimens. Here we report the results of a preliminary study of 19 human brain tumors obtained by applying this method. Among these 19 cases were 2 low-grade astrocyto...

journal_title：Cancer research

authors： Cheng LL,Chang IW,Louis DN,Gonzalez RG

更新日期：1998-05-01 00:00:00

abstract：:There have been few reported visual observations of metastatic cancer cell arrest in vivo. To seek evidence that inducible vascular adhesive properties can regulate hepatic metastasis, groups of 9-14 c57bl/6 mice were given 1.5 microg of interleukin-1alpha (IL-1alpha) 4 h before the injection of 3 x 10(5) B16F1 melano...

journal_title：Cancer research

authors： Scherbarth S,Orr FW

更新日期：1997-09-15 00:00:00

abstract：:Allelic loss of chromosome 9p21 is common in small cell lung cancer (SCLC), but inactivation of the tumor suppressor gene CDKN2a is rare, implying the existence of another target gene at 9p21. A recent deletion mapping study of chromosome 9p has also identified a site of deletion in non-small cell lung cancer (NSCLC) ...

journal_title：Cancer research

authors： Cairns P,Okami K,King P,Bonacum J,Ahrendt S,Wu L,Mao L,Jen J,Sidransky D

更新日期：1997-12-01 00:00:00

abstract：:Nm23-H1 has been identified as a metastasis suppressor gene, but its protein interactions have yet to be understood with any mechanistic clarity. In this study, we evaluated the proteomic spectrum of interactions made by Nm23-H1 in 4T1 murine breast cancer cells derived from tissue culture, primary mammary tumors, and...

journal_title：Cancer research

authors： Marino N,Marshall JC,Collins JW,Zhou M,Qian Y,Veenstra T,Steeg PS

更新日期：2013-10-01 00:00:00

abstract：:The human MAGE-3 gene encodes a melanoma antigenic epitope recognized by specific cytotoxic T lymphocytes, but its gene product has not been identified thus far. We produced a recombinant MAGE-3 gene product by expression cloning of the entire reading frame in the context of a fusion protein characterized by a 10-hist...

journal_title：Cancer research

authors： Kocher T,Schultz-Thater E,Gudat F,Schaefer C,Casorati G,Juretic A,Willimann T,Harder F,Heberer M,Spagnoli GC

更新日期：1995-06-01 00:00:00

abstract：:Inactivation of the tumor suppressor p53 through somatic mutations, observed in 50% of human cancers, is one of the leading causes of tumorigenesis. Clinical and experimental evidence also reveals that p53 mutations sometimes occur in tumor-associated fibroblasts, which correlate with an increased rate of metastases a...

journal_title：Cancer research

authors： Guo G,Marrero L,Rodriguez P,Del Valle L,Ochoa A,Cui Y

更新日期：2013-03-15 00:00:00