Abstract：
:Mantle cell lymphoma (MCL) is an aggressive and incurable subtype of B-cell non-Hodgkin lymphomas. Although patients often respond initially to first-line treatment with chemotherapy plus monoclonal antibodies, relapse and decreased response to further lines of treatment eventually occurs. Harnessing the immune system to elicit its exquisite specificity and long-lasting protection might provide sustained MCL immunity that could potentially eradicate residual malignant cells responsible for disease relapse. Here, we show that genetic or pharmacologic disruption of Stat3 in malignant B cells augments their immunogenicity leading to better activation of antigen-specific CD4(+) T cells and restoration of responsiveness of tolerized T cells. In addition, treatment of MCL-bearing mice with a specific Stat3 inhibitor resulted in decreased Stat3 phosphorylation in malignant B cells and anti-lymphoma immunity in vivo. Our findings therefore indicate that Stat3 inhibition may represent a therapeutic strategy to overcome tolerance to tumor antigens and elicit a strong immunity against MCL and other B-cell malignancies.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Cheng F,Wang H,Horna P,Wang Z,Shah B,Sahakian E,Woan KV,Villagra A,Pinilla-Ibarz J,Sebti S,Smith M,Tao J,Sotomayor EMdoi
10.1158/0008-5472.CAN-11-3619subject
Has Abstractpub_date
2012-09-01 00:00:00pages
4440-8issue
17eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-11-3619journal_volume
72pub_type
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