Inhibition of ribonucleotide reductase activity and nucleic acid synthesis in tumor cells by the dialdehyde derivatives of inosine (NSC 118994) and inosinic acid.

abstract：:We examined whether herpes simplex virus thymidine kinase (HSV-TK) gene expression driven by the promoter of the vascular endothelial growth factor (VEGF) gene that is activated by hypoxia is effective in killing highly metastatic Lewis lung carcinoma A11 cells under hypoxic conditions. We isolated the promoter region...

journal_title：Cancer research

authors： Koshikawa N,Takenaga K,Tagawa M,Sakiyama S

更新日期：2000-06-01 00:00:00

abstract：:The use of rat testicular seminiferous tubular basement membrane (STBM) segments as a model substratum for the in vitro maintenance of tumor cells dissociated from a transplantable pancreatic acinar rat carcinoma (J. K. Reddy and M. S. Rao, Science (Wash. DC), 198: 78-80, 1977) is described. Ultrastructurally pure, ho...

journal_title：Cancer research

authors： Watanabe TK,Hansen LJ,Reddy NK,Kanwar YS,Reddy JK

更新日期：1984-11-01 00:00:00

abstract：:Angiogenesis inhibitor TNP-470, 6-O-(N-chloroacetyl-carbamoyl)-fumagillol, semisynthetic analogue of fumagillin, has strong inhibitory activities against in vivo tumor growth and metastasis in a wide variety of tumors. However, it is still unknown whether this agent inhibits bone metastasis. We examined the effects of...

journal_title：Cancer research

authors： Sasaki A,Alcalde RE,Nishiyama A,Lim DD,Mese H,Akedo H,Matsumura T

更新日期：1998-02-01 00:00:00

abstract：:Primary and metastatic bone cancers are difficult to eradicate and novel approaches are needed to improve treatment and extend life. As bone cancer grows, osteoclasts, the principal bone-resorbing cells of the body, are recruited to and activated at sites of cancer. In this investigation, we determined if osteoclast l...

journal_title：Cancer research

authors： Ramnaraine ML,Mathews WE,Donohue JM,Lynch CM,Goblirsch MJ,Clohisy DR

更新日期：2006-11-15 00:00:00

abstract：:The semaphorins and their receptors, the neuropilins and the plexins, are constituents of a complex regulatory system that controls axonal guidance. Moreover, many types of tumor cells express various members of semaphorins and receptors, but the biological activities within tumor mass and the signal transduction mech...

journal_title：Cancer research

authors： Catalano A,Lazzarini R,Di Nuzzo S,Orciari S,Procopio A

更新日期：2009-02-15 00:00:00

abstract：:Mutations in the p53 gene were identified in five of eight non-melanoma skin tumors in the sun-exposed areas of xeroderma pigmentosum patients by the polymerase chain reaction and single strand conformation polymorphism analysis followed by sequencing of the DNA. All mutations occurred at the dipyrimidine sites, indic...

journal_title：Cancer research

authors： Sato M,Nishigori C,Zghal M,Yagi T,Takebe H

更新日期：1993-07-01 00:00:00

abstract：:Although peptide immunization often leads to the induction of strong T-cell responses, it is seldom effective against established tumors. One possibility is that these T-cell responses are not strong enough or do not last sufficiently long to have an effect in tumor eradication. Here, we examined the role of synthetic...

journal_title：Cancer research

authors： Davila E,Kennedy R,Celis E

更新日期：2003-06-15 00:00:00

abstract：:Liposome formulations of camptothecins have been actively pursued because of the potential for significant pharmacologic advantages from successful drug delivery of this important class of anticancer drugs. We describe nanoliposomal CPT-11, a novel nanoparticle/liposome construct containing CPT-11 (irinotecan) with un...

journal_title：Cancer research

authors： Drummond DC,Noble CO,Guo Z,Hong K,Park JW,Kirpotin DB

更新日期：2006-03-15 00:00:00

abstract：:The histone demethylase KDM4B is frequently overexpressed in various cancer types, and previous studies have indicated that the primary oncogenic function of KDM4B is its ability to demethylate H3K9me3 in different tumors, resulting in altered gene expression and genome instability. A genome-wide analysis to evaluate ...

journal_title：Cancer research

authors： Xiang Y,Yan K,Zheng Q,Ke H,Cheng J,Xiong W,Shi X,Wei L,Zhao M,Yang F,Wang P,Lu X,Fu L,Lu X,Li F

更新日期：2019-01-01 00:00:00

abstract：:Certain ductal carcinoma in situ (DCIS) lesions overexpress the HER-2/neu receptor at this early stage of breast cancer development. Recently, we showed that a HER-2-targeted dendritic cell vaccine could be used to eliminate HER-2-overexpressing cells in patients that harbor these high-risk DCIS lesions. Our findings ...

journal_title：Cancer research

authors： Czerniecki BJ,Roses RE,Koski GK

更新日期：2007-07-15 00:00:00

abstract：:The sodium iodide symporter (NIS) is a classical iodide pump typically localized within the cell plasma membrane in thyroid cells, where NIS expression is believed to ensure success of mainstay radioiodide therapy in thyroid cancers. Although radioiodide uptake is generally reduced in thyroid cancer tissue, intracellu...

journal_title：Cancer research

authors： Feng F,Yehia L,Ni Y,Chang YS,Jhiang SM,Eng C

更新日期：2018-11-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a deadly and aggressive cancer. Understanding mechanisms that drive preneoplastic pancreatic lesions is necessary to improve early diagnostic and therapeutic strategies. Mutations and inactivation of activin-like kinase (ALK4) have been demonstrated to favor PDAC onset. Surpr...

journal_title：Cancer research

authors： Zhao Y,Wu Z,Chanal M,Guillaumond F,Goehrig D,Bachy S,Principe M,Ziverec A,Flaman JM,Collin G,Tomasini R,Pasternack A,Ritvos O,Vasseur S,Bernard D,Hennino A,Bertolino P

更新日期：2020-08-15 00:00:00

abstract：:Whole chromosomal instability (CIN), manifested as unequal chromosome distribution during cell division, is a distinguishing feature of most cancer types. CIN is generally considered to drive tumorigenesis, but a threshold level exists whereby further increases in CIN frequency in fact hinder tumor growth. While this ...

journal_title：Cancer research

authors： Lee HS,Lee NC,Kouprina N,Kim JH,Kagansky A,Bates S,Trepel JB,Pommier Y,Sackett D,Larionov V

更新日期：2016-02-15 00:00:00

abstract：:The cross-linked dimer of bovine pancreatic RNase (M.W. 28,000) is significantly more effective than the monomer in inhibiting tumor development in mice when administered i.p. 1 day after inoculation with sarcoma 180J ascites cells. Animals bearing solid tumors were not affected. In AKR/J mice with advanced leukemia, ...

journal_title：Cancer research

authors： Tarnowski GS,Kassel RL,Mountain IM,Blackburn P,Wilson G,Wang D

更新日期：1976-11-01 00:00:00

abstract：:Recent work has begun to explore the instrumental role that small noncoding RNA species, particularly microRNAs (miRNA), have both in classifying human tumors and in directing embryonic development. These studies suggest that developmental programs in essentially all organisms studied are set, in part, by varied expre...

journal_title：Cancer research

authors： Marsit CJ,Eddy K,Kelsey KT

更新日期：2006-11-15 00:00:00

abstract：:Diethyldithiocarbamate (DDTC) has been shown to protect against the toxicity of cis-diamminedichloroplatinum(II) (DDP) without inhibition of antitumor effect. We report here that DDTC is unreactive toward DDP complexes in which both chlorides have been replaced by guanine residues but removes platinum from a variety o...

journal_title：Cancer research

authors： Bodenner DL,Dedon PC,Keng PC,Borch RF

更新日期：1986-06-01 00:00:00

abstract：:Twenty-four patients suspected of having ovarian carcinoma received i.v. injection with a combination of radiolabeled intact IgG (1 mg) and F(ab')2 fragments (1 mg) of the chimeric monoclonal antibody MOv18, each form labeled with 1.85 MBq 131I or 125I. Laparotomy was performed either 2 or 6 days after injection, and ...

journal_title：Cancer research

authors： Buist MR,Kenemans P,den Hollander W,Vermorken JB,Molthoff CJ,Burger CW,Helmerhorst TJ,Baak JP,Roos JC

更新日期：1993-11-15 00:00:00

abstract：:Currently, no curative therapy for metastatic prostate cancer exists. Causing prostate cancer cells to express functionally active sodium iodide symporter (NIS) would enable those cells to concentrate iodide from plasma and might offer the ability to treat prostate cancer with radioiodine. Therefore, the aim of our st...

journal_title：Cancer research

authors： Spitzweg C,Zhang S,Bergert ER,Castro MR,McIver B,Heufelder AE,Tindall DJ,Young CY,Morris JC

更新日期：1999-05-01 00:00:00

abstract：:Aromatase plays a critical role in breast cancer development by converting androgen to estrogen. In this report, results are presented to demonstrate that estrogen, the product of aromatase, can up-regulate its expression. Estrogen receptor (ER) transient transfection experiments were performed using the SK-BR-3 breas...

journal_title：Cancer research

authors： Kinoshita Y,Chen S

更新日期：2003-07-01 00:00:00

abstract：:Cytidine dialdehyde inhibited the growth of leukemia L1210 cells in culture at a 50% inhibitory concentration of 3.5 X 10(-5) M and, when administered i.p. at 200 mg/kg daily for 5 days, increased the mean survival of L1210 tumor-bearing mice by up to 171%. Given by the s.c. or i.v. routes, the compound was ineffectiv...

journal_title：Cancer research

authors： Kinahan JJ,Pavelic ZP,Leonard RJ,Bloch A,Grindey GB

更新日期：1980-03-01 00:00:00

abstract：:The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found that DX2 expression w...

journal_title：Cancer research

authors： Oh AY,Jung YS,Kim J,Lee JH,Cho JH,Chun HY,Park S,Park H,Lim S,Ha NC,Park JS,Park CS,Song GY,Park BJ

更新日期：2016-08-15 00:00:00

abstract：:The metabolism and mutagenic activation of the model carcinogens benzo(a)pyrene [B(a)P] and 2-acetylaminofluorene (AAF) by human and rat kidney cells were measured. A slicing technique followed by enzyme digestion was utilized to obtain the kidney cells. Although levels of total metabolism of B(a)P by rat and human ki...

journal_title：Cancer research

authors： Rudo KM,Dauterman WC,Langenbach R

更新日期：1989-03-01 00:00:00

abstract：:The expression of the chemokine CC-chemokine ligand 20 (CCL20)/macrophage inflammatory protein (MIP)-3alpha and its receptor CC-chemokine receptor 6 (CCR6) by multiple myeloma (MM) and microenvironment cells and their potential relationship with osteoclast (OC) formation and osteolytic bone lesions in MM patients was ...

journal_title：Cancer research

authors： Giuliani N,Lisignoli G,Colla S,Lazzaretti M,Storti P,Mancini C,Bonomini S,Manferdini C,Codeluppi K,Facchini A,Rizzoli V

更新日期：2008-08-15 00:00:00

abstract：:Serum galactosyltransferase isoenzyme II (GT-II) was assayed in 409 coded serum samples obtained from the National Cancer Institute Tumor Serum Bank using a monoclonal antibody-based immunoassay. The serum panel consisted of samples from patients with confirmed, metastatic ovarian, breast, stomach, esophageal, pancrea...

journal_title：Cancer research

authors： Uemura M,Winant RC,Brandt AE

更新日期：1988-09-15 00:00:00

abstract：:Astrocytes, the most abundant type of glial cells in the brain, play critical roles in supporting neuronal development and brain function. Although astrocytes have been frequently detected in brain tumors, including medulloblastoma (MB), their functions in tumorigenesis are not clear. Here, we demonstrate that astrocy...

journal_title：Cancer research

authors： Liu Y,Yuelling LW,Wang Y,Du F,Gordon RE,O'Brien JA,Ng JMY,Robins S,Lee EH,Liu H,Curran T,Yang ZJ

更新日期：2017-12-01 00:00:00

abstract：:We have established and characterized a diploid cell strain of normal human endothelial cells, RuBa 7E. RuBa 7E cells have an average cloning efficiency of 20% during early passages and undergo approximately 50 doublings in vitro before senescing spontaneously. At confluence, RuBa 7E cells form a homogeneous monolayer...

journal_title：Cancer research

authors： Reznikoff CA,DeMars R

更新日期：1981-03-01 00:00:00

abstract：:Medulloblastoma (MB) represents the most frequent malignant brain tumor of childhood but only a few cell lines and animal models of this primitive neuroectodermal tumor (PNET) have thus far been established. Using specific cell culture conditions, we were able to derive four human MB cell lines (MHH-MED-1-4) as well a...

journal_title：Cancer research

authors： Pietsch T,Scharmann T,Fonatsch C,Schmidt D,Ockler R,Freihoff D,Albrecht S,Wiestler OD,Zeltzer P,Riehm H

更新日期：1994-06-15 00:00:00

abstract：:Nonmyeloablative hematopoietic cell transplantation can cure patients with hematologic malignancies but has reported limited success against solid tumors. This is possibly because of profound peripheral tolerance mechanisms and/or suboptimal tumor recognition by effector T lymphocytes. We report that in mice developin...

journal_title：Cancer research

authors： Hess Michelini R,Freschi M,Manzo T,Jachetti E,Degl'Innocenti E,Grioni M,Basso V,Bonini C,Simpson E,Mondino A,Bellone M

更新日期：2010-05-01 00:00:00

abstract：:Although common in hematologic and mesenchymal malignancies, recurrent gene fusions have not been well characterized in epithelial carcinomas. Recently, using a novel bioinformatic approach, we identified recurrent gene fusions between TMPRSS2 and the ETS family members ERG or ETV1 in the majority of prostate cancers....

journal_title：Cancer research

authors： Tomlins SA,Mehra R,Rhodes DR,Smith LR,Roulston D,Helgeson BE,Cao X,Wei JT,Rubin MA,Shah RB,Chinnaiyan AM

更新日期：2006-04-01 00:00:00

abstract：:Two human pancreatic cell lines, MIA PaCa 2 and Capan 2, were treated by photodynamic therapy in vitro with Photophrin (0.01-25 micrograms/ml; 24 h) and then light (1-50 J/cm2; lambda = 630 nm). The following model was fit to 6 datasets with weighted nonlinear regression: [sequence: see text] The symbols are: E, cell ...

journal_title：Cancer research

authors： Moesta KT,Greco WR,Nurse-Finlay SO,Parsons JC,Mang TS

更新日期：1995-07-15 00:00:00