Abstract：
:The relationship between adenosine deaminase (ADA) and a human membrane thymus leukemia (HTL) antigen-detected by an antithymocyte serum was explored. A freeze-thaw extract of the T-cell-derived cell line, MOLT 4, was applied to an immunoabsorbant column of a rabbit antiserum to calf ADA. The bound MOLT 4 ADA was eluted with 6 M urea. The recovered ADA had a specific activity of 490 mumol of adenosine deaminated per min per mg protein, and the yield was 32%. No HTL antigenic activity was detected in the purified ADA. In addition, no ADA activity was detected in the unbound fraction containing the HTL antigenic activity, supporting the conclusion that ADA and HTL antigen are independent molecules. Affinity-purified anti-calf ADA was not cytotoxic for several HTL antigen-positive cells, including thymocytes, MOLT 4, and thymus-derived acute leukemia lymphoblasts.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Dowell BL,Segars JH,Metzgar RSsubject
Has Abstractpub_date
1981-01-01 00:00:00pages
343-5issue
1eissn
0008-5472issn
1538-7445journal_volume
41pub_type
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