Abstract：
:The importance of invasion in the complex process of metastasis, although now well established, has been studied with increasing molecular detail due to the development of robust in vitro experimental assays. In this issue of Cancer Research, we highlight a paper published by George Poste and colleagues that compared and contrasted several different invasion assays. The authors concluded that various barriers impose different selective pressures and that simply enriching for invasive ability did not necessarily translate into greater metastasis efficiency. Although perhaps obvious now, these findings were surprising when they were published. Certainly, the data highlight the importance of tumor cell-microenvironment interactions and the necessity to interpret experiments taking the context into consideration. Cancer Res; 76(7); 1675-6. ©2016 AACRSee related article by Poste et al., Cancer Res 1980;40:1636-44.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Welch DRdoi
10.1158/0008-5472.CAN-16-0550subject
Has Abstractpub_date
2016-04-01 00:00:00pages
1675-6issue
7eissn
0008-5472issn
1538-7445pii
76/7/1675journal_volume
76pub_type
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