Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer.

abstract：:Despite esophageal adenocarcinoma (EAC) being the most widespread among gastrointestinal cancers, with an 11-fold increase in the risk of cancer for patients with Barrett esophagus (BE), its prognosis is still poor. There is a critical need to better perceive the biology of cancer progression and identification of spe...

journal_title：Cancer research

authors： Urbanska AM,Ponnazhagan S,Mozafari M

更新日期：2018-07-15 00:00:00

abstract：:Groups of 120 male and 120 female rats were exposed by inhalation to 0, 2, 6, or 15 ppm formaldehyde vapor 6 hr/day, 5 days/week, for 18 months of a 24-month study. The present communication describes interim findings based on data available after 18 months of exposure. Squamous cell carcinomas occurred in the nasal c...

journal_title：Cancer research

authors： Swenberg JA,Kerns WD,Mitchell RI,Gralla EJ,Pavkov KL

更新日期：1980-09-01 00:00:00

abstract：:The term "Turcot's syndrome" has been used to describe approximatively 55 patients with an association of colonic polyposis and primary neuroepithelial tumors of the central nervous system. The p53 tumor suppressor gene is a possible candidate underlying the syndrome because (a) mutations in the p53 gene are ubiquitou...

journal_title：Cancer research

authors： Kikuchi T,Rempel SA,Rutz HP,de Tribolet N,Mulligan L,Cavenee WK,Jothy S,Leduy L,Van Meir EG

更新日期：1993-03-01 00:00:00

abstract：:Meningiomas are rich in progestin receptors, whereas estrogen receptors (ER) are virtually undetectable. The present experiments were performed to evaluate whether the absence of ER from the majority of human meningioma cytosols can be attributed to: occurrence of only a small number of ER-positive cells in an otherwi...

journal_title：Cancer research

authors： Blankenstein MA,Berns PM,Blaauw G,Mulder E,Thijssen JH

更新日期：1986-08-01 00:00:00

abstract：:Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily of structurally related cytokines. TWEAK acts on responsive cells via binding to a cell surface receptor named Fn14. Recent studies have demonstrated that TWEAK can stimulate numerous cellular responses in...

journal_title：Cancer research

authors： Ho DH,Vu H,Brown SA,Donohue PJ,Hanscom HN,Winkles JA

更新日期：2004-12-15 00:00:00

abstract：:9-beta-D-Arabinofuranosyladenine (ara-A) is an inhibitor of DNA replication with antitumor and antiviral activity. The molecular basis for this inhibitory effect has remained unclear. The present work has examined the effects of 9-beta-D-arabinofuranosyladenine-triphosphate on DNA polymerase-beta. These studies were p...

journal_title：Cancer research

authors： Ohno Y,Spriggs D,Matsukage A,Ohno T,Kufe D

更新日期：1989-04-15 00:00:00

abstract：:"Self" melanocyte differentiation antigens are potential targets for specific melanoma immunotherapy. Vaccination against murine tyrosinase-related protein (TRP)-1/gp75 was shown recently to cause melanoma rejection, which was accompanied by autoimmune skin depigmentation (vitiligo). To further explore the linkage bet...

journal_title：Cancer research

authors： Bronte V,Apolloni E,Ronca R,Zamboni P,Overwijk WW,Surman DR,Restifo NP,Zanovello P

更新日期：2000-01-15 00:00:00

abstract：:CD26 is an antigen with key role in T-cell biology and is expressed on selected subsets of aggressive T-cell malignancies. To elucidate the role of CD26 in tumor behavior, we examine the effect of CD26 depletion by small interfering RNA transfection of T-anaplastic large cell lymphoma Karpas 299. We show that the resu...

journal_title：Cancer research

authors： Sato T,Yamochi T,Yamochi T,Aytac U,Ohnuma K,McKee KS,Morimoto C,Dang NH

更新日期：2005-08-01 00:00:00

abstract：:The caudal-related homeobox transcription factor CDX2 has a key role in intestinal development and differentiation. CDX2 heterozygous mutant mice develop colonic polyps, and loss of CDX2 expression is seen in a subset of colon carcinomas in humans. Ectopic CDX2 expression in the stomach of transgenic mice promotes int...

journal_title：Cancer research

authors： Takakura Y,Hinoi T,Oue N,Sasada T,Kawaguchi Y,Okajima M,Akyol A,Fearon ER,Yasui W,Ohdan H

更新日期：2010-09-01 00:00:00

abstract：:Twenty-four patients suspected of having ovarian carcinoma received i.v. injection with a combination of radiolabeled intact IgG (1 mg) and F(ab')2 fragments (1 mg) of the chimeric monoclonal antibody MOv18, each form labeled with 1.85 MBq 131I or 125I. Laparotomy was performed either 2 or 6 days after injection, and ...

journal_title：Cancer research

authors： Buist MR,Kenemans P,den Hollander W,Vermorken JB,Molthoff CJ,Burger CW,Helmerhorst TJ,Baak JP,Roos JC

更新日期：1993-11-15 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is etiologically associated with adult T-cell leukemia/lymphoma (ATL). Nevertheless, most individuals infected with HTLV-1 do not develop ATL. To attempt to identify genetic factors promoting the progression to ATL, we investigated in HTLV-1 carriers the relationship between ...

journal_title：Cancer research

authors： Tsukasaki K,Miller CW,Kubota T,Takeuchi S,Fujimoto T,Ikeda S,Tomonaga M,Koeffler HP

更新日期：2001-05-01 00:00:00

abstract：:We used somatic cell hybridization to determine whether the regressor phenotype exhibited by UV-induced murine tumors was dominant or recessive and whether this technique could confer immunogenic properties on nonimmunogenic syngeneic tumors. We transfected a highly antigenic UV-induced C3H mouse tumor cell line (UV-2...

journal_title：Cancer research

authors： Chen PW,Kaba DS,Ananthaswamy HN

更新日期：1990-03-01 00:00:00

abstract：:Nitric oxide (NO) is a potent tumor radiosensitizer; however, its clinical use is limited by systemic side effects. We have demonstrated previously that gene transfer of the human inducible NO synthase (iNOS) gene into tumor cells and tumors induces high-output NO production that significantly enhances tumor radioresp...

journal_title：Cancer research

authors： Cook T,Wang Z,Alber S,Liu K,Watkins SC,Vodovotz Y,Billiar TR,Blumberg D

更新日期：2004-11-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a highly aggressive, heterogeneous disease with poor prognosis and no effective targeted therapies. EGFR is highly expressed in basal-like TNBC and is considered as a potential therapeutic target. However, EGFR targeting exerts only marginal clinical benefits, possibly due to ac...

journal_title：Cancer research

authors： Verma N,Müller AK,Kothari C,Panayotopoulou E,Kedan A,Selitrennik M,Mills GB,Nguyen LK,Shin S,Karn T,Holtrich U,Lev S

更新日期：2017-01-01 00:00:00

abstract：:High-risk human papilloma viruses are known to be associated with cervical cancers. We have reported previously that the high-risk human papillomavirus (HPV) E6 oncoprotein interacts with E6TP1, a novel Rap GTPase-activating protein (RapGAP). Similar to p53 tumor suppressor protein, the high-risk HPV E6 oncoproteins t...

journal_title：Cancer research

authors： Gao Q,Kumar A,Singh L,Huibregtse JM,Beaudenon S,Srinivasan S,Wazer DE,Band H,Band V

更新日期：2002-06-01 00:00:00

abstract：:When nitric oxide (NO) is produced at micromolar concentrations, as during inflammation, exposure to surrounding cells is potentially cytotoxic. The NO-dependent signaling pathways that initiate cell death are thought to involve the tumor suppressor protein p53, but the degree to which this factor contributes to NO-in...

journal_title：Cancer research

authors： McLaughlin LM,Demple B

更新日期：2005-07-15 00:00:00

abstract：:The distribution of alkylated deoxynucleosides and bases has been determined in the DNA of a sensitive and a resistant human glioma-derived cell line exposed to therapeutic levels of [3H]N-(2-chloroethyl)-N-nitrosourea in vitro. The resistant cell line is 5-fold less sensitive to the cytotoxic effects of N-(2-chloroet...

journal_title：Cancer research

authors： Bodell WJ,Tokuda K,Ludlum DB

更新日期：1988-08-15 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00

abstract：:Human epithelial tumor progression and metastasis involve cellular invasion, dissemination in the vasculature, and regrowth at metastatic sites. Notch signaling has been implicated in metastatic progression but its roles have yet to be fully understood. Here we report the important role of Notch signaling in maintaini...

journal_title：Cancer research

authors： Bajaj J,Maliekal TT,Vivien E,Pattabiraman C,Srivastava S,Krishnamurthy H,Giri V,Subramanyam D,Krishna S

更新日期：2011-07-15 00:00:00

abstract：:Colitis-associated cancer (CAC) is a complication of inflammatory bowel disease (IBD). Binding of extracellular ATP to the purinergic receptor P2RX7 has emerged as a critical event in controlling intestinal inflammation, acting to limit elevation of proinflammatory mast cells and cytokines and promote survival of regu...

journal_title：Cancer research

authors： Hofman P,Cherfils-Vicini J,Bazin M,Ilie M,Juhel T,Hébuterne X,Gilson E,Schmid-Alliana A,Boyer O,Adriouch S,Vouret-Craviari V

更新日期：2015-03-01 00:00:00

abstract：:Renal cell carcinoma is frequently infiltrated by cells of the immune system. This makes it important to understand interactions between cancer cells and immune cells so they can be manipulated to bring clinical benefit. Here, we analyze subsets and functions of T lymphocytes infiltrating renal cell tumors directly ex...

journal_title：Cancer research

authors： Attig S,Hennenlotter J,Pawelec G,Klein G,Koch SD,Pircher H,Feyerabend S,Wernet D,Stenzl A,Rammensee HG,Gouttefangeas C

更新日期：2009-11-01 00:00:00

abstract：:UV radiation has been shown to play a role in the initiation of human cutaneous melanoma, but its role in the development of malignant melanoma to the metastatic state is not very well defined. Although previous studies have concentrated on the effect of UV-B on the host immune response, the effect of UV-B on the tumo...

journal_title：Cancer research

authors： Singh RK,Gutman M,Reich R,Bar-Eli M

更新日期：1995-08-15 00:00:00

abstract：:The metabolic changes in rat hepatoma cell line, AH70 cells, after coculturing with Kupffer cells were visualized using a silicon-intensified target camera and subsequent processing with a computer-assisted digital imaging processor. In cocultured tumor cells, nonactivated Kupffer cells reduced mitochondrial energizat...

journal_title：Cancer research

authors： Kurose I,Miura S,Fukumura D,Yonei Y,Saito H,Tada S,Suematsu M,Tsuchiya M

更新日期：1993-06-01 00:00:00

abstract：:The acidic glycosphingolipid composition of human uterine endometrial adenocarcinoma was compared with those of normal uterine endometrium at the proliferative and the secretory phases. Upon chemical composition analysis, no significant transformation-associated change of these glycolipids was observed. However, when ...

journal_title：Cancer research

authors： Kubushiro K,Tsukazaki K,Tanaka J,Takamatsu K,Kiguchi K,Mikami M,Nozawa S,Nagai Y,Iwamori M

更新日期：1992-02-15 00:00:00

abstract：:The protein tyrosine phosphatase gamma (PTP gamma) gene has recently been suggested as a candidate tumor suppressor gene involved in the oncogenesis of human lung and renal cancers, although no direct evidence for PTP gamma mutations has been demonstrated thus far. We explored the status of PTP gamma in 31 human lung ...

journal_title：Cancer research

authors： Tsukamoto T,Takahashi T,Ueda R,Hibi K,Saito H,Takahashi T

更新日期：1992-06-15 00:00:00

abstract：:Normal bronchial epithelial cells (NBECs) are at risk for damage from inhaled and endogenous oxidative species and from epoxide metabolites of inhaled polycyclic aromatic hydrocarbons. Epidemiological and in vitro data suggest that interindividual variation in this risk may result from variation in NBEC expression of ...

journal_title：Cancer research

authors： Crawford EL,Khuder SA,Durham SJ,Frampton M,Utell M,Thilly WG,Weaver DA,Ferencak WJ,Jennings CA,Hammersley JR,Olson DA,Willey JC

更新日期：2000-03-15 00:00:00

abstract：:Nude mice bearing s.c. xenografts of the human colon adenocarcinoma HT29 were given intratumor injections of a mixture of 125I-labeled specific antibody (AUA1) and 131I-labeled control antibody (HMFG1), or with the labels reversed. After dissection at 1 and 4 h postadministration, both specific and control antibodies ...

journal_title：Cancer research

authors： Rowlinson-Busza G,Bamias A,Krausz T,Epenetos AA

更新日期：1991-06-15 00:00:00

abstract：:Loss of hSNF5 function is usually observed in malignant rhabdoid tumor (MRT), a highly aggressive pediatric neoplasm. Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A), p21(CIP1/WAF1), and cyclin D1 playing key roles in MRT cell growth control. However...

journal_title：Cancer research

authors： Kuwahara Y,Charboneau A,Knudsen ES,Weissman BE

更新日期：2010-03-01 00:00:00

abstract：:The biosynthesis, structure, and topology of a melanoma-associated antigen, previously defined with the monoclonal antibody NKI/C-3 was studied. A polyclonal rabbit antiserum was raised against the antigen with a broader reactivity than the previously used monoclonal antibody NKI/C-3. The antigen was shown to consist ...

journal_title：Cancer research

authors： Gruters RA,Calafat J,Vennegoor CJ,Jansen H,Ploegh HL

更新日期：1989-01-15 00:00:00

abstract：:Twenty-seven patients with advanced cancer were entered in a phase I study of bolus i.v. 5-fluorouracil at a dose of 370 mg/m2/day for 5 days combined with a continuous i.v. infusion of (6S)-folinic acid for 5.5 days, starting 24 h in advance of the first 5-fluorouracil dose. The dose of (6S)-folinic acid was escalate...

journal_title：Cancer research

authors： Newman EM,Akman SA,Harrison JS,Leong LA,Margolin KA,Morgan RJ,Raschko JW,Somlo G,Ahn CW,Doroshow JH

更新日期：1992-05-01 00:00:00