Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis.

abstract：:Noscapine, a benzylisoquinoline alkaloid derived from opium, was recently reported to exhibit activity against a variety of cancers through a poorly understood mechanism. Because the transcription factor NF-kappaB has been linked with inflammation, survival, proliferation, invasion, and angiogenesis in tumors, we hypo...

journal_title：Cancer research

authors： Sung B,Ahn KS,Aggarwal BB

更新日期：2010-04-15 00:00:00

abstract：:Aberrant methylation of CpG islands acquired in tumor cells in promoter regions is one method for loss of gene function. We determined the frequency of aberrant promoter methylation (referred to as methylation) of the genes retinoic acid receptor beta-2 (RARbeta), tissue inhibitor of metalloproteinase 3 (TIMP-3), p16I...

journal_title：Cancer research

authors： Zöchbauer-Müller S,Fong KM,Virmani AK,Geradts J,Gazdar AF,Minna JD

更新日期：2001-01-01 00:00:00

abstract：:Colitis-associated cancer (CAC) is a complication of inflammatory bowel disease (IBD). Binding of extracellular ATP to the purinergic receptor P2RX7 has emerged as a critical event in controlling intestinal inflammation, acting to limit elevation of proinflammatory mast cells and cytokines and promote survival of regu...

journal_title：Cancer research

authors： Hofman P,Cherfils-Vicini J,Bazin M,Ilie M,Juhel T,Hébuterne X,Gilson E,Schmid-Alliana A,Boyer O,Adriouch S,Vouret-Craviari V

更新日期：2015-03-01 00:00:00

abstract：:DNA repair status is recognized as an important determinant of the clinical efficacy of cancer chemotherapy. To assess the role that a mammalian DNA glycosylase plays in modulating the toxicity and clastogenicity of the chemotherapeutic DNA cross-linking alkylating agents, we compared the sensitivity of wild-type muri...

journal_title：Cancer research

authors： Allan JM,Engelward BP,Dreslin AJ,Wyatt MD,Tomasz M,Samson LD

更新日期：1998-09-01 00:00:00

abstract：:A phenolic amine compound, 4-S-cysteaminylphenol (4-S-CAP), is a potent depigmenting agent. To develop more efficacious antimelanoma agents, we synthesized four homologues of 4-S-CAP: N-acetyl-4-S-CAP (N-Ac-4-S-CAP), alpha-methyl-4-S-CAP, 4-S-homo-CAP, and N,N'-dimethyl-4-S-CAP. We tested these five compounds in mice ...

journal_title：Cancer research

authors： Alena F,Jimbow K,Ito S

更新日期：1990-06-15 00:00:00

abstract：:Cancers of the upper aerodigestive tract (UADT) include malignant tumors of the oral cavity, pharynx, larynx, and esophagus and account for 6.4% of all new cancers in Europe. In the context of a multicenter case-control study conducted in 14 centers within 10 European countries and comprising 1,511 cases and 1,457 con...

journal_title：Cancer research

authors： Canova C,Hashibe M,Simonato L,Nelis M,Metspalu A,Lagiou P,Trichopoulos D,Ahrens W,Pigeot I,Merletti F,Richiardi L,Talamini R,Barzan L,Macfarlane GJ,Macfarlane TV,Holcátová I,Bencko V,Benhamou S,Bouchardy C,Kjaerheim

更新日期：2009-04-01 00:00:00

abstract：:Some of the possible mechanisms by which polyethylene glycol (PEG) augments the ability of MOPC-315 tumor bearer spleen cells to mediate in vitro antitumor cytotoxicity were evaluated. The level of antitumor cytotoxicity obtained in 5-day cultures of tumor bearer spleen cell suspensions correlated inversely with the p...

journal_title：Cancer research

authors： Mokyr MB,Przepiorka D,Dray S

更新日期：1982-07-01 00:00:00

abstract：:TNF-α, produced by most malignant cells, orchestrates the interplay between malignant cells and myeloid cells, which have been linked to tumor growth and metastasis. Although TNF-α can exist as one of two isoforms, a 26-kDa membrane tethered form (mTNF-α) or a soluble 17-kDa cytokine (sTNF-α), the vast majority of pub...

journal_title：Cancer research

authors： Ardestani S,Li B,Deskins DL,Wu H,Massion PP,Young PP

更新日期：2013-07-01 00:00:00

abstract：:To enable antibodies to function as cytotoxic anticancer agents, they are modified either via attachment to protein toxins or highly potent, low-molecular-weight drugs. Such molecules, termed immunotoxins and antibody-drug conjugates, respectively, represent a second revolution in antibody-mediated cancer therapy. Thu...

journal_title：Cancer research

authors： FitzGerald DJ,Wayne AS,Kreitman RJ,Pastan I

更新日期：2011-10-15 00:00:00

abstract：:Angiogenesis is characteristic of solid tumor growth and a surrogate marker for metastasis in many human cancers. Inhibition of tumor angiogenesis using antiangiogenic drugs and gene transfer approaches has suggested the potential of this form of therapy in controlling tumor growth. However, for long-term tumor-free s...

journal_title：Cancer research

authors： Ponnazhagan S,Mahendra G,Kumar S,Shaw DR,Stockard CR,Grizzle WE,Meleth S

更新日期：2004-03-01 00:00:00

abstract：:Accumulation of sulfolipids associated with elevated levels of glycolipid sulfotransferase activities has previously been demonstrated in renal cell carcinoma cells. To investigate the role of protein kinase C in the synthesis of sulfolipids, the effects of 12-O-tetradecanoylphorbol-13-acetate and protein kinase C inh...

journal_title：Cancer research

authors： Kobayashi T,Honke K,Gasa S,Sugiura M,Miyazaki T,Ishizuka I,Makita A

更新日期：1993-06-01 00:00:00

abstract：:Osimertinib, a mutant-specific third-generation EGFR tyrosine kinase inhibitor, is emerging as the preferred first-line therapy for EGFR-mutant lung cancer, yet resistance inevitably develops in patients. We modeled acquired resistance to osimertinib in transgenic mouse models of EGFRL858R -induced lung adenocarcinoma...

journal_title：Cancer research

authors： Starrett JH,Guernet AA,Cuomo ME,Poels KE,van Alderwerelt van Rosenburgh IK,Nagelberg A,Farnsworth D,Price KS,Khan H,Ashtekar KD,Gaefele M,Ayeni D,Stewart TF,Kuhlmann A,Kaech SM,Unni AM,Homer R,Lockwood WW,Michor F,G

更新日期：2020-05-15 00:00:00

abstract：:Although chemokine and growth factor receptors are attractive and popular targets for cancer therapeutic intervention, structure-based targeting of the ligands themselves is generally not considered practical. New evidence indicates that a notable exception to this is macrophage migration inhibitory factor (MIF). MIF,...

journal_title：Cancer research

authors： Winner M,Meier J,Zierow S,Rendon BE,Crichlow GV,Riggs R,Bucala R,Leng L,Smith N,Lolis E,Trent JO,Mitchell RA

更新日期：2008-09-15 00:00:00

abstract：:Early phase evaluation of anticancer drugs has traditionally used toxicity (usually hematological) rather than efficacy end points to establish appropriate dosing schedules. To establish a biochemical efficacy end point for overcoming alkylguanine DNA alkyltransferase (AGT)-mediated tumor cell resistance to 1,3-bis(2-...

journal_title：Cancer research

authors： Spiro TP,Gerson SL,Liu L,Majka S,Haaga J,Hoppel CL,Ingalls ST,Pluda JM,Willson JK

更新日期：1999-05-15 00:00:00

abstract：:We have constructed a DNA plasmid encoding the full length complementary DNA for human carcinoembryonic antigen (CEA) driven by the cytomegalovirus early promoter/enhancer (plasmid DNA encoding human CEA) and demonstrated that this plasmid can function as a polynucleotide vaccine. This polynucleotide vaccine induced h...

journal_title：Cancer research

authors： Conry RM,LoBuglio AF,Kantor J,Schlom J,Loechel F,Moore SE,Sumerel LA,Barlow DL,Abrams S,Curiel DT

更新日期：1994-03-01 00:00:00

abstract：:Radiotherapy is used to treat many types of cancer, but many treated patients relapse with local tumor recurrence. Tumor-infiltrating myeloid cells (TIM), including CD11b (ITGAM)(+)F4/80 (EMR1)+ tumor-associated macrophages (TAM), and CD11b(+)Gr-1 (LY6G)+ myeloid-derived suppressor cells (MDSC), respond to cancer-rela...

journal_title：Cancer research

authors： Xu J,Escamilla J,Mok S,David J,Priceman S,West B,Bollag G,McBride W,Wu L

更新日期：2013-05-01 00:00:00

abstract：:Cancer in a host induces responses that increase the ability of the microenvironment to sustain the growing mass, for example, angiogenesis, but cancer cells can have varying sensitivities to these sustainability signals. Here, we show that these sensitivities are significant determinants of ultimate tumor fate, espec...

journal_title：Cancer research

authors： Wilkie KP,Hahnfeldt P

更新日期：2013-06-15 00:00:00

abstract：:Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis that is associated with cell growth and tumor formation. Existing catalytic inhibitors of ODC have lacked efficacy in clinical testing or displayed unacceptable toxicity. In this study, we report the identification of a...

journal_title：Cancer research

authors： Kim DJ,Roh E,Lee MH,Oi N,Lim DY,Kim MO,Cho YY,Pugliese A,Shim JH,Chen H,Cho EJ,Kim JE,Kang SC,Paul S,Kang HE,Jung JW,Lee SY,Kim SH,Reddy K,Yeom YI,Bode AM,Dong Z

更新日期：2016-03-01 00:00:00

abstract：:ADAMTS metalloprotease family member ADAMTS9 maps to 3p14.2 and shows significant associations with the aerodigestive tract cancers esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). However, the functional impact of ADAMTS9 on cancer development has not been explored. In this study, we eval...

journal_title：Cancer research

authors： Lo PH,Lung HL,Cheung AK,Apte SS,Chan KW,Kwong FM,Ko JM,Cheng Y,Law S,Srivastava G,Zabarovsky ER,Tsao SW,Tang JC,Stanbridge EJ,Lung ML

更新日期：2010-07-01 00:00:00

abstract：:Regional measurements of blood flow (F) were performed in transplanted intracerebral RG-2 rat gliomas using [14C]iodoantipyrine, Kety-Schmidt blood flow equations, and quantitative autoradiography. Twenty-nine intracranial tumors in ten rats were analyzed by location; 18 intraparenchymal, seven meningeal, two third-ve...

journal_title：Cancer research

authors： Groothuis DR,Pasternak JF,Fischer JM,Blasberg RG,Bigner DD,Vick NA

更新日期：1983-07-01 00:00:00

abstract：:Plasma membrane preparations from Chinese hamster lung cells, which are resistant to the antitumor agent Adriamycin, were analyzed using fluorescence polarization of the membrane lipid probe trans-parinaric acid. The results of these studies reveal that membranes from several drug-resistant isolates have a substantial...

journal_title：Cancer research

authors： Rintoul DA,Center MS

更新日期：1984-11-01 00:00:00

abstract：:Alkylating agents, such as temozolomide, are among the most effective cytotoxic agents used for malignant gliomas, but responses remain very poor. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) plays an important role in cellular resistance to alkylating agents. IFN-beta can act as a drug sensiti...

journal_title：Cancer research

authors： Natsume A,Ishii D,Wakabayashi T,Tsuno T,Hatano H,Mizuno M,Yoshida J

更新日期：2005-09-01 00:00:00

abstract：:Chinese hamster ovary cells synchronized by mitotic detachment were treated with 5-fluorodeoxyuridine (FdUrd), 0.2 micrograms/ml, at various times in the cell cycle. FdUrd treatment in the early S period induced resistance to 6-thioguanine. Treatment of asynchronous cells with FdUrd caused little increase in 6-thiogua...

journal_title：Cancer research

authors： Aebersold PM

更新日期：1979-03-01 00:00:00

abstract：:DMBT1 is a candidate tumor suppressor gene located at 10q25.3-26.1. Homozygous deletion of the gene was found in a subset of medulloblastoma and glioblastoma multiforme; lack of expression was noted in the majority of these tumors. In adult tissues, DMBT1 is highly expressed only in lung and small intestine tissues, i...

journal_title：Cancer research

authors： Wu W,Kemp BL,Proctor ML,Gazdar AF,Minna JD,Hong WK,Mao L

更新日期：1999-04-15 00:00:00

abstract：:A transplanted rat lymphosarcoma (SGT-4), induced by Gross virus and inoculated s.c. into the foot of a normal syngeneic rat, initially grew but ultimately regressed. The tumor cells metastasized to the regional popliteal, lumbar, and inguinal lymph nodes and formed massive metastatic foci there. These lymph node meta...

journal_title：Cancer research

authors： Kodama T,Gotohda E,Takeichi N,Kuzumaki N,Kobayashi H

更新日期：1975-07-01 00:00:00

abstract：:The development of colon carcinomas is associated with allelic deletions on chromosomes 5q, 17p, and 18q. The DCC gene located on chromosome 18q21.3 codes for a potential tumor suppressor gene related to cellular adhesion receptors. We investigated the expression of this gene in several pancreatic carcinoma cell lines...

journal_title：Cancer research

authors： Höhne MW,Halatsch ME,Kahl GF,Weinel RJ

更新日期：1992-05-01 00:00:00

abstract：:1-beta-D-Arabinofuranosylcytosine (araC) is an effective drug in the i.p. therapy of ovarian carcinoma but little is known of its transport and metabolism in this tumor. Influx of araC at 1 microM into cultured human ovarian carcinoma cells (CI 80-13S) was largely inhibited by nanomolar concentrations of the nucleosid...

journal_title：Cancer research

authors： Jamieson GP,Snook MB,Bradley TR,Bertoncello I,Wiley JS

更新日期：1989-01-15 00:00:00

abstract：:Microcephalin (MCPH1) is a BRCA1 COOH terminal (BRCT) domain containing protein involved in the cellular response to DNA damage that has been implicated in autosomal recessive primary microcephaly. MCPH1 is recruited to sites of DNA double-strand breaks by phosphorylated histone H2AX (gammaH2AX), but the mechanism by ...

journal_title：Cancer research

authors： Wu X,Mondal G,Wang X,Wu J,Yang L,Pankratz VS,Rowley M,Couch FJ

更新日期：2009-07-01 00:00:00

abstract：:We have recently reported that apoptosis of T cells induced by squamous cell carcinoma of the head and neck (SCCHN) is partly Fas dependent. This tumor-induced T-cell death is mediated by the activities of caspase-8 and caspase-3 and is partially inhibited by antibodies to either Fas or Fas ligand. We report here that...

journal_title：Cancer research

authors： Gastman BR,Yin XM,Johnson DE,Wieckowski E,Wang GQ,Watkins SC,Rabinowich H

更新日期：2000-12-15 00:00:00

abstract：:Four glutathione transferases (EC 2.5.1.18), glutathione transferases A, B, and C and a hitherto unknown form, termed X, were purified to apparent homogeneity from rat liver cytosol. They were investigated for their abilities to inactivate two mutagenic epoxides derived from the polycyclic aromatic hydrocarbon benz(a)...

journal_title：Cancer research

authors： Glatt H,Friedberg T,Grover PL,Sims P,Oesch F

更新日期：1983-12-01 00:00:00