Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.

abstract：:Fas (Apo-1/CD95) belongs to the tumor necrosis factor/nerve growth factor receptor family and transmits apoptotic signals by binding to its ligand. Interleukin-1beta-converting enzyme (ICE), which shows substantial homology to the product of the cell death gene, ced-3, of Caenorhabditis elegans, is reported to be invo...

journal_title：Cancer research

authors： Hasegawa J,Kamada S,Kamiike W,Shimizu S,Imazu T,Matsuda H,Tsujimoto Y

更新日期：1996-04-15 00:00:00

abstract：:The pancreatic carcinogen N-nitrosobis(2-oxopropyl)-amine was administered to Syrian golden hamsters after cholecystoduodenostomy and choledochostomy to investigate a possible bile reflux mechanism as a factor in pancreatic carcinogenesis. The induced lesions were similar in morphology, multiplicity, and distribution ...

journal_title：Cancer research

authors： Pour P,Donnelly T

更新日期：1978-07-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) represent a primary mechanism of immune evasion in tumors and have emerged as a major obstacle for cancer immunotherapy. The immunoinhibitory activity of MDSC is tightly regulated by the tumor microenvironment and occurs through mechanistic mediators that remain unclear. Here, w...

journal_title：Cancer research

authors： Trillo-Tinoco J,Sierra RA,Mohamed E,Cao Y,de Mingo-Pulido Á,Gilvary DL,Anadon CM,Costich TL,Wei S,Flores ER,Ruffell B,Conejo-Garcia JR,Rodriguez PC

更新日期：2019-10-01 00:00:00

abstract：:Treatment of rats with either intermittent bolus i.v. injections or continuous i.v. infusions of the same sublethal daily dose of tumor necrosis factor (TNF) results in decreased food intake and decreased nitrogen balance compared to saline-treated control rats. After 4 days of treatment, rats treated with intermitten...

journal_title：Cancer research

authors： Darling G,Fraker DL,Jensen JC,Gorschboth CM,Norton JA

更新日期：1990-07-01 00:00:00

abstract：:The Lewis lung carcinoma is a transplantable metastatic tumor of the C57BL mouse strain. When cells derived from this tumor are inoculated onto the chorioallantoic membrane (CAM) of 9- to 11-day-old chick embryos, large tumors are produced. Although most of these tumors contain mouse cells, they can no longer be trans...

journal_title：Cancer research

authors： Belin D,Ossowski L

更新日期：1983-07-01 00:00:00

abstract：:A widely held tenet of present day oncology is that tumor cells treated with anticancer agents die from apoptosis, and that cells resistant to apoptosis are resistant to cancer treatment. We suggest, in this review, that this tenet may need to be reexamined for human tumors of nonhematological origin, for two principa...

journal_title：Cancer research

authors： Brown JM,Wouters BG

更新日期：1999-04-01 00:00:00

abstract：:The effect of culture conditions on the glutamylation of methotrexate by intact H35 hepatoma cells and folylpolyglutamate synthetase (FPGS) activity in the corresponding crude extracts has been examined. The rate of cellular glutamylation of methotrexate observed in rapidly dividing cultures was 4-fold higher than con...

journal_title：Cancer research

authors： Johnson TB,Nair MG,Galivan J

更新日期：1988-05-01 00:00:00

abstract：:The zinc finger gene MZF-1 is preferentially expressed in primitive hematopoietic cells and plays an important role in regulating myelopoiesis. Regulators of development are potential targets for neoplastic transformation. This study investigated whether unregulated expression of MZF-1 could function as an oncogene. R...

journal_title：Cancer research

authors： Hromas R,Morris J,Cornetta K,Berebitsky D,Davidson A,Sha M,Sledge G,Rauscher F 3rd

更新日期：1995-08-15 00:00:00

abstract：:Ovarian cancer is mainly confined in peritoneal cavity and its metastasis is often associated with the formation of malignant ascites. As lysophosphatidic acid (LPA) is present at high levels in ascites of ovarian cancer patients and potently stimulates cell migration, we reason that LPA-stimulated cell migration may ...

journal_title：Cancer research

authors： Chen H,Wu X,Pan ZK,Huang S

更新日期：2010-12-01 00:00:00

abstract：:Vinblastine (VLB) is moderately active clinically against advanced breast cancer. Since VLB is extensively taken up by platelets and thus only partially available to tumor cells, to enhance the therapeutic index of VLB we have therefore administered this agent by continuous i.v. infusion to patients with advanced brea...

journal_title：Cancer research

authors： Lu K,Yap HY,Loo TL

更新日期：1983-03-01 00:00:00

abstract：:A partial-length A-myb complementary DNA recently cloned by low-stringency hybridization with a c-myb probe to complementary DNA libraries derived from human cell lines showed a high degree of homology with the DNA-binding domain of c-myb and B-myb, suggesting that A-myb also encoded a DNA-binding protein. We report h...

journal_title：Cancer research

authors： Ma XP,Calabretta B

更新日期：1994-12-15 00:00:00

abstract：:The presence of a quinone group in the structure of a series of model compounds was shown to produce cell kill by a mechanism involving free radicals and active oxygen species. Furthermore, the ability of the compound to bind to DNA appeared to enhance its cytocidal activity. The same model compounds were used to inve...

journal_title：Cancer research

authors： Begleiter A,Blair GW

更新日期：1984-01-01 00:00:00

abstract：:The fusion transcript AML1/ETO was detected in the bone marrow of two t(8;21)-negative acute myelogenous leukemia (AML) patients by means of reverse transcription-polymerase chain reaction. This fusion transcript is identical to the one transcribed from the t(8;21) translocation base, as deduced from (a) the size and ...

journal_title：Cancer research

authors： Maruyama F,Yang P,Stass SA,Cork A,Freireich EJ,Lee MS,Chang KS

更新日期：1993-10-01 00:00:00

abstract：:A putative tumor suppressor gene, p53, has been shown to be altered in a variety of human tumor types. The primary mechanism of p53 inactivation is believed to be mutation of one allele followed by loss of the second allele. Malignant mesothelioma is a tumor that has been highly associated with exposure to asbestos fi...

journal_title：Cancer research

authors： Cote RJ,Jhanwar SC,Novick S,Pellicer A

更新日期：1991-10-01 00:00:00

abstract：:The Bcl-2 antagonist ABT-737 targets Bcl-2/Bcl-xL but not Mcl-1, which may confer resistance to this novel agent. Here, we show that Mcl-1 down-regulation by the cyclin-dependent kinase (CDK) inhibitor roscovitine or Mcl-1-shRNA dramatically increases ABT-737 lethality in human leukemia cells. ABT-737 induces Bax conf...

journal_title：Cancer research

authors： Chen S,Dai Y,Harada H,Dent P,Grant S

更新日期：2007-01-15 00:00:00

abstract：:The human papillomavirus (HPV) 16 E7 oncoprotein has been reported previously to stimulate DNA damage and to activate host cell DNA damage checkpoints. How HPV-16 E7 maintains proliferation despite activated DNA damage checkpoints is incompletely understood. Here, we provide evidence that cells expressing the HPV-16 E...

journal_title：Cancer research

authors： Spardy N,Covella K,Cha E,Hoskins EE,Wells SI,Duensing A,Duensing S

更新日期：2009-09-01 00:00:00

abstract：:In female nude mice, epidermal growth factor (EGF) was present at a mean concentration of 42.8 +/- 16.9 (SD) ng/mg wet tissue in the submandibular gland and 0.28 +/- 0.13 ng/ml in the plasma. Sialoadenectomy (removal of the submandibular glands) decreased circulating EGF to undetectable levels (less than 0.1 ng/ml). T...

journal_title：Cancer research

authors： Tsutsumi O,Tsutsumi A,Oka T

更新日期：1987-09-01 00:00:00

abstract：:Several members of the kinesin family of microtubule motor proteins play essential roles in mitotic spindle function and are potential targets for the discovery of novel antimitotic cancer therapies. KSP, also known as HsEg5, is a kinesin that plays an essential role in formation of a bipolar mitotic spindle and is re...

journal_title：Cancer research

authors： Sakowicz R,Finer JT,Beraud C,Crompton A,Lewis E,Fritsch A,Lee Y,Mak J,Moody R,Turincio R,Chabala JC,Gonzales P,Roth S,Weitman S,Wood KW

更新日期：2004-05-01 00:00:00

abstract：:The human promyelocytic leukemia cell line HL-60 and monoblastic leukemia cell line U937 undergo differentiation when induced by lymphokine and cytokine preparations. Growth inhibition, acquisition of immunoglobulin Fc receptors, increased expression of monocyte-related surface antigens, and an increase in lysosomal e...

journal_title：Cancer research

authors： Harris PE,Ralph P,Gabrilove J,Welte K,Karmali R,Moore MA

更新日期：1985-07-01 00:00:00

abstract：:A transplantable bladder tumor (Chapman R-4909) of the rat, when first received in our laboratory, grew with a complex histopathology. The predominant component was transitional cell carcinoma, but there were foci of keratinization, including pearl formation, and foci of a less well-defined cystic appearance. We repor...

journal_title：Cancer research

authors： Toyoshima K,Abaza N,Leighton J

更新日期：1976-08-01 00:00:00

abstract：:MTW9, a transplantable mammary tumor in Wistar Furth rats, shows little growth unless host serum prolactin is increased. This study compares the response to ovariectomy of MTW9-MtT, a tumor developed in rats bearing the mammosomatotropic tumor MtTW10 (serum prolactin 500 to 7000 ng/ml) with MTW9-P developed in rats gi...

journal_title：Cancer research

authors： Diamond EJ,Koprak S,Shen SK,Hollander VP

更新日期：1976-01-01 00:00:00

abstract：:Levels of epidermal growth factor receptor (EGF-R) and insulin-like growth factor receptor (IGF-R) in breast cancer tissue were evaluated. The binding of growth factors was compared to the content of estrogen receptors (ER) and progesterone receptors (PgR). EGF-R correlated negatively to the ER and PgR (Kendall correl...

journal_title：Cancer research

authors： Pekonen F,Partanen S,Mäkinen T,Rutanen EM

更新日期：1988-03-01 00:00:00

abstract：:A murine monoclonal antibody 14.18 specifically recognizes disialoganglioside GD2, the major ganglioside expressed on the surface of human neuroblastoma cells. This monoclonal antibody (Mab) is of immunoglobulin G3 isotype, has an affinity constant (KA) of 3.5 X 10(8) M-1, and reacts preferentially with tumor cells an...

journal_title：Cancer research

authors： Mujoo K,Cheresh DA,Yang HM,Reisfeld RA

更新日期：1987-02-15 00:00:00

abstract：:Interleukin 4, a T cell-derived 20-kDa glycoprotein, plays an important role in regulating the immune response of B cells, T cells, and macrophages against infections and malignant cells. For this reason recombinant human interleukin 4 (rhIL-4) has entered early clinical trials in cancer patients. In the present study...

journal_title：Cancer research

authors： Topp MS,Papadimitriou CA,Eitelbach F,Koenigsmann M,Oelmann E,Koehler B,Oberberg D,Reufi B,Stein H,Thiel E

更新日期：1995-05-15 00:00:00

abstract：:The lethal and bone marrow toxicity and antitumor activity of the cis- and trans-2-hydroxylated metabolites of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) have been correlated with their relative in vitro alkylating and carbamoylating activities. Both the isomers have considerably greater alkylating activity a...

journal_title：Cancer research

authors： Heal JM,Fox PA,Doukas D,Schein PS

更新日期：1978-04-01 00:00:00

abstract：:The antitumor activity of combination therapy with recombinant tumor necrosis-alpha (rhTNF-alpha) and recombinant interleukin-2 (rhIL-2) was assessed against established immunogenic (MCA-106) and nonimmunogenic (MCA-102) sarcomas at both s.c. and visceral (hepatic) sites. C57BL/6 (B6) mice were treated with a single i...

journal_title：Cancer research

authors： McIntosh JK,Mulé JJ,Merino MJ,Rosenberg SA

更新日期：1988-07-15 00:00:00

abstract：:Fatigue is the most common symptom of cancer at diagnosis, yet causes and effective treatments remain elusive. As tumors can be highly inflammatory, it is generally accepted that inflammation mediates cancer-related fatigue. However, evidence to support this assertion is mostly correlational. In this study, we directl...

journal_title：Cancer research

authors： Grossberg AJ,Vichaya EG,Christian DL,Molkentine JM,Vermeer DW,Gross PS,Vermeer PD,Lee JH,Dantzer R

更新日期：2018-02-01 00:00:00

abstract：:Solid tumors often contain poorly vascularized necrotic regions. In order to determine how such regions are formed within tumors and to identify substances which affect their formation, we have transformed nontumorigenic BALB/c 3T3 cells with an activated Ha-ras oncogene. Cells that were derived from independent clone...

journal_title：Cancer research

authors： Peretz D,Kimel N,Fujii DK,Neufeld G

更新日期：1993-01-01 00:00:00

abstract：:Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism in breast cancer cells remains poorly understood. Here, we show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer cells. Loss of ZMYND8 triggered ac...

journal_title：Cancer research

authors： Wang Y,Luo M,Chen Y,Wang Y,Zhang B,Ren Z,Bao L,Wang Y,Wang JE,Fu YX,Luo W,Wang Y

更新日期：2020-11-04 00:00:00

abstract：:Elevated levels of TGFβ are a negative prognostic indicator for patients diagnosed with pancreatic cancer; as a result, the TGFβ pathway is an attractive target for therapy. However, clinical application of pharmacologic inhibition of TGFβ remains challenging because TGFβ has tumor suppressor functions in many epithel...

journal_title：Cancer research

authors： Ostapoff KT,Cenik BK,Wang M,Ye R,Xu X,Nugent D,Hagopian MM,Topalovski M,Rivera LB,Carroll KD,Brekken RA

更新日期：2014-09-15 00:00:00