Distinct differentiation-inducing activities of gamma-interferon and cytokine factors acting on the human promyelocytic leukemia cell line HL-60.

abstract：:Hyaluronic acid (HA) binds to cell-surface receptors such as CD44, and seems to be involved in cell adhesion, motility, and tumor progression in brain. To identify gene expression changes that are initiated by HA, we explored human cytokine arrays in U87MG glioma cells and identified osteopontin, a secreted matrix pro...

journal_title：Cancer research

authors： Kim MS,Park MJ,Moon EJ,Kim SJ,Lee CH,Yoo H,Shin SH,Song ES,Lee SH

更新日期：2005-02-01 00:00:00

abstract：:The nucleus has been shown to be a site for the inositol lipid cycle that can be affected by treatment of quiescent cells with growth factors such as insulin-like growth factor I (IGF-I). Indeed, the exposure of Swiss 3T3 cells to IGF-I results in a rapid and transient increase in nuclear phospholipase C (PLC) beta1 a...

journal_title：Cancer research

authors： Manzoli L,Billi AM,Rubbini S,Bavelloni A,Faenza I,Gilmour RS,Rhee SG,Cocco L

更新日期：1997-06-01 00:00:00

abstract：:Given the prevalence of Ras mutations in human cancer, it is critical to understand the effector pathways downstream of oncogenic Ras leading to transformation. To directly assess the requirement for Rac1 in K-ras-induced tumorigenesis, we employed a model of lung cancer in which an oncogenic allele of K-ras could be ...

journal_title：Cancer research

authors： Kissil JL,Walmsley MJ,Hanlon L,Haigis KM,Bender Kim CF,Sweet-Cordero A,Eckman MS,Tuveson DA,Capobianco AJ,Tybulewicz VL,Jacks T

更新日期：2007-09-01 00:00:00

abstract：:Adenocarcinoma of the rete testis is an exceptionally rare and malignant testicular neoplasm. Although treatment of pregnant women with diethylstilbestrol (DES) results in reproductive tract abnormalities in their male offspring, increased incidence of testicular tumors has not been verified. However, recently three c...

journal_title：Cancer research

authors： Newbold RR,Bullock BC,McLachlan JA

更新日期：1985-10-01 00:00:00

abstract：:About two thirds of laryngeal cancers originate at the vocal cords. Early-stage detection of malignant vocal fold alterations, including a discrimination of premalignant lesions, represents a major challenge in laryngology as precancerous vocal fold lesions and small carcinomas are difficult to distinguish by means of...

journal_title：Cancer research

authors： Unger J,Lohscheller J,Reiter M,Eder K,Betz CS,Schuster M

更新日期：2015-01-01 00:00:00

abstract：:In spite of preclinical efficacy and recent randomized, controlled studies with adenoviral vectors expressing herpes simplex virus-1 thymidine kinase (HSV1-TK) showing statistically significant increases in survival, most clinical trials using single therapies have failed to provide major therapeutic breakthroughs. Be...

journal_title：Cancer research

authors： Ali S,King GD,Curtin JF,Candolfi M,Xiong W,Liu C,Puntel M,Cheng Q,Prieto J,Ribas A,Kupiec-Weglinski J,van Rooijen N,Lassmann H,Lowenstein PR,Castro MG

更新日期：2005-08-15 00:00:00

abstract：:Bile acids increase the proliferative activity of rat colonic epithelium. However, the mechanisms responsible are unknown. The present study examined the relationships between deoxycholate (DOC) induced surface cell sloughing, as measured by loss of DNA into the lumen and by light microscopy, and the subsequent increa...

journal_title：Cancer research

authors： Craven PA,Pfanstiel J,Saito R,DeRubertis FR

更新日期：1986-11-01 00:00:00

abstract：:Resistance of human renal cell carcinoma (RCC) and melanoma to the apoptosis-inducing effects of IFNs was postulated to result from epigenetic silencing of genes by DNA methylation, a common feature of human cancers. To reverse silencing, 5-AZA-deoxycytidine (5-AZA-dC) or selective depletion of DNA methyltransferase 1...

journal_title：Cancer research

authors： Reu FJ,Leaman DW,Maitra RR,Bae SI,Cherkassky L,Fox MW,Rempinski DR,Beaulieu N,MacLeod AR,Borden EC

更新日期：2006-03-01 00:00:00

abstract：:The mechanism of action of the synthetic glucocorticoid antagonist, RU 38486, has yet to be completely elucidated. Although RU 38486 is a potent antiglucocorticoid in vivo, several studies have indicated that it has some agonist activities in vitro, such as high-affinity steroid binding to the receptor, activation, an...

journal_title：Cancer research

authors： Lindemeyer RG,Robertson NM,Litwack G

更新日期：1990-12-15 00:00:00

abstract：:Oncogenic transformation of mouse 10T 1/2 fibroblasts induced upon exposure to X-ray or N-methyl-N'-nitro-N-nitrosoguanidine was suppressed if lipopolysaccharide (LPS) was present in the culture medium. The suppressive effect of LPS was exerted within 24 h after irradiation. Suppression was dependent on the concentrat...

journal_title：Cancer research

authors： Sakiyama H,Yasukawa M,Terasima T,Kanegasaki S

更新日期：1986-08-01 00:00:00

abstract：:Busulfan, a bifunctional alkylating agent, is a mainstay of myeloablative preparative regimens before hematopoietic stem cell transplantation. The apparent oral clearance of busulfan expressed relative to body surface area is 2-3-fold higher in children 1-4 years old than it is in adults. The first step in busulfan el...

journal_title：Cancer research

authors： Gibbs JP,Murray G,Risler L,Chien JY,Dev R,Slattery JT

更新日期：1997-12-15 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) regulates growth of various cells, and inactivation of the TGF-beta signaling pathway contributes to tumor progression. Smad2 is phosphorylated and activated by TGF-beta, resulting in the antiproliferative effects of TGF-beta signaling. Smurf2 (Smad ubiquitination regulatory ...

journal_title：Cancer research

authors： Fukuchi M,Fukai Y,Masuda N,Miyazaki T,Nakajima M,Sohda M,Manda R,Tsukada K,Kato H,Kuwano H

更新日期：2002-12-15 00:00:00

abstract：:XPC protein is a critical DNA damage recognition factor in nucleotide excision repair for which genetic deficiency confers a predisposition to cancer. In this study, we show that XPC has a function that is independent of its canonical function in DNA repair, potentially altering the interpretation of how XPC deficienc...

journal_title：Cancer research

authors： Wang QE,Han C,Zhang B,Sabapathy K,Wani AA

更新日期：2012-02-01 00:00:00

abstract：:We evaluated whether antibody response correlates with tumor therapy by cytokine gene-modified tumor cell vaccines. To characterize the antibody (Ab) response against a known antigen, colon carcinoma C26 cells and C26 variants engineered to produce interleukin (IL) 12 or IL-4 were further transduced to express the hum...

journal_title：Cancer research

authors： Rodolfo M,Melani C,Zilocchi C,Cappetti B,Luison E,Arioli I,Parenza M,Canevari S,Colombo MP

更新日期：1998-12-15 00:00:00

abstract：:The major transmission route for Kaposi sarcoma-associated herpesvirus (KSHV) infection is the oral cavity through saliva. Kaposi sarcoma (KS) frequently occurs in the oral cavity in HIV-positive individuals and is often the first presenting sign of AIDS. However, the oral target cells for KSHV infection and the cellu...

journal_title：Cancer research

authors： Li Y,Zhong C,Liu D,Yu W,Chen W,Wang Y,Shi S,Yuan Y

更新日期：2018-01-01 00:00:00

abstract：:A historical cohort of 68 female breast cancer patients from one institution who were enrolled in a multicenter randomized controlled trial between 1971 and 1973 were followed up to the beginning of 1986. Weight and height at the time of mastectomy were transformed into two indices of body size, namely the Quetelet In...

journal_title：Cancer research

authors： Suissa S,Pollak M,Spitzer WO,Margolese R

更新日期：1989-06-01 00:00:00

abstract：:Activation of activator protein 1 (AP-1) and nuclear factor kappaB (NFkappaB)-dependent transcription is required for tumor promotion in cell culture models and transgenic mice. Dominant-negative c-Jun (TAM67) blocks AP-1 activation by dimerizing with Jun or Fos family proteins and blocks NFkappaB activation by intera...

journal_title：Cancer research

authors： Matthews CP,Birkholz AM,Baker AR,Perella CM,Beck GR Jr,Young MR,Colburn NH

更新日期：2007-03-15 00:00:00

abstract：:Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) accumulates in the nucleus in aggressive transitional cell carcinoma (TCC) cells and this histologic feature is a marker of poor prognosis in human bladder cancer tissues. Here we report that HB-EGF can be exported from the nucleus during stimul...

journal_title：Cancer research

authors： Kim J,Adam RM,Freeman MR

更新日期：2005-09-15 00:00:00

abstract：:The bcl-2 family of genes code for proteins that contain anti-apoptotic or pro-apoptotic activity. The human bfl-1 gene contains an open reading frame for a 175-amino acid Bcl-2 family protein. Among the various Bcl-2 family members, the Bfl-1 protein shares the highest homology with the mouse A1 protein. These two pr...

journal_title：Cancer research

authors： D'Sa-Eipper C,Subramanian T,Chinnadurai G

更新日期：1996-09-01 00:00:00

abstract：:Data are presented in support of the hypothesis that malignant tumors, containing abnormally permeable, degenerating cells, can be selectively detected using monoclonal antibodies to intracellular antigens. Biodistribution, imaging, and autoradiographic studies were performed in nude mice transplanted with four differ...

journal_title：Cancer research

authors： Epstein AL,Chen FM,Taylor CR

更新日期：1988-10-15 00:00:00

abstract：:The MCT-1 oncogene was originally identified from lymphoma cell lines. Herein we establish that MCT-1 is highly expressed in 85% of human diffuse large B-cell lymphomas (DLBCL) and that knocking down MCT-1 by a specific short hairpin RNA in DLBCL cells induces apoptosis, supporting a critical role for MCT-1 in DLBCL c...

journal_title：Cancer research

authors： Dai B,Zhao XF,Hagner P,Shapiro P,Mazan-Mamczarz K,Zhao S,Natkunam Y,Gartenhaus RB

更新日期：2009-10-01 00:00:00

abstract：:Early phase evaluation of anticancer drugs has traditionally used toxicity (usually hematological) rather than efficacy end points to establish appropriate dosing schedules. To establish a biochemical efficacy end point for overcoming alkylguanine DNA alkyltransferase (AGT)-mediated tumor cell resistance to 1,3-bis(2-...

journal_title：Cancer research

authors： Spiro TP,Gerson SL,Liu L,Majka S,Haaga J,Hoppel CL,Ingalls ST,Pluda JM,Willson JK

更新日期：1999-05-15 00:00:00

abstract：:Paclitaxel is a standard-of-care chemotherapy for breast cancer, despite the increasing recognition of its poor effectiveness in the treatment of patients with advanced disease. Here, we report that adenovirus-type 5 E1A-mediated elevation of the miRNA-processing enzyme Dicer is sufficient to enhance paclitaxel sensit...

journal_title：Cancer research

authors： Chang TY,Chen HA,Chiu CF,Chang YW,Kuo TC,Tseng PC,Wang W,Hung MC,Su JL

更新日期：2016-07-01 00:00:00

abstract：:The mitotic kinase Aurora A is an important therapeutic target for cancer therapy. This study evaluated new mechanism-based pharmacodynamic biomarkers in cancer patients in two phase I studies of MLN8054, a small-molecule inhibitor of Aurora A kinase. Patients with advanced solid tumors received MLN8054 orally for 7 c...

journal_title：Cancer research

authors： Chakravarty A,Shinde V,Tabernero J,Cervantes A,Cohen RB,Dees EC,Burris H,Infante JR,Macarulla T,Elez E,Andreu J,Rodriguez-Braun E,Rosello S,von Mehren M,Meropol NJ,Langer CJ,ONeil B,Bowman D,Zhang M,Danaee H,Faron

更新日期：2011-02-01 00:00:00

abstract：:Despite strong evidence of an association between Helicobacter pylori and gastric cancer, the benefit of eradicating H. pylori infection is unknown. Our aim was to test the hypothesis that exposure to high doses of antibiotics reduces risk for gastric cancer via possible eradication of H. pylori We conducted a nationw...

journal_title：Cancer research

authors： Akre K,Signorello LB,Engstrand L,Bergström R,Larsson S,Eriksson BI,Nyrén O

更新日期：2000-11-15 00:00:00

abstract：:Cyclooxygenase-2 (Cox-2) expression can induce mammary tumorigenesis in transgenic mice, and selective Cox-2 inhibitors are both chemopreventive and chemotherapeutic in rat models of breast cancer. We analyzed the expression of Cox-2 protein by immunohistochemistry in tissue array specimens of 1576 invasive breast can...

journal_title：Cancer research

authors： Ristimäki A,Sivula A,Lundin J,Lundin M,Salminen T,Haglund C,Joensuu H,Isola J

更新日期：2002-02-01 00:00:00

abstract：:A novel chromosomal translocation, t(2;11)(q31;p15), was identified in a patient with therapy-related acute myelogenous leukemia (t-AML). Fluorescence in situ hybridization experiments mapped the breakpoint near NUP98; Southern blot analysis demonstrated that the nucleoporin gene NUP98 was disrupted by this translocat...

journal_title：Cancer research

authors： Raza-Egilmez SZ,Jani-Sait SN,Grossi M,Higgins MJ,Shows TB,Aplan PD

更新日期：1998-10-01 00:00:00

abstract：:gamma-Interferon (IFN-gamma) was shown to amplify cytotoxin release from murine bone marrow-adherent macrophages in response to an animal lectin as a second stimulus. This stimulation of cytotoxin release was demonstrated both in vitro and in vivo and was maximal 2 h after treatment with IFN-gamma. No change in expres...

journal_title：Cancer research

authors： Okutomi T,Yamazaki M

更新日期：1988-04-01 00:00:00

abstract：:Two lines of human colonic carcinoma cells have different sensitivities to 5-fluorouracil and 1-(2-chlorethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (methyl-CCNU). The growth of the BE line is 50% inhibited by 330 microM 5-fluorouracil and 15 microM methyl-CCNU, and the HT-29 line is 50% inhibited by 85 and 140 microM,...

journal_title：Cancer research

authors： Sutton JE,Roos IA,Hillcoat BL

更新日期：1982-12-01 00:00:00

abstract：:Regulation of tyrosine aminotransferase gene expression was studied in an adult rat hepatocyte line (RALA255-10G) which is temperature sensitive for the maintenance of the differentiated liver phenotype. Glucocorticoid hormones such as cortisol were necessary for expression of the aminotransferase gene. In the absence...

journal_title：Cancer research

authors： Chou JY,Yeoh GC

更新日期：1987-10-15 00:00:00