Essential role for nuclear phospholipase C beta1 in insulin-like growth factor I-induced mitogenesis.

abstract：:Inflammatory bowel disease (IBD) is a gastrointestinal disorder of unknown etiology or cure. One complication of IBD is an increased risk for development of colon cancer. The aims of this study were to use a previously established rat model of colitis to develop a new model of colitis-associated colon cancer and ascer...

journal_title：Cancer research

authors： Santiago C,Pagán B,Isidro AA,Appleyard CB

更新日期：2007-11-15 00:00:00

abstract：:The conversion of transforming growth factor beta (TGF-beta) from a tumor suppressor to a tumor promoter occurs frequently during mammary tumorigenesis, yet the molecular mechanisms underlying this phenomenon remain undefined. We show herein that TGF-beta repressed nuclear factor-kappaB (NF-kappaB) activity in normal ...

journal_title：Cancer research

authors： Neil JR,Schiemann WP

更新日期：2008-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) was thought historically to arise from hepatocytes, but gene expression studies have suggested that it can also arise from fetal progenitor cells or their adult progenitor progeny. Here, we report the identification of a unique population of fetal liver progenitor cells in mice that can ...

journal_title：Cancer research

authors： Mokkapati S,Niopek K,Huang L,Cunniff KJ,Ruteshouser EC,deCaestecker M,Finegold MJ,Huff V

更新日期：2014-08-15 00:00:00

abstract：:The selective pressures leading to cancers with mutations in both KRAS and PIK3CA are unclear. Here, we show that somatic cell knockin of both KRAS G12V and oncogenic PIK3CA mutations in human breast epithelial cells results in cooperative activation of the phosphoinositide 3-kinase (PI3K) and mitogen-activated protei...

journal_title：Cancer research

authors： Wang GM,Wong HY,Konishi H,Blair BG,Abukhdeir AM,Gustin JP,Rosen DM,Denmeade SR,Rasheed Z,Matsui W,Garay JP,Mohseni M,Higgins MJ,Cidado J,Jelovac D,Croessmann S,Cochran RL,Karnan S,Konishi Y,Ota A,Hosokawa Y,Arga

更新日期：2013-06-01 00:00:00

abstract：:This study was undertaken to examine relationships of the phenotype of malignant cells to target cell properties and to events early in the transformation process. Eighteen transformed lines were obtained by Kirsten murine sarcoma virus infection of cells from adrenal glands of rats ages 4 to 30 weeks, at first or sec...

journal_title：Cancer research

authors： Auersperg N,Wan MW,Sanderson RA,Wong KS,Mauldin D

更新日期：1981-05-01 00:00:00

abstract：:T-cell receptor (TCR) gene transfer for cancer immunotherapy is limited by the availability of large numbers of tumor-specific T cells. TCR alpha and beta chains were isolated from a highly lytic HLA-A2-restricted cytotoxic T lymphocyte (CTL) clone recognizing the melanoma-associated Melan-A/MART-1 antigen and inserte...

journal_title：Cancer research

authors： Bobisse S,Rondina M,Merlo A,Tisato V,Mandruzzato S,Amendola M,Naldini L,Willemsen RA,Debets R,Zanovello P,Rosato A

更新日期：2009-12-15 00:00:00

abstract：:The antitumor effects of two immunotoxins were evaluated in vitro and in vivo against the human ovarian carcinoma cell line, OVCAR-3. The immunotoxins used were composed of recombinant ricin A chain (rRTA) covalently attached to a monoclonal antibody directed toward the human transferrin receptor (45412/rRTA, also cal...

journal_title：Cancer research

authors： Pearson JW,Hedrick E,Fogler WE,Bull RL,Ferris DK,Riggs CW,Wiltrout RH,Sivam G,Morgan AC,Groves E

更新日期：1990-10-01 00:00:00

abstract：:Cytogenetic analyses of intraspecies human HeLa X fibroblast hybrid cell populations have provided tentative evidence for the correlation of loss of a single copy of chromosomes 11 and 14 with reexpression of tumorigenicity. In this study paired combinations of nontumorigenic and tumorigenic segregant HeLa X fibroblas...

journal_title：Cancer research

authors： Srivatsan ES,Benedict WF,Stanbridge EJ

更新日期：1986-12-01 00:00:00

abstract：:Tumor-associated angiogenesis is critical for tumor growth and metastasis and is controlled by various pro- and antiangiogenic factors. The Eph family of receptor tyrosine kinases has emerged as one of the pivotal regulators of angiogenesis. Here we report that interfering with EphA signaling resulted in a pronounced ...

journal_title：Cancer research

authors： Dobrzanski P,Hunter K,Jones-Bolin S,Chang H,Robinson C,Pritchard S,Zhao H,Ruggeri B

更新日期：2004-02-01 00:00:00

abstract：:Curcumin, a plant polyphenol, is a widely studied chemopreventive agent with demonstrated antitumor activities in preclinical studies and low toxicity profiles in multiple clinical trials against human malignancies. We previously showed that curcumin radiosensitizes cervical tumor cells without increasing the cytotoxi...

journal_title：Cancer research

authors： Javvadi P,Hertan L,Kosoff R,Datta T,Kolev J,Mick R,Tuttle SW,Koumenis C

更新日期：2010-03-01 00:00:00

abstract：:Blood group determinants have been found in five carcinoembryonic antigen (CEA) preparations with a lectin and antibody-binding assay using polyethylene glycol 6000 to separate free from bound radiolabeled antigen. The assay described gives excellent sensitivity for the binding or inhibition of binding of various lect...

journal_title：Cancer research

authors： Pompecki R,Shively JE,Todd CW

更新日期：1981-05-01 00:00:00

abstract：:The gene of phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) has been implicated as an oncogene in ovarian cancer [L. Shayesteh et al., Nat. Genet., 21: 99-102, 1999]. In this study, we examined the expression of PIK3CA mRNA and its p110alpha protein product in human ovarian carcinoma and investigated it...

journal_title：Cancer research

authors： Zhang L,Yang N,Katsaros D,Huang W,Park JW,Fracchioli S,Vezzani C,Rigault de la Longrais IA,Yao W,Rubin SC,Coukos G

更新日期：2003-07-15 00:00:00

abstract：:Possible mechanisms whereby alcohol abuse and alcohol-related diseases may promote the development of cancer are analyzed. The mechanisms discussed include: (a) contact-related local effects on the upper gastrointestinal tract; (b) the presence of low levels of carcinogens in alcoholic beverages; (c) induction of micr...

journal_title：Cancer research

authors： Lieber CS,Seitz HK,Garro AJ,Worner TM

更新日期：1979-07-01 00:00:00

abstract：:Nm23-H1 has been identified as a metastasis suppressor gene, but its protein interactions have yet to be understood with any mechanistic clarity. In this study, we evaluated the proteomic spectrum of interactions made by Nm23-H1 in 4T1 murine breast cancer cells derived from tissue culture, primary mammary tumors, and...

journal_title：Cancer research

authors： Marino N,Marshall JC,Collins JW,Zhou M,Qian Y,Veenstra T,Steeg PS

更新日期：2013-10-01 00:00:00

abstract：:The concentration of potassium (K+) and sodium (Na+) was measured in breast cyst fluid (BCF) from 611 cysts greater than 3 ml aspirated in 520 women with gross cystic disease of the breast. These women were enrolled, from 1983 on, in a cohort study aimed at assessing the relationship between cyst type, as defined by t...

journal_title：Cancer research

authors： Naldoni C,Costantini M,Dogliotti L,Bruzzi P,Bucchi L,Buzzi G,Torta M,Angeli A

更新日期：1992-04-01 00:00:00

abstract：:Cultured normal and malignant human lung cells were examined for their different sensitivities to the cytocidal action of nine antitumor and three non-antitumor agents. The malignant cells were killed preferentially at lower concentrations and in a shorter time with each antitumor agent, Adriamycin, neocarzinostatin, ...

journal_title：Cancer research

authors： Tsukeda H,Mizuno S,Nitta K

更新日期：1978-08-01 00:00:00

abstract：:Epithelial ovarian cancer comprises three major histological subtypes (serous, mucinous, and endometrioid), and it is becoming clear that the developmental pathways for these subtypes are fundamentally different. In particular, endometrioid ovarian cancers probably arise by the malignant transformation of ectopic endo...

journal_title：Cancer research

authors： Obata K,Morland SJ,Watson RH,Hitchcock A,Chenevix-Trench G,Thomas EJ,Campbell IG

更新日期：1998-05-15 00:00:00

abstract：:The osteolytic bone destruction associated with breast cancer skeletal metastases represents a serious and incurable clinical condition. However, the molecular mechanisms regulating tumor cell expression of factors involved in the generation of osteolytic disease remain elusive. We demonstrated recently that breast ca...

journal_title：Cancer research

authors： Barnes GL,Hebert KE,Kamal M,Javed A,Einhorn TA,Lian JB,Stein GS,Gerstenfeld LC

更新日期：2004-07-01 00:00:00

abstract：:Strategies to address resistance to platin drugs are greatly needed in human epithelial cancers (e.g., ovarian, head/neck, and lung) where platins are used widely and resistance occurs commonly. We found that upon ΔNp63α overexpression, AKT1 and phospho-AKT1 levels are upregulated in cancer cells. Investigations using...

journal_title：Cancer research

authors： Sen T,Sen N,Brait M,Begum S,Chatterjee A,Hoque MO,Ratovitski E,Sidransky D

更新日期：2011-02-01 00:00:00

abstract：:Natural killer (NK) immune cells mediate antibody-dependent cellular cytotoxicity (ADCC) by aggregating FcγRIIIA/CD16, contributing significantly to the therapeutic effect of CD20 monoclonal antibodies (mAb). In this study, we show that CD16 ligation on primary human NK cells by the anti-CD20 mAb rituximab or ofatumum...

journal_title：Cancer research

authors： Capuano C,Romanelli M,Pighi C,Cimino G,Rago A,Molfetta R,Paolini R,Santoni A,Galandrini R

更新日期：2015-10-01 00:00:00

abstract：:A major problem remaining in the evaluation of boronated compounds for neutron capture therapy (NCT) is the need to know the intra- or extracellular microdistribution of boron. This is a consequence of the short range of the 10B(n,alpha)7Li reaction products (approximately 10 microns), such that biological efficacy is...

journal_title：Cancer research

authors： Fairchild RG,Kahl SB,Laster BH,Kalef-Ezra J,Popenoe EA

更新日期：1990-08-15 00:00:00

abstract：:Blood coagulation factor VII (fVII) is physiologically synthesized in the liver and released into the blood. Binding of fVII to tissue factor (TF) at sites of vascular injury triggers coagulation and hemostasis. TF/fVIIa complex formation on the surface of cancer cells plays important roles in cancer biology. Although...

journal_title：Cancer research

authors： Koizume S,Jin MS,Miyagi E,Hirahara F,Nakamura Y,Piao JH,Asai A,Yoshida A,Tsuchiya E,Ruf W,Miyagi Y

更新日期：2006-10-01 00:00:00

abstract：:Activin, a member of the transforming growth factor beta (TGFbeta) superfamily, regulates diverse processes, such as cellular growth and differentiation. There is increasing evidence that TGFbeta and its signaling effectors are key determinants of tumor cell behavior. Loss of sensitivity to TGFbeta-induced growth arre...

journal_title：Cancer research

authors： Razanajaona D,Joguet S,Ay AS,Treilleux I,Goddard-Léon S,Bartholin L,Rimokh R

更新日期：2007-08-01 00:00:00

abstract：:Linkage to a prostate cancer susceptibility locus was recently reported on chromosome 16q23. We now report a region exhibiting a high frequency of allelic imbalance (AI) corresponding to this locus in tumors from 51 men diagnosed with prostate cancer using the same linked markers. The highest frequency of AI was found...

journal_title：Cancer research

authors： Paris PL,Witte JS,Kupelian PA,Levin H,Klein EA,Catalona WJ,Casey G

更新日期：2000-07-01 00:00:00

abstract：:The exposure of rats to a feeding regimen containing N-2-acetylaminofluorene (2AAF) causes an accumulation of lesions on liver DNA and a progressive impairment in DNA repair capacity. We used the in vivo experimental model of Teebor and Becker (Cancer Res., 31:1-3, 1971) with the carcinogen given to rats during four c...

journal_title：Cancer research

authors： Cesarone CF,Scovassi AI,Scarabelli L,Izzo R,Orunesu M,Bertazzoni U

更新日期：1988-07-01 00:00:00

abstract：:Hypoxia within solid tumors decreases therapeutic efficacy, and identification of hypoxia markers may influence the choice of therapeutic modality. Here, we used a proteomic approach to identify hypoxia-regulated proteins and validated their use as endogenous indicators of tumor hypoxia. Using two-dimensional gel elec...

journal_title：Cancer research

authors： Chen Y,Shi G,Xia W,Kong C,Zhao S,Gaw AF,Chen EY,Yang GP,Giaccia AJ,Le QT,Koong AC

更新日期：2004-10-15 00:00:00

abstract：:Recombinant human tumor necrosis factor and recombinant human interleukin 2 were administered in a sequential schedule to 30 dogs with a variety of spontaneous neoplasms. Dose escalation of both drugs was performed, and a maximally tolerated dose of recombinant human tumor necrosis factor of 125 mg/m2 i.v. for 3 days,...

journal_title：Cancer research

authors： Moore AS,Theilen GH,Newell AD,Madewell BR,Rudolf AR

更新日期：1991-01-01 00:00:00

abstract：:Pristane (2,6,10,14-tetramethylpentadecane) is a C19-isoalkane that promotes the development of plasmacytomas in genetically susceptible BALB/c mice. Similarities between the effects of pristane and protein kinase C (PKC)-activating phorbol esters suggested that the tumor promoting activity of pristane might involve t...

journal_title：Cancer research

authors： Janz S,Gawrisch K,Lester DS

更新日期：1995-02-01 00:00:00

abstract：:Viral vectors for cancer can be classified into those that do not replicate (replication-defective vectors) and those that selectively replicate in neoplastic cells (replication-conditional or oncolytic vectors). Both of these can deliver anticancer cDNAs for therapeutic purposes. Opposite hypotheses can be made regar...

journal_title：Cancer research

authors： Ichikawa T,Chiocca EA

更新日期：2001-07-15 00:00:00

abstract：:The environmental contaminant 6-nitrochrysene (6-NC) has been shown to induce adenomas and adenocarcinomas in the colons of rats. The present study aimed at providing a better understanding of mechanisms that are responsible for this effect. Three female CD rats were injected i.p. with [3,4,9,10-3H]6-NC [9 mumol/rat (...

journal_title：Cancer research

authors： Chae YH,Delclos KB,Blaydes B,el-Bayoumy K

更新日期：1996-05-01 00:00:00