Alcohol-related diseases and carcinogenesis.

abstract：:We examined whether herpes simplex virus thymidine kinase (HSV-TK) gene expression driven by the promoter of the vascular endothelial growth factor (VEGF) gene that is activated by hypoxia is effective in killing highly metastatic Lewis lung carcinoma A11 cells under hypoxic conditions. We isolated the promoter region...

journal_title：Cancer research

authors： Koshikawa N,Takenaga K,Tagawa M,Sakiyama S

更新日期：2000-06-01 00:00:00

abstract：:Triple-negative breast cancers (TNBC), which include the basal-like and claudin-low disease subtypes, are aggressive malignancies for which effective therapeutic targets are lacking. NF-κB activation has an established role in breast malignancy, and it is higher in TNBC than other breast cancer subtypes. On this basis...

journal_title：Cancer research

authors： Ito-Kureha T,Koshikawa N,Yamamoto M,Semba K,Yamaguchi N,Yamamoto T,Seiki M,Inoue J

更新日期：2015-01-01 00:00:00

abstract：:Human breast cancers are known to preferentially metastasize to skeletal sites, however, the mechanisms that mediate the skeletal preference (orthotropism) of specific types of cancers remains poorly understood. There is a significant clinical correlation between the expression of bone sialoprotein (BSP) and skeletal ...

journal_title：Cancer research

authors： Barnes GL,Javed A,Waller SM,Kamal MH,Hebert KE,Hassan MQ,Bellahcene A,Van Wijnen AJ,Young MF,Lian JB,Stein GS,Gerstenfeld LC

更新日期：2003-05-15 00:00:00

abstract：:Pathologic conditions associated with hyperinsulinemia, such as obesity, metabolic syndrome, and diabetes, seem to increase the risk of breast cancer. Here, we studied molecular mechanisms by which insulin activates the expression of leptin, an obesity hormone that has been shown to promote breast cancer progression i...

journal_title：Cancer research

authors： Bartella V,Cascio S,Fiorio E,Auriemma A,Russo A,Surmacz E

更新日期：2008-06-15 00:00:00

abstract：:From February 7-11, 2011, the multidisciplinary Lorentz Workshop Circulating Tumor Cell (CTC) Isolation and Diagnostics: Toward Routine Clinical Use was held in Leiden (The Netherlands) to discuss progress and define challenges and potential solutions for development of clinically useful circulating tumor cell (CTC) d...

journal_title：Cancer research

authors： van de Stolpe A,Pantel K,Sleijfer S,Terstappen LW,den Toonder JM

更新日期：2011-09-15 00:00:00

abstract：:We have shown previously that the pathways leading to Fas-mediated apoptosis in prostatic carcinoma cell lines are intact, because apoptosis can be triggered either by Fas ligation alone in the Fas-sensitive cell lines PC3 and ALVA31 or by rendering the Fas-resistant cell lines DU145 and JCA1 Fas-sensitive by combined...

journal_title：Cancer research

authors： Gewies A,Rokhlin OW,Cohen MB

更新日期：2000-04-15 00:00:00

abstract：:Microarray gene expression profiling is a powerful tool for generating molecular cancer classifications. However, elucidating biological insights from these large data sets has been challenging. Previously, we identified a gene expression-based classification of primary uveal melanomas that accurately predicts metasta...

journal_title：Cancer research

authors： Onken MD,Ehlers JP,Worley LA,Makita J,Yokota Y,Harbour JW

更新日期：2006-05-01 00:00:00

abstract：:Loss of heterozygosity (LOH) reduces genes to hemizygosity in cancer cells and presents an absolute difference between normal and cancer cells. The regions of LOH are usually much larger than the tumor suppressor gene, which is lost, and are expected to contain genes that are essential for cell survival. Single nucleo...

journal_title：Cancer research

authors： Fluiter K,ten Asbroek AL,van Groenigen M,Nooij M,Aalders MC,Baas F

更新日期：2002-04-01 00:00:00

abstract：:Neurofibromas are benign tumors of the peripheral nerve sheath, which occur sporadically and in association with the common familial cancer syndrome, neurofibromatosis type 1. There are intriguing links between the growth of neurofibromas and levels of circulating hormones: neurofibromas often first appear around the ...

journal_title：Cancer research

authors： McLaughlin ME,Jacks T

更新日期：2003-02-15 00:00:00

abstract：:The base excision repair protein MED1 (also known as MBD4), an interactor with the mismatch repair protein MLH1, has a central role in the maintenance of genomic stability with dual functions in DNA damage response and repair. MED1 acts as a thymine and uracil DNA N-glycosylase on T:G and U:G mismatches that occur at ...

journal_title：Cancer research

authors： Turner DP,Cortellino S,Schupp JE,Caretti E,Loh T,Kinsella TJ,Bellacosa A

更新日期：2006-08-01 00:00:00

abstract：:Suramin is a polyanionic agent which has been found to be an effective antineoplastic agent against various human tumors including adrenal, renal and prostatic cancer, and osteosarcoma. Recently, suramin has been shown to inhibit bone resorption in organ cultures of mouse calvarial bones. In the present study, we exam...

journal_title：Cancer research

authors： Yoneda T,Williams P,Rhine C,Boyce BF,Dunstan C,Mundy GR

更新日期：1995-05-01 00:00:00

abstract：:The A-240T and I/D polymorphisms in the angiotensin I-converting enzyme (ACE) gene are markers of circulating ACE levels and have been associated with numerous cardiovascular disease outcomes. More recently, the low-activity A and I alleles at these polymorphic sites have been inversely related with breast cancer risk...

journal_title：Cancer research

authors： Haiman CA,Henderson SO,Bretsky P,Kolonel LN,Henderson BE

更新日期：2003-10-15 00:00:00

abstract：:The proto-oncogene, c-src, has been implicated in the tumorigenesis in breast cancer. However, the relationship of c-src with distant metastasis is unclear. Moreover, the role of c-src in organ-preferential metastasis of breast cancer is unknown. Because breast cancer has a strong predilection for metastasizing to bon...

journal_title：Cancer research

authors： Myoui A,Nishimura R,Williams PJ,Hiraga T,Tamura D,Michigami T,Mundy GR,Yoneda T

更新日期：2003-08-15 00:00:00

abstract：:The alternative reading frame (ARF) tumor suppressor exerts both p53-dependent and p53-independent activities critical to the prevention of cancer in mice and humans. Recent evidence from mouse models suggests that when p53 is absent, further loss of ARF can widen the tumor spectrum, and potentiate invasion and metast...

journal_title：Cancer research

authors： Paliwal S,Kovi RC,Nath B,Chen YW,Lewis BC,Grossman SR

更新日期：2007-10-01 00:00:00

abstract：:The interleukin (IL)-13 receptor alpha2 (IL-13Ralpha2) chain is a primary binding and internalization subunit for a Th2-derived immune regulatory cytokine, IL-13. Although extremely high levels of IL-13Ralpha2 chain are expressed on a variety of human tumor cells and specimens, its precise role in tumor immunology has...

journal_title：Cancer research

authors： Kawakami K,Terabe M,Kawakami M,Berzofsky JA,Puri RK

更新日期：2006-04-15 00:00:00

abstract：:The relative amounts of HLA-A,B,C antigens, beta 2-microglobulin (beta 2m), and trophoblast antigens (Trop-1 and Trop-2) were determined on nine choriocarcinoma cell lines including seven lines of gestational origin and two lines of nongestational origin (from ovary and stomach) by quantitative immunofluorescence anal...

journal_title：Cancer research

authors： Kawata M,Sizer K,Sekiya S,Parnes JR,Herzenberg LA

更新日期：1984-09-01 00:00:00

abstract：:Endogenous formation of N-nitrosoproline (NPRO) was demonstrated by monitoring its excretion in the urine of a male volunteer who had ingested vegetable juice, as a source of nitrate, and proline. The resulting NPRO was analyzed after derivatization by combined gas-liquid chromatography thermal energy analysis. The am...

journal_title：Cancer research

authors： Ohshima H,Bartsch H

更新日期：1981-09-01 00:00:00

abstract：:TP53 is the most frequently altered gene in head and neck squamous cell carcinoma (HNSCC), with mutations occurring in over two thirds of cases; however, the predictive response of these mutations to cisplatin-based therapy remains elusive. In the current study, we evaluate the ability of the Evolutionary Action score...

journal_title：Cancer research

authors： Osman AA,Neskey DM,Katsonis P,Patel AA,Ward AM,Hsu TK,Hicks SC,McDonald TO,Ow TJ,Alves MO,Pickering CR,Skinner HD,Zhao M,Sturgis EM,Kies MS,El-Naggar A,Perrone F,Licitra L,Bossi P,Kimmel M,Frederick MJ,Lichtarge

更新日期：2015-04-01 00:00:00

abstract：:alpha(v)beta(3) integrin was investigated in multiple myeloma in relation to the in vitro osteoclast-like activity of malignant plasma cells. Myeloma cells from patients with skeleton involvement overexpressed alpha(v)beta(3) and produced erosion pits on bone substrates, whereas this effect was not observed by cells f...

journal_title：Cancer research

authors： Tucci M,De Palma R,Lombardi L,Rodolico G,Berrino L,Dammacco F,Silvestris F

更新日期：2009-08-15 00:00:00

abstract：:Extravasation of tumor cells is a pivotal step in metastasis formation. This step is initiated by an interaction of extravasating tumor cells with endothelial cells. Among the molecules mediating tumor-endothelium interactions are selectins and their fucosylated ligands. In a previous study, we demonstrated that the f...

journal_title：Cancer research

authors： Zipin A,Israeli-Amit M,Meshel T,Sagi-Assif O,Yron I,Lifshitz V,Bacharach E,Smorodinsky NI,Many A,Czernilofsky PA,Morton DL,Witz IP

更新日期：2004-09-15 00:00:00

abstract：:The LNCaP cell line was established from a metastatic lesion of human prostatic adenocarcinoma. The LNCaP cells grow readily in vitro (up to 8 x 10(5) cells/sq cm; doubling time, 60 hr), form clones in semisolid media, are highly resistant to human fibroblast interferon, and show an aneuploid (modal number, 76 to 91) ...

journal_title：Cancer research

authors： Horoszewicz JS,Leong SS,Kawinski E,Karr JP,Rosenthal H,Chu TM,Mirand EA,Murphy GP

更新日期：1983-04-01 00:00:00

abstract：:Mismatch repair (MMR) deficiency was reported to increase resistance of mammalian cells to killing by several genotoxic substances. However, although MMR-deficient cells are approximately 100-fold more resistant to killing by S(N)1 type methylating agents than MMR-proficient controls, the sensitivity differences repor...

journal_title：Cancer research

authors： Papouli E,Cejka P,Jiricny J

更新日期：2004-05-15 00:00:00

abstract：:The PDLIM2 protein regulates stability of transcription factors including NF-κB and STATs in epithelial and hemopoietic cells. PDLIM2 is strongly expressed in certain cancer cell lines that exhibit an epithelial-to-mesenchymal phenotype, and its suppression is sufficient to reverse this phenotype. PDLIM2 supports the ...

journal_title：Cancer research

authors： Cox OT,Edmunds SJ,Simon-Keller K,Li B,Moran B,Buckley NE,Bustamante-Garrido M,Healy N,O'Flanagan CH,Gallagher WM,Kennedy RD,Bernards R,Caldas C,Chin SF,Marx A,O'Connor R

更新日期：2019-05-15 00:00:00

abstract：:Gene expression signatures for a basal-like breast cancer (BLBC) subtype have been associated with poor clinical outcomes, but a molecular basis for this disease remains unclear. Here, we report overexpression of the transcription factor FOXC1 as a consistent feature of BLBC compared with other molecular subtypes of b...

journal_title：Cancer research

authors： Ray PS,Wang J,Qu Y,Sim MS,Shamonki J,Bagaria SP,Ye X,Liu B,Elashoff D,Hoon DS,Walter MA,Martens JW,Richardson AL,Giuliano AE,Cui X

更新日期：2010-05-15 00:00:00

abstract：:Evidence from pathology and epidemiology studies has been provided for a human model of gastric carcinogenesis with the following sequential stages: chronic gastritis; atrophy; intestinal metaplasia; and dysplasia. The initial stages of gastritis and atrophy have been linked to excessive salt intake and infection with...

journal_title：Cancer research

authors： Correa P

更新日期：1992-12-15 00:00:00

abstract：:Inhibin is a heterodimeric TGFβ family ligand that is expressed in many cancers and is a selective biomarker for ovarian cancers; however, its tumor-specific functions remain unknown. Here, we demonstrate that the α subunit of inhibin (INHA), which is critical for the functionality of dimeric inhibin A/B, correlates w...

journal_title：Cancer research

authors： Singh P,Jenkins LM,Horst B,Alers V,Pradhan S,Kaur P,Srivastava T,Hempel N,Győrffy B,Broude EV,Lee NY,Mythreye K

更新日期：2018-06-01 00:00:00

abstract：:Reconstituted basement membrane matrix (Matrigel) has been utilized for in vitro assay of tumor cell invasion in recent years. In the conventional chamber for the invasion assay, however, a large number of cells passed easily through the center of the Matrigel-coated filter because the Matrigel layer could not be comp...

journal_title：Cancer research

authors： Imamura H,Takao S,Aikou T

更新日期：1994-07-01 00:00:00

abstract：:Cell proliferation kinetics during growth of an estrogen receptor-positive human breast carcinoma cell line, T-47D, was defined, and some factors which modify its response to tamoxifen were investigated in vitro. T-47D cells were estrogen responsive when grown in charcoal-stripped fetal calf serum, but the addition of...

journal_title：Cancer research

authors： Reddel RR,Murphy LC,Sutherland RL

更新日期：1984-06-01 00:00:00

abstract：:The effects of an altered content of dietary iodine and fat on the development of N-nitrosomethylurea-induced mammary tumors in rats were studied and correlated with thyroid and pituitary function studies. In three separate experiments, animals fed a semisynthetic diet containing 11.8% fat had an earlier time of tumor...

journal_title：Cancer research

authors： Cave WT Jr,Dunn JT,MacLeod RM

更新日期：1979-03-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)-C is a lymphangiogenic factor implicated in lymphatic metastasis. In this study, we investigated the role of the type I insulin-like growth factor receptor (IGF-IR) in the regulation of VEGF-C expression. We used Lewis lung carcinoma subline M-27 cells transfected with human I...

journal_title：Cancer research

authors： Tang Y,Zhang D,Fallavollita L,Brodt P

更新日期：2003-03-15 00:00:00