Comparative analyses of transgene delivery and expression in tumors inoculated with a replication-conditional or -defective viral vector.

abstract：:The effect of overexpression of p21waf1 on drug sensitivity was studied in an osteosarcoma cell line (SaOs-2) lacking both p53 and functional retinoblastoma protein using a tetracycline (TC)-inducible expression system. p21waf1 expression was barely detectable in SaOS-2 cells incubated in the presence of TC. After TC ...

journal_title：Cancer research

authors： Li WW,Fan J,Hochhauser D,Bertino JR

更新日期：1997-06-01 00:00:00

abstract：:The capacity of lymph nodes to eradicate cancer is a controversial issue. The purpose of this study was to determine the interplay between tumor growth and host resistance at early stages of lymph node metastasis. A metastasis model was made in the rat mesenteric lymph node, and migration of cancer cells was visualize...

journal_title：Cancer research

authors： Nagata H,Arai T,Soejima Y,Suzuki H,Ishii H,Hibi T

更新日期：2004-11-15 00:00:00

abstract：:Genotoxicity-induced hair loss from chemotherapy and radiotherapy is often encountered in cancer treatment, and there is a lack of effective treatment. In growing hair follicles (HF), quiescent stem cells (SC) are maintained in the bulge region, and hair bulbs at the base contain rapidly dividing, yet genotoxicity-sen...

journal_title：Cancer research

authors： Huang WY,Lai SF,Chiu HY,Chang M,Plikus MV,Chan CC,Chen YT,Tsao PN,Yang TL,Lee HS,Chi P,Lin SJ

更新日期：2017-11-15 00:00:00

abstract：:Apoptosis is a mode of cell death that is carefully regulated based on cellular and environmental signals. The ability to modulate the individual cellular machinery and thereby to promote apoptosis is an important strategy in cancer therapy. It has previously been shown that overexpression of the transcription factor ...

journal_title：Cancer research

authors： Hunt KK,Deng J,Liu TJ,Wilson-Heiner M,Swisher SG,Clayman G,Hung MC

更新日期：1997-11-01 00:00:00

abstract：:[3H]Pregn-4-ene-3,20-dione ([3H]progesterone)-receptor complexes from human mammary carcinoma were found to be stabilized in the presence of glycerol. The dissociation rate constant was lowered and the equilibrium dissociation constant was decreased (KD=3 nM in the absence of glycerol and 1.1 nM in the presence of 30%...

journal_title：Cancer research

authors： Pichon MF,Milgrom E

更新日期：1977-02-01 00:00:00

abstract：:In Sarcoma 180 and L1210 ascites tumor models, the initial rate of methotrexate accumulation in tumor cells in the peritoneal cavity and in small intestine (intracellularly) after s.c. doses up to 800 mg/kg, showed saturation kinetics. These results and the fact that initial uptake in these tissues within this dosage ...

journal_title：Cancer research

authors： Sirotnak FM,Donsbach RC,Dorick DM,Moccio DM

更新日期：1976-12-01 00:00:00

abstract：:The early detection of prostate cancer is a life-saving event in patients harboring potentially aggressive disease. With the development of malignancy, there is a dramatic reduction in the zinc content of prostate tissue associated with the inability of cancer cells to accumulate the ion. In the current study, we used...

journal_title：Cancer research

authors： Ghosh SK,Kim P,Zhang XA,Yun SH,Moore A,Lippard SJ,Medarova Z

更新日期：2010-08-01 00:00:00

abstract：:The in vivo efficacy of the antitumor, immunosuppressive antibiotic mycophenolic acid is known to be limited by its rapid conversion to the biologically inactive 7-0-glucuronide, catalyzed by UDP-glucuronosyl transferase activity, which is widely distributed among normal tissues, including intestinal epithelium. We ha...

journal_title：Cancer research

authors： Franklin TJ,Jacobs V,Jones G,Plé P,Bruneau P

更新日期：1996-03-01 00:00:00

abstract：:Positive therapeutic effects of interferons (IFNs) in combination with other therapies will depend on defining modalities, doses, and timing of treatment in the setting of varied tumor burdens. When 10(4) P388 leukemia cells were inoculated i.p. on day 0 in BALB/c x DBA/2 F1 mice, all mice died within 18 days if left ...

journal_title：Cancer research

authors： Borden EC,Sidky YA,Hatcher JF,Bryan GT

更新日期：1988-05-01 00:00:00

abstract：:cis- and trans-diamminedichloroplatinum(II) (PDD) produced a DNA cross-linking effect in mouse leukemia L1210 cells, which was demonstrable after subtoxic treatments with the DNA alkaline elution technique. Cross-linking effects developed following treatments with concentrations as low as 1 micron for cis-PDD and 5 mi...

journal_title：Cancer research

authors： Zwelling LA,Kohn KW,Ross WE,Ewig RA,Anderson T

更新日期：1978-06-01 00:00:00

abstract：:Multiple tobacco smoke-related premalignant and malignant lesions develop synchronously or metachronously in various organ sites, including the oral cavity. Both field cancerization and clonal migration seem to contribute to the occurrence of multiple tumors. Although the importance of endogenous factors (e.g., oncoge...

journal_title：Cancer research

authors： Du B,Leung H,Khan KM,Miller CG,Subbaramaiah K,Falcone DJ,Dannenberg AJ

更新日期：2007-09-15 00:00:00

abstract：:Transfer RNA methylase (tRNA methylase) activity and capacity were monitored in whole-rat-liver preparations during the induction of hepatocellular carcinomas by an 8-week aflatoxin B1 dosing regimen that produced minimal toxic effects. Significant phases of elevated tRNA methylase capacity occurred at 6 to 9 weeks (2...

journal_title：Cancer research

authors： Busby WF Jr,Paglialunga S,Newberne PM,Wogan GN

更新日期：1976-06-01 00:00:00

abstract：:A potential tumor suppressor gene, STK11 , encoding a serine threonine kinase, has recently been identified on chromosome 19p13. Germ-line mutations of this gene have been found in patients with Peutz-Jeghers syndrome (PJS). To further investigate the relevance of STK11 mutations in PJS, we analyzed its coding sequenc...

journal_title：Cancer research

authors： Resta N,Simone C,Mareni C,Montera M,Gentile M,Susca F,Gristina R,Pozzi S,Bertario L,Bufo P,Carlomagno N,Ingrosso M,Rossini FP,Tenconi R,Guanti G

更新日期：1998-11-01 00:00:00

abstract：:Thirty-one patients with metastatic hormone-refractory prostatic adenocarcinoma were investigated scintigraphically with the 111In-labeled somatostatin analogue [DTPA-D-Phe1]-octreotide (OctreoScan) and with 99mTc-labeled HDP. In vitro somatostatin receptor autoradiography was performed on biopsies obtained from eight...

journal_title：Cancer research

authors： Nilsson S,Reubi JC,Kalkner KM,Laissue JA,Horisberger U,Olerud C,Westlin JE

更新日期：1995-12-01 00:00:00

abstract：:Quinocarmycin monicitrate (KW2152) and its analogue, DX-52-1, demonstrated specificity for melanomas in the National Cancer Institute in vitro human tumor cell line drug screen. In contrast to most cell lines, a 50% reduction in tumor cell burden (as measured protein) at the end of a 48-h drug incubation was produced ...

journal_title：Cancer research

authors： Plowman J,Dykes DJ,Narayanan VL,Abbott BJ,Saito H,Hirata T,Grever MR

更新日期：1995-02-15 00:00:00

abstract：:The peptide N-formyl-Met-Leu-Phe stimulates chemotaxis and metastasis in rat Walker carcinosarcoma cells by a receptor-mediated pathway. Since oxygen radical generation follows chemotactic stimulation in leukocytes, we looked for similar responses in the Walker tumor. Upon incubation with 10(-6) M N-formyl-Met-Leu-Phe...

journal_title：Cancer research

authors： Leroyer V,Werner L,Shaughnessy S,Goddard GJ,Orr FW

更新日期：1987-09-15 00:00:00

abstract：:Tumor-derived cell lines are used as in vitro cancer models, but their ability to accurately reflect the phenotype and genotype of the parental histology remains questionable, given the prevalence of documented cell line-specific cytogenetic changes. We have addressed the issue of whether copy number alterations seen ...

journal_title：Cancer research

authors： Greshock J,Nathanson K,Martin AM,Zhang L,Coukos G,Weber BL,Zaks TZ

更新日期：2007-04-15 00:00:00

abstract：:Although interleukin-15 (IL-15) is a powerful immunomodulatory factor that has been proposed for cancer immunotherapy, its intratumoral expression may be correlated with tumor progression and/or poor clinical outcome. Therefore, neoplasias potentially sensitive to immunotherapy should be checked for their IL-15 expres...

journal_title：Cancer research

authors： Khawam K,Giron-Michel J,Gu Y,Perier A,Giuliani M,Caignard A,Devocelle A,Ferrini S,Fabbi M,Charpentier B,Ludwig A,Chouaib S,Azzarone B,Eid P

更新日期：2009-02-15 00:00:00

abstract：:Amplification and rearrangement of the epidermal growth factor receptor (EGFR) gene are characteristics of many types of tumors. One class of EGFR mutations, EGFRvIII, is characterized by an in-frame deletion resulting in a truncated external domain of the receptor. EGFRvIII was first identified in a subset of gliomas...

journal_title：Cancer research

authors： Reist CJ,Archer GE,Kurpad SN,Wikstrand CJ,Vaidyanathan G,Willingham MC,Moscatello DK,Wong AJ,Bigner DD,Zalutsky MR

更新日期：1995-10-01 00:00:00

abstract：:Protein kinase Ciota (PKCiota) is an oncogene required for maintenance of the transformed phenotype of non-small cell lung cancer cells. However, the role of PKCiota in lung tumor development has not been investigated. To address this question, we established a mouse model in which oncogenic Kras(G12D) is activated by...

journal_title：Cancer research

authors： Regala RP,Davis RK,Kunz A,Khoor A,Leitges M,Fields AP

更新日期：2009-10-01 00:00:00

abstract：:We have evaluated 4 radioiodinated mouse monoclonal anticarcinoembryonic antigen antibodies (MAbs) by using the GW-39 human colorectal tumor xenograft transplanted i.m. in immunocompetent hamsters to determine whether there were any differences in their tumor localization properties. Additional comparisons were made t...

journal_title：Cancer research

authors： Sharkey RM,Primus FJ,Shochat D,Goldenberg DM

更新日期：1988-04-01 00:00:00

abstract：:Rhabdomyosarcomas are the most frequent malignant soft tissue tumors of childhood; however, because current multimodality treatments fail to improve the poor survival rate of children with metastatic rhabdomyosarcoma, new treatments are required. We previously identified the gamma-subunit of the fetal acetylcholine re...

journal_title：Cancer research

authors： Gattenlöhner S,Marx A,Markfort B,Pscherer S,Landmeier S,Juergens H,Müller-Hermelink HK,Matthews I,Beeson D,Vincent A,Rossig C

更新日期：2006-01-01 00:00:00

abstract：:The breast and ovarian cancer specific tumor suppressor BRCA1, bound to BARD1, has multiple functions aimed at maintaining genomic stability in the cell. We have shown earlier that the BRCA1/BARD1 E3 ubiquitin ligase activity regulates centrosome-dependent microtubule nucleation. In this study, we tested which domains...

journal_title：Cancer research

authors： Sankaran S,Starita LM,Simons AM,Parvin JD

更新日期：2006-04-15 00:00:00

abstract：:Many malignancies exhibit distinct patterns of metastasis that appear to be mediated by receptor/ligand-like interactions between tumor cells and organ-specific vascular endothelium. In order to study endothelial cell surface molecules involved in the binding of metastatic cells, we developed a perfusion method to iso...

journal_title：Cancer research

authors： Johnson RC,Augustin-Voss HG,Zhu DZ,Pauli BU

更新日期：1991-01-01 00:00:00

abstract：:We constructed a genome-wide transcriptome map of non-small cell lung carcinomas based on gene-expression profiles generated by serial analysis of gene expression (SAGE) using primary tumors and bronchial epithelial cells of the lung. Using the human genome working draft and the public databases, 25,135 nonredundant U...

journal_title：Cancer research

authors： Fujii T,Dracheva T,Player A,Chacko S,Clifford R,Strausberg RL,Buetow K,Azumi N,Travis WD,Jen J

更新日期：2002-06-15 00:00:00

abstract：:In a previous study, we found that the small-molecule epidermal growth factor receptor (EGFR) inhibitor gefitinib (ZD1839, Iressa) blocked cell proliferation at biologically relevant concentrations in approximately one third (6 of 17) of human bladder cancer cell lines examined. Here, we studied the effects of gefitin...

journal_title：Cancer research

authors： Shrader M,Pino MS,Lashinger L,Bar-Eli M,Adam L,Dinney CP,McConkey DJ

更新日期：2007-02-15 00:00:00

abstract：:The presence of a non-small cell lung carcinoma (NSCLC)-related gene or genes on chromosome band 11p15.5 is of particular interest, given the specific loss of heterozygosity (LOH) measured in this region for lung as well as many other pediatric and adult neoplasms. We have undertaken high-density polymorphic marker an...

journal_title：Cancer research

authors： Tran YK,Newsham IF

更新日期：1996-07-01 00:00:00

abstract：:Protein kinases of the Raf family act as signal-transducing elements downstream of activated cell surface receptors and are involved in the regulation of proliferation, differentiation, and cell survival. Whereas the role of c-Raf-1 as a mitogen-activated protein/extracellular signal-regulated kinase activator within ...

journal_title：Cancer research

authors： Kalmes A,Hagemann C,Weber CK,Wixler L,Schuster T,Rapp UR

更新日期：1998-07-15 00:00:00

abstract：:Small molecule inhibitors of DNA repair are emerging as potent and selective anticancer therapies, but the sheer magnitude of the protein networks involved in DNA repair processes poses obstacles to discovery of effective candidate drugs. To address this challenge, we used a subtractive combinatorial selection approac...

journal_title：Cancer research

authors： Moeller BJ,Sidman RL,Pasqualini R,Arap W

更新日期：2011-03-01 00:00:00

abstract：:[SP-4-3-(R)]-[1,1-cyclobutanedicarboxylato(2-)](2-methyl-1,4- butane-diamine-N,N')platinum (CI-973) is a cisplatin analogue that is currently in clinical trial. Preclinically, CI-973 retained activity against L1210, P388, K562, and human ovarian carcinoma sublines resistant to cisplatin in vitro. CI-973 also retained ...

journal_title：Cancer research

authors： Elliott WL,Roberts BJ,Howard CT,Leopold WR 3rd

更新日期：1994-08-15 00:00:00