Interaction between the protein kinase B-Raf and the alpha-subunit of the 11S proteasome regulator.

abstract：:In solid tumors, cancer cells subjected to ischemic conditions trigger distinct signaling pathways contributing to angiogenic stimulation and tumor development. Characteristic features of tumor ischemia include hypoxia and glucose deprivation, leading to the activation of hypoxia-inducible factor-1-dependent signaling...

journal_title：Cancer research

authors： Drogat B,Auguste P,Nguyen DT,Bouchecareilh M,Pineau R,Nalbantoglu J,Kaufman RJ,Chevet E,Bikfalvi A,Moenner M

更新日期：2007-07-15 00:00:00

abstract：:We have explored the therapeutic effects of anti-epidermal growth factor receptor monoclonal antibodies (MAbs) 225 and 528 on well established A431 epidermoid carcinoma xenografts, approximately 400 mm3 (1 cm in diameter) at the start of treatment. In previous reports we demonstrated that MAbs 225 and 528 prevented th...

journal_title：Cancer research

authors： Fan Z,Baselga J,Masui H,Mendelsohn J

更新日期：1993-10-01 00:00:00

abstract：:Dickkopf3 (DKK3) is a secretory protein that belongs to the DKK family, but exhibits structural divergence from other family members, and its corresponding receptors remain to be identified. Although DKK3 has been shown to have oncogenic functions in certain cancer types, the underlying mechanism by which DKK3 promote...

journal_title：Cancer research

authors： Kajiwara C,Fumoto K,Kimura H,Nojima S,Asano K,Odagiri K,Yamasaki M,Hikita H,Takehara T,Doki Y,Morii E,Kikuchi A

更新日期：2018-11-01 00:00:00

abstract：:After the Chernobyl accident, the incidence of urinary bladder cancers in the Ukraine population increased gradually from 26.2 to 36.1 per 100,000 between 1986 and 1996. Urinary bladder epithelium biopsied from 45 male patients with benign prostatic hyperplasia living in radiocontaminated areas of Ukraine demonstrated...

journal_title：Cancer research

authors： Yamamoto S,Romanenko A,Wei M,Masuda C,Zaparin W,Vinnichenko W,Vozianov A,Lee CC,Morimura K,Wanibuchi H,Tada M,Fukushima S

更新日期：1999-08-01 00:00:00

abstract：:The cell line AR230 was established from the peripheral blood mononuclear cells of a patient with chronic myeloid leukemia and t(9;22) translocation bearing a variant type of BCR/ABL rearrangement. AR230 expresses a BCR/ABL fusion protein with a molecular mass of 230 kilodaltons (kDa) due to the insertion of 180 amino...

journal_title：Cancer research

authors： Wada H,Mizutani S,Nishimura J,Usuki Y,Kohsaki M,Komai M,Kaneko H,Sakamoto S,Delia D,Kanamaru A

更新日期：1995-07-15 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a known diagnostic and, although controversial, prognostic marker of human glioblastoma multiforme (GBM). However, its functional role and biological significance in GBM remain elusive. Here, we show that multiple GBM cell subpopulations could be purified from the specimens o...

journal_title：Cancer research

authors： Mazzoleni S,Politi LS,Pala M,Cominelli M,Franzin A,Sergi Sergi L,Falini A,De Palma M,Bulfone A,Poliani PL,Galli R

更新日期：2010-10-01 00:00:00

abstract：:Cell culture studies have been performed to compare the mutagenic potential and the induction of sister chromatid exchanges for hematoporphyrin derivative photoradiation, ionizing radiation, and UV radiation. The mutation frequency in Chinese hamster ovary cells at the hypoxanthine-guanine phosphoribosyltransferase lo...

journal_title：Cancer research

authors： Gomer CJ,Rucker N,Banerjee A,Benedict WF

更新日期：1983-06-01 00:00:00

abstract：:The ability of polyribosomes, obtained from several bacterial species, to suppress the development of cutaneous SaD2 fibrosarcomas in DBA/2 mice were evaluated. Suppression of tumor appearance depended upon the tumor load at the time of treatment, dose of polyribosomes, and species source of polyribosomes, with Serrat...

journal_title：Cancer research

authors： Urban RW,Edwards BS,Segal W

更新日期：1980-05-01 00:00:00

abstract：:The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development of estrogen-dependent malignancies, such as breast cancer. However, no prospective studies of cadmium exposure and breast cancer risk have been reported. We examined the association between dietary cadmium expo...

journal_title：Cancer research

authors： Julin B,Wolk A,Bergkvist L,Bottai M,Akesson A

更新日期：2012-03-15 00:00:00

abstract：:The expression of cytochrome P450 genes directly within target cells is an important determinant of human susceptibility to cancers, birth defects, and other chemically initiated diseases. One pivotal gene, CYP1A1, codes for an inducible cytochrome P450 isozyme (P450IA1) responsible for the bioactivation of numerous c...

journal_title：Cancer research

authors： Omiecinski CJ,Redlich CA,Costa P

更新日期：1990-07-15 00:00:00

abstract：:Although the murine reticulum cell sarcoma M5076 is highly malignant in vivo, in vitro it displays many of the functional characteristics of an activated macrophage, such as phagocytosis and tumor cytotoxicity. This study was designed to determine what effect macrophage-activating agents would have on the function and...

journal_title：Cancer research

authors： Talmadge JE,Donovan PA,Hart IR

更新日期：1982-05-01 00:00:00

abstract：:Fluorescein-labeled dextrans (FITC-D) from 3 to 5000 kDa (Stokes' radii from 1 to 40 nm) were used to study influx from the plasma into the peritoneum and efflux from the peritoneal cavity into the plasma in normal and ascites tumor-bearing mice and in mice whose peritoneal vessels had been rendered hyperpermeable by ...

journal_title：Cancer research

authors： Nagy JA,Herzberg KT,Masse EM,Zientara GP,Dvorak HF

更新日期：1989-10-01 00:00:00

abstract：:The lysyl oxidase gene family members function as extracellular matrix modulating enzymes. We have found that another member of this family, lysyl oxidase related protein-1 (LOR-1), is highly expressed in metastatic breast cancer-derived cell lines but not in the nonmetastatic estrogen-dependent MCF-7 cells. Furthermo...

journal_title：Cancer research

authors： Akiri G,Sabo E,Dafni H,Vadasz Z,Kartvelishvily Y,Gan N,Kessler O,Cohen T,Resnick M,Neeman M,Neufeld G

更新日期：2003-04-01 00:00:00

abstract：:Hypoxia occurs in two forms in tumors. Chronic or diffusion-limited hypoxia is relatively well characterized. In contrast, intermittent or perfusion-limited hypoxia is not well characterized, and it is not known how common it is in tumors. The purpose of this study was to determine whether spontaneous fluctuations in ...

journal_title：Cancer research

authors： Kimura H,Braun RD,Ong ET,Hsu R,Secomb TW,Papahadjopoulos D,Hong K,Dewhirst MW

更新日期：1996-12-01 00:00:00

abstract：:Since tumor suppressor gene DCC exhibits amino acid sequence homology to the neural cell adhesion molecule, there is a possibility that DCC might be related to tumor metastasis. In the present study, we examined 51 cases of primary esophageal carcinomas with regard to point mutations and loss of the DCC gene. We detec...

journal_title：Cancer research

authors： Miyake S,Nagai K,Yoshino K,Oto M,Endo M,Yuasa Y

更新日期：1994-06-01 00:00:00

abstract：:Although the cancer cell cytoskeleton is a clinically validated target, few new strategies have emerged for selectively targeting cell division by modulating the cytoskeletal structure, particularly ways that could avoid the cardiotoxic and neurotoxic effects of current agents such as taxanes. We address this gap by d...

journal_title：Cancer research

authors： Lash LL,Wallar BJ,Turner JD,Vroegop SM,Kilkuskie RE,Kitchen-Goosen SM,Xu HE,Alberts AS

更新日期：2013-11-15 00:00:00

abstract：:10-Ethyl-10-deazaaminopterin (10-EdAM) is an antifolate compound with greater therapeutic activity than methotrexate against transplanted tumors in mice. When given weekly for 3 weeks, the 10% lethal dose in rats was 125 mg/kg (i.p.) and in dogs it was 2.5 mg/kg (i.v.). The major histopathological findings in intoxica...

journal_title：Cancer research

authors： Fanucchi MP,Kinahan JJ,Samuels LL,Hancock C,Chou TC,Niedzwiecki D,Farag F,Vidal PM,DeGraw JI,Sternberg SS

更新日期：1987-05-01 00:00:00

abstract：:Intradermally injected tumor necrosis factor alpha (TNF-alpha) mimics the effects of UV B light (UVB) radiation and neutralizing anti-TNF-alpha antibodies abolish the deleterious effects of UVB on induction of contact hypersensitivity suggesting that TNF-alpha is the major mediator of UVB effects on cutaneous immunity...

journal_title：Cancer research

authors： Vincek V,Kurimoto I,Medema JP,Prieto E,Streilein JW

更新日期：1993-02-15 00:00:00

abstract：:RS7, a murine IgG1 antibody raised against human lung carcinoma, possesses pancarcinoma reactivity. The antigen defined by this antibody is present in tumors of the lung, stomach, bladder, breast, ovary, uterus, and prostate. Efficient targeting and therapy by radiolabeled RS7 has been demonstrated previously in anima...

journal_title：Cancer research

authors： Shih LB,Xuan H,Aninipot R,Stein R,Goldenberg DM

更新日期：1995-12-01 00:00:00

abstract：:In this paper, we describe the role of chemokine receptor CXCR4 activation by its natural ligand, the chemokine stromal cell-derived factor (SDF-1) (CXCL12), in glioblastoma cell growth in vitro. We show that both CXC chemokine receptor 4 (CXCR4) and SDF-1 mRNA are expressed in several human glioblastoma multiforme tu...

journal_title：Cancer research

authors： Barbero S,Bonavia R,Bajetto A,Porcile C,Pirani P,Ravetti JL,Zona GL,Spaziante R,Florio T,Schettini G

更新日期：2003-04-15 00:00:00

abstract：:Amplification and overexpression of erbB2 (Her-2/neu) proto-oncogene has been linked to human malignancies including tumors of the breast, ovary, and stomach. It has been implicated in tumor growth, sensitivity to standard chemotherapy, prognosis of patients, and disease-free survival. Although the clinical use of tra...

journal_title：Cancer research

authors： Jani JP,Finn RS,Campbell M,Coleman KG,Connell RD,Currier N,Emerson EO,Floyd E,Harriman S,Kath JC,Morris J,Moyer JD,Pustilnik LR,Rafidi K,Ralston S,Rossi AM,Steyn SJ,Wagner L,Winter SM,Bhattacharya SK

更新日期：2007-10-15 00:00:00

abstract：:We have screened 57 cases of primary, nonfunctional, pituitary adenomas for loss of heterozygosity of markers on chromosome 9p. Using a panel of 11 microsatellite markers, we found hemizygous deletion with at least one of the markers in 18 tumors (31.5%). The frequency of loss was similar in both noninvasive (8 of 26;...

journal_title：Cancer research

authors： Farrell WE,Simpson DJ,Bicknell JE,Talbot AJ,Bates AS,Clayton RN

更新日期：1997-07-01 00:00:00

abstract：:There is an unmet need for pharmacodynamic and predictive biomarkers for antiangiogenic agents. Recent studies have shown that soluble vascular endothelial growth factor receptor 2 (sVEGFR2), VEGF, and several other soluble factors may be modulated by VEGF pathway inhibitors. We conducted a broad profiling of cytokine...

journal_title：Cancer research

authors： Nikolinakos PG,Altorki N,Yankelevitz D,Tran HT,Yan S,Rajagopalan D,Bordogna W,Ottesen LH,Heymach JV

更新日期：2010-03-15 00:00:00

abstract：:Mutations in RAS proteins occur widely in human cancer. Prompted by the confirmation of KRAS mutation as a predictive biomarker of response to epidermal growth factor receptor (EGFR)-targeted therapies, limited clinical testing for RAS pathway mutations has recently been adopted. We performed a multiplatform genomic a...

journal_title：Cancer research

authors： Janakiraman M,Vakiani E,Zeng Z,Pratilas CA,Taylor BS,Chitale D,Halilovic E,Wilson M,Huberman K,Ricarte Filho JC,Persaud Y,Levine DA,Fagin JA,Jhanwar SC,Mariadason JM,Lash A,Ladanyi M,Saltz LB,Heguy A,Paty PB,Solit

更新日期：2010-07-15 00:00:00

abstract：:Anthracycline, either daunomycin or doxorubicin, was site specifically attached to the carbohydrate moiety of a monoclonal anticarcinoembryonic antigen antibody by using amino-dextran as the intermediate carrier. The reaction resulted in an immunoconjugate that contains approximately 20 to 25 molecules of drug per mol...

journal_title：Cancer research

authors： Shih LB,Goldenberg DM,Xuan H,Lu H,Sharkey RM,Hall TC

更新日期：1991-08-15 00:00:00

abstract：:Human intraepithelial lymphocytes (IEL), predominantly CD8+ T-lymphocytes located between intestinal epithelial cells (EC), may represent the first-line immune defense against colon cancer. The mechanism by which IEL bind to the colon cancer line, DLD-1, was evaluated. A larger fraction of IEL than peripheral blood mo...

journal_title：Cancer research

authors： Roberts AI,O'Connell SM,Ebert EC

更新日期：1993-04-01 00:00:00

abstract：:Loss of heterozygosity (LOH) and replication error (RER) are important phenomena in tumor development, with diagnostic and prognostic relevance. Therefore, screening for LOH and RER is a desirable first step in the molecular analysis of tumors. We used semiautomated procedures based on multicolor fluorescently labeled...

journal_title：Cancer research

authors： Canzian F,Salovaara R,Hemminki A,Kristo P,Chadwick RB,Aaltonen LA,de la Chapelle A

更新日期：1996-07-15 00:00:00

abstract：:Host resistance to neoplastic growth and invasiveness is recognized to be an important factor in determining the occurrence, the progress, and the eventual outcome of every cancer illness. The factors involved in host resistance are briefly reviewed, and the relationship between these factors and ascorbic acid metabol...

journal_title：Cancer research

authors： Cameron E,Pauling L,Leibovitz B

更新日期：1979-03-01 00:00:00

abstract：:Previous molecular analyses of human astrocytomas have identified many genetic changes associated with astrocytoma formation and progression. In an effort to identify novel gene expression changes associated with astrocytoma formation, which might reveal new potential targets for glioma therapeutic drug design, we use...

journal_title：Cancer research

authors： Huang ZY,Wu Y,Burke SP,Gutmann DH

更新日期：2003-06-01 00:00:00

abstract：:The MCT-1 oncogene was originally identified from lymphoma cell lines. Herein we establish that MCT-1 is highly expressed in 85% of human diffuse large B-cell lymphomas (DLBCL) and that knocking down MCT-1 by a specific short hairpin RNA in DLBCL cells induces apoptosis, supporting a critical role for MCT-1 in DLBCL c...

journal_title：Cancer research

authors： Dai B,Zhao XF,Hagner P,Shapiro P,Mazan-Mamczarz K,Zhao S,Natkunam Y,Gartenhaus RB

更新日期：2009-10-01 00:00:00