IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo.

abstract：:Combination of chemotherapy and immunotherapy to increase the effectiveness of an antitumor immune response is currently regarded as an attractive antitumor strategy. In a pilot clinical trial, we have recently documented an increase of melanoma antigen A (Melan-A)-specific, tumor-reactive, long-lasting effector-memor...

journal_title：Cancer research

authors： Palermo B,Del Bello D,Sottini A,Serana F,Ghidini C,Gualtieri N,Ferraresi V,Catricalà C,Belardelli F,Proietti E,Natali PG,Imberti L,Nisticò P

更新日期：2010-09-15 00:00:00

abstract：:Copy number alterations are crucial for the development of colorectal cancer. Our whole-genome analysis identified tocopherol alpha transfer protein-like (TTPAL) as preferentially amplified in colorectal cancer. Here we demonstrate that frequent copy number gain of TTPAL leads to gene overexpression in colorectal canc...

journal_title：Cancer research

authors： Gou H,Liang JQ,Zhang L,Chen H,Zhang Y,Li R,Wang X,Ji J,Tong JH,To KF,Sung JJY,Chan FKL,Fang JY,Yu J

更新日期：2019-07-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSC) aid in tissue maintenance and repair by differentiating into specialized cell types. Due to this ability, hMSC are currently being evaluated for cell-based therapies of tissue injury and degenerative diseases. However, extensive expansion ex vivo is a prerequisite to obtain the cell...

journal_title：Cancer research

authors： Røsland GV,Svendsen A,Torsvik A,Sobala E,McCormack E,Immervoll H,Mysliwietz J,Tonn JC,Goldbrunner R,Lønning PE,Bjerkvig R,Schichor C

更新日期：2009-07-01 00:00:00

abstract：:Neuroblastomas often undergo spontaneous differentiation and/or regression in vivo, which is at least partly regulated by the signals through neurotrophins and their receptors. Recently, glial cell line-derived neurotrophic factor (GDNF) and a second family member, neurturin (NTN), have been found to mediate their sig...

journal_title：Cancer research

authors： Hishiki T,Nimura Y,Isogai E,Kondo K,Ichimiya S,Nakamura Y,Ozaki T,Sakiyama S,Hirose M,Seki N,Takahashi H,Ohnuma N,Tanabe M,Nakagawara A

更新日期：1998-05-15 00:00:00

abstract：:In this study, we examine the potential role of receptor-associated protein 80 (RAP80), a nuclear protein containing two ubiquitin-interacting motifs (UIM), in DNA damage response and double-strand break (DSB) repair. We show that following ionizing radiation and treatment with DNA-damaging agents, RAP80 translocates ...

journal_title：Cancer research

authors： Yan J,Kim YS,Yang XP,Li LP,Liao G,Xia F,Jetten AM

更新日期：2007-07-15 00:00:00

abstract：:Through a bladder cancer surveillance protocol, a sizable population of patients suitable for characterizing the dynamics and patterns of recurrent superficial transitional cell carcinoma has been identified. One hundred thirty-three patients have been followed after their first occurrence of transitional cell carcino...

journal_title：Cancer research

authors：

更新日期：1977-08-01 00:00:00

abstract：:Phosphoglucose isomerase (PGI) is a multifunctional enzyme that functions in glucose metabolism as a glycolytic enzyme catalyzing an interconversion between glucose and fructose inside the cell, while it acts as cytokine outside the cell, with properties that include autocrine motility factor (AMF)-regulating tumor ce...

journal_title：Cancer research

authors： Niinaka Y,Harada K,Fujimuro M,Oda M,Haga A,Hosoki M,Uzawa N,Arai N,Yamaguchi S,Yamashiro M,Raz A

更新日期：2010-11-15 00:00:00

abstract：:Methyl-CpG binding domain (MBD) proteins have been shown to couple DNA methylation to transcriptional repression. This biological property suggests a role for MBD proteins in the silencing of tumor suppressor genes that are hypermethylated at their promoter CpG islands in cancer cells. Despite the demonstration of the...

journal_title：Cancer research

authors： Lopez-Serra L,Ballestar E,Fraga MF,Alaminos M,Setien F,Esteller M

更新日期：2006-09-01 00:00:00

abstract：:Hypoxia within solid tumors decreases therapeutic efficacy, and identification of hypoxia markers may influence the choice of therapeutic modality. Here, we used a proteomic approach to identify hypoxia-regulated proteins and validated their use as endogenous indicators of tumor hypoxia. Using two-dimensional gel elec...

journal_title：Cancer research

authors： Chen Y,Shi G,Xia W,Kong C,Zhao S,Gaw AF,Chen EY,Yang GP,Giaccia AJ,Le QT,Koong AC

更新日期：2004-10-15 00:00:00

abstract：:The purpose of the present study was to define the immunogenicity of two transplantable rat gliomas, designated F98 and D74, and to relate this to the phenotype and functional activity of tumor-infiltrating lymphocytes (TIL). Fischer rats, immunized with irradiated F98 tumor cells and challenged with intracerebral imp...

journal_title：Cancer research

authors： Tzeng JJ,Barth RF,Orosz CG,James SM

更新日期：1991-05-01 00:00:00

abstract：:The expression of epidermal growth factor (EGF) receptor was examined immunohistochemically in a total of 122 gastric and 61 colonic carcinomas, out of which 16 gastric and 8 colonic carcinomas were also examined by 125I-labeled EGF binding analysis and Western blotting. The values of EGF binding were 12.68 +/- 1.98 (...

journal_title：Cancer research

authors： Yasui W,Sumiyoshi H,Hata J,Kameda T,Ochiai A,Ito H,Tahara E

更新日期：1988-01-01 00:00:00

abstract：:This study was conducted to further characterize the previously described phenomenon of growth inhibition of neoplastically transformed C3H/10T1/2 cells (T10T1/2) by nontransformed C3H/10T1/2 clone 8 mouse embryo fibroblast (10T1/2) cells in the presence of inhibitors of cyclic adenosine 3':5'-monophosphate (cAMP) pho...

journal_title：Cancer research

authors： Bertram JS,Faletto MB

更新日期：1985-05-01 00:00:00

abstract：:DNA topoisomerase I (topo I) has been identified as a principal target of a plant alkaloid camptothecin (CPT) and its derivative (CPT-11). The latter compound is expected to be a clinically useful antitumor agent. Three human tumor cell lines resistant to CPT (A549/CPT, HT-29/CPT, St-4/CPT) were isolated in vitro, and...

journal_title：Cancer research

authors： Sugimoto Y,Tsukahara S,Oh-hara T,Isoe T,Tsuruo T

更新日期：1990-11-01 00:00:00

abstract：:One major rationale for using interleukin-2 and IFN-alpha in cancer immunotherapy is to activate tumor-specific T cells at the tumor site. To study the in situ T-cell response, we determined the T-cell receptor (TCR) repertoire in six melanoma metastases regressing after cytokine treatment obtained from five patients....

journal_title：Cancer research

authors： Willhauck M,Scheibenbogen C,Pawlita M,Möhler T,Thiel E,Keilholz U

更新日期：2003-07-01 00:00:00

abstract：:Viral vectors for cancer can be classified into those that do not replicate (replication-defective vectors) and those that selectively replicate in neoplastic cells (replication-conditional or oncolytic vectors). Both of these can deliver anticancer cDNAs for therapeutic purposes. Opposite hypotheses can be made regar...

journal_title：Cancer research

authors： Ichikawa T,Chiocca EA

更新日期：2001-07-15 00:00:00

abstract：:The effect of sodium taurocholate on the biliary export of stable mutagenic phenolic glucuronide metabolites of benzo(a)pyrene from livers of corn oil- or 3-methylcholanthrene-treated rats was studied using a nonrecirculating perfusion system. Sterile bile samples were collected every 4 min and assayed for mutagens us...

journal_title：Cancer research

authors： Kari FW,Kauffman FC,Thurman RG

更新日期：1985-04-01 00:00:00

abstract：:The molecular pathways driving mesenchymal glioblastoma (GBM) are still not well understood. We report here that truncated glioma-associated oncogene homolog 1 (tGLI1) is a tumor-specific transcription factor that facilitates GBM growth, is enriched in the mesenchymal subtype of GBM and glioma stem cells (GSC), and pr...

journal_title：Cancer research

authors： Rimkus TK,Carpenter RL,Sirkisoon S,Zhu D,Pasche BC,Chan MD,Lesser GJ,Tatter SB,Watabe K,Debinski W,Lo HW

更新日期：2018-05-15 00:00:00

abstract：:A nationwide study of all 3183 female patients with breast cancer in Israel diagnosed over a 7-year period (1960 to 1966) was conducted. Monthly series analysis showed a clear seasonal pattern in the symptomatology of the disease most pronounced in patients younger than 55 years, in all ethnic groups, mainly confined ...

journal_title：Cancer research

authors： Cohen P,Wax Y,Modan B

更新日期：1983-02-01 00:00:00

abstract：:Colorectal cancers with widespread CpG island methylation display a number of distinct clinicopathological features, and it has been suggested that the condition has an inheritable genetic component. To address this possibility, histories of cancer were obtained from 562 individuals undergoing curative surgery for uns...

journal_title：Cancer research

authors： Ward RL,Williams R,Law M,Hawkins NJ

更新日期：2004-10-15 00:00:00

abstract：:We have investigated the behavior of dissociated cells of a moderately differentiated Longnecker transplantable pancreatic acinar carcinoma (Longnecker et al., Cancer Lett., 7: 197-202, 1979) maintained in vitro on acellular seminiferous tubular basement membranes of rat testis. The tumor cells, which grow as solid ma...

journal_title：Cancer research

authors： Reddy JK,Kanwar YS,Rao MS,Watanabe TK,Reddy MK,Parsa I,Longnecker DS,Tafuri S

更新日期：1986-01-01 00:00:00

abstract：:After many years of productive study on the signaling networks, posttranslational regulatory control of effector molecules remains an intensely investigated and continuously evolving field of research to connect signaling with phenotypic changes. In recent years, there have been intriguing results on the interaction o...

journal_title：Cancer research

authors： Kumar R,Hung MC

更新日期：2005-04-01 00:00:00

abstract：:Epidemiological and animal model studies indicate that increased calorie intake increases the risk for colon cancer development. Previous studies in animal models restricted the calorie intake severely, and none of these studies have investigated a dose-response effect of different levels of calorie restriction on col...

journal_title：Cancer research

authors： Kumar SP,Roy SJ,Tokumo K,Reddy BS

更新日期：1990-09-15 00:00:00

abstract：:Normal bone marrow progenitors and some leukemic cells develop only a limited amount of thermotolerance. Further, once developed, thermotolerance decays at a faster rate than that normally observed in cells of nonhemopoietic origin. Thermotolerance induction and maintenance correlates with reduced levels of expression...

journal_title：Cancer research

authors： Mivechi NF,Ouyang H,Hahn GM

更新日期：1992-12-15 00:00:00

abstract：:A monoclonal antibody (IgG1) has been prepared that specifically detects Chinese hamster ovary cells expressing a multidrug-resistant phenotype. This antibody recognizes the membrane P-glycoprotein (Mr 170,000) associated with drug resistance as determined by enzyme-linked immunosorbent assay with purified P-glycoprot...

journal_title：Cancer research

authors： Lathan B,Edwards DP,Dressler LG,Von Hoff DD,McGuire WL

更新日期：1985-10-01 00:00:00

abstract：:The early detection of prostate cancer is a life-saving event in patients harboring potentially aggressive disease. With the development of malignancy, there is a dramatic reduction in the zinc content of prostate tissue associated with the inability of cancer cells to accumulate the ion. In the current study, we used...

journal_title：Cancer research

authors： Ghosh SK,Kim P,Zhang XA,Yun SH,Moore A,Lippard SJ,Medarova Z

更新日期：2010-08-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is centrally involved in cell growth, metabolism, and angiogenesis. While showing clinical efficacy in a subset of tumors, rapamycin and rapalogs are specific and allosteric inhibitors of mTOR complex 1 (mTORC1), but they do not directly inhibit mTOR complex 2 (mTORC2), an emer...

journal_title：Cancer research

authors： Yu K,Toral-Barza L,Shi C,Zhang WG,Lucas J,Shor B,Kim J,Verheijen J,Curran K,Malwitz DJ,Cole DC,Ellingboe J,Ayral-Kaloustian S,Mansour TS,Gibbons JJ,Abraham RT,Nowak P,Zask A

更新日期：2009-08-01 00:00:00

abstract：:The presence of tumor cells in the circulation may predict disease recurrence and metastases. We have developed a sensitive technique for the detection of carcinoma cells in blood, using immunomagnetic beads to enrich for epithelial cells and the polymerase chain reaction to identify a tumor marker. The colon carcinom...

journal_title：Cancer research

authors： Hardingham JE,Kotasek D,Farmer B,Butler RN,Mi JX,Sage RE,Dobrovic A

更新日期：1993-08-01 00:00:00

abstract：:5,6-Dimethylxanthenone-4-acetic acid (DMXAA) and combretastatin A4 phosphate (CA-4-P) markedly inhibit tumor blood flow in mice and are both currently in clinical trial. One of the challenges in clinical evaluation of antivascular agents is the monitoring of tumor blood flow inhibition in individual patients. This stu...

journal_title：Cancer research

authors： Siim BG,Laux WT,Rutland MD,Palmer BN,Wilson WR

更新日期：2000-08-15 00:00:00

abstract：:Tumor-specific immune tolerance limits the effectiveness of cancer vaccines. In addition, tumor vaccines alone have a limited potential for the treatment of measurable tumor burdens. This highlights the importance of identifying more potent cancer vaccine strategies for clinical testing. We tested immune-modulating do...

journal_title：Cancer research

authors： Machiels JP,Reilly RT,Emens LA,Ercolini AM,Lei RY,Weintraub D,Okoye FI,Jaffee EM

更新日期：2001-05-01 00:00:00

abstract：:This study investigates the possible molecular basis leading to failure in a treatment that is composed of hypoxia and chemotherapy in a rat orthotopic hepatoma model. Hypoxia was induced by hepatic artery ligation, whereas chemotherapeutic effect was achieved by intraportal injection of cisplatin. High-dose sodium sa...

journal_title：Cancer research

authors： Yang ZF,Poon RT,To J,Ho DW,Fan ST

更新日期：2004-08-01 00:00:00