Immunological detection of Chinese hamster ovary cells expressing a multidrug resistance phenotype.

abstract：:Here, we provide the first evidence that sphingosine kinase 1 (SphK1), an oncogenic lipid kinase balancing the intracellular level of key signaling sphingolipids, modulates the transcription factor hypoxia inducible factor 1alpha (HIF-1alpha), master regulator of hypoxia. SphK1 activity is stimulated under low oxygen ...

journal_title：Cancer research

authors： Ader I,Brizuela L,Bouquerel P,Malavaud B,Cuvillier O

更新日期：2008-10-15 00:00:00

abstract：:Promoter hypermethylation and histone deacetylation are common epigenetic mechanisms implicated in the transcriptional silencing of tumor suppressor genes in human cancer. We treated two immortalized glioma cell lines, T98 and U87, and 10 patient-derived primary glioma cell lines with trichostatin A (TSA), a histone d...

journal_title：Cancer research

authors： Foltz G,Ryu GY,Yoon JG,Nelson T,Fahey J,Frakes A,Lee H,Field L,Zander K,Sibenaller Z,Ryken TC,Vibhakar R,Hood L,Madan A

更新日期：2006-07-01 00:00:00

abstract：:The prodrug of 9-beta-D-arabinosylguanine (ara-G), nelarabine, demonstrated efficacy against T-cell acute lymphoblastic leukemia, and its effectiveness correlated with the accumulation of the triphosphate form (ara-GTP). Although in vitro investigations using purified deoxycytidine kinase (dCK) or deoxyguanosine kinas...

journal_title：Cancer research

authors： Rodriguez CO Jr,Mitchell BS,Ayres M,Eriksson S,Gandhi V

更新日期：2002-06-01 00:00:00

abstract：:A cascade of events leading to hypertrophy has been proposed and implicated in growth regulation in a variety of normal and neoplastic cells and tissues. There is a tightly coupled temporal sequence: (a) cyclic adenosine 3':5'-monophosphate-dependent protein kinase (cAPK) activation; (b) ornithine decarboxylase (ODC) ...

journal_title：Cancer research

authors： Olson JW,Russell DH

更新日期：1980-12-01 00:00:00

abstract：:In the present study, we assessed the susceptibility of freshly isolated neuroblastoma cells to killing mediated by normal human natural killer (NK) cells and analyzed the receptor-ligand interactions that regulate this event. We show that killing of freshly isolated neuroblasts, similar to neuroblastoma cell lines, i...

journal_title：Cancer research

authors： Castriconi R,Dondero A,Corrias MV,Lanino E,Pende D,Moretta L,Bottino C,Moretta A

更新日期：2004-12-15 00:00:00

abstract：:Cellular retinoic acid-binding protein (cRABP) was detected in the cytosol of virus-induced papilloma (Shope) of rabbit skin. The Shope papilloma cRABP showed the same ligand specificity and sedimentation value (2S) as was found in other animal species. The level of cRABP in the papillomatous tissue was significantly ...

journal_title：Cancer research

authors： Rattanapanone V,Tashiro S,Tokuda H,Rattanapanone N,Ito Y

更新日期：1981-04-01 00:00:00

abstract：:Suspensions of an oxygen-sensitive (MT-7) and of an oxygen-insensitive(M109) tumor cell line were injected i.v. into BALB/c mice. Exposure to 100% O2 after injection of the cells did not modify the initial arrest of either cell line in the lung. Exposure of animals given injections of MT-7 cells for 60 h to 100% oxyge...

journal_title：Cancer research

authors： Margaretten NC,Witschi H

更新日期：1988-05-15 00:00:00

abstract：:Active-specific immunotherapy with dendritic cells loaded with peptide derived from the melanoma antigen, gp100, failed to mediate regression of established B16F10 melanoma in normal mice. Dendritic cell vaccination induced activation and subsequent deletion of adoptively transferred naive CD8+ T-cell receptor transge...

journal_title：Cancer research

authors： Wang LX,Li R,Yang G,Lim M,O'Hara A,Chu Y,Fox BA,Restifo NP,Urba WJ,Hu HM

更新日期：2005-11-15 00:00:00

abstract：:Macrophages play important roles in both physiologic and pathologic processes and arise from successive waves of embryonic and adult hematopoiesis. Monocyte-derived macrophages (MOMF) exert distinct functions under pathologic conditions, and leukemia-associated macrophages (LAM) show considerable diversities in activa...

journal_title：Cancer research

authors： Yang F,Feng W,Wang H,Wang L,Liu X,Wang R,Chen C,Yang X,Zhang D,Ren Q,Zheng G

更新日期：2020-09-01 00:00:00

abstract：:Energy restriction (ER) inhibits mammary carcinogenesis and results in a marked reduction in tumor size, effects likely to be explained by ER-mediated induction of apoptosis. The goal of this study was to investigate the molecular mechanism(s) accounting for apoptosis induction. To do this, chemically induced mammary ...

journal_title：Cancer research

authors： Thompson HJ,Zhu Z,Jiang W

更新日期：2004-02-15 00:00:00

abstract：:Solid tumors contain a subset of stem-like cells that are resistant to the cytotoxic effects of chemotherapy/radiotherapy, but their susceptibility to cytolytic T lymphocyte (CTL) effector mechanisms has not been well characterized. Using a panel of early-passage human brain tumor stem/initiating cell (BTSC) lines der...

journal_title：Cancer research

authors： Brown CE,Starr R,Martinez C,Aguilar B,D'Apuzzo M,Todorov I,Shih CC,Badie B,Hudecek M,Riddell SR,Jensen MC

更新日期：2009-12-01 00:00:00

abstract：:The p53 tumor suppressor gene product is known to be active in mediating radiation-induced G1-S cell cycle arrest and apoptosis in a number of normal cell lines. These functions are compromised by inactivation of p53, which promotes tumor progression. Because the p53 gene appears to play an important role in the cellu...

journal_title：Cancer research

authors： Gallardo D,Drazan KE,McBride WH

更新日期：1996-11-01 00:00:00

abstract：:The nucleotide sequence complexity of murine leukemia virus *MuLV)-related RNA has been measured by RNA-complementary DNA hybridization analysis in nuclear and cytoplasmic RNA isolated from liver and brain of low-leukemia-strain C57BL/6J mice of different ages. In these two tissues, an approximate 1.5- to 2-fold incre...

journal_title：Cancer research

authors： Florine DL,Ono T,Cutler RG,Getz MJ

更新日期：1980-03-01 00:00:00

abstract：:The human glioma-derived cell line D-54 MG and the human medulloblastoma-derived cell line TE-671 have been shown to be sensitive in culture to the pharmacological interference with glutamine metabolism by acivicin, 6-diazo-5-oxo-L-norleucine, and methionine sulfoximine. Using as a guide the multiple contributions of ...

journal_title：Cancer research

authors： Dranoff G,Elion GB,Friedman HS,Bigner DD

更新日期：1985-09-01 00:00:00

abstract：:Nickel is a toxic, mutagenic, and carcinogenic metal of significant occupational and environmental concern. Although several cellular targets of nickel have been identified, considerable evidence suggests that it can act indirectly upon DNA by inducing the formation of oxidized purines or pyrimidines that constitute p...

journal_title：Cancer research

authors： Higinbotham KG,Rice JM,Diwan BA,Kasprzak KS,Reed CD,Perantoni AO

更新日期：1992-09-01 00:00:00

abstract：:DNA mismatch repair (MMR) plays a key role in the cytotoxic response of human cells to methylating agents, however, the cascade of events leading to cell cycle arrest and cell death has yet to be characterized. We studied the role of MMR in the transcriptional response to DNA methylation damage in two human cellular m...

journal_title：Cancer research

authors： di Pietro M,Marra G,Cejka P,Stojic L,Menigatti M,Cattaruzza MS,Jiricny J

更新日期：2003-12-01 00:00:00

abstract：:Elongation factor-2 kinase (eEF-2 kinase), also known as Ca(2+)/calmodulin-dependent kinase III, regulates protein synthesis by controlling the rate of peptide chain elongation. The activity of eEF-2 kinase is increased in glioblastoma and other malignancies, yet its role in neoplasia is uncertain. Recent evidence sug...

journal_title：Cancer research

authors： Wu H,Yang JM,Jin S,Zhang H,Hait WN

更新日期：2006-03-15 00:00:00

abstract：:Elevated tumor cyclooxygenase-2 (COX-2) expression is associated with tumor invasion, metastasis, and poor prognosis in non-small cell lung cancer (NSCLC). Here, we report that COX-2-dependent pathways contribute to the modulation of E-cadherin expression in NSCLC. First, whereas genetically modified COX-2-sense (COX-...

journal_title：Cancer research

authors： Dohadwala M,Yang SC,Luo J,Sharma S,Batra RK,Huang M,Lin Y,Goodglick L,Krysan K,Fishbein MC,Hong L,Lai C,Cameron RB,Gemmill RM,Drabkin HA,Dubinett SM

更新日期：2006-05-15 00:00:00

abstract：:A novel matrix-degrading enzyme was identified from human breast cancer cells. This enzyme appears as major gelatinase in hormone-dependent breast cancer cell lines and has as an apparent molecular mass of 80 kDa on gelatin zymography. The 80-kDa enzyme has a unique metal ion specificity. In addition to calcium ions, ...

journal_title：Cancer research

authors： Shi YE,Torri J,Yieh L,Wellstein A,Lippman ME,Dickson RB

更新日期：1993-03-15 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] inhibited the secretion of gamma-interferon from human T-lymphocytes activated by the calcium ionophore, A23187, or phytohemagglutinin with or without 12-O-tetradecanoylphorbol-13-acetate. The agent also inhibited cell proliferation and interleukin 2 secretion by these cells. Th...

journal_title：Cancer research

authors： Matsui T,Takahashi R,Nakao Y,Koizumi T,Katakami Y,Mihara K,Sugiyama T,Fujita T

更新日期：1986-11-01 00:00:00

abstract：:Vaccination with irradiated tumor cells genetically modified to secrete granulocyte-macrophage colony-stimulating factor (GM-CSF tumor vaccine) induces a potent systemic antitumor immunity. To develop a protocol for cancer therapy to further augment the host immune response, we examined the effects of the GM-CSF tumor...

journal_title：Cancer research

authors： Wakimoto H,Abe J,Tsunoda R,Aoyagi M,Hirakawa K,Hamada H

更新日期：1996-04-15 00:00:00

abstract：:We describe a method to postlabel, in vivo, biotinylated monoclonal antibodies pretargeted onto tumor deposits when most of the non-tumor-bound antibodies have already been cleared as avidin-bound complexes. The application of this principle to tumor detection by immunoscintigraphy was tested in 20 patients with histo...

journal_title：Cancer research

authors： Paganelli G,Magnani P,Zito F,Villa E,Sudati F,Lopalco L,Rossetti C,Malcovati M,Chiolerio F,Seccamani E

更新日期：1991-11-01 00:00:00

abstract：:The role of glutathione (GSH) as a determinant of cellular sensitivity to the cytotoxic and DNA-damaging effects of cyclophosphamide (CP) was studied in a dual culture system of rat hepatocytes and K562 human chronic myeloid leukemia cells, which have elevated aldehyde dehydrogenase activity with a corresponding insen...

journal_title：Cancer research

authors： Crook TR,Souhami RL,Whyman GD,McLean AE

更新日期：1986-10-01 00:00:00

abstract：:Angiopoietin-1 (Ang1) mediates angiogenesis by enhancing endothelial cell survival and migration. It is also known that Ang1 activates Tie2, an endothelial-specific tyrosine kinase receptor, but the molecular mechanism of this process is not clear. In this study, we investigated whether reactive oxygen species (ROS) p...

journal_title：Cancer research

authors： Kim YM,Kim KE,Koh GY,Ho YS,Lee KJ

更新日期：2006-06-15 00:00:00

abstract：:We analyzed the epidermal growth factor receptor gene using a complementary DNA probe of the epidermal growth factor receptor gene in 21 uncultured primary breast carcinomas and found that the gene was amplified in three of these tumors. We further demonstrated by immunohistochemistry using a monoclonal antibody to th...

journal_title：Cancer research

authors： Ro J,North SM,Gallick GE,Hortobagyi GN,Gutterman JU,Blick M

更新日期：1988-01-01 00:00:00

abstract：:Integrins interact with extracellular matrix (ECM) and deliver intracellular signaling for cell proliferation, survival, and motility. During tumor metastasis, integrin-mediated cell adhesion to and migration on the ECM proteins are required for cancer cell survival and adaptation to the new microenvironment. Using st...

journal_title：Cancer research

authors： Chen Y,Lu B,Yang Q,Fearns C,Yates JR 3rd,Lee JD

更新日期：2009-04-15 00:00:00

abstract：:Anaplastic large cell lymphomas (ALCL) are mainly characterized by the reciprocal translocation t(2;5)(p23;q35) that involves the anaplastic lymphoma kinase (ALK) gene and generates the fusion protein NPM-ALK with intrinsic tyrosine kinase activity. NPM-ALK triggers several signaling cascades, leading to increased cel...

journal_title：Cancer research

authors： Voena C,Conte C,Ambrogio C,Boeri Erba E,Boccalatte F,Mohammed S,Jensen ON,Palestro G,Inghirami G,Chiarle R

更新日期：2007-05-01 00:00:00

abstract：:Aggressive cancer cells typically show a high rate of energy-consuming anabolic processes driving the synthesis of lipids, proteins, and DNA. Here, we took advantage of the ability of the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside to increase the intracellular levels of AICA ribotide, an ...

journal_title：Cancer research

authors： Swinnen JV,Beckers A,Brusselmans K,Organe S,Segers J,Timmermans L,Vanderhoydonc F,Deboel L,Derua R,Waelkens E,De Schrijver E,Van de Sande T,Noël A,Foufelle F,Verhoeven G

更新日期：2005-03-15 00:00:00

abstract：:Proline is a readily released stress substrate that can be metabolized by proline oxidase (POX) to generate either reactive oxygen species (ROS) to induce apoptosis or autophagy or ATP during times of nutrient stress. However, the contribution of proline metabolism to tumorigenesis in hypoxic microenvironments has not...

journal_title：Cancer research

authors： Liu W,Glunde K,Bhujwalla ZM,Raman V,Sharma A,Phang JM

更新日期：2012-07-15 00:00:00

abstract：:The retinoblastoma (Rb) family consists of the tumor suppressor pRb and related proteins p107 and pRb2/p130. Ectopic expression of pRb and p107 results in a growth arrest of sensitive cells in the G1 phase of the cell cycle. We demonstrated here that the growth-suppressive properties of pRb2/p130 were also specific fo...

journal_title：Cancer research

authors： Claudio PP,De Luca A,Howard CM,Baldi A,Firpo EJ,Koff A,Paggi MG,Giordano A

更新日期：1996-05-01 00:00:00