Hydrogen peroxide produced by angiopoietin-1 mediates angiogenesis.

abstract：:Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-...

journal_title：Cancer research

authors： Huang Z,Fasco MJ,Spivack S,Kaminsky LS

更新日期：1997-07-01 00:00:00

abstract：:Tumor endothelial marker 8 (TEM8) is a recently described protein that is preferentially expressed within tumor endothelium. We have developed a fusion protein that targets TEM8 and disrupts tumor vasculature by promoting localized thrombosis. Fusion protein specificity and function were evaluated using Western blot a...

journal_title：Cancer research

authors： Fernando S,Fletcher BS

更新日期：2009-06-15 00:00:00

abstract：:The Ras proto-oncogene has been implicated in the in vivo development of tumors and in the in vitro transformation of cultured cell lines. In both of these conditions, Ras-mediated disruption of cell cycle-regulatory mechanisms leads to unregulated cellular proliferation, although the exact mechanisms by which Ras acc...

journal_title：Cancer research

authors： LaRue KE,Bradbury EM,Freyer JP

更新日期：1998-03-15 00:00:00

abstract：:The development of colon carcinomas is associated with allelic deletions on chromosomes 5q, 17p, and 18q. The DCC gene located on chromosome 18q21.3 codes for a potential tumor suppressor gene related to cellular adhesion receptors. We investigated the expression of this gene in several pancreatic carcinoma cell lines...

journal_title：Cancer research

authors： Höhne MW,Halatsch ME,Kahl GF,Weinel RJ

更新日期：1992-05-01 00:00:00

abstract：:We recently reported trophic response of transplantable mouse colon cancer cells (MC-26) to pentagastrin, in vivo, and demonstrated gastrin receptors on MC-26 cells, in vitro. In the present study, growth of MC-26 cells in mice, in response to pentagastrin, was studied in relation to binding kinetics and capacity of g...

journal_title：Cancer research

authors： Singh P,Walker JP,Townsend CM Jr,Thompson JC

更新日期：1986-04-01 00:00:00

abstract：:This study was conducted to further characterize the previously described phenomenon of growth inhibition of neoplastically transformed C3H/10T1/2 cells (T10T1/2) by nontransformed C3H/10T1/2 clone 8 mouse embryo fibroblast (10T1/2) cells in the presence of inhibitors of cyclic adenosine 3':5'-monophosphate (cAMP) pho...

journal_title：Cancer research

authors： Bertram JS,Faletto MB

更新日期：1985-05-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (IHCC) is a primary cancer of the liver with an increasing incidence and poor prognosis. Preclinical studies of the etiology and treatment of this disease are hampered by the relatively small number of available IHCC cell lines or genetically faithful animal models. Here we report the d...

journal_title：Cancer research

authors： O'Dell MR,Huang JL,Whitney-Miller CL,Deshpande V,Rothberg P,Grose V,Rossi RM,Zhu AX,Land H,Bardeesy N,Hezel AF

更新日期：2012-03-15 00:00:00

abstract：:The addition of B-cell lymphoma 2 (Bcl-2) antisense to dacarbazine in the treatment of metastatic melanoma demonstrates improved response rates and progression-free survival when compared with dacarbazine alone. Studies on small cohorts of melanoma patients have shown variability in Bcl-2 expression (60%-96% positive)...

journal_title：Cancer research

authors： Divito KA,Berger AJ,Camp RL,Dolled-Filhart M,Rimm DL,Kluger HM

更新日期：2004-12-01 00:00:00

abstract：:Previous studies have demonstrated the suitability of image analysis of tetrazolium-stained colonies to assess growth and drug sensitivity of human tumor cells cultivated in soft agar culture. In the present study, the potential utility of colorimetric analysis to expedite experimental drug evaluations using human tum...

journal_title：Cancer research

authors： Alley MC,Pacula-Cox CM,Hursey ML,Rubinstein LR,Boyd MR

更新日期：1991-02-15 00:00:00

abstract：:Using alternative reading frames, the human ARF-INK4a locus encodes two unrelated proteins that both function in tumor suppression. p16(INK4a) maintains the retinoblastoma protein in its growth-suppressive state through inhibition of cyclin D-dependent kinase activity, whereas ARF binds with MDM2 and stabilizes p53. T...

journal_title：Cancer research

authors： Yarbrough WG,Bessho M,Zanation A,Bisi JE,Xiong Y

更新日期：2002-02-15 00:00:00

abstract：:In this study, using the carcinoembryonic antigen (CEA)-expressing C15 murine colon carcinoma system in syngeneic C57BL/6 mice, we have evaluated the efficacy of bone marrow-derived dendritic cells (DCs) pulsed with the murine anti-idiotype antibody 3H1 as a tumor vaccine. Anti-idiotype 3H1 mimics a distinct and speci...

journal_title：Cancer research

authors： Saha A,Chatterjee SK,Foon KA,Primus FJ,Bhattacharya-Chatterjee M

更新日期：2003-06-01 00:00:00

abstract：:Sphingosine kinase 1 (SK1) plays an important role in estrogen-dependent breast tumorigenesis, but its regulation is poorly understood. A subset of microRNAs (miRNA, miR) is regulated by estrogen and contributes to cellular proliferation and cancer progression. Here, we describe that miR-515-5p is transcriptionally re...

journal_title：Cancer research

authors： Pinho FG,Frampton AE,Nunes J,Krell J,Alshaker H,Jacob J,Pellegrino L,Roca-Alonso L,de Giorgio A,Harding V,Waxman J,Stebbing J,Pchejetski D,Castellano L

更新日期：2013-10-01 00:00:00

abstract：:Whether oncogenic human papilloma viruses (HPVs) are involved in the pathogenesis of prostate cancers has been a subject of great controversy. To clarify the contradictory results of investigations, with the aim of detecting viral nucleic acids in prostate cancers, we have carried out a comparative quantitation of the...

journal_title：Cancer research

authors： Serth J,Panitz F,Paeslack U,Kuczyk MA,Jonas U

更新日期：1999-02-15 00:00:00

abstract：:Non-small cell lung cancer (N-SCLC) is generally unresponsive to chemotherapy even without previous drug treatment, as opposed to small cell lung cancer (SCLC), which is initially responsive to chemotherapy. The mechanisms of this intrinsic resistance are unknown. This study was designed to investigate the role of DNA...

journal_title：Cancer research

authors： Zeng-Rong N,Paterson J,Alpert L,Tsao MS,Viallet J,Alaoui-Jamali MA

更新日期：1995-11-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) plays critical roles in many biological processes and in tumorigenesis. Here, we show that two mutated EGFRs found in lung and other malignancies, EGFR-G719S and EGFR-L858R, could transform Ba/F3 cells to interleukin-3 (IL-3)-independent growth, in a ligand-independent manner, a...

journal_title：Cancer research

authors： Jiang J,Greulich H,Jänne PA,Sellers WR,Meyerson M,Griffin JD

更新日期：2005-10-01 00:00:00

abstract：:Human prostate cancer is associated with a reactive stroma typified by an increase in the proportion of myofibroblast type cells and elevated synthesis of extracellular matrix proteins. Increased vascular density has been identified in the reactive stroma compartment adjacent to both precancerous and cancerous prostat...

journal_title：Cancer research

authors： McAlhany SJ,Ressler SJ,Larsen M,Tuxhorn JA,Yang F,Dang TD,Rowley DR

更新日期：2003-09-15 00:00:00

abstract：:The small leucine-rich proteoglycan lumican was identified from a human placenta cDNA library by the expression cloning method as a gene product that interacts with membrane-type matrix metalloproteinase-1 (MT1-MMP). Coexpression of MT1-MMP with lumican in HEK293T cells reduced the concentration of lumican secreted in...

journal_title：Cancer research

authors： Li Y,Aoki T,Mori Y,Ahmad M,Miyamori H,Takino T,Sato H

更新日期：2004-10-01 00:00:00

abstract：:To elucidate the role of cyclin E in cell growth and tumorigenesis in mammary epithelial cells, we have used retrovirus-mediated transduction to generate derivatives of the nontransformed HC11 mouse mammary epithelial cell line that stably express a human cyclin E cDNA (HU4). These derivatives expressed two distinct f...

journal_title：Cancer research

authors： Sgambato A,Han EK,Zhou P,Schieren I,Weinstein IB

更新日期：1996-03-15 00:00:00

abstract：:mtCLIC/CLIC4 is a p53 and tumor necrosis factor alpha (TNFalpha) regulated intracellular chloride channel protein that localizes to cytoplasm and organelles and induces apoptosis when overexpressed in several cell types of mouse and human origin. CLIC4 is elevated during TNFalpha-induced apoptosis in human osteosarcom...

journal_title：Cancer research

authors： Suh KS,Mutoh M,Gerdes M,Crutchley JM,Mutoh T,Edwards LE,Dumont RA,Sodha P,Cheng C,Glick A,Yuspa SH

更新日期：2005-01-15 00:00:00

abstract：:The enhancer pioneer transcription factor FoxA1 is a global mediator of steroid receptor (SR) action in hormone-dependent cancers. In castration-resistant prostate cancer (CRPC), FoxA1 acts as an androgen receptor cofactor to drive G₂ to M-phase cell-cycle transit. Here, we describe a mechanistically distinct SR-indep...

journal_title：Cancer research

authors： Zhang C,Wang L,Wu D,Chen H,Chen Z,Thomas-Ahner JM,Zynger DL,Eeckhoute J,Yu J,Luo J,Brown M,Clinton SK,Nephew KP,Huang TH,Li W,Wang Q

更新日期：2011-11-01 00:00:00

abstract：:Four bifunctional and one trifunctional alpha-chloro ethers were tested for carcinogenicity. These compounds were bis-1,2-(chloromethoxy)ethane (Compound I), bis-1,4-(chloromethoxy)butane (Compound II), bis-1,6-(chloromethoxy) hexane (Compound III), bis-1,4-(chloromethoxy)-p-xylene (Compound IV), and tris-1,2,3-(chlor...

journal_title：Cancer research

authors： Van Duuren BL,Goldschmidt BM,Seidman I

更新日期：1975-09-01 00:00:00

abstract：:The effect of the adenosine diphosphoribosyltransferase inhibitors, the substituted benzamides, on the cytotoxicity of 6-thioguanine (6TG) was investigated. Nontoxic concentrations of benzamides potentiated the cytotoxicity of 6TG with a dose enhancement factor of 2, producing a 6-fold increase in cell killing at 10% ...

journal_title：Cancer research

authors： Moses K,Harris AL,Durkacz BW

更新日期：1988-10-15 00:00:00

abstract：:Accurate diagnosis of primitive childhood sarcomas continues to be a formidable problem because these malignancies generally demonstrate very little morphological evidence of their tissue of origin. One of these tumor classes, the Ewing's sarcoma family of peripheral primitive neuroectodermal tumors (pPNETs), are thou...

journal_title：Cancer research

authors： Sorensen PH,Shimada H,Liu XF,Lim JF,Thomas G,Triche TJ

更新日期：1995-03-15 00:00:00

abstract：:Milk from a number of species (e.g., man, mouse, rat, dog, and cow) contains inhibitors of the RNA-directed DNA polymerase. When attempts are made to isolate virions from the milk, part of the inhibitors follow the virions in the purification. The amount of inhibitors varies in different milk samples. These inhibitors...

journal_title：Cancer research

authors： Sanner T

更新日期：1976-02-01 00:00:00

abstract：:A synthetic DNA template has been constructed that is suitable for the quantitation of mRNAs encoding gastrin, transforming growth factor alpha (TGF alpha), cholecystokinin, and the 78-kDa gastrin-binding protein. The template was used to measure levels of gastrin and TGF alpha mRNA in 7 colonic and 2 gastric carcinom...

journal_title：Cancer research

authors： Baldwin GS,Zhang QX

更新日期：1992-04-15 00:00:00

abstract：:We analyzed the karyotype of 27 B-cell lymphomas of human origin that developed in mice with severe combined immunodeficiency disease following the injection of peripheral blood leukocytes from Epstein-Barr virus-seropositive donors. Three tumors had clonal abnormalities detected with conventional techniques, 2 had tr...

journal_title：Cancer research

authors： Thangavelu M,Snyder L,Anastasi J,Le Beau MM,Kirven M,Picchio G,Mosier DE,Rowley JD

更新日期：1992-09-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) inhibitors are approved for treatment of cancers with BRCA1 or BRCA2 defects. In this study, we prepared and characterized a very long-acting PARP inhibitor. Synthesis of a macromolecular prodrug of talazoparib (TLZ) was achieved by covalent conjugation to a PEG40kDa carrier via a β-...

journal_title：Cancer research

authors： Fontaine SD,Ashley GW,Houghton PJ,Kurmasheva RT,Diolaiti M,Ashworth A,Peer CJ,Nguyen R,Figg WD,Beckford-Vera DR,Santi DV

更新日期：2020-12-15 00:00:00

abstract：:Von Hippel-Lindau (VHL) tumor suppressor protein is expressed in neurons of the central nervous system and plays an important role during the neuronal differentiation of central nervous system progenitor cells. To elucidate the neuronal differentiating potential of VHL protein in neuroblastoma cells, we overexpressed ...

journal_title：Cancer research

authors： Murata H,Tajima N,Nagashima Y,Yao M,Baba M,Goto M,Kawamoto S,Yamamoto I,Okuda K,Kanno H

更新日期：2002-12-01 00:00:00

abstract：:MdmX and Mdm2 regulate p53 tumor suppressor functions by controlling p53 transcriptional activity and/or stability in cells exposed to DNA damage. Accumulating evidence indicates that ATM-mediated phosphorylation and degradation of Mdm2 and MdmX may be the initial driving force that induces p53 activity during the ear...

journal_title：Cancer research

authors： Zhang X,Lin L,Guo H,Yang J,Jones SN,Jochemsen A,Lu X

更新日期：2009-10-15 00:00:00

abstract：:Neuroblastoma is a neural crest-derived embryonal malignancy, which accounts for 13% of all pediatric cancer mortality, primarily due to tumor recurrence. Therapy-resistant cancer stem cells are implicated in tumor relapse, but definitive phenotypic evidence of the existence of these cells has been lacking. In this st...

journal_title：Cancer research

authors： Hsu DM,Agarwal S,Benham A,Coarfa C,Trahan DN,Chen Z,Stowers PN,Courtney AN,Lakoma A,Barbieri E,Metelitsa LS,Gunaratne P,Kim ES,Shohet JM

更新日期：2013-07-01 00:00:00