Abstract：
:Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-length and splice variants of these mRNAs in human lung tissue and tumors are reported for the first time and are compared in order to probe the potential for differential CYP2D6 regulation in lung normal tissue and tumors. The splice variant profiles differed within the same individual, but no consistent differences were detected.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Huang Z,Fasco MJ,Spivack S,Kaminsky LSsubject
Has Abstractpub_date
1997-07-01 00:00:00pages
2589-92issue
13eissn
0008-5472issn
1538-7445journal_volume
57pub_type
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