Studies of effects of recombinant human tumor necrosis factor on autochthonous tumor and transplanted normal tissue in mice.

abstract：:To study the long-term effects of estrogen deprivation on breast cancer, MCF-7Ca human estrogen receptor-positive breast cancer cells stably transfected with human aromatase gene were cultured in the steroid-depleted medium for 6 to 8 months until they had acquired the ability to grow. Proliferation of these cells (UM...

journal_title：Cancer research

authors： Sabnis GJ,Jelovac D,Long B,Brodie A

更新日期：2005-05-01 00:00:00

abstract：:Dog and rat animal models have been developed for repeated intravascular administrations to the liver. However, mice have generally been considered too small to use for these models. This study describes the development of mouse models that permit the establishment of liver metastases that can be subsequently treated ...

journal_title：Cancer research

authors： Kasuya H,Kuruppu DK,Donahue JM,Choi EW,Kawasaki H,Tanabe KK

更新日期：2005-05-01 00:00:00

abstract：:beta-Catenin is an ubiquitously expressed cytoplasmic protein that has a crucial role in both cadherin-mediated cell-cell adhesion and as a downstream signaling molecule in the wingless/Wnt pathway. Activating mutations in exon 3 of the beta-catenin gene, at the phosphorylation sites for ubiquitination and degradation...

journal_title：Cancer research

authors： Rashid A,Gao YT,Bhakta S,Shen MC,Wang BS,Deng J,Fraumeni JF Jr,Hsing AW

更新日期：2001-04-15 00:00:00

abstract：:Cell proliferation kinetics during growth of an estrogen receptor-positive human breast carcinoma cell line, T-47D, was defined, and some factors which modify its response to tamoxifen were investigated in vitro. T-47D cells were estrogen responsive when grown in charcoal-stripped fetal calf serum, but the addition of...

journal_title：Cancer research

authors： Reddel RR,Murphy LC,Sutherland RL

更新日期：1984-06-01 00:00:00

abstract：:Barrett's esophagus, a columnar metaplasia of the lower esophagus epithelium related to gastroesophageal reflux disease, is the strongest known risk factor for the development of esophageal adenocarcinoma (EAC). Understanding the signal transduction events involved in esophageal epithelium carcinogenesis may provide i...

journal_title：Cancer research

authors： Yen CJ,Izzo JG,Lee DF,Guha S,Wei Y,Wu TT,Chen CT,Kuo HP,Hsu JM,Sun HL,Chou CK,Buttar NS,Wang KK,Huang P,Ajani J,Hung MC

更新日期：2008-04-15 00:00:00

abstract：:Glycerol and D2O can provide a protective effect to Chinese hamster V79 cells receiving heat treatment. The mechanism for this effect is assumed to be the ability of these agents to stabilize proteins which implies that one of the possible heat-killing mechanisms is the inactivation of a heat-sensitive molecule (prote...

journal_title：Cancer research

authors： Lin PS,Hefter K,Ho KC

更新日期：1984-12-01 00:00:00

abstract：:Premature ovarian failure and reduced fecundity are well-documented consequences of cytotoxic chemotherapy used to treat patients with malignant diseases. To investigate the ability of different hormonal agents to block the effects of cyclophosphamide (CTX) on reproductive function, sexually mature female Long-Evans r...

journal_title：Cancer research

authors： Montz FJ,Wolff AJ,Gambone JC

更新日期：1991-04-15 00:00:00

abstract：:Medulloblastoma is frequently disseminated throughout the central nervous system by the time of diagnosis. Conventional therapeutic approaches have not reduced the high mortality associated with metastatic medulloblastoma and little is known regarding the molecular mechanisms that promote tumor invasion. Previously, w...

journal_title：Cancer research

authors： Hernan R,Fasheh R,Calabrese C,Frank AJ,Maclean KH,Allard D,Barraclough R,Gilbertson RJ

更新日期：2003-01-01 00:00:00

abstract：:The discovery of Epstein-Barr virus (EBV) in 1964 gave birth to the field of viral oncology. Despite significant scientific and clinical developments in research on several other viruses discovered and linked to cancer risk much later, our understanding of EBV as a carcinogen and a possible target for therapeutic inte...

journal_title：Cancer research

authors： Mbulaiteye SM,Prokunina-Olsson L

更新日期：2019-12-01 00:00:00

abstract：:Severe weight loss is associated with many malignant diseases of humans and animals. Avian reticuloendotheliosis viruses (RE viruses) induce runting in experimentally infected chickens. Chickens infected with a replication-competent RE virus, reticuloendotheliosis-associated virus, weighed 30-50% less than control bir...

journal_title：Cancer research

authors： Garry RF,Shackleford GM,Berry LJ,Bose HR Jr

更新日期：1985-10-01 00:00:00

abstract：:The chemotherapeutic effect of B859-35, the (-)-enantiomer of dihydropyrine 3-methyl-5-3-(4,4-diphenyl-1-piperidinyl)-propyl-1,4-dihydro-2,6-dimethy l-4- (3-nitrophenyl)-pyridine-3,5-dicarboxylate-hydrochloride (niguldipine), was tested on tumors induced in Syrian golden hamsters by N-nitrosodiethylamine (DEN). Periph...

journal_title：Cancer research

authors： Schuller HM,Correa E,Orloff M,Reznik GK

更新日期：1990-03-01 00:00:00

abstract：:Receptor protein-tyrosine kinases (RPTKs) are tightly regulated during normal cellular processes including cell growth, differentiation, and metabolism. Recently, a RPTK-like molecule named novel oncogene with kinase-domain (NOK) has been cloned and characterized. Overexpression of NOK caused severe cellular transform...

journal_title：Cancer research

authors： Chen Y,Li YH,Chen XP,Gong LM,Zhang SP,Chang ZJ,Zhang XF,Fu XY,Liu L

更新日期：2005-12-01 00:00:00

abstract：:Between February 1987 and July 1988, 45 patients with advanced refractory cancer were treated with LY186641, a diarylsulfonylurea that has shown a broad spectrum of activity in preclinical testing. Patients received a weekly p.o. dose of LY186641 for 6 consecutive weeks; responding and stable patients continued weekly...

journal_title：Cancer research

authors： Hainsworth JD,Hande KR,Satterlee WG,Kuttesch J,Johnson DH,Grindey G,Jackson LE,Greco FA

更新日期：1989-09-15 00:00:00

abstract：:By the use of a variety of cell culture and separation methods, four cell lines were isolated from a single autochthonous BALB/cfC3H mammary tumor. These lines differ markedly from each other in culture morphology, various in vitro growth properties, expression of murine mammary tumor virus antigen, and karyotype, yet...

journal_title：Cancer research

authors： Dexter DL,Kowalski HM,Blazar BA,Fligiel Z,Vogel R,Heppner GH

更新日期：1978-10-01 00:00:00

abstract：:Cyclooxygenase-2 and prostaglandin E(2) (PGE(2)) levels are increased in colorectal cancers and a subset of adenomas. PGE(2) signaling through the EP4 receptor has previously been associated with colorectal tumorigenesis. However, changes in EP4 expression during adenoma to carcinoma progression have not been investig...

journal_title：Cancer research

authors： Chell SD,Witherden IR,Dobson RR,Moorghen M,Herman AA,Qualtrough D,Williams AC,Paraskeva C

更新日期：2006-03-15 00:00:00

abstract：:We have investigated the effect of a combined chemoimmunotherapy protocol with liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE), 5-fluorouracil (5-FU), and 5-formyltetrahydrofolate (leucovorin) on the growth of hepatic metastases using carcinoma H-59, a liver-homing subline of the Lewis lung carcinoma (P...

journal_title：Cancer research

authors： Asao T,Shibata HR,Batist G,Brodt P

更新日期：1992-11-15 00:00:00

abstract：:The epidermal growth factor (EGF) receptor in two colon carcinoma lines and in one vulval carcinoma line tested contains carbohydrate determinants that are recognized by monoclonal antibodies to tumor-associated antigens. These antibodies are directed to sialylated Lea and to difucosylated structures of the Y type. Ce...

journal_title：Cancer research

authors： Basu A,Murthy U,Rodeck U,Herlyn M,Mattes L,Das M

更新日期：1987-05-15 00:00:00

abstract：:We developed a novel approach for conducting multisample, multigene, ultradeep bisulfite sequencing analysis of DNA methylation patterns in clinical samples. A massively parallel sequencing-by-synthesis method (454 sequencing) was used to directly sequence >100 bisulfite PCR products in a single sequencing run without...

journal_title：Cancer research

authors： Taylor KH,Kramer RS,Davis JW,Guo J,Duff DJ,Xu D,Caldwell CW,Shi H

更新日期：2007-09-15 00:00:00

abstract：:Germ-line p53 mutations have been identified in most families with Li-Fraumeni syndrome (LFS). For germ-line p53 mutation carriers, there is considerable variability with respect to age of cancer onset and tumor type, suggesting that additional genetic effects influence the clinical severity and tumor spectrum. To ide...

journal_title：Cancer research

authors： Wu CC,Shete S,Amos CI,Strong LC

更新日期：2006-08-15 00:00:00

abstract：:An approach to stimulating an immune response against tumors is to transduce tumor cells with bacterial genes, which represent a "danger signal" and can induce a wide immune response. Mycobacterium tuberculosis genes and their encoded proteins play a pivotal role in linking innate and cell-mediated adaptive immunity a...

journal_title：Cancer research

authors： Sfondrini L,Rodolfo M,Singh M,Colombo MP,Colnaghi MI,Ménard S,Balsari A

更新日期：2000-07-15 00:00:00

abstract：:Although androgen ablation therapy is effective in treating primary prostate cancers, a significant number of patients develop incurable castration-resistant disease. Recent studies have suggested a potential synergy between vaccination and androgen ablation, yet the enhanced T-cell function is transient. Using a defi...

journal_title：Cancer research

authors： Tang S,Moore ML,Grayson JM,Dubey P

更新日期：2012-04-15 00:00:00

abstract：:DNA polymerase beta is a nuclear protein essential to DNA repair in mammalian cells. A high frequency of mutations in this gene has been reported in colorectal cancers. To clarify the tumorigenesis steps of human prostate cancers in the molecular basis, we examined the entire coding region of the human DNA polymerase ...

journal_title：Cancer research

authors： Dobashi Y,Shuin T,Tsuruga H,Uemura H,Torigoe S,Kubota Y

更新日期：1994-06-01 00:00:00

abstract：:Mutations of the tumor suppressor E-cadherin and overexpression of the receptor tyrosine kinase epidermal growth factor receptor (EGFR) are among the most frequent genetic alterations associated with diffuse-type gastric carcinoma. Accumulating evidence suggests a functional relationship between E-cadherin and EGFR th...

journal_title：Cancer research

authors： Bremm A,Walch A,Fuchs M,Mages J,Duyster J,Keller G,Hermannstädter C,Becker KF,Rauser S,Langer R,von Weyhern CH,Höfler H,Luber B

更新日期：2008-02-01 00:00:00

abstract：:O6-Benzylguanine is an inactivator of O6-alkylguanine-DNA alkyltransferases (AGT) which is currently entering clinical trials as an agent improving the cancer chemotherapeutic activity of chloroethylnitrosoureas and other alkylating agents. O6-Benzylguanine acts by virtue of its ability to serve as a substrate for the...

journal_title：Cancer research

authors： Crone TM,Goodtzova K,Edara S,Pegg AE

更新日期：1994-12-01 00:00:00

abstract：:Some of the possible mechanisms by which polyethylene glycol (PEG) augments the ability of MOPC-315 tumor bearer spleen cells to mediate in vitro antitumor cytotoxicity were evaluated. The level of antitumor cytotoxicity obtained in 5-day cultures of tumor bearer spleen cell suspensions correlated inversely with the p...

journal_title：Cancer research

authors： Mokyr MB,Przepiorka D,Dray S

更新日期：1982-07-01 00:00:00

abstract：:Cholangiocarcinoma is a devastating cancer of biliary origin with limited treatment options. Symptoms are usually evident after blockage of the bile duct by the tumor, and at this late stage, they are relatively resistant to chemotherapy and radiation therapy. Therefore, it is imperative that alternative treatment opt...

journal_title：Cancer research

authors： Alpini G,Invernizzi P,Gaudio E,Venter J,Kopriva S,Bernuzzi F,Onori P,Franchitto A,Coufal M,Frampton G,Alvaro D,Lee SP,Marzioni M,Benedetti A,DeMorrow S

更新日期：2008-11-15 00:00:00

abstract：:Chemoprevention, especially through the use of naturally occurring phytochemicals capable of impeding the process of one or more steps of carcinogenesis process, is a promising approach for cancer management. Despite promising results in preclinical settings, its applicability to humans has met with limited success la...

journal_title：Cancer research

authors： Siddiqui IA,Adhami VM,Bharali DJ,Hafeez BB,Asim M,Khwaja SI,Ahmad N,Cui H,Mousa SA,Mukhtar H

更新日期：2009-03-01 00:00:00

abstract：:SOX9 is a member of the SOX [Sry-related high-mobility group (HMG) box] family of HMG DNA-binding domain transcription factors and is required for the development and differentiation of multiple cell lineages. This report shows that basal epithelial cells express SOX9 in normal prostate, with no detectable expression ...

journal_title：Cancer research

authors： Wang H,McKnight NC,Zhang T,Lu ML,Balk SP,Yuan X

更新日期：2007-01-15 00:00:00

abstract：:Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF) are particularly aggressive. To identify key signaling pathways that drive disease aggressiveness in tumors with high MIF expression, we analyzed the expression of coding and noncoding genes in high and low MIF-expressing tumor...

journal_title：Cancer research

authors： Yang S,He P,Wang J,Schetter A,Tang W,Funamizu N,Yanaga K,Uwagawa T,Satoskar AR,Gaedcke J,Bernhardt M,Ghadimi BM,Gaida MM,Bergmann F,Werner J,Ried T,Hanna N,Alexander HR,Hussain SP

更新日期：2016-07-01 00:00:00

abstract：:Loss of DNA mismatch repair (MMR) increases the risk of spontaneous mutations. We sought to determine whether there was an interaction between hypoxia and MMR deficiency that might contribute to the phenomenon of tumor progression. Human colon carcinoma HCT116+ch2 (MMR-deficient) and HCT116+ch3 (MMR-proficient) sublin...

journal_title：Cancer research

authors： Kondo A,Safaei R,Mishima M,Niedner H,Lin X,Howell SB

更新日期：2001-10-15 00:00:00