Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate.

abstract：:Experimentally induced breast cancer is often preceded by the appearance of preneoplastic lesions which possess the attributes of hyperplastic normal tissue. These lesions can be isolated and carried as stably transplantable outgrowth lines which continue to morphologically resemble differentiating mammary tissue (Med...

journal_title：Cancer research

authors： Smith GH,Vonderhaar BK,Graham DE,Medina D

更新日期：1984-08-01 00:00:00

abstract：:The effect of type (corn oil or lard) and quantity (5 or 20%) of dietary fat and 1,2-dimethylhydrazine (DMH) on the composition of biliary bile acids, fecal bile acids, and neutral sterols was studied in rats exposed to a given regimen for two generations prior to s.c. treatment with DMH for 20 weeks. Biliary excretio...

journal_title：Cancer research

authors： Reddy BS,Mangat S,Sheinfil A,Weisburger JH,Wynder EL

更新日期：1977-07-01 00:00:00

abstract：:The discovery of oncogenic driver mutations and the subsequent developments in targeted therapies have led to improved outcomes for subsets of lung cancer patients. The identification of additional oncogenic and drug-sensitive alterations may similarly lead to new therapeutic approaches for lung cancer. We identify an...

journal_title：Cancer research

authors： Tanizaki J,Ercan D,Capelletti M,Dodge M,Xu C,Bahcall M,Tricker EM,Butaney M,Calles A,Sholl LM,Hammerman PS,Oxnard GR,Wong KK,Jänne PA

更新日期：2015-08-01 00:00:00

abstract：:The effect of i.v. administration of the nitric oxide synthase (NOS) inhibitor N(omega)-nitro-L-arginine (L-NNA) on tumor blood flow compared with normal tissue blood flow was studied in anesthetized BD9 rats bearing subcutaneous P22 carcinosarcomas. Blood flow was measured by the tissue uptake of radiolabeled iodoant...

journal_title：Cancer research

authors： Tozer GM,Prise VE,Chaplin DJ

更新日期：1997-03-01 00:00:00

abstract：:Thirty-one patients with metastatic hormone-refractory prostatic adenocarcinoma were investigated scintigraphically with the 111In-labeled somatostatin analogue [DTPA-D-Phe1]-octreotide (OctreoScan) and with 99mTc-labeled HDP. In vitro somatostatin receptor autoradiography was performed on biopsies obtained from eight...

journal_title：Cancer research

authors： Nilsson S,Reubi JC,Kalkner KM,Laissue JA,Horisberger U,Olerud C,Westlin JE

更新日期：1995-12-01 00:00:00

abstract：:The ability of the phorbol ester tumor promoter 12-O-tetradecanoylphorbol- 13-acetate (TPA) to lead to the activation of cyclic adenosine 3':5'-monophosphate (cAMP)-dependent protein kinase was investigated in three cell lines. In the Reuber H35 hepatoma cells, TPA (1.6 microM) led to an increase in the protein kinase...

journal_title：Cancer research

authors： Byus CV,Trevillyan JM,Cavit LJ,Fletcher WH

更新日期：1983-07-01 00:00:00

abstract：:Epidemiological and animal model studies indicate that increased calorie intake increases the risk for colon cancer development. Previous studies in animal models restricted the calorie intake severely, and none of these studies have investigated a dose-response effect of different levels of calorie restriction on col...

journal_title：Cancer research

authors： Kumar SP,Roy SJ,Tokumo K,Reddy BS

更新日期：1990-09-15 00:00:00

abstract：:A multilaminar alteration of endoplasmic reticulum (ER) has been observed in tumor cells of eight patients with Hodgkin's disease and a patient with histiocytic lymphoma. These multilaminar structures are more numerous in dividing cells and thus appear to arise primarily during mitosis. The stacked membranes in the mu...

journal_title：Cancer research

authors： Parmley RT,Spicer SS,Garvin AJ

更新日期：1976-05-01 00:00:00

abstract：:An extract of a human cervical squamous carcinoma was used to produce rabbit antiserum with immunoreactivity against an antigen in several types of normal and neoplastic tissues. This antigen was abundant in cervical cancer as well as in normal adult and fetal kidney and liver. The antigen had a beta mobility in immun...

journal_title：Cancer research

authors： Goldenberg DM,Garner TF,Pant KD,van Nagell JR Jr

更新日期：1978-05-01 00:00:00

abstract：:Previously, we have shown that the expression of Wnt-1-induced signaling protein-2 (WISP-2), also known as CCN5, can be regulated by multiple stimulants in estrogen receptor (ER)-positive breast tumor cells to exert their mitogenic action in these cells. Here, we show that insulin-like growth factor-1 (IGF-1), a stron...

journal_title：Cancer research

authors： Dhar K,Banerjee S,Dhar G,Sengupta K,Banerjee SK

更新日期：2007-02-15 00:00:00

abstract：:Protein kinase C (PKC) has been implicated in enhancing cellular sensitivity to cis-diamminedichloroplatinum(II) (CP). We have synthesized a series of novel analogues of lyngbyatoxin A (7-linalylindolactam V), a natural tumor promoter and a potent activator of PKC, and investigated the effects of these synthetic compo...

journal_title：Cancer research

authors： Basu A,Kozikowski AP,Sato K,Lazo JS

更新日期：1991-05-15 00:00:00

abstract：:Extravasation of tumor cells is a pivotal step in metastasis formation. This step is initiated by an interaction of extravasating tumor cells with endothelial cells. Among the molecules mediating tumor-endothelium interactions are selectins and their fucosylated ligands. In a previous study, we demonstrated that the f...

journal_title：Cancer research

authors： Zipin A,Israeli-Amit M,Meshel T,Sagi-Assif O,Yron I,Lifshitz V,Bacharach E,Smorodinsky NI,Many A,Czernilofsky PA,Morton DL,Witz IP

更新日期：2004-09-15 00:00:00

abstract：:T-cell infiltration of solid tumors is associated with improved prognosis and favorable responses to immunotherapy. Mechanisms that enable tumor infiltration of CD8+ T cells have not been defined, nor have drugs that assist this process been discovered. Here we address these issues with a focus on VE-cadherin, a major...

journal_title：Cancer research

authors： Zhao Y,Ting KK,Li J,Cogger VC,Chen J,Johansson-Percival A,Ngiow SF,Holst J,Grau G,Goel S,Muller T,Dejana E,McCaughan G,Smyth MJ,Ganss R,Vadas MA,Gamble JR

更新日期：2017-08-15 00:00:00

abstract：:Activated ras oncogene transfection into suitable recipient cells has been shown to induce the metastatic phenotype (Thorgeirsson, et al., Mol. Cell. Biol., 5: 259-262, 1985). We have used this model system to study the correlation of basement membrane collagenolysis with metastatic propensity. The c-Ha-ras oncogene a...

journal_title：Cancer research

authors： Garbisa S,Pozzatti R,Muschel RJ,Saffiotti U,Ballin M,Goldfarb RH,Khoury G,Liotta LA

更新日期：1987-03-15 00:00:00

abstract：:Using the phage lambdaLIZ-based transgenic in vivo mutagenesis assay, mean mutant rates were determined in the spleen of mice exposed to sustained oxidative stress and were found to be increased approximately 3-fold in plasmacytoma-susceptible BALB/c and C.D2-Idh1-Pep3 mice, but not in plasmacytoma-resistant DBA/2N mi...

journal_title：Cancer research

authors： Felix K,Kelliher K,Bornkamm GW,Janz S

更新日期：1998-04-15 00:00:00

abstract：:We showed recently that Helicobacter infection induces expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in the mouse stomach, and that transgenic mice expressing both cyclooxygenase-2 and microsomal prostaglandin E synthase-1 (K19-C2mE mice) develop hyperplastic gastric tumors with inflammatory...

journal_title：Cancer research

authors： Oshima M,Oshima H,Matsunaga A,Taketo MM

更新日期：2005-10-15 00:00:00

abstract：:Melanomas harboring BRAF mutations can be treated with BRAF inhibitors (BRAFi), but responses are varied and tumor recurrence is inevitable. Here we used an integrative approach of experimentation and mathematical flux balance analyses in BRAF-mutated melanoma cells to discover that elevated antioxidant capacity is li...

journal_title：Cancer research

authors： Paudel BB,Lewis JE,Hardeman KN,Hayford CE,Robbins CJ,Stauffer PE,Codreanu SG,Sherrod SD,McLean JA,Kemp ML,Quaranta V

更新日期：2020-10-15 00:00:00

abstract：:This study describes a novel approach to the treatment of brain tumors with the combination of recombinant L-methionine-alpha-deamino-gamma-lyase and chemotherapeutic regimens that are currently used against such tumors. The growth of Daoy, SWB77, and D-54 xenografts in athymic mice was arrested after the depletion of...

journal_title：Cancer research

authors： Kokkinakis DM,Hoffman RM,Frenkel EP,Wick JB,Han Q,Xu M,Tan Y,Schold SC

更新日期：2001-05-15 00:00:00

abstract：:The EphA2 receptor tyrosine kinase is overexpressed in many different types of human cancers where it functions as a powerful oncoprotein. Dramatic changes in the subcellular localization and function of EphA2 have also been linked with cancer, and in particular, unstable cancer cell-cell contacts prevent EphA2 from s...

journal_title：Cancer research

authors： Coffman KT,Hu M,Carles-Kinch K,Tice D,Donacki N,Munyon K,Kifle G,Woods R,Langermann S,Kiener PA,Kinch MS

更新日期：2003-11-15 00:00:00

abstract：:To better understand the events occurring during immunotherapy of liver metastases with effector cells, we have developed a clinically relevant animal model in which both effector-tumor cell interactions and survival can be evaluated. A cell line of human gastric carcinoma (HR) metastatic to the liver has been establi...

journal_title：Cancer research

authors： Yasumura S,Lin WC,Hirabayashi H,Vujanovic NL,Herberman RB,Whiteside TL

更新日期：1994-07-15 00:00:00

abstract：:The purpose of this study was to determine the effect of route of hepatic administration of drug on the regional pharmacokinetics and systemic exposure of 5-fluorouracil (FUra) and 5-bromo-2-deoxyuridine (BrdUrd). A total of 13 mixed-breed male and female dogs were used in these acute studies. Each dog was administere...

journal_title：Cancer research

authors： Kuan HY,Smith DE,Ensmiger WD,Knol JA,DeRemer SJ,Yang Z,Stetson PL

更新日期：1996-10-15 00:00:00

abstract：:A mammalian cell expression plasmid, pH beta-Aro, containing the human placenta aromatase complementary DNA was constructed. The prepared plasmid was used to transfect breast cancer cells (MCF-7), noncancerous breast cells (HBL-100), and Chinese hamster ovary cells by a stable expression method. While the maximum velo...

journal_title：Cancer research

authors： Zhou DJ,Pompon D,Chen SA

更新日期：1990-11-01 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation and class switch recombination of the immunoglobulin (IG) genes in B cells. It has recently been proposed that AID, as the newly identified DNA mutator in man, may be instrumental in initiation and progression of B-cell non-Hodgkin's ly...

journal_title：Cancer research

authors： Smit LA,Bende RJ,Aten J,Guikema JE,Aarts WM,van Noesel CJ

更新日期：2003-07-15 00:00:00

abstract：:A possible involvement of gender-dependent factors has been postulated in development of human non-small-cell lung cancers (NSCLC), but its details remain unclear. In this study, we examined biological significance of progesterone receptor in NSCLCs. Progesterone receptor immunoreactivity was detected in 106 of 228 NS...

journal_title：Cancer research

authors： Ishibashi H,Suzuki T,Suzuki S,Niikawa H,Lu L,Miki Y,Moriya T,Hayashi S,Handa M,Kondo T,Sasano H

更新日期：2005-07-15 00:00:00

abstract：:Selectins bind to carbohydrate ligands in a calcium-dependent manner and play critical roles in host defense and possibly in tumor metastasis. To isolate peptides that mimic E-selectin ligands, we screened a phage peptide library using E-selectin as a target molecule. This attempt unexpectedly failed, probably because...

journal_title：Cancer research

authors： Fukuda MN,Ohyama C,Lowitz K,Matsuo O,Pasqualini R,Ruoslahti E,Fukuda M

更新日期：2000-01-15 00:00:00

abstract：:Histopathological assessment of lymph node metastases (LNM) depends on subjective analysis of cellular morphology with inter-/intraobserver variability. In this study, LNM from esophageal adenocarcinoma was objectively detected using desorption electrospray ionization-mass spectrometry imaging (DESI-MSI). Ninety lymph...

journal_title：Cancer research

authors： Abbassi-Ghadi N,Golf O,Kumar S,Antonowicz S,McKenzie JS,Huang J,Strittmatter N,Kudo H,Jones EA,Veselkov K,Goldin R,Takats Z,Hanna GB

更新日期：2016-10-01 00:00:00

abstract：:Antiangiogenic therapies like bevacizumab offer promise for cancer treatment, but acquired resistance, which often includes an aggressive mesenchymal phenotype, can limit the use of these agents. Upregulation of β1 integrin (ITGB1) occurs in some bevacizumab-resistant glioblastomas (BRG) whereby, mediating tumor-micro...

journal_title：Cancer research

authors： Carbonell WS,DeLay M,Jahangiri A,Park CC,Aghi MK

更新日期：2013-05-15 00:00:00

abstract：:Treatment of non-T/non-B human leukemic cell line REH with 5 X 10(-9) M 12-O-tetradecanoylphorbol-13-acetate (TPA) at 37 degrees resulted in their adherence to culture flasks by 24 to 36 hr and, after 72 hr, the entire surface of the flask/coverslips became covered with macrophage-like cells containing pseudopodia. Wr...

journal_title：Cancer research

authors： Srivastava BI,Koga M,Srivastava P

更新日期：1984-07-01 00:00:00

abstract：:In this experiment, a segment of the left colon including the upper part of the rectum was transposed to the upper jejunum, and a segment of upper jejunum was transposed to the left colon of the same animal. In another group, the same colon and jejunum segments were transsected and reanastomosed in place. A third grou...

journal_title：Cancer research

authors： Celik C,Mittelman A,Paolini NS Jr,Lewis D,Evans JT

更新日期：1981-07-01 00:00:00

abstract：:Ovarian cancer is resistant to the antiproliferative effects of transforming growth factor-beta (TGF-beta); however, the mechanism of this resistance remains unclear. We used oligonucleotide arrays to profile 37 undissected, 68 microdissected advanced-stage, and 14 microdissected early-stage papillary serous cancers t...

journal_title：Cancer research

authors： Sunde JS,Donninger H,Wu K,Johnson ME,Pestell RG,Rose GS,Mok SC,Brady J,Bonome T,Birrer MJ

更新日期：2006-09-01 00:00:00