Identification of Oncogenic and Drug-Sensitizing Mutations in the Extracellular Domain of FGFR2.

abstract：:Neuroblastoma arises from the embryonal neural crest secondary to a block in differentiation. Long-term patient survival correlates inversely with the extent of differentiation, and treatment with retinoic acid or other prodifferentiation agents improves survival modestly. In this study, we show the histone chaperone ...

journal_title：Cancer research

authors： Barbieri E,De Preter K,Capasso M,Chen Z,Hsu DM,Tonini GP,Lefever S,Hicks J,Versteeg R,Pession A,Speleman F,Kim ES,Shohet JM

更新日期：2014-02-01 00:00:00

abstract：:We have previously reported that rodent tumor cell lines secrete a potent vascular permeability factor with a molecular weight of 34,000-42,000 (Senger et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science (Wash. DC), 219: 983-985, 1983). This tumor-secreted vas...

journal_title：Cancer research

authors： Senger DR,Perruzzi CA,Feder J,Dvorak HF

更新日期：1986-11-01 00:00:00

abstract：:Reported estimates of ras mutation prevalence in lung adenocarcinoma of 15-24% may be underestimates because of the insensitivity of the assays used. We have devised a rapid, non-radioactive assay for ras mutations, which detects 1 mutant allele/10(3) normal alleles and have used it to study DNA isolated from 53 lung ...

journal_title：Cancer research

authors： Mills NE,Fishman CL,Rom WN,Dubin N,Jacobson DR

更新日期：1995-04-01 00:00:00

abstract：:Tumor dormancy is a clinical phenomenon related to immune equilibrium during cancer immunoediting. The mechanisms involved in dormant metastases are poorly understood due to the lack of preclinical models. Here, we present a nontransgenic mouse model in which spontaneous metastases remain in permanent immunomediated d...

journal_title：Cancer research

authors： Romero I,Garrido C,Algarra I,Collado A,Garrido F,Garcia-Lora AM

更新日期：2014-04-01 00:00:00

abstract：:Sphingosine-1-phosphate is a potent lipid mediator formed by phosphorylation of sphingosine, a metabolite of sphingolipids, catalyzed by two sphingosine kinase (SphK) isoenzymes, SphK1 and SphK2. Expression of SphK2, which is enriched in the nucleus of MCF7 human breast cancer cells, increased expression of the cyclin...

journal_title：Cancer research

authors： Sankala HM,Hait NC,Paugh SW,Shida D,Lépine S,Elmore LW,Dent P,Milstien S,Spiegel S

更新日期：2007-11-01 00:00:00

abstract：:The inactivation of p53 functions enhances the efficiency and decreases the latency of producing induced pluripotent stem cells (iPSC) in culture. The formation of iPSCs in culture starts with a rapid set of cell divisions followed by an epigenetic reprogramming of the DNA and chromatin. The mechanisms by which the p5...

journal_title：Cancer research

authors： Yi L,Lu C,Hu W,Sun Y,Levine AJ

更新日期：2012-11-01 00:00:00

abstract：:A HeLa cell line synchronized by double thymidine block and mitotic shake off was shown to have a characteristic surface morphology for each of the different cell cycle stages. Inhibitors of cell multiplication were used to arrest cells in specific cell cycle phases, and these cells had a surface morphology similar to...

journal_title：Cancer research

authors： Lundgren E,Roos G

更新日期：1976-11-01 00:00:00

abstract：:In this study, we show that rodent albumin is expressed by and cell surface localized on at least some murine tumor cells. We have been able to purify this tumor-expressed albumin from in vivo grown tumor masses. The tumor-expressed albumin, unlike normal serum albumin purified from blood, is capable of inhibiting T-c...

journal_title：Cancer research

authors： Graner MW,Likhacheva A,Davis J,Raymond A,Brandenberger J,Romanoski A,Thompson S,Akporiaye E,Katsanis E

更新日期：2004-11-01 00:00:00

abstract：:Traditional chemotherapeutic drugs are often restricted by severe side effects and lack of tumor specificity. Peptide prodrugs cleavable by peptidases present in the tumor environment have been explored to improve the therapeutic index of cytotoxic drugs. One such prodrug of doxorubicin (Dox), CPI-0004Na [N-succinyl-b...

journal_title：Cancer research

authors： Pan C,Cardarelli PM,Nieder MH,Pickford LB,Gangwar S,King DJ,Yarranton GT,Buckman D,Roscoe W,Zhou F,Salles A,Chen TH,Horgan K,Wang YH,Nguyen T,Bebbington CR

更新日期：2003-09-01 00:00:00

abstract：:The objective of this investigation was to throw light on the biological behavior and metabolic regulation of hepatic enzymes of the nonoxidative branch of the pentose phosphate pathway. The activities of transaldolase (EC 2.2.1.2) and trasketolase (EC 2.2.1.1) Were compared in biological conditions that involve modu...

journal_title：Cancer research

authors： Heinrich PC,Morris HP,Weber G

更新日期：1976-09-01 00:00:00

abstract：:Genetic changes found in human osteogenic sarcoma cells, including loss of the p53 and Rb tumor suppressor elements and overexpression of the cyclin G1 (CYCG1) proto-oncogene, suggest the potential of gene transfer as a treatment for metastatic disease. In this study, we examined the effects of antisense cyclin G1, in...

journal_title：Cancer research

authors： Skotzko M,Wu L,Anderson WF,Gordon EM,Hall FL

更新日期：1995-12-01 00:00:00

abstract：:It has previously been shown that 6-nitrochrysene can be activated to electrophilic species capable of reacting with DNA through metabolic pathways that form N-hydroxy-6-aminochrysene or trans-1,2-dihydroxy-1,2-dihydro-6-aminochrysene as critical intermediates. Since the lung is a known target tissue for the carcinoge...

journal_title：Cancer research

authors： Delclos KB,el-Bayoumy K,Casciano DA,Walker RP,Kadlubar FF,Hecht SS,Shivapurkar N,Mandal S,Stoner GD

更新日期：1989-06-01 00:00:00

abstract：:The growth of human melanoma cells FO-1 in nude mice is strongly inhibited or even abrogated when the cells are stably transfected with a plasmid expressing an antisense RNA to the insulin-like growth factor 1 receptor (IGF-1R) RNA, which causes a marked reduction in the number of IGF-1 receptors. When a tumor arises ...

journal_title：Cancer research

authors： Resnicoff M,Coppola D,Sell C,Rubin R,Ferrone S,Baserga R

更新日期：1994-09-15 00:00:00

abstract：:The role of active oxygen species and lipid peroxidation in the antitumor effect of hyperthermia was studied in an experimental rabbit model. VX2 tumors were transplanted into rabbit hind legs, and the effect of hyperthermia on tumor growth was measured at 7 and 14 days after heating. As an index of lipid peroxidation...

journal_title：Cancer research

authors： Yoshikawa T,Kokura S,Tainaka K,Itani K,Oyamada H,Kaneko T,Naito Y,Kondo M

更新日期：1993-05-15 00:00:00

abstract：:Targeting of steroidogenic enzymes (e.g., abiraterone acetate targeting CYP17A1) has been developed as a novel therapeutic strategy against metastatic castration-resistant prostate cancer (CRPC). However, resistance to steroidal inhibitors inevitably develops in patients, the mechanisms of which remain largely unknown...

journal_title：Cancer research

authors： Xiao L,Wang Y,Xu K,Hu H,Xu Z,Wu D,Wang Z,You W,Ng CF,Yu S,Chan FL

更新日期：2018-05-01 00:00:00

abstract：:Analyses of losses of heterozygosity and linkage studies have implicated a gene(s) on chromosome 17q in the genesis of sporadic and early-onset familial breast carcinomas, respectively. To define the critical region of 17q, we examined DNAs from a series of 20 sporadic breast carcinomas and corresponding blood samples...

journal_title：Cancer research

authors： Futreal PA,Söderkvist P,Marks JR,Iglehart JD,Cochran C,Barrett JC,Wiseman RW

更新日期：1992-05-01 00:00:00

abstract：:It has been claimed that the commercially available Ki-67 monoclonal antibody recognizes a nuclear antigen which is solely expressed in cycling cells. Therefore, at present, Ki-67 is increasingly used as a tool in evaluating growth fractions (GFs) of human tumors. Here we describe specific patterns in the expression a...

journal_title：Cancer research

authors： van Dierendonck JH,Keijzer R,van de Velde CJ,Cornelisse CJ

更新日期：1989-06-01 00:00:00

abstract：:Four hundred and forty-seven human tumor specimens were accessioned and processed for clonogenic assay, yielding 374 specimens, representing 23 different histiotypes, adequate for culture. Different levels of viable cell inoculum density produced contrasting effects between 255 solid tumors as compared to 72 malignant...

journal_title：Cancer research

authors： Page RH,Tilchen EJ,Davis HL

更新日期：1988-07-15 00:00:00

abstract：:The tumorigenicity of dexamethasone-treated tissue-cultured mammary tumor cells was compared to that of untreated mammary tumor cells. The dexamethasone-induced cells progressed faster in normal syngeneic animals than did untreated mammary tumor cells. The fact that the growth rate differential was also observed in at...

journal_title：Cancer research

authors： Gillette RW,Wunderlich DA

更新日期：1978-10-01 00:00:00

abstract：:Lectin-affinity electrophoretic separation of serum alpha-fetoprotein (AFP) was carried out using AFP Differentiation Kits, which used Lens culinaris agglutinin-A (Kit L) and erythroagglutinating phytohemagglutinin (Kit P). Separated AFP bands were detected with a sensitive antibody-affinity blotting technique and det...

journal_title：Cancer research

authors： Taketa K,Endo Y,Sekiya C,Tanikawa K,Koji T,Taga H,Satomura S,Matsuura S,Kawai T,Hirai H

更新日期：1993-11-15 00:00:00

abstract：:C57BL/6J-Min/+mice (n = 56), heterozygous for a nonsense mutation in the Apc gene, were randomized at weaning to seven groups, including groups treated with piroxicam at 0, 50, 100, and 200 ppm in the AIN93G diet. After only 6 weeks of treatment, intestinal adenomas and aberrant crypt foci were counted, and serum leve...

journal_title：Cancer research

authors： Jacoby RF,Marshall DJ,Newton MA,Novakovic K,Tutsch K,Cole CE,Lubet RA,Kelloff GJ,Verma A,Moser AR,Dove WF

更新日期：1996-02-15 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TIL) are potent mediators of an antitumor response. However, their function is attenuated in solid tumors. CD8+ T-cell effector functions, such as cytokine and granzyme production, depend on cytoplasmic Ca2+, which is controlled by ion channels. In particular, Kv1.3 channels regulate th...

journal_title：Cancer research

authors： Chimote AA,Hajdu P,Sfyris AM,Gleich BN,Wise-Draper T,Casper KA,Conforti L

更新日期：2017-01-01 00:00:00

abstract：:In vivo tumor inhibitory activity of polymorphonuclear leukocytes (PMN) treated in vitro with lymphokine(s) (LK) was investigated with Winn's assay. Culture supernatants of BALB/c mouse spleen cells incubated with a streptococcal preparation, OK-432, were used as an LK source. With the use of a [3H]uridine release ass...

journal_title：Cancer research

authors： Fujii Y,Kimura S,Arai S,Sendo F

更新日期：1987-11-15 00:00:00

abstract：:Chromosomal aberrations associated with lung cancer are frequently observed in the long arm of chromosome 6. A candidate susceptibility locus at 6q23-25 for lung cancer was recently identified; however, no tumor suppressor genes inactivated by mutation have been identified in this locus. Genetic, epigenetic, gene expr...

journal_title：Cancer research

authors： Tessema M,Willink R,Do K,Yu YY,Yu W,Machida EO,Brock M,Van Neste L,Stidley CA,Baylin SB,Belinsky SA

更新日期：2008-03-15 00:00:00

abstract：:Mantle cell lymphoma (MCL) is an aggressive and incurable subtype of B-cell non-Hodgkin lymphomas. Although patients often respond initially to first-line treatment with chemotherapy plus monoclonal antibodies, relapse and decreased response to further lines of treatment eventually occurs. Harnessing the immune system...

journal_title：Cancer research

authors： Cheng F,Wang H,Horna P,Wang Z,Shah B,Sahakian E,Woan KV,Villagra A,Pinilla-Ibarz J,Sebti S,Smith M,Tao J,Sotomayor EM

更新日期：2012-09-01 00:00:00

abstract：:Blood vessels deliver oxygen and nutrients to tissues, and vascular networks are spatially organized to meet the metabolic needs for maintaining homeostasis. In contrast, the vasculature of tumors is immature and leaky, resulting in insufficient delivery of nutrients and oxygen. Vasculogenic processes occur normally i...

journal_title：Cancer research

authors： Sasajima J,Mizukami Y,Sugiyama Y,Nakamura K,Kawamoto T,Koizumi K,Fujii R,Motomura W,Sato K,Suzuki Y,Tanno S,Fujiya M,Sasaki K,Shimizu N,Karasaki H,Kono T,Kawabe J,Ii M,Yoshiara H,Kamiyama N,Ashida T,Bardeesy N,

更新日期：2010-08-01 00:00:00

abstract：:High levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type p53 allele, suggesting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. To test this hypothesis in vivo, we generated transgenic mice with widespread expression of Mdm4. Two independe...

journal_title：Cancer research

authors： Xiong S,Pant V,Suh YA,Van Pelt CS,Wang Y,Valentin-Vega YA,Post SM,Lozano G

更新日期：2010-09-15 00:00:00

abstract：:Inactivation of p53 signaling by mutation of p53 itself or abrogation of its normal function by other transfactors, such as MDM2, is a key event in the development of most human cancers. To identify novel regulators of p53, we have used a phenotype-based selection in which a total cDNA library in a retroviral vector h...

journal_title：Cancer research

authors： Agarwal MK,Ruhul Amin AR,Agarwal ML

更新日期：2007-01-01 00:00:00

abstract：:The estrogen receptor (ER) is a nuclear protein with a hormone- and a DNA-binding domain. We examined the DNA binding of ER in MCF-7 cells and 79 primary breast cancers by gel mobility shift assay using as a probe the estrogen response element (ERE). The mobility shift assay showed saturable, specific binding of ER to...

journal_title：Cancer research

authors： Foster BD,Cavener DR,Parl FF

更新日期：1991-07-01 00:00:00

abstract：:Smad3, a major intracellular mediator of TGFβ signaling, functions as both a positive and negative regulator in carcinogenesis. In response to TGFβ, the TGFβ receptor phosphorylates serine residues at the Smad3 C-tail. Cancer cells often contain high levels of the MAPK and CDK activities, which can lead to the Smad3 l...

journal_title：Cancer research

authors： Bae E,Sato M,Kim RJ,Kwak MK,Naka K,Gim J,Kadota M,Tang B,Flanders KC,Kim TA,Leem SH,Park T,Liu F,Wakefield LM,Kim SJ,Ooshima A

更新日期：2014-11-01 00:00:00