Abstract：
:In this study, we show that rodent albumin is expressed by and cell surface localized on at least some murine tumor cells. We have been able to purify this tumor-expressed albumin from in vivo grown tumor masses. The tumor-expressed albumin, unlike normal serum albumin purified from blood, is capable of inhibiting T-cell activation, proliferation, and function in both in vitro and in vivo settings. Tumor-expressed albumin does not appear to affect antigen processing or presentation by professional antigen-presenting cells. The activity appears to lie in relatively small, lipid-like moieties that are presumably cargo for tumor-expressed albumin, and that activity can be removed from the albumin by lipid removal or treatment with lipase. Thus, we herein report of a novel form of tumor-induced immune suppression attributable to lipid-like entities, cloaked by albumin produced by tumors.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Graner MW,Likhacheva A,Davis J,Raymond A,Brandenberger J,Romanoski A,Thompson S,Akporiaye E,Katsanis Edoi
10.1158/0008-5472.CAN-04-1871subject
Has Abstractpub_date
2004-11-01 00:00:00pages
8085-92issue
21eissn
0008-5472issn
1538-7445pii
64/21/8085journal_volume
64pub_type
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