Quantitative changes in adenosine deaminase isoenzymes in human colorectal adenocarcinomas.

abstract：:Carcinomas of the exocrine pancreas are poorly understood and have a poor prognosis because of their highly malignant nature. Using two human pancreatic cancer cell lines, AsPc-1 and Capan-2, we have investigated avenues that might be useful in targeting the delivery of antineoplastic agents to such cancers. Qualitati...

journal_title：Cancer research

authors： Gonzalez DE,Covitz KM,Sadée W,Mrsny RJ

更新日期：1998-02-01 00:00:00

abstract：:Members of the INK4 family of cyclin-dependent kinase (CDK) inhibitors specifically bind and inhibit the G1-specific CDK molecules CDK4 and CDK6. One of the INK4 molecules, p16, is also known as multiple tumor suppressor and has been found to be mutated or deleted in various tumors and cell lines. We have previously i...

journal_title：Cancer research

authors： Noh SJ,Li Y,Xiong Y,Guan KL

更新日期：1999-02-01 00:00:00

abstract：:We have identified a human placenta cDNA coding for a new member of the matrix metalloproteinase (MMP) family. The isolated cDNA encodes a polypeptide of 261 amino acids, the smallest MMP identified to date, which contains several structural features of MMPs including the signal sequence, the prodomain involved in enz...

journal_title：Cancer research

authors： Uría JA,López-Otín C

更新日期：2000-09-01 00:00:00

abstract：:Cancer is associated with a prothrombogenic state capable of platelet activation. Platelets, on the other hand, can support angiogenesis, a process involved in the progression of tumor growth and metastasis. However, it is unclear whether platelet/tumor interactions substantially contribute to tumor physiology. We inv...

journal_title：Cancer research

authors： Ho-Tin-Noé B,Goerge T,Cifuni SM,Duerschmied D,Wagner DD

更新日期：2008-08-15 00:00:00

abstract：:In an attempt to develop better combination therapies for use with local radiation, the interaction between bleomycin and hyperthermia +/- radiation was studied in the FSaIIC tumor system. In cells exposed in vitro to bleomycin at 37 degrees C and at pH 7.40, the drug was substantially more toxic toward normally oxyge...

journal_title：Cancer research

authors： Teicher BA,Herman TS,Holden SA

更新日期：1988-11-15 00:00:00

abstract：:Creation of a nuclear export signal (NES) motif and loss of tryptophans (W) 288 and 290 (or 290 only) at the COOH terminus of nucleophosmin (NPM) are both crucial for NPM aberrant cytoplasmic accumulation in acute myelogenous leukemia (AML) carrying NPM1 mutations. Hereby, we clarify how these COOH-terminal alteration...

journal_title：Cancer research

authors： Bolli N,Nicoletti I,De Marco MF,Bigerna B,Pucciarini A,Mannucci R,Martelli MP,Liso A,Mecucci C,Fabbiano F,Martelli MF,Henderson BR,Falini B

更新日期：2007-07-01 00:00:00

abstract：:MLK3 kinase activates multiple mitogen-activated protein kinases and plays a critical role in cancer cell migration and invasion. In the tumor microenvironment, prometastatic factors drive breast cancer invasion and metastasis, but their associated signaling pathways are not well-known. Here, we provide evidence that ...

journal_title：Cancer research

authors： Chen J,Gallo KA

更新日期：2012-08-15 00:00:00

abstract：:The effect of dietary orotic acid (OA) in liver-pancreas carcinogenesis induced in female Syrian hamsters by N-Nitroso(2-hydroxypropyl) (2-oxopropyl)amine (HPOP) was evaluated. All animals infused with the carcinogen received the same doses. Results of the control group which received no OA or carcinogen were compared...

journal_title：Cancer research

authors： Kokkinakis DM,Albores-Saavedra J

更新日期：1994-10-15 00:00:00

abstract：:Sentinel lymph nodes set the stance of the immune system to a localized tumor and are often the first site to be colonized by neoplastic cells that metastasize. To investigate how the presence of neoplastic cells in sentinel lymph nodes may trigger pathways associated with metastatic progression, we analyzed the trans...

journal_title：Cancer research

authors： Vallacchi V,Vergani E,Camisaschi C,Deho P,Cabras AD,Sensi M,De Cecco L,Bassani N,Ambrogi F,Carbone A,Crippa F,Vergani B,Frati P,Arienti F,Patuzzo R,Villa A,Biganzoli E,Canevari S,Santinami M,Castelli C,Rivoltini L

更新日期：2014-01-01 00:00:00

abstract：:The most deadly phase in cancer progression is attributed to the inappropriate acquisition of molecular machinery leading to metastatic transformation and spread of disease to distant organs. Although it is appreciated that metastasis involves epithelial-mesenchymal interplay, the underlying mechanism defining this pr...

journal_title：Cancer research

authors： Powell AE,Anderson EC,Davies PS,Silk AD,Pelz C,Impey S,Wong MH

更新日期：2011-02-15 00:00:00

abstract：:3,4-Dihydro-2,2-dimethyl-2H-naptho[1,2,-b]pyran-5,6-dione (beta-lapachone) is a novel DNA repair inhibitor. It was tested for synergistic X-ray-induced lethality in combination with several halogenated pyrimidine radiosensitizers. Logarithmic-phase growing human epidermoid laryngeal carcinoma (HEp-2) cells were allowe...

journal_title：Cancer research

authors： Boothman DA,Greer S,Pardee AB

更新日期：1987-10-15 00:00:00

abstract：:Thirty patients with cisplatin-refractory germ cell tumor were treated with high-dose carboplatin, etoposide, and cyclophosphamide and autologous bone marrow transplantation. The total dose of carboplatin was 1500 mg/m2, etoposide 1200 mg/m2, and cyclophosphamide was increased by increments from 60 to 150 mg/kg. Twent...

journal_title：Cancer research

authors： Motzer RJ,Gulati SC,Tong WP,Menendez-Botet C,Lyn P,Mazumdar M,Vlamis V,Lin S,Bosl GJ

更新日期：1993-08-15 00:00:00

abstract：:Three loci have been implicated in the etiology of familial breast cancer; the BRCA1 locus on 17q, the p53 gene on 17p, and the androgen receptor gene on the X chromosome. However, it has been estimated that in approximately 50% of all breast cancer families the predisposing genetic defect is not linked to any of thes...

journal_title：Cancer research

authors： Lindblom A,Skoog L,Rotstein S,Werelius B,Larsson C,Nordenskjöld M

更新日期：1993-09-15 00:00:00

abstract：:Plasma membrane preparations from Chinese hamster lung cells, which are resistant to the antitumor agent Adriamycin, were analyzed using fluorescence polarization of the membrane lipid probe trans-parinaric acid. The results of these studies reveal that membranes from several drug-resistant isolates have a substantial...

journal_title：Cancer research

authors： Rintoul DA,Center MS

更新日期：1984-11-01 00:00:00

abstract：:Chromosomal rearrangements involving receptor tyrosine kinases (RTK) are a clinically relevant oncogenic mechanism in human cancers. These chimeric oncoproteins often contain the C-terminal kinase domain of the RTK joined in cis to various N-terminal, nonkinase fusion partners. The functional role of the N-terminal fu...

journal_title：Cancer research

authors： Neel DS,Allegakoen DV,Olivas V,Mayekar MK,Hemmati G,Chatterjee N,Blakely CM,McCoach CE,Rotow JK,Le A,Karachaliou N,Rosell R,Riess JW,Nichols R,Doebele RC,Bivona TG

更新日期：2019-02-01 00:00:00

abstract：:We tried to purify carcinoembryonic antigen (CEA)-related antigens in normal human feces and found that, besides nonspecific cross-reacting antigen (fecal NCA), there are three other molecular species of CEA-related antigens which have been inclusively called normal fecal antigen (NFA). These were designated normal fe...

journal_title：Cancer research

authors： Kuroki M,Koga Y,Matsuoka Y

更新日期：1981-02-01 00:00:00

abstract：:The effect of an i.p. injection of glucose on the thermal response of murine tissues was studied. Animal tumors were early generation isotransplants of a spontaneous fibrosarcoma, FSa-II. Tumors were transplanted into the foot pad, and hyperthermia was given by immersing the foot into a constant-temperature water bath...

journal_title：Cancer research

authors： Urano M,Montoya V,Booth A

更新日期：1983-02-01 00:00:00

abstract：:Motility related protein-1 (MRP-1) is a transmembrane glycoprotein that is identical to the CD9 antigen. In previous studies, we showed that various types of cultured tumor cells transfected with MRP-1/CD9 cDNA have low motility and diminished metastatic potential to the lung. More recently we used immunohistochemical...

journal_title：Cancer research

authors： Higashiyama M,Taki T,Ieki Y,Adachi M,Huang CL,Koh T,Kodama K,Doi O,Miyake M

更新日期：1995-12-15 00:00:00

abstract：:Kras is a decisive oncogene in pancreatic ductal adenocarcinoma (PDAC). PIN1 is a key effector involved in the Kras/ERK axis, synergistically mediating various cellular events. However, the underlying mechanism by which PIN1 promotes the development of PDAC remains unclear. Here we sought to elucidate the effect of PI...

journal_title：Cancer research

authors： Liang C,Shi S,Liu M,Qin Y,Meng Q,Hua J,Ji S,Zhang Y,Yang J,Xu J,Ni Q,Li M,Yu X

更新日期：2019-01-01 00:00:00

abstract：:Although initially reported as an androgen-repressed gene in the rat prostate, the functional role of testosterone-repressed prostate message-2 (TRPM-2) in apoptosis remains undefined. Inhibition of castration-induced apoptosis by calcium channel blocker treatment in androgen-dependent Shionogi tumors resulted in the ...

journal_title：Cancer research

authors： Miyake H,Nelson C,Rennie PS,Gleave ME

更新日期：2000-01-01 00:00:00

abstract：:A cell line derived from early passage of a transplantable tumor in athymic mice that initially had been injected with human breast adenocarcinoma cells produced a substantial amount of RNA sequences related to the Kirsten murine leukemia virus. The cell line derived from later passage of transplantation of these tumo...

journal_title：Cancer research

authors： Kuo MT,Sen S,Teeter L,Cailleau RM,Knesek JE,Bowen J

更新日期：1984-08-01 00:00:00

abstract：:: Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer cells into the cell-cycle plays an important role in cancer recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complementary mechanisms to promote cancer cell quiescence by facilitating stabilizat...

journal_title：Cancer research

authors： La T,Liu GZ,Farrelly M,Cole N,Feng YC,Zhang YY,Sherwin SK,Yari H,Tabatabaee H,Yan XG,Guo ST,Liu T,Thorne RF,Jin L,Zhang XD

更新日期：2018-12-01 00:00:00

abstract：:Tumor production of parathyroid hormone-related protein (PTHRP) is responsible for most cases of hypercalcemia of malignancy. The transplantable rat Leydig tumor H-500 is known to cause hypercalcemia in rats by the release of abundant PTHRP and to closely reproduce the human syndrome. We have demonstrated recently tha...

journal_title：Cancer research

authors： Aklilu F,Gladu J,Goltzman D,Rabbani SA

更新日期：2000-03-15 00:00:00

abstract：:In an attempt to identify phytochemicals contributing to the well-documented preventive effect of plant-based diets on cancer incidence and mortality, we have previously shown that certain flavonoids inhibit in vitro angiogenesis. Here, we show that the flavonoid luteolin inhibited tumor growth and angiogenesis in a m...

journal_title：Cancer research

authors： Bagli E,Stefaniotou M,Morbidelli L,Ziche M,Psillas K,Murphy C,Fotsis T

更新日期：2004-11-01 00:00:00

abstract：:To investigate the mechanisms underlying contraction of the stomach wall in cases of gastric scirrhous carcinoma, we have developed an in vitro model for gastric cancer, in which both fibroblasts and gastric carcinoma cells are embedded within a collagen matrix. Gastric carcinoma cells of the scirrhous type (KATO-III)...

journal_title：Cancer research

authors： Ura H,Obara T,Yokota K,Shibata Y,Okamura K,Namiki M

更新日期：1991-07-01 00:00:00

abstract：:CTLA4 is a cell surface receptor on T cells that functions as an immune checkpoint molecule to enforce tolerance to cognate antigens. Anti-CTLA4 immunotherapy is highly effective at reactivating T-cell responses against melanoma, which is postulated to be due to targeting CTLA4 on T cells. Here, we report that CTLA4 i...

journal_title：Cancer research

authors： Mo X,Zhang H,Preston S,Martin K,Zhou B,Vadalia N,Gamero AM,Soboloff J,Tempera I,Zaidi MR

更新日期：2018-01-15 00:00:00

abstract：:We have studied the effects of low-power-density microwave (MW) radiation (continuous and pulsed wave with average power density of 10 milliwatts/sq cm and range of 5 to 50 milliwatts/sq cm; frequency, 1.0 GHz) on the uptake and action of methotrexate (MTX), the inhibition of DNA synthesis in L1210 murine leukemia cel...

journal_title：Cancer research

authors： Chang BK,Huang AT,Joines WT

更新日期：1980-04-01 00:00:00

abstract：:Mutations in the ret proto-oncogene constitute the germ line defect in patients with inherited forms of medullary thyroid carcinoma (MTC) and are also present in tumor DNA from a subset of patients with sporadic forms of MTC. We now show that the TT cell line of human MTC can be induced within 48 h to resemble mature ...

journal_title：Cancer research

authors： Carson EB,McMahon M,Baylin SB,Nelkin BD

更新日期：1995-05-15 00:00:00

abstract：:Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer and is phenotypically distinct from other forms of locally advanced breast cancer. In a previous study, we identified specific genetic alterations of IBC that could account for a highly invasive phenotype. RhoC GTPase was overexpressed in 90...

journal_title：Cancer research

authors： van Golen KL,Wu ZF,Qiao XT,Bao LW,Merajver SD

更新日期：2000-10-15 00:00:00

abstract：:To evaluate the role of chronic inflammation in the development of gallstones and biliary tract cancer, we examined the risk associated with 62 single nucleotide polymorphisms (SNPs), in 22 inflammation-related genes, in a population-based case-control study conducted in Shanghai, China, where the incidence of biliary...

journal_title：Cancer research

authors： Hsing AW,Sakoda LC,Rashid A,Andreotti G,Chen J,Wang BS,Shen MC,Chen BE,Rosenberg PS,Zhang M,Niwa S,Chu L,Welch R,Yeager M,Fraumeni JF Jr,Gao YT,Chanock SJ

更新日期：2008-08-01 00:00:00