An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2.

abstract：:When nitric oxide (NO) is produced at micromolar concentrations, as during inflammation, exposure to surrounding cells is potentially cytotoxic. The NO-dependent signaling pathways that initiate cell death are thought to involve the tumor suppressor protein p53, but the degree to which this factor contributes to NO-in...

journal_title：Cancer research

authors： McLaughlin LM,Demple B

更新日期：2005-07-15 00:00:00

abstract：:When the human cell line NHIK 3025 was exposed to retinoic acid (1 nM; 10 microM), the cell cycle time was prolonged. Experiments using cells synchronized by mitotic selection showed that the retinoic acid induced growth delay was barely seen within the first cell cycle after exposure to 10 microM retinoic acid, where...

journal_title：Cancer research

authors： Bakke O

更新日期：1986-03-01 00:00:00

abstract：:Breast tumor cytosol has been analyzed for the presence of a progesterone-binding protein (PBCP), commonly present in benign breast cysts in huge concentrations. In 377 primary carcinoma investigated PBCP was present in measurable quantities in 60.7% using "rocket" immunoelectrophoresis. Concentrations of PBCP ranged ...

journal_title：Cancer research

authors： Lea OA,Kvinnsland S,Thorsen T

更新日期：1987-12-01 00:00:00

abstract：:Mortality or incidence rates of ten major neoplasms in migrants from several countries, their respective countries of origin, their American-born offspring, and United States whites were compared. Rates in succeeding generations of Americans increased most rapidly for colon cancer and most slowly for breast cancer, wi...

journal_title：Cancer research

authors： Thomas DB,Karagas MR

更新日期：1987-11-01 00:00:00

abstract：:The development of toxicity to 4'-demethylepipodophyllotoxin-9-(4,6,-O-thenylidene-beta-glucopyranoside) an epipodophyllotoxin with oncolytic activity, was characterized in mice treated three times at 3-day intervals with 10 mg of drug i.p. per kg of body weight. Changes in organ function and general metabolism were d...

journal_title：Cancer research

authors： Hacker M,Roberts DW

更新日期：1975-07-01 00:00:00

abstract：:A new type of monoclonal antibody (mAb)-based, highly specific phototherapy (photoimmunotherapy; PIT) that uses a near infrared (NIR) phthalocyanine dye, IRDye700DX (IR700) conjugated with a mAb, has recently been described. NIR light exposure leads to immediate, target-selective necrotic cell death in vitro. Detectin...

journal_title：Cancer research

authors： Nakajima T,Sano K,Mitsunaga M,Choyke PL,Kobayashi H

更新日期：2012-09-15 00:00:00

abstract：:The tropism of breast cancer cells for bone and their tendency to induce an osteolytic phenotype are a result of interactions between breast cancer cells and stromal cells and are of paramount importance for bone metastasis. However, the underlying molecular mechanisms remain poorly understood. We hypothesize that tum...

journal_title：Cancer research

authors： Nannuru KC,Futakuchi M,Varney ML,Vincent TM,Marcusson EG,Singh RK

更新日期：2010-05-01 00:00:00

abstract：:Activity increase of the cytosolic isozyme of thymidine kinase (TK) in resected specimens of lung tumor patients would be a useful marker for tumor malignancy and prognosis. In 24 resected cases of malignant lung tumors, the whole enzyme extracts of the tumorous part of the specimens showed that the activities of TK, ...

journal_title：Cancer research

authors： Yusa T,Yamaguchi Y,Ohwada H,Hayashi Y,Kuroiwa N,Morita T,Asanagi M,Moriyama Y,Fujimura S

更新日期：1988-09-01 00:00:00

abstract：:Overexpression of the polycomb group protein enhancer of zeste homologue 2 (EZH2) occurs in diverse malignancies, including prostate cancer, breast cancer, and glioblastoma multiforme (GBM). Based on its ability to modulate transcription of key genes implicated in cell cycle control, DNA repair, and cell differentiati...

journal_title：Cancer research

authors： Suvà ML,Riggi N,Janiszewska M,Radovanovic I,Provero P,Stehle JC,Baumer K,Le Bitoux MA,Marino D,Cironi L,Marquez VE,Clément V,Stamenkovic I

更新日期：2009-12-15 00:00:00

abstract：:The increase of interleukin-4 (IL-4) level in tumor environment and the up-regulation of IL-4 receptor (IL-4R) on tumor cells have been long observed. However, their significance for tumor development has not been investigated. Here, we found that endogenous IL-4 promotes tumor growth because neutralizing IL-4 by 11B1...

journal_title：Cancer research

authors： Li Z,Jiang J,Wang Z,Zhang J,Xiao M,Wang C,Lu Y,Qin Z

更新日期：2008-11-01 00:00:00

abstract：:ADAMTS metalloprotease family member ADAMTS9 maps to 3p14.2 and shows significant associations with the aerodigestive tract cancers esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). However, the functional impact of ADAMTS9 on cancer development has not been explored. In this study, we eval...

journal_title：Cancer research

authors： Lo PH,Lung HL,Cheung AK,Apte SS,Chan KW,Kwong FM,Ko JM,Cheng Y,Law S,Srivastava G,Zabarovsky ER,Tsao SW,Tang JC,Stanbridge EJ,Lung ML

更新日期：2010-07-01 00:00:00

abstract：:The mechanism(s) by which high-linear energy transfer a particles, like those emitted by inhaled radon and radon daughters, cause lung cancer has not been elucidated. Conceivably, DNA damage that is induced by a particles may be mediated by the metabolic generation of reactive oxygen species (ROS), in addition to dire...

journal_title：Cancer research

authors： Narayanan PK,Goodwin EH,Lehnert BE

更新日期：1997-09-15 00:00:00

abstract：:A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance of KB 8-5 and KB 8-5-11 human epidermoid carcinoma cells in vitro but did not potentiate drug toxicity in drug-sensitiv...

journal_title：Cancer research

authors： Coon JS,Knudson W,Clodfelter K,Lu B,Weinstein RS

更新日期：1991-02-01 00:00:00

abstract：:Cells that overexpress high-mobility group A1 (HMGA1) proteins exhibit deficient nucleotide excision repair (NER) after exposure to DNA-damaging agents, a condition ameliorated by artificially lowering intracellular levels of these nonhistone proteins. One possible mechanism for this NER inhibition is down-regulation ...

journal_title：Cancer research

authors： Adair JE,Maloney SC,Dement GA,Wertzler KJ,Smerdon MJ,Reeves R

更新日期：2007-07-01 00:00:00

abstract：:Hexosaminidase activity in prostatic tissue has been compared in 15 patients with benign prostatic hyperplasia and 15 patients with prostatic carcinoma. The ratio of enzymatic activity for the two substrates tested (p-nitrophenyl-2-acetamido-2-deoxy-beta-D-glucopyranoside and p-nitrophenyl-2-acetamido-2-deoxy-beta-D-g...

journal_title：Cancer research

authors： Whitehurst GB,Mashburn JP,Pretlow TG 2nd,Bradley EL Jr,Boohaker EA

更新日期：1982-10-01 00:00:00

abstract：:A novel, substituted 4-quinolinecarboxylic acid (NSC 339768) demonstrated antitumor activity against L1210 leukemia and B16 melanoma in the National Cancer Institute's Developmental Therapeutics Program. An extensive analogue synthesis program was initiated; over 200 derivatives were synthesized and tested for antican...

journal_title：Cancer research

authors： Dexter DL,Hesson DP,Ardecky RJ,Rao GV,Tippett DL,Dusak BA,Paull KD,Plowman J,DeLarco BM,Narayanan VL

更新日期：1985-11-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are lysophospholipid mediators of diverse cellular processes important for cancer progression. S1P is produced by two sphingosine kinases, SphK1 and SphK2. Expression of SphK1 is elevated in many cancers. Here, we report that LPA markedly enhanced SphK1 mRN...

journal_title：Cancer research

authors： Shida D,Fang X,Kordula T,Takabe K,Lépine S,Alvarez SE,Milstien S,Spiegel S

更新日期：2008-08-15 00:00:00

abstract：:Forty patients with relapsed (26) or refractory (14) myeloma were treated with epirubicin of doses of 75, 90, 105, and 120 mg/m2 in groups of 6 or more patients to test for response, maximum tolerated dose, and toxicity. Thirteen patients had received prior doxorubicin and were included in the dose findings part of th...

journal_title：Cancer research

authors： Case DC Jr,Ervin TJ,Gams R,Sonneborn HL,Paul SD,Oldham FB

更新日期：1988-11-01 00:00:00

abstract：:Using alternative reading frames, the human ARF-INK4a locus encodes two unrelated proteins that both function in tumor suppression. p16(INK4a) maintains the retinoblastoma protein in its growth-suppressive state through inhibition of cyclin D-dependent kinase activity, whereas ARF binds with MDM2 and stabilizes p53. T...

journal_title：Cancer research

authors： Yarbrough WG,Bessho M,Zanation A,Bisi JE,Xiong Y

更新日期：2002-02-15 00:00:00

abstract：:Elimination of both alleles of the gene that encodes the cyclin kinase inhibitor p21(WAF1/cip1) increases the frequency and size of intestinal tumors in Apc1638+/- mice that inherit a mutant allele of the Apc gene, and intermediate effects are seen if a single p21 allele is inactivated. The increased tumor formation i...

journal_title：Cancer research

authors： Yang WC,Mathew J,Velcich A,Edelmann W,Kucherlapati R,Lipkin M,Yang K,Augenlicht LH

更新日期：2001-01-15 00:00:00

abstract：:A monoclonal antibody, CSTO-1, has been produced against a stomach adenocarcinoma-associated antigen. The antibody is cytotoxic to stomach, colon, and lung adenocarcinoma lines but is completely noncytotoxic to normal blood elements and leukemic cell lines. The monoclonal antibody reacts with tumor cell membranes in e...

journal_title：Cancer research

authors： Togashi H,Terasaki PI,Chia D,Kukes G,Mugishima H,Kasai K,Suyama N,Fukushima K,Hirota M

更新日期：1984-09-01 00:00:00

abstract：:We examined patterns of covalent modifications of DNA produced in rat liver after exposure to single and multiple doses of aflatoxin B1. The principal product, previously identified as 2,3-dihydro-3-hydroxy(N7-guanyl) aflatoxin B1, was removed rapidly from liver DNA in vivo after a 0.6-mg/kg dose was administered i.p....

journal_title：Cancer research

authors： Croy RG,Wogan GN

更新日期：1981-01-01 00:00:00

abstract：:Laminin (LN)-5, a heterotrimer of alpha3, beta3, and gamma2 chains, has been suggested to be involved in tumor cell invasion. The present immunohistochemical study investigated the distribution of the LN gamma2 chain in 48 different human gastric adenocarcinomas. The immunohistochemical analysis showed two distinct pa...

journal_title：Cancer research

authors： Koshikawa N,Moriyama K,Takamura H,Mizushima H,Nagashima Y,Yanoma S,Miyazaki K

更新日期：1999-11-01 00:00:00

abstract：:CD38 is a leukocyte differentiation antigen that has been thought to be a phenotypic marker of different subpopulations of T- and B-lymphocytes. In myeloid cells, CD38 is expressed during early stages of differentiation. Virtually no information is available on regulation and functions of CD38. Recently we reported th...

journal_title：Cancer research

authors： Drach J,McQueen T,Engel H,Andreeff M,Robertson KA,Collins SJ,Malavasi F,Mehta K

更新日期：1994-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) was thought historically to arise from hepatocytes, but gene expression studies have suggested that it can also arise from fetal progenitor cells or their adult progenitor progeny. Here, we report the identification of a unique population of fetal liver progenitor cells in mice that can ...

journal_title：Cancer research

authors： Mokkapati S,Niopek K,Huang L,Cunniff KJ,Ruteshouser EC,deCaestecker M,Finegold MJ,Huff V

更新日期：2014-08-15 00:00:00

abstract：:The issue of resistance to targeted drug therapy is of pressing concern, as it constitutes a major barrier to progress in managing cancer. One important aspect is the role of stochasticity in determining the nature of the patient response. We examine two particular experiments. The first measured the maximal response ...

journal_title：Cancer research

authors： Kessler DA,Austin RH,Levine H

更新日期：2014-09-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is an aggressive clinical subtype accounting for up to 20% of all breast cancers, but its malignant determinants remain largely undefined. Here, we show that in TNBC the overexpression of Fra-1, a component of the transcription factor AP-1, offers prognostic potential. Fra-1 deplet...

journal_title：Cancer research

authors： Zhao C,Qiao Y,Jonsson P,Wang J,Xu L,Rouhi P,Sinha I,Cao Y,Williams C,Dahlman-Wright K

更新日期：2014-07-15 00:00:00

abstract：:For two decades, the antigen recognized by the Pathologische Anatomie Leiden-Endothelium (PAL-E) monoclonal antibody, a standard vascular endothelial cell marker, has remained elusive. Here, we used a combinatorial phage display-based approach ("epitope mapping") to select peptides binding to the original PAL-E antibo...

journal_title：Cancer research

authors： Jaalouk DE,Ozawa MG,Sun J,Lahdenranta J,Schlingemann RO,Pasqualini R,Arap W

更新日期：2007-10-15 00:00:00

abstract：:The influence of microtubule-associated proteins on the interaction of vincristine with microtubules and tubulin was examined. Microtubules containing associated proteins were prepared in vitro from tubulin preparations which contained the proteins or from pure 6S tubulin and isolated microtubule-associated proteins. ...

journal_title：Cancer research

authors： Donoso JA,Haskins KM,Himes RH

更新日期：1979-05-01 00:00:00

abstract：:Recent studies have indicated that angiogenesis may be regulated, in part, by p53 tumor suppressor gene function. We hypothesized that wild-type p53 replacement would down-regulate vascular endothelial growth factor (VEGF) expression and inhibit angiogenesis. KM12L4 and SW620, human colon cancer cell lines with p53 mu...

journal_title：Cancer research

authors： Bouvet M,Ellis LM,Nishizaki M,Fujiwara T,Liu W,Bucana CD,Fang B,Lee JJ,Roth JA

更新日期：1998-06-01 00:00:00