The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1.

abstract：:Invasion and metastasis are the hallmarks of malignant tumor progression and the main cause of death in cancer. The embryonic program "epithelial-mesenchymal transition" (EMT) is thought to trigger invasion by allowing tumor cell dissemination. Here, we describe that the EMT-inducing transcriptional repressor ZEB1 pro...

journal_title：Cancer research

authors： Spaderna S,Schmalhofer O,Wahlbuhl M,Dimmler A,Bauer K,Sultan A,Hlubek F,Jung A,Strand D,Eger A,Kirchner T,Behrens J,Brabletz T

更新日期：2008-01-15 00:00:00

abstract：:The alternative reading frame (ARF) tumor suppressor mediates growth arrest or apoptosis through activation of the p53 tumor suppressor. A prevailing concept is that ARF uses p21Cip1/Waf1, a p53-responsive gene and cyclin-dependent kinase (Cdk) inhibitor, to block cell cycle progression. Using p21 nullizygous cells, w...

journal_title：Cancer research

authors： Modestou M,Puig-Antich V,Korgaonkar C,Eapen A,Quelle DE

更新日期：2001-04-01 00:00:00

abstract：:Human and mouse paralogues of the evolutionarily conserved mammalian HRAD9 and Mrad9 cell cycle checkpoint control genes have been isolated and called HRAD9B and Mrad9B, respectively. HRAD9B encodes a protein that is 414 amino acids long and is 55% similar and 35% identical to the HRAD9 gene product. The Mrad9B protei...

journal_title：Cancer research

authors： Hopkins KM,Wang X,Berlin A,Hang H,Thaker HM,Lieberman HB

更新日期：2003-09-01 00:00:00

abstract：:The immune system is a robust and often untapped accomplice of many standard cancer therapies. A majority of tumors exist in a state of immune tolerance where the patient's immune system has become insensitive to the cancer cells. Because of its lymphodepleting effects, chemotherapy has the potential to break this tol...

journal_title：Cancer research

authors： Park DS,Robertson-Tessi M,Luddy KA,Maini PK,Bonsall MB,Gatenby RA,Anderson ARA

更新日期：2019-10-15 00:00:00

abstract：:The clinical effects and pharmacokinetics of high-dose uridine were determined in seven patients with advanced-stage cancer and in one healthy volunteer. Uridine was also examined for its effect on 5-fluorouracil toxicity in two patients. Uridine was administered as a 1-hr i.v. infusion at doses of 1 to 12 g/sq m. Pla...

journal_title：Cancer research

authors： Leyva A,van Groeningen CJ,Kraal I,Gall H,Peters GJ,Lankelma J,Pinedo HM

更新日期：1984-12-01 00:00:00

abstract：:Radiation therapy combined with adjuvant hyperthermia has the potential to provide outstanding local-regional control for refractory disease. However, achieving therapeutic thermal dose can be problematic. In the current investigation, we used a chemistry-driven approach with the goal of designing and synthesizing nov...

journal_title：Cancer research

authors： Sekhar KR,Sonar VN,Muthusamy V,Sasi S,Laszlo A,Sawani J,Horikoshi N,Higashikubo R,Bristow RG,Borrelli MJ,Crooks PA,Lepock JR,Roti Roti JL,Freeman ML

更新日期：2007-01-15 00:00:00

abstract：:Successful treatment of many patients with osteosarcoma requires more effective chemotherapy. Since new agents are needed, we have developed an immunotoxin using TP-3, an IgG2b mAb which recognizes human and canine osteosarcomas and budding capillaries of tumors. The plant hemitoxin, pokeweed antiviral protein (PAP), ...

journal_title：Cancer research

authors： Anderson PM,Meyers DE,Hasz DE,Covalcuic K,Saltzman D,Khanna C,Uckun FM

更新日期：1995-03-15 00:00:00

abstract：:A large proportion of human tumor-derived cell lines and primary tumor cells show methionine-dependent growth. This phenomenon refers to the ability of cells to grow in media containing methionine and the inability of cells to grow in media supplemented with methionine's precursor, homocysteine (Hcy). Methionine can b...

journal_title：Cancer research

authors： Tang B,Li YN,Kruger WD

更新日期：2000-10-01 00:00:00

abstract：:To better understand immune responses to brain tumors and to develop possible approaches for immunotherapy, we have investigated the leukocyte populations infiltrating the rat 9L gliosarcoma. By immunocytochem-ical analyses of the cells infiltrating the tumor, we observed a substantial number of cells expressing natur...

journal_title：Cancer research

authors： Chambers WH,Bozik ME,Brissette-Storkus SC,Basse P,Redgate E,Watkins S,Boggs SS

更新日期：1996-08-01 00:00:00

abstract：:The expression of epidermal growth factor receptor and transglutaminase type I, polyamine (putrescine, spermidine, and spermine) levels, ornithine decarboxylase activity, and micronuclei occurrence were assessed in the 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch model to elucidate the role and t...

journal_title：Cancer research

authors： Shin DM,Gimenez IB,Lee JS,Nishioka K,Wargovich MJ,Thacher S,Lotan R,Slaga TJ,Hong WK

更新日期：1990-04-15 00:00:00

abstract：:Disease recurrence and metastasis are frequently observed in many successfullytreated localized cancers, including hepatocellular carcinoma in which intrahepatic and extrahepatic recurrence (metastasis) are frequently observed after curative resection. The present study aimed at identifying metastasis-associated genes...

journal_title：Cancer research

authors： Cheung ST,Chen X,Guan XY,Wong SY,Tai LS,Ng IO,So S,Fan ST

更新日期：2002-08-15 00:00:00

abstract：:Kras is a decisive oncogene in pancreatic ductal adenocarcinoma (PDAC). PIN1 is a key effector involved in the Kras/ERK axis, synergistically mediating various cellular events. However, the underlying mechanism by which PIN1 promotes the development of PDAC remains unclear. Here we sought to elucidate the effect of PI...

journal_title：Cancer research

authors： Liang C,Shi S,Liu M,Qin Y,Meng Q,Hua J,Ji S,Zhang Y,Yang J,Xu J,Ni Q,Li M,Yu X

更新日期：2019-01-01 00:00:00

abstract：:Gene-targeting studies have shown that Delta-like 4 (Dll4) is required for normal embryonic vascular remodeling, but the mechanisms underlying Dll4 regulatory functions are not well defined. We generated primary human umbilical vascular endothelial cells that express Dll4 protein to study Dll4 function and previously ...

journal_title：Cancer research

authors： Williams CK,Segarra M,Sierra Mde L,Sainson RC,Tosato G,Harris AL

更新日期：2008-03-15 00:00:00

abstract：:We investigated primary human lung cancers resected surgically or obtained at autopsy. Included were squamous cell carcinoma (SQC) (five cases), adenocarcinoma (ADC) (six cases), large cell carcinoma (LCC) (four cases), and small cell carcinoma (SCC) (two cases). The objective of the study was to search for the presen...

journal_title：Cancer research

authors： Shigematsu K,Kataoka Y,Kamio T,Kurihara M,Niwa M,Tsuchiyama H

更新日期：1990-04-15 00:00:00

abstract：:Sixteen clones (RASK-1 to -16) of murine monoclonal antibodies were raised against ras Mr 21,000 protein (p21). The p21 produced by Escherichia coli with inserted v-Ki-ras genes was used as immunogen. RASK-1 was found to be specific for Ki-ras p21, whereas RASK-2 to -16 reacted with the p21s of Ki-, N-, and Ha-ras gen...

journal_title：Cancer research

authors： Yoshida K,Hamatani K,Koide H,Ikeda H,Nakamura N,Akiyama M,Tsuchiyama H,Nakayama E,Shiku H

更新日期：1988-10-01 00:00:00

abstract：:The specific delivery of radioisotopes to a tumor at minimal radiation of normal tissue is the ultimate aim of radioimmunotherapy. In this respect a two-step pretargeting regimen generally leads to an improved tumor to normal tissue uptake ratio compared to direct administration of radioimmunoconjugates. In this paper...

journal_title：Cancer research

authors： Bos ES,Kuijpers WH,Meesters-Winters M,Pham DT,de Haan AS,van Doornmalen AM,Kaspersen FM,van Boeckel CA,Gougeon-Bertrand F

更新日期：1994-07-01 00:00:00

abstract：:Normal young and postmenopausal women were placed into groups according to the ratio of the estrogens in their urine. Women whose ratio was greater than 1.3 if young and greater than 3.2 if postmenopausal were compared to women whose ratio was less than 0.7 and less than 2.1 for young and postmenopausal, respectively....

journal_title：Cancer research

authors： Longcope C,Pratt JH

更新日期：1978-11-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) functions as a tumor suppressor of the prostate through mechanisms that remain unresolved. Although TGF-beta receptors directly activate both Smads 2 and 3, to date, Smad3 has been shown to be the essential mediator of most Smad-dependent TGF-beta responses, including control...

journal_title：Cancer research

authors： Yang J,Wahdan-Alaswad R,Danielpour D

更新日期：2009-03-15 00:00:00

abstract：:Hybridoma-derived monoclonal anti-colorectal carcinoma antibodies suppressed the growth of colorectal carcinoma in nude mice as evidenced by a lower incidence of tumors, a longer latency period, and a smaller volume of tumors in antibody-treated than in control animals. The growth-inhibiting properties of monoclonal a...

journal_title：Cancer research

authors： Herlyn DM,Steplewski Z,Herlyn MF,Koprowski H

更新日期：1980-03-01 00:00:00

abstract：:Induction of T-cell activation requires multiple signals provided by cell surface receptor interactions and/or cytokines. T-cell stimulation via the T-cell receptor/CD3 complex provides an important initial activation event which, when combined with the proper costimulatory signals, results in an activated effector T ...

journal_title：Cancer research

authors： Kroesen BJ,Bakker A,van Lier RA,The HT,de Leij L

更新日期：1995-10-01 00:00:00

abstract：:A synergistic interaction of Bcl-2 and c-Myc plays a role in lymphomagenesis in mice and in some patients as well. Progression of follicular lymphoma to a more aggressive lymphoma is seen in the majority of patients, and approximately 10% of the transformed lymphomas have a translocation of c-myc in addition to the tr...

journal_title：Cancer research

authors： Arcinas M,Heckman CA,Mehew JW,Boxer LM

更新日期：2001-07-01 00:00:00

abstract：:Inflammation predisposes to tumorigenesis in various organs by potentiating a susceptibility to genetic aberrations. The mechanism underlying the enhanced genetic instability through chronic inflammation, however, is not clear. Here, we demonstrated that TNFα stimulation induced transcriptional downregulation of MSH2,...

journal_title：Cancer research

authors： Eso Y,Takai A,Matsumoto T,Inuzuka T,Horie T,Ono K,Uemoto S,Lee K,Edelmann W,Chiba T,Marusawa H

更新日期：2016-08-01 00:00:00

abstract：:This study investigates whether and to what extent cyclooxygenase type-2 (COX-2) and inducible nitric oxide-synthase (iNOS), both known to have an immunosuppressive effect, are expressed in human ovarian tumors. Because COX-2 and iNOS can be expressed by activated macrophages, the presence of tumor-associated macropha...

journal_title：Cancer research

authors： Klimp AH,Hollema H,Kempinga C,van der Zee AG,de Vries EG,Daemen T

更新日期：2001-10-01 00:00:00

abstract：:Epidemiologic data and animal experiments suggest that dietary fat may influence risk of breast cancer. To determine whether intervention with a low-fat, high-carbohydrate diet would reduce breast cancer incidence in women at increased risk of the disease, we carried out a randomized controlled trial in Canada. We rec...

journal_title：Cancer research

authors： Martin LJ,Li Q,Melnichouk O,Greenberg C,Minkin S,Hislop G,Boyd NF

更新日期：2011-01-01 00:00:00

abstract：:The antitumor effect of combined use of cis-diamminedichloroplatinum(II) (CDDP) and verapamil, a calcium influx blocker, was examined in neuroblastoma transplanted to BALB/c athymic mice. The response of the tumor to CDDP was related to the dose administered. Regression of the tumor was observed when CDDP was administ...

journal_title：Cancer research

authors： Ikeda H,Nakano G,Nagashima K,Sakamoto K,Harasawa N,Kitamura T,Nakamura T,Nagamachi Y

更新日期：1987-01-01 00:00:00

abstract：:Prostate cancer has become epidemic, and environmental factors such as cadmium may be partly responsible. This study reports malignant transformation of the nontumorigenic human prostatic epithelial cell line RWPE-1 by in vitro cadmium exposure. The cadmium-transformed cells exhibited a loss of contact inhibition in v...

journal_title：Cancer research

authors： Achanzar WE,Diwan BA,Liu J,Quader ST,Webber MM,Waalkes MP

更新日期：2001-01-15 00:00:00

abstract：:Male Wistar rats were given 50 mug of aflatoxin B1 twice a week for 4 weeks, and thereafter 75 mug twice a week for 10 weeks. Their livers were investigated histologically and histochemically for glycogen, RNA, fat, alkaline and acid phosphatases, adenosine triphosphatase, 5'-nucleotidase, glucose-6-phosphatase, gluco...

journal_title：Cancer research

authors： Kalengayi MM,Desmet VJ

更新日期：1975-10-01 00:00:00

abstract：:Neuroblastomas are extremely aggressive, although heterogeneous, cancers with a poor prognosis upon metastasis. Some evidence has suggested a correlative silencing of caspase-8 with MYCN amplification in neuroblastoma. A prognostic effect of this silencing, however, has been disputed. We report here hitherto undescrib...

journal_title：Cancer research

authors： Finlay D,Vuori K

更新日期：2007-12-15 00:00:00

abstract：:There is increasing evidence that high doses of radiotherapy, like those delivered in stereotactic body radiotherapy (SBRT), trigger indirect mechanisms of cell death. Such effect seems to be two-fold. High doses may trigger an immune response and may cause vascular damage, leading to cell starvation and death. Develo...

journal_title：Cancer research

authors： Rodríguez-Barbeito P,Díaz-Botana P,Gago-Arias A,Feijoo M,Neira S,Guiu-Souto J,López-Pouso Ó,Gómez-Caamaño A,Pardo-Montero J

更新日期：2019-12-01 00:00:00

abstract：:Intravesical mitomycin C (MMC) therapy is used to treat superficial bladder cancer. This study was to establish the intra- and intersubject variabilities in the systemic (plasma) and target site (bladder) exposure to the drug and to identify the factors which contribute to these variabilities. The pharmacokinetics of ...

journal_title：Cancer research

authors： Dalton JT,Wientjes MG,Badalament RA,Drago JR,Au JL

更新日期：1991-10-01 00:00:00