Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor.

abstract：:Data are presented in support of the hypothesis that malignant tumors, containing abnormally permeable, degenerating cells, can be selectively detected using monoclonal antibodies to intracellular antigens. Biodistribution, imaging, and autoradiographic studies were performed in nude mice transplanted with four differ...

journal_title：Cancer research

authors： Epstein AL,Chen FM,Taylor CR

更新日期：1988-10-15 00:00:00

abstract：:A method for the preparation of biologically active [3H]- and [13C]bleomycin A2 is described. Demethyl Cu(II):bleomycin A2, isolated after pyrolysis of Cu(II):bleomycin A2, was methylated with either [3H]-or [13C]methyl iodide, which resulted in Cu(II):bleomycin A2 labeled in the dimethylsulfonium moiety. Copper was r...

journal_title：Cancer research

authors： Roy SN,Orr GA,Brewer CF,Horwitz SB

更新日期：1981-11-01 00:00:00

abstract：:A phenolic amine compound, 4-S-cysteaminylphenol (4-S-CAP), is a potent depigmenting agent. To develop more efficacious antimelanoma agents, we synthesized four homologues of 4-S-CAP: N-acetyl-4-S-CAP (N-Ac-4-S-CAP), alpha-methyl-4-S-CAP, 4-S-homo-CAP, and N,N'-dimethyl-4-S-CAP. We tested these five compounds in mice ...

journal_title：Cancer research

authors： Alena F,Jimbow K,Ito S

更新日期：1990-06-15 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its agonistic antibodies, which are currently in early clinical trials for treating various malignancies, induce apoptosis through triggering of either TRAIL-R1 or TRAIL-R2. Based on studies using agonistic monoclonal antibodies, we recently proposed ...

journal_title：Cancer research

authors： MacFarlane M,Kohlhaas SL,Sutcliffe MJ,Dyer MJ,Cohen GM

更新日期：2005-12-15 00:00:00

abstract：:Epidemiological and animal studies suggest a role for calcium in the chemoprevention of colorectal neoplasia. This study was designed to investigate whether supplemental oral calcium has a suppressant effect on colonic mucosal ornithine decarboxylase (ODC) and tyrosine kinase activities in patients with adenomatous po...

journal_title：Cancer research

authors： Lans JI,Jaszewski R,Arlow FL,Tureaud J,Luk GD,Majumdar AP

更新日期：1991-07-01 00:00:00

abstract：:EBV-infected B-cell lymphomas are a potentially life-threatening complication in bone marrow and solid organ transplant recipients. Immunosuppressive drugs required to prevent allograft rejection also impair anti-EBV T-cell immunity, thereby increasing the risk of EBV-associated disease. Here we demonstrate that the i...

journal_title：Cancer research

authors： Nepomuceno RR,Balatoni CE,Natkunam Y,Snow AL,Krams SM,Martinez OM

更新日期：2003-08-01 00:00:00

abstract：:We studied the effect of the anticancer drug taxol on the cytotoxic mechanism of major histocompatibility complex nonrestricted lymphocytes and their activation with interleukin 2. Unseparated lymphocytes or highly enriched natural killer or T-cells were treated with 0.2-10 micrograms/ml of taxol for various times and...

journal_title：Cancer research

authors： Chuang LT,Lotzová E,Heath J,Cook KR,Munkarah A,Morris M,Wharton JT

更新日期：1994-03-01 00:00:00

abstract：:Immunization to multiple defined tumor antigens for specific immune therapy of human cancer has thus far proven difficult. Eighteen HLA A*0201(+) patients with metastatic melanoma received injections s.c. of CD34(+)progenitor-derived autologous dendritic cells (DCs), which included Langerhans cells. DCs were pulsed wi...

journal_title：Cancer research

authors： Banchereau J,Palucka AK,Dhodapkar M,Burkeholder S,Taquet N,Rolland A,Taquet S,Coquery S,Wittkowski KM,Bhardwaj N,Pineiro L,Steinman R,Fay J

更新日期：2001-09-01 00:00:00

abstract：:We are developing a noninvasive approach for targeting imaging and therapeutic radionuclides to prostate cancer. Our method, Enzyme-Mediated Cancer Imaging and Therapy (EMCIT), aims to use enzyme-dependent, site-specific, in vivo precipitation of a radioactive molecule within the extracellular space of solid tumors. A...

journal_title：Cancer research

authors： Pospisil P,Wang K,Al Aowad AF,Iyer LK,Adelstein SJ,Kassis AI

更新日期：2007-03-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor that secretes various angiogenic factors. The main inhibitor of plasminogen activators, PAI-1 (SERPINE1), has been implicated in tumor progression and angiogenesis, and high PAI-1 expression has been associated with poor prognosis in MPM patients. I...

journal_title：Cancer research

authors： Takayama Y,Hattori N,Hamada H,Masuda T,Omori K,Akita S,Iwamoto H,Fujitaka K,Kohno N

更新日期：2016-06-01 00:00:00

abstract：:The in vitro growth rates of different classifications of human mammary epithelium were compared. Samples included 4 established breast cell lines and excised tissue or breast fluid cells originating WOMEN FOR 40 DIFFERENT AND comprising 3 classifications: normal, nonmalignant atypical, and malignant. Growth was quant...

journal_title：Cancer research

authors： Buehring GC,Williams RR

更新日期：1976-10-01 00:00:00

abstract：:Modest clinical outcomes of dendritic cell (DC) vaccine trials call for novel strategies. In this study, we have created a chimeric CD40 molecule that incorporates a single chain Fv (scFv) molecule specific for human ErbB2 antigen and fusing to the membrane spanning and cytosolic domains of murine CD40. After adenovir...

journal_title：Cancer research

authors： Wei H,Wang H,Lu B,Li B,Hou S,Qian W,Fan K,Dai J,Zhao J,Guo Y

更新日期：2008-05-15 00:00:00

abstract：:The aim of this study was to evaluate to what extent tumor necrosis factor alpha (TNF-alpha) and interleukin 1 may explain the development of experimental cancer cachexia. For this purpose, C57BL/6J mice bearing a transplantable low differentiated rapidly growing tumor were passively immunized every other day with rab...

journal_title：Cancer research

authors： Gelin J,Moldawer LL,Lönnroth C,Sherry B,Chizzonite R,Lundholm K

更新日期：1991-01-01 00:00:00

abstract：:HsRec2/Rad51B is a 350-amino acid protein with a molecular mass of 38,300 Da that appears to be involved in cell cycle regulation and UV-induced apoptosis. The mouse and human genes were isolated based on their homology to a recombinational repair gene from Ustilago maydis and contain functional domains to hRAD51 and ...

journal_title：Cancer research

authors： Havre PA,Rice MC,Noe M,Kmiec EB

更新日期：1998-10-15 00:00:00

abstract：:The androgen receptor (AR) regulates gene transcription by binding to androgen response elements in target gene promoters. The prostate-specific antigen (PSA) gene has a polymorphic androgen response element sequence with two alleles, A and G. We hypothesize that allelic differences in AR-driven PSA expression may inf...

journal_title：Cancer research

authors： Xue W,Irvine RA,Yu MC,Ross RK,Coetzee GA,Ingles SA

更新日期：2000-02-15 00:00:00

abstract：:In vivo tumor cells interact with a variety of host cells such as endothelial cells and platelets, and these interactions are mediated by integrins GPIIb/IIIa and alphavbeta3. We used chimeric (c) 7E3 Fab (ReoPro) and murine (m) 7E3 F(ab')(2) to elucidate the role of these integrins in angiogenesis, tumor growth, and ...

journal_title：Cancer research

authors： Trikha M,Zhou Z,Timar J,Raso E,Kennel M,Emmell E,Nakada MT

更新日期：2002-05-15 00:00:00

abstract：:Several studies have suggested that calmodulin (CAM) levels increase in cells as a consequence of transformation by RNA tumor viruses. This study examines factors affecting CAM levels in normal and transformed chick embryo fibroblasts. Significant differences in CAM levels of normal and transformed cells were observed...

journal_title：Cancer research

authors： Veigl ML,Vanaman TC,Branch ME,Sedwick WD

更新日期：1984-08-01 00:00:00

abstract：:Although chrysotile asbestos is a proven human carcinogen, several studies have concluded that these fibers are not mutagenic to cultured mammalian cells. We show here, on the other hand, that when tested using the AL cell system that detects both intragenic and multilocus mutations, chrysotile is indeed mutagenic and...

journal_title：Cancer research

authors： Hei TK,Piao CQ,He ZY,Vannais D,Waldren CA

更新日期：1992-11-15 00:00:00

abstract：:WWOX is a tumor suppressor that functions as a modular protein partner of transcription factors. WWOX contains two WW domains that mediate protein-protein interactions. In this report, we show that WWOX, via its first WW domain, specifically associates with the proline-rich motif of c-Jun proto-oncogene. Our data show...

journal_title：Cancer research

authors： Gaudio E,Palamarchuk A,Palumbo T,Trapasso F,Pekarsky Y,Croce CM,Aqeilan RI

更新日期：2006-12-15 00:00:00

abstract：:Tumor production of parathyroid hormone-related protein (PTHRP) is responsible for most cases of hypercalcemia of malignancy. The transplantable rat Leydig tumor H-500 is known to cause hypercalcemia in rats by the release of abundant PTHRP and to closely reproduce the human syndrome. We have demonstrated recently tha...

journal_title：Cancer research

authors： Aklilu F,Gladu J,Goltzman D,Rabbani SA

更新日期：2000-03-15 00:00:00

abstract：:Ten patients with metastatic adenocarcinomas of the colon or pancreas were treated with multiple injections of monoclonal antibody 17.1A. For each injection, antibody concentration in the patients' sera plateaued during the entire treatment course, and then decreased, with faster antibody clearance in patients given p...

journal_title：Cancer research

authors： Blottière HM,Maurel C,Douillard JY

更新日期：1987-10-01 00:00:00

abstract：:Epigenetic changes in pediatric neuroblastoma may contribute to the aggressive pathophysiology of this disease, but little is known about the basis for such changes. In this study, we examined a role for the DNA methyltransferase DNMT3B, in particular, the truncated isoform DNMT3B7, which is generated frequently in ca...

journal_title：Cancer research

authors： Ostler KR,Yang Q,Looney TJ,Zhang L,Vasanthakumar A,Tian Y,Kocherginsky M,Raimondi SL,DeMaio JG,Salwen HR,Gu S,Chlenski A,Naranjo A,Gill A,Peddinti R,Lahn BT,Cohn SL,Godley LA

更新日期：2012-09-15 00:00:00

abstract：:Loss of imprinting (LOI) of the insulin-like growth factor II (IGFII) gene is a frequent phenomenon in colorectal tumor tissues. Previous reports indicated that subjects with colorectal neoplasias show LOI of IGFII in circulating lymphocytes. Furthermore, LOI of IGFII is strongly related to the methylation of a differ...

journal_title：Cancer research

authors： Kaaks R,Stattin P,Villar S,Poetsch AR,Dossus L,Nieters A,Riboli E,Palmqvist R,Hallmans G,Plass C,Friesen MD

更新日期：2009-07-01 00:00:00

abstract：:Several members of the kinesin family of microtubule motor proteins play essential roles in mitotic spindle function and are potential targets for the discovery of novel antimitotic cancer therapies. KSP, also known as HsEg5, is a kinesin that plays an essential role in formation of a bipolar mitotic spindle and is re...

journal_title：Cancer research

authors： Sakowicz R,Finer JT,Beraud C,Crompton A,Lewis E,Fritsch A,Lee Y,Mak J,Moody R,Turincio R,Chabala JC,Gonzales P,Roth S,Weitman S,Wood KW

更新日期：2004-05-01 00:00:00

abstract：:The interaction of hypoxia-inducible factor 1alpha and the CH1 domain of the transcriptional coactivator p300/CBP is necessary for the expression of hypoxia responsive genes and tumor angiogenesis. The transcription factor CITED2 binds p300/CBP at the CH1 domain and functions as a negative regulator of hypoxia signali...

journal_title：Cancer research

authors： Fox SB,Bragança J,Turley H,Campo L,Han C,Gatter KC,Bhattacharya S,Harris AL

更新日期：2004-09-01 00:00:00

abstract：:The pharmacokinetic disposition of tiazofurin in plasma and cerebrospinal fluid was examined in rhesus monkeys. Tiazofurin was readily detectable in both plasma and cerebrospinal fluid within 20 min of commencement and for 24 h after a short i.v. infusion of the drug. The mean clearance of tiazofurin from plasma was 7...

journal_title：Cancer research

authors： Grygiel JJ,Balis FM,Collins JM,Lester CM,Poplack DG

更新日期：1985-05-01 00:00:00

abstract：:Breast cancer is a heterogeneous disease with distinct molecular subtypes characterized by differential response to targeted and chemotherapeutic agents. Enhanced understanding of the genetic alterations characteristic of different subtypes is needed to pave the way for more personalized administration of therapeutic ...

journal_title：Cancer research

authors： O'Brien C,Cavet G,Pandita A,Hu X,Haydu L,Mohan S,Toy K,Rivers CS,Modrusan Z,Amler LC,Lackner MR

更新日期：2008-07-01 00:00:00

abstract：:To study antitumor functions of T-lymphocyte subpopulations in the blood [peripheral blood lymphocytes (PBLs)] and tumor-draining lymph nodes (LNs) of patients (n = 26) with squamous cell carcinoma of the head and neck (SCCHN), antibody-coated devices were used to positively select CD8+ or CD4+ cells. The mean percent...

journal_title：Cancer research

authors： Letessier EM,Heo DS,Okarma T,Johnson JT,Herberman RB,Whiteside TL

更新日期：1991-08-01 00:00:00

abstract：:We analyzed a case-control study of bladder cancer in Torino (512 male and 55 female cases; 596 male and 202 female controls) with emphasis on the timing of cigarette smoking and the use of black or blond tobacco. The risk of bladder cancer was 2 to 3 times higher among smokers of black tobacco than among smokers of b...

journal_title：Cancer research

authors： Vineis P,Esteve J,Hartge P,Hoover R,Silverman DT,Terracini B

更新日期：1988-07-01 00:00:00

abstract：:Cells lacking the tumor suppressor gene LKB1/STK11 alter their metabolism to match the demands of accelerated growth, leaving them highly vulnerable to stress. However, targeted therapy for LKB1-deficient cancers has yet to be reported. In both Kras/p53/Lkb1 cell lines and a genetically engineered mouse model of Kras/...

journal_title：Cancer research

authors： Liu Y,Li Y,Wang X,Liu F,Gao P,Quinn MM,Li F,Merlino AA,Benes C,Liu Q,Gray NS,Wong KK

更新日期：2017-09-15 00:00:00