Abstract：
:Prostate cancer has become epidemic, and environmental factors such as cadmium may be partly responsible. This study reports malignant transformation of the nontumorigenic human prostatic epithelial cell line RWPE-1 by in vitro cadmium exposure. The cadmium-transformed cells exhibited a loss of contact inhibition in vitro and rapidly formed highly invasive and occasionally metastatic adenocarcinomas upon inoculation into mice. The transformed cells also showed increased secretion of MMP-2 and MMP-9, a phenomenon observed in human prostate tumors and linked to aggressive behavior. Cadmium-induced malignant transformation of human prostate epithelial cells strongly fortifies the evidence for a potential role of cadmium in prostate cancer.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Achanzar WE,Diwan BA,Liu J,Quader ST,Webber MM,Waalkes MPsubject
Has Abstractpub_date
2001-01-15 00:00:00pages
455-8issue
2eissn
0008-5472issn
1538-7445journal_volume
61pub_type
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