Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells.

abstract：:Integrin β3 is critical for tumor invasion, neoangiogenesis, and inflammation, making it a promising cancer target. However, preclinical and clinical data of integrin β3 antagonists have demonstrated no benefit or worse outcomes. We hypothesized that integrin β3 could affect tumor immunity and evaluated tumors in mice...

journal_title：Cancer research

authors： Su X,Esser AK,Amend SR,Xiang J,Xu Y,Ross MH,Fox GC,Kobayashi T,Steri V,Roomp K,Fontana F,Hurchla MA,Knolhoff BL,Meyer MA,Morgan EA,Tomasson JC,Novack JS,Zou W,Faccio R,Novack DV,Robinson SD,Teitelbaum SL,DeNar

更新日期：2016-06-15 00:00:00

abstract：:Two monoclonal antibodies, OC 125 and OC 133, bind to distinct determinants on the surface of human epithelial ovarian carcinoma cell lines. OC 125 and OC 133 recognize determinants on molecules with molecular weights greater than 200,000 and 80,000, respectively. When binding to four different cell lines was compared...

journal_title：Cancer research

authors： Masuho Y,Zalutsky M,Knapp RC,Bast RC Jr

更新日期：1984-07-01 00:00:00

abstract：:The mechanisms by which estrogens and antiestrogens modulate breast cancer growth have not been totally defined. We have examined the cell cycle kinetic effects of estrogens and antiestrogens in cultured human breast cancer cell lines. In a previous study, we showed that tamoxifen induces a transition delay in early t...

journal_title：Cancer research

authors： Osborne CK,Boldt DH,Estrada P

更新日期：1984-04-01 00:00:00

abstract：:The c-Fes protein-tyrosine kinase exhibits strong expression in myeloid hematopoietic cells. Previous studies have shown that Fes induces differentiation in the chronic myelogenous leukemia-derived cell line K-562, suggesting that the Fes signal for differentiation is dominant to the Bcr-Abl signal for transformation ...

journal_title：Cancer research

authors： Lionberger JM,Smithgall TE

更新日期：2000-02-15 00:00:00

abstract：:The p53 gene has been implicated as a tumor suppressor gene involved in the pathogenesis of lung cancer. Our previous study revealed that the p53 gene is frequently mutated with a distinct nucleotide substitution pattern in small cell lung cancer specimens in Japanese patients. In this study, we examined 30 primary, r...

journal_title：Cancer research

authors： Suzuki H,Takahashi T,Kuroishi T,Suyama M,Ariyoshi Y,Takahashi T,Ueda R

更新日期：1992-02-01 00:00:00

abstract：:The role of acidic glycosphingolipids in cell growth and differentiation was investigated using the multipotent leukemia cell line K562. When GM3 was added to cell culture media, the growth of K562 cells was remarkably inhibited and the cells were shown to have megakaryocytoid morphology. Ultrastructural study demonst...

journal_title：Cancer research

authors： Nakamura M,Kirito K,Yamanoi J,Wainai T,Nojiri H,Saito M

更新日期：1991-04-01 00:00:00

abstract：:Pleural fluid from a child previously treated for rhabdomyosarcoma produced colonies in vitro. Cells from these colonies appeared to have the light and electron microscopic appearance of rhabdomyosarcoma cells. In this case, the malignant nature of the effusion had been suspected because of the patient's previous hist...

journal_title：Cancer research

authors： Altman AJ,Crussi FG,Rierden WJ,Baehner RL

更新日期：1975-07-01 00:00:00

abstract：:We have previously shown that N-cadherin expression is associated with tumor invasion, and that some cancer cells respond to specific extracellular matrix molecules by up-regulating N-cadherin. Pancreatic cancer is characterized by excessive deposition of type I collagen. Here, we show that human pancreatic cancer cel...

journal_title：Cancer research

authors： Shintani Y,Hollingsworth MA,Wheelock MJ,Johnson KR

更新日期：2006-12-15 00:00:00

abstract：:Despite esophageal adenocarcinoma (EAC) being the most widespread among gastrointestinal cancers, with an 11-fold increase in the risk of cancer for patients with Barrett esophagus (BE), its prognosis is still poor. There is a critical need to better perceive the biology of cancer progression and identification of spe...

journal_title：Cancer research

authors： Urbanska AM,Ponnazhagan S,Mozafari M

更新日期：2018-07-15 00:00:00

abstract：:The estimated growth rates for five lines of human fibroblasts (Human Genetic Mutant Cell Repository designations 0011, 2936B , 0038A , 2912A , and 3529), during the first few population doublings after establishment of the lines, were within the expected range, i.e., equivalent to doubling times from 16 to 28 hr, wit...

journal_title：Cancer research

authors： Tamm I,Kikuchi T,Wang E,Pfeffer LM

更新日期：1984-06-01 00:00:00

abstract：:The i.p. inoculation of C3H mice with 5 times 10-6 cells of a transplantable ovarian carcinoma invariably evokes accumulation of large amounts of ascitic fluid. Histological and pharmacotherapeutic studies indicate that obstruction to peritoneal lymphatic drainage is a key factor in the formation of carcinomatous asci...

journal_title：Cancer research

authors： Feldman GB

更新日期：1975-02-01 00:00:00

abstract：:The aim of this study was to evaluate the promoter methylation status and loss of heterozygosity (LOH) of the SEMA3B in non-small cell lung cancers (NSCLCs). We analyzed the methylation status of semaphorin 3B (SEMA3B) promoter and LOH at 3p21.3 in eight NSCLC cell lines and 27 primary tumors. Hypermethylation of SEMA...

journal_title：Cancer research

authors： Kuroki T,Trapasso F,Yendamuri S,Matsuyama A,Alder H,Williams NN,Kaiser LR,Croce CM

更新日期：2003-06-15 00:00:00

abstract：:Stem cells are under strict regulation by both intrinsic factors and the microenvironment. There is increasing evidence that many cancers initiate through acquisition of genetic mutations (loss of intrinsic control) in stem cells or their progenitors, followed by alterations of the surrounding microenvironment (loss o...

journal_title：Cancer research

authors： Le LQ,Liu C,Shipman T,Chen Z,Suter U,Parada LF

更新日期：2011-07-01 00:00:00

abstract：:We compared the effect of nine N-nitroso compounds, given by gavage to adult rats, on specific radioactivity of the trichloroacetic acid-precipitable liver proteins, 1 hr after the injection of [14C]leucine. The specific radioactivity was decreased by dimethylnitrosamine, diethylnitrosamine, methyl-n-butylnitrosamine,...

journal_title：Cancer research

authors： Chu C,Mirvish SS

更新日期：1977-05-01 00:00:00

abstract：:The evidence for tumor suppressor genes at 8p is well supported by many somatic deletion studies and genetic linkage studies. However, it remains a challenge to pinpoint the tumor suppressor genes at 8p primarily because the implicated regions are broad. In this study, we attempted to narrow down the implicated region...

journal_title：Cancer research

authors： Chang BL,Liu W,Sun J,Dimitrov L,Li T,Turner AR,Zheng SL,Isaacs WB,Xu J

更新日期：2007-05-01 00:00:00

abstract：:The conditions for growing preneoplastic mammary epithelial cells in primary cell cultures with serum-free factor-defined medium were established in a series of experiments. The cells, grown in Dulbecco's modified Eagle's medium with 0.6 mM Ca2+, epidermal growth factor, transferrin, insulin, and Na2SeO3, were fibrobl...

journal_title：Cancer research

authors： Medina D,Oborn CJ

更新日期：1980-11-01 00:00:00

abstract：:It is well established that small cell lung carcinomas (SCLCs) express receptors for acetylcholine (ACh) and that stimulation of these receptors by nicotine or other cholinergic agonists stimulates cell growth via activation of nicotinic cholinergic receptors (nAChRs) and/or muscarinic cholinergic receptors (mAChRs). ...

journal_title：Cancer research

authors： Song P,Sekhon HS,Jia Y,Keller JA,Blusztajn JK,Mark GP,Spindel ER

更新日期：2003-01-01 00:00:00

abstract：:Current standard of care for patients with pediatric acute lymphoblastic leukemia (ALL) is mainly effective, with high remission rates after treatment. However, the genetic perturbations that give rise to this disease remain largely undefined, limiting the ability to address resistant tumors or develop less toxic targ...

journal_title：Cancer research

authors： Ding LW,Sun QY,Tan KT,Chien W,Mayakonda A,Yeoh AEJ,Kawamata N,Nagata Y,Xiao JF,Loh XY,Lin DC,Garg M,Jiang YY,Xu L,Lim SL,Liu LZ,Madan V,Sanada M,Fernández LT,Hema Preethi SS,Lill M,Kantarjian HM,Kornblau SM,

更新日期：2017-01-15 00:00:00

abstract：:To understand the biological basis of resistance to endocrine therapy is of utmost importance in patients with steroid hormone receptor-positive breast cancer. Not only will this allow us prediction of therapy success, it may also lead to novel therapies for patients resistant to current endocrine therapy. DNA methyla...

journal_title：Cancer research

authors： Martens JW,Nimmrich I,Koenig T,Look MP,Harbeck N,Model F,Kluth A,Bolt-de Vries J,Sieuwerts AM,Portengen H,Meijer-Van Gelder ME,Piepenbrock C,Olek A,Höfler H,Kiechle M,Klijn JG,Schmitt M,Maier S,Foekens JA

更新日期：2005-05-15 00:00:00

abstract：:The pharmacokinetic disposition of tiazofurin in plasma and cerebrospinal fluid was examined in rhesus monkeys. Tiazofurin was readily detectable in both plasma and cerebrospinal fluid within 20 min of commencement and for 24 h after a short i.v. infusion of the drug. The mean clearance of tiazofurin from plasma was 7...

journal_title：Cancer research

authors： Grygiel JJ,Balis FM,Collins JM,Lester CM,Poplack DG

更新日期：1985-05-01 00:00:00

abstract：:The breast cancer susceptibility gene BRCA2 is expressed in a wide range of tissues as an 11-kb mRNA transcript encoding a 3418-amino acid protein, which is involved in the response to DNA damage. To obtain a better molecular characterization of BRCA2 expression in breast tissue, we analyzed full-length BRCA2 mRNA by ...

journal_title：Cancer research

authors： Bièche I,Lidereau R

更新日期：1999-06-01 00:00:00

abstract：:The ability of glucocorticoids (GCs) to induce death in lymphoid-origin cells is the basis for their frequent use in the therapy of various human hematological malignancies. However, the occurrence of primary or secondary GC resistance limits their clinical usefulness. Prior investigations into the mechanism of GC res...

journal_title：Cancer research

authors： Geley S,Hartmann BL,Hala M,Strasser-Wozak EM,Kapelari K,Kofler R

更新日期：1996-11-01 00:00:00

abstract：:Cancer cells with germline deleterious mutations of BRCA1 or BRCA2 are deficient in homologous recombination repair and therefore sensitive to PARP inhibitor treatment. However, wild-type BRCA1/2-expressing cells with defects in other DNA damage repair pathway components may also exhibit "BRCAness," which in combinati...

journal_title：Cancer research

authors： Cai C

更新日期：2020-07-15 00:00:00

abstract：:Successful chemotherapy accounts for both tumor-related factors and host immune response. Compelling evidence suggests that some chemotherapeutic agents can induce an immunogenic type of cell death stimulating tumor-specific immunity. Here, we show that cyclophosphamide (CTX) exerts two types of actions relevant for t...

journal_title：Cancer research

authors： Schiavoni G,Sistigu A,Valentini M,Mattei F,Sestili P,Spadaro F,Sanchez M,Lorenzi S,D'Urso MT,Belardelli F,Gabriele L,Proietti E,Bracci L

更新日期：2011-02-01 00:00:00

abstract：:The role of oxygen free radicals in the toxicity and antitumor effect of tumor necrosis factor was investigated in vivo. Treatment of non-tumor-bearing mice and mice bearing methylcholanthrene-induced sarcomas with bovine CuZn superoxide dismutase or recombinant human CuZn superoxide dismutase afforded significant pro...

journal_title：Cancer research

authors： Hauser GJ,McIntosh JK,Travis WD,Rosenberg SA

更新日期：1990-06-15 00:00:00

abstract：:Pyrazine diazohydroxide (PZDH) is a novel antineoplastic agent that appears to form DNA adducts via the reactive pyrazine diazonium ion and produces substantial antitumor activity in preclinical models. We conducted a phase I trial to determine the maximally tolerated dose of PZDH that could be administered as a 5-min...

journal_title：Cancer research

authors： Vogelzang NJ,Mick R,Janisch L,Berezin F,Schilsky RL,Ratain MJ

更新日期：1994-01-01 00:00:00

abstract：:Multiple myeloma is a B-cell malignancy for which no curative therapies exist to date, despite enormous research efforts. The remarkable activity of the proteasome inhibitor bortezomib (PS-341, Velcade) observed in clinical trials of patients with relapsed refractory myeloma has led to investigations of the role of th...

journal_title：Cancer research

authors： Altun M,Galardy PJ,Shringarpure R,Hideshima T,LeBlanc R,Anderson KC,Ploegh HL,Kessler BM

更新日期：2005-09-01 00:00:00

abstract：:Ewing sarcoma is a rare but aggressive disease most common in young adults. This cancer is driven by a unique chimeric fusion oncogene but targeted strategies have been elusive. Here we report the identification of the protein kinase PKC-ß (PRKCB) as a disease-specific druggable target for treatment of Ewing sarcoma. ...

journal_title：Cancer research

authors： Surdez D,Benetkiewicz M,Perrin V,Han ZY,Pierron G,Ballet S,Lamoureux F,Rédini F,Decouvelaere AV,Daudigeos-Dubus E,Geoerger B,de Pinieux G,Delattre O,Tirode F

更新日期：2012-09-01 00:00:00

abstract：:We recently identified the immunoglobulin-CAM CD155/PVR (the poliovirus receptor) as a regulator of cancer invasiveness and glioma migration, but the mechanism through which CD155/PVR controls these processes is unknown. Here, we show that expression of CD155/PVR in rat glioma cells that normally lack this protein enh...

journal_title：Cancer research

authors： Sloan KE,Stewart JK,Treloar AF,Matthews RT,Jay DG

更新日期：2005-12-01 00:00:00

abstract：:In a study of human breast carcinomas in short-term organ culture, in which plasminogen activator modulation by estrogen was used as a test of estrogen sensitivity (R. Mira-y-Lopez and L. Ossowski, Cancer Res., 47: 3558-3564, 1987), we found that the number of estrogen and progesterone receptor-positive cancers showin...

journal_title：Cancer research

authors： Mira-y-Lopez R,Ossowski L

更新日期：1990-01-01 00:00:00